{"id":"https://openalex.org/W1995017465","doi":"https://doi.org/10.2174/156720111797635513","title":"The Release and Induced Immune Responses of a Plant-Made and Delivered Antigen in the Mouse Gut","display_name":"The Release and Induced Immune Responses of a Plant-Made and Delivered Antigen in the Mouse Gut","publication_year":2011,"publication_date":"2011-10-10","ids":{"openalex":"https://openalex.org/W1995017465","doi":"https://doi.org/10.2174/156720111797635513","mag":"1995017465","pmid":"https://pubmed.ncbi.nlm.nih.gov/21864256"},"language":"en","primary_location":{"id":"doi:10.2174/156720111797635513","doi":"https://doi.org/10.2174/156720111797635513","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156720111797635513","pdf_url":null,"source":{"id":"https://openalex.org/S16973894","display_name":"Current Drug Delivery","issn_l":"1567-2018","issn":["1567-2018","1875-5704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Assunta Pelosi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Assunta Pelosi","raw_affiliation_strings":["School of Biological Sciences, Monash University, Clayton, Victoria, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Monash University, Clayton, Victoria, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060511656","display_name":"Robert Shepherd","orcid":"https://orcid.org/0000-0003-3152-3122","observed_orcids":["https://orcid.org/0000-0003-3152-3122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Shepherd","raw_affiliation_strings":["School of Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076812952","display_name":"Giorgio De Guzman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giorgio De Guzman","raw_affiliation_strings":["School of Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113974820","display_name":"John D. Hamill","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John D. Hamill","raw_affiliation_strings":["School of Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088496687","display_name":"Els N.T. Meeusen","orcid":"https://orcid.org/0000-0003-1239-6287","observed_orcids":["https://orcid.org/0000-0003-1239-6287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Els Meeusen","raw_affiliation_strings":["Physiology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048684148","display_name":"Gordon Sanson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon Sanson","raw_affiliation_strings":["School of Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028062856","display_name":"Amanda Maree Walmsley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Amanda M. Walmsley","raw_affiliation_strings":["School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia.,Australia","School of Biological Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biological Sciences, Monash University, Clayton, Victoria 3800, Australia.,Australia","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"School of Biological Sciences","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.912,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.80734419,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"6","first_page":"612","last_page":"621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plant-based-vaccines","display_name":"plant-made vaccines","score":0.8320000171661377},{"id":"https://openalex.org/keywords/oral-vaccine-delivery","display_name":"oral vaccine delivery","score":0.777999997138977},{"id":"https://openalex.org/keywords/antigen-release","display_name":"antigen release","score":0.8600000143051147},{"id":"https://openalex.org/keywords/hairy-roots","display_name":"hairy roots","score":0.7979999780654907},{"id":"https://openalex.org/keywords/leaves","display_name":"leaves","score":0.5329999923706055},{"id":"https://openalex.org/keywords/fruits","display_name":"fruits","score":0.6309999823570251},{"id":"https://openalex.org/keywords/lipid-based-formulations","display_name":"lipid-based formulations","score":0.8930000066757202},{"id":"https://openalex.org/keywords/antigen-encapsulation","display_name":"antigen encapsulation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/mucosal-immune-response","display_name":"mucosal immune response","score":0.7390000224113464},{"id":"https://openalex.org/keywords/systemic-immune-response","display_name":"systemic immune response","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gastrointestinal-tract","display_name":"gastrointestinal tract","score":0.7279999852180481},{"id":"https://openalex.org/keywords/immunogenicity","display_name":"immunogenicity","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7672443389892578},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6615584492683411},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5354663729667664},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41094696521759033}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000907","descriptor_name":"Antibodies, Bacterial","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001424","descriptor_name":"Bacterial Infections","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004768","descriptor_name":"Enterotoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014611","descriptor_name":"Vaccination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018928","descriptor_name":"Immunity, Mucosal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019684","descriptor_name":"Magnoliopsida","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019684","descriptor_name":"Magnoliopsida","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060054","descriptor_name":"Agrobacterium","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D060054","descriptor_name":"Agrobacterium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2174/156720111797635513","doi":"https://doi.org/10.2174/156720111797635513","is_oa":false,"landing_page_url":"https://doi.org/10.2174/156720111797635513","pdf_url":null,"source":{"id":"https://openalex.org/S16973894","display_name":"Current Drug Delivery","issn_l":"1567-2018","issn":["1567-2018","1875-5704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Delivery","raw_type":"journal-article"},{"id":"pmid:21864256","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21864256","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug delivery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1964246821","https://openalex.org/W1974103061","https://openalex.org/W1978909811","https://openalex.org/W1980475055","https://openalex.org/W1988957510","https://openalex.org/W1994093841","https://openalex.org/W1997354058","https://openalex.org/W2003384499","https://openalex.org/W2009083280","https://openalex.org/W2024556021","https://openalex.org/W2025104339","https://openalex.org/W2036680634","https://openalex.org/W2045439285","https://openalex.org/W2045946307","https://openalex.org/W2046739387","https://openalex.org/W2054480634","https://openalex.org/W2059087130","https://openalex.org/W2065035248","https://openalex.org/W2074807817","https://openalex.org/W2084529148","https://openalex.org/W2087295288","https://openalex.org/W2093059427","https://openalex.org/W2098425163","https://openalex.org/W2139357859","https://openalex.org/W2148995643","https://openalex.org/W2150946801","https://openalex.org/W2162425865","https://openalex.org/W2314359712","https://openalex.org/W2465375028"],"related_works":["https://openalex.org/W2089797687","https://openalex.org/W2024049958","https://openalex.org/W1982676247","https://openalex.org/W2491695726","https://openalex.org/W1974103061","https://openalex.org/W2592914824","https://openalex.org/W2020316159","https://openalex.org/W84446816","https://openalex.org/W2080299794","https://openalex.org/W2136395496"],"abstract_inverted_index":{"This":[0],"study":[1],"investigated":[2],"the":[3,16,62,92,99,102,128,139,146,181,193],"site":[4,171],"of":[5,7,47,61,98,136,172,180],"release":[6,49,56,83,135,173],"a":[8],"model":[9,182],"vaccine":[10,119,131],"antigen":[11,48,55,82,100,107,137,183],"from":[12,84,127,133],"plant":[13,22,51,86,93,169,185],"cells":[14,52],"and":[15,26,29,33,70,105,121,178,196],"corresponding":[17],"induced":[18,126,150],"immune":[19,124,148,199],"response.":[20],"Three":[21],"tissues":[23],"(leaf,":[24],"fruit":[25],"hairy":[27,77],"root)":[28],"two":[30,38],"formulations":[31,80],"(aqueous":[32],"lipid)":[34],"were":[35,154],"compared":[36],"in":[37,67,76,91,101,138,184,188],"mouse":[39,140],"trials.":[40],"A":[41],"developed":[42],"technique":[43],"that":[44,54],"enabled":[45],"detection":[46],"by":[50,151,160],"determined":[53,159],"occurred":[57],"at":[58,71],"early":[59],"sites":[60,73],"gastrointestinal":[63,103,141],"tract":[64,104],"when":[65,74],"delivered":[66,75,130],"leaf":[68],"material":[69,186],"later":[72],"roots.":[78],"Lipid":[79],"delayed":[81],"all":[85],"materials":[87],"tested.":[88],"While":[89],"encapsulation":[90],"cell":[94],"provided":[95,192],"some":[96],"protection":[97],"influenced":[106],"release,":[108],"formulation":[109,175,191],"medium":[110],"was":[111],"also":[112],"an":[113,189],"important":[114],"consideration":[115],"with":[116,164],"regard":[117],"to":[118,145,157],"delivery":[120,179],"immunogenicity.":[122],"Systemic":[123],"responses":[125],"orally":[129],"benefited":[132],"late":[134],"tract.":[142],"The":[143],"influences":[144],"mucosal":[147],"response":[149],"these":[152],"vaccines":[153],"too":[155],"complex":[156],"be":[158],"studies":[161],"performed":[162],"here":[163],"no":[165],"clear":[166],"trend":[167],"regarding":[168],"tissue":[170],"or":[174],"medium.":[176],"Expression":[177],"prepared":[187],"aqueous":[190],"optimal":[194],"systemic":[195],"mucosal,":[197],"antigen-specific":[198],"responses.":[200]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
