{"id":"https://openalex.org/W1995006259","doi":"https://doi.org/10.1136/hrt.2010.208967.519","title":"e0519 Rapamycin suppress Kr\u00dcppel-Like Factor 2 expression: mechanism of endothelial dysfunction associated with drug-eluting stents","display_name":"e0519 Rapamycin suppress Kr\u00dcppel-Like Factor 2 expression: mechanism of endothelial dysfunction associated with drug-eluting stents","publication_year":2010,"publication_date":"2010-10-01","ids":{"openalex":"https://openalex.org/W1995006259","doi":"https://doi.org/10.1136/hrt.2010.208967.519","mag":"1995006259"},"language":"en","primary_location":{"id":"doi:10.1136/hrt.2010.208967.519","doi":"https://doi.org/10.1136/hrt.2010.208967.519","is_oa":true,"landing_page_url":"https://doi.org/10.1136/hrt.2010.208967.519","pdf_url":"https://heart.bmj.com/content/heartjnl/96/Suppl_3/A161.3.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://heart.bmj.com/content/heartjnl/96/Suppl_3/A161.3.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ma Qian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ma Qian","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103221264","display_name":"Z. Yujie","orcid":"https://orcid.org/0000-0003-1392-3069","observed_orcids":["https://orcid.org/0000-0003-1392-3069"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Yujie","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nie Xiaomin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nie Xiaomin","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050659313","display_name":"Yazhou Miao","orcid":"https://orcid.org/0000-0002-4803-7035","observed_orcids":["https://orcid.org/0000-0002-4803-7035"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Miao","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044290945","display_name":"Gao Fei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gao Fei","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076083707","display_name":"Wang Zhijian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wang Zhijian","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113532982","display_name":"Nie Bin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nie Bin","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102289268","display_name":"Yan Zhenxian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhenxian","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070172927","display_name":"Hailong Ge","orcid":"https://orcid.org/0000-0002-8349-985X","observed_orcids":["https://orcid.org/0000-0002-8349-985X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ge Hailong","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068665833","display_name":"Jia Dean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jia Dean","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059127720","display_name":"Yang Shiwei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Shiwei","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Liu Xiaoli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liu Xiaoli","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028795541","display_name":"Han Hongya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Han Hongya","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]},{"author_position":"last","author":{"id":null,"display_name":"Hu Bin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210119028","display_name":"Beijing Anzhen Hospital","ror":"https://ror.org/02h2j1586","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210119028"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hu Bin","raw_affiliation_strings":["Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210119028"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"96","issue":"Suppl 3","first_page":"A161.3","last_page":"A161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13426","display_name":"Kruppel-like factors research","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.17960000038146973,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":1.0},{"id":"https://openalex.org/keywords/drug-eluting-stents","display_name":"drug-eluting stents","score":0.9089999794960022},{"id":"https://openalex.org/keywords/klf2","display_name":"KLF2","score":0.9150000214576721},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8529999852180481},{"id":"https://openalex.org/keywords/stent-thrombosis","display_name":"stent thrombosis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-nitric-oxide-synthase","display_name":"endothelial nitric oxide synthase","score":0.9850000143051147},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.9909999966621399},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/coronary-endothelium","display_name":"coronary endothelium","score":0.5419999957084656}],"concepts":[{"id":"https://openalex.org/C2777350992","wikidata":"https://www.wikidata.org/wiki/Q18035329","display_name":"KLF2","level":4,"score":0.9446718692779541},{"id":"https://openalex.org/C2778326061","wikidata":"https://www.wikidata.org/wiki/Q1761022","display_name":"Enos","level":4,"score":0.7693169116973877},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.7567106485366821},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.7003739476203918},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.6362917423248291},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6182147264480591},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.5355173945426941},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4871682822704315},{"id":"https://openalex.org/C2777151630","wikidata":"https://www.wikidata.org/wiki/Q14878075","display_name":"Tissue factor pathway inhibitor","level":4,"score":0.48357221484184265},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4762275815010071},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.46668586134910583},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38153570890426636},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3587726652622223},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33806711435317993},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3313755989074707},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24311122298240662},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1386154294013977},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.13026565313339233},{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.11984452605247498},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.07776999473571777},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07242429256439209},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/hrt.2010.208967.519","doi":"https://doi.org/10.1136/hrt.2010.208967.519","is_oa":true,"landing_page_url":"https://doi.org/10.1136/hrt.2010.208967.519","pdf_url":"https://heart.bmj.com/content/heartjnl/96/Suppl_3/A161.3.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1136/hrt.2010.208967.519","doi":"https://doi.org/10.1136/hrt.2010.208967.519","is_oa":true,"landing_page_url":"https://doi.org/10.1136/hrt.2010.208967.519","pdf_url":"https://heart.bmj.com/content/heartjnl/96/Suppl_3/A161.3.full.pdf","source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1995006259.pdf","grobid_xml":"https://content.openalex.org/works/W1995006259.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2067757913","https://openalex.org/W7095602853","https://openalex.org/W2109048031","https://openalex.org/W2090329722","https://openalex.org/W2415458927","https://openalex.org/W1967481270","https://openalex.org/W2074934448","https://openalex.org/W1921639537","https://openalex.org/W2049812539","https://openalex.org/W2134738156"],"abstract_inverted_index":{"Objects":[0],"Although":[1],"rapamycin":[2,54,145,194],"released":[3],"from":[4],"drug-eluting":[5],"stents":[6],"(DESs)":[7],"affect":[8],"the":[9,15,51,89,123,197],"antithrombogenic":[10],"function":[11],"of":[12,36,53,57,85,110,127,168,199,231,233],"endothelial":[13,37,59,141,224],"cells,":[14],"exactly":[16],"mechanisms":[17],"underlying":[18],"these":[19],"effects":[20],"are":[21],"incompletely":[22],"understood.":[23],"We":[24,49],"hypothesised":[25],"that":[26,193],"Kr\u00fcppel-Like":[27],"Factor":[28],"2":[29],"(KLF2),":[30],"a":[31,229],"novel":[32],"and":[33,71,93,98,104,125,133,149,154,160,165,173,176,179,205,207,211],"potent":[34],"regulator":[35],"gene":[38],"expression,":[39,181],"might":[40,227],"play":[41],"an":[42,215],"important":[43,216],"role":[44,217],"in":[45,75,218],"stent":[46,219,234],"thrombosis.":[47],"Methods":[48],"observed":[50],"effect":[52],"on":[55],"expression":[56,124,175,198],"KLF2,":[58,86,200],"NO":[60],"synthase":[61],"(eNOS),":[62],"tissue-plasminogen":[63],"activator":[64,67],"(t-PA),":[65],"plasminogen":[66],"inhibitor":[68],"1":[69],"(PAI-1)":[70],"tissue":[72],"factor":[73],"(TF)":[74],"Human":[76],"Umbilical":[77],"Vein":[78],"Endothelial":[79],"Cells":[80],"(HUVECs).":[81],"Then,":[82],"with":[83,237],"overexpression":[84],"we":[87],"mensurated":[88,101],"above":[90],"mentioned":[91],"mRNA":[92,97],"protein,":[94],"respectively.":[95],"The":[96,190],"protein":[99,183],"were":[100],"by":[102,114,131,152,163],"RT-PCR":[103],"Western":[105],"Blot":[106],"Analysis.":[107],"Furthermore,":[108],"activation":[109,126],"KLF2":[111,128,169,213],"was":[112],"evaluated":[113],"Electrophoretic":[115],"Mobility":[116],"Shift":[117],"Assay":[118],"(EMSA).":[119],"Results":[120],"Rapamycin":[121],"made":[122,146],"strongly":[129,170,195],"reduce":[130],"75.6%":[132],"78.2%":[134],"so":[135],"as":[136],"to":[137,186,222],"induce":[138],"long-term":[139],"coronary":[140],"dysfunction.":[142],"In":[143],"HUVECs,":[144],"basal":[147,158],"eNOS":[148,172],"t-PA":[150,174],"decrease":[151],"80%":[153],"87.8%,":[155],"while":[156],"making":[157],"PAI-1":[159,178],"TF":[161,180],"increase":[162],"2.5":[164],"1.5-fold.":[166],"Overexpression":[167],"induced":[171,208],"reduced":[177,202],"reversing":[182],"above-mentioned":[184],"near":[185],"normal":[187],"state.":[188],"Conclusions":[189],"data":[191],"indicated":[192],"inhibited":[196],"meanwhile,":[201],"anticoagulants":[203],"(eNOS":[204],"t-PA)":[206],"procoagulants":[209],"(PAI-1":[210],"TF).":[212],"played":[214],"thrombosis":[220,235],"owing":[221],"rapamycin-induced":[223],"dysfunction,":[225],"which":[226],"be":[228],"part":[230],"mechanism":[232],"associated":[236],"DESs.":[238]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}