{"id":"https://openalex.org/W1994985180","doi":"https://doi.org/10.1054/drup.2000.0122","title":"The pH difference between tumor and normal tissue offers a tumor specific target for the treatment of cancer","display_name":"The pH difference between tumor and normal tissue offers a tumor specific target for the treatment of cancer","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W1994985180","doi":"https://doi.org/10.1054/drup.2000.0122","mag":"1994985180","pmid":"https://pubmed.ncbi.nlm.nih.gov/11498365"},"language":"en","primary_location":{"id":"doi:10.1054/drup.2000.0122","doi":"https://doi.org/10.1054/drup.2000.0122","is_oa":false,"landing_page_url":"https://doi.org/10.1054/drup.2000.0122","pdf_url":null,"source":{"id":"https://openalex.org/S47159833","display_name":"Drug Resistance Updates","issn_l":"1368-7646","issn":["1368-7646","1532-2084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Resistance Updates","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113516156","display_name":"Leo E. Gerweck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leo E. Gerweck","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Boston, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Boston, USA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113516156"],"corresponding_institution_ids":["https://openalex.org/I4210087915"],"apc_list":{"value":5410,"currency":"USD","value_usd":5410},"apc_paid":null,"fwci":0.135,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.46366298,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"3","issue":"1","first_page":"49","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9541000127792358,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-acidosis","display_name":"tumor acidosis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/extracellular-ph","display_name":"extracellular pH","score":0.9430000185966492},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.6039999723434448},{"id":"https://openalex.org/keywords/tumor-targeted-therapy","display_name":"tumor-targeted therapy","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5639340877532959},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.47776782512664795},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38096654415130615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32931989431381226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2977556586265564},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.283140629529953},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2684176564216614}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1054/drup.2000.0122","doi":"https://doi.org/10.1054/drup.2000.0122","is_oa":false,"landing_page_url":"https://doi.org/10.1054/drup.2000.0122","pdf_url":null,"source":{"id":"https://openalex.org/S47159833","display_name":"Drug Resistance Updates","issn_l":"1368-7646","issn":["1368-7646","1532-2084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Resistance Updates","raw_type":"journal-article"},{"id":"pmid:11498365","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11498365","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1488083143","https://openalex.org/W1956944003","https://openalex.org/W1999334756","https://openalex.org/W2029293048","https://openalex.org/W2114985606","https://openalex.org/W2147550222","https://openalex.org/W2165884308","https://openalex.org/W2271921151","https://openalex.org/W2410902290"],"related_works":["https://openalex.org/W1488083143","https://openalex.org/W2103071253","https://openalex.org/W2148812205","https://openalex.org/W1574897998","https://openalex.org/W19308927","https://openalex.org/W3212603713","https://openalex.org/W1948560807","https://openalex.org/W2586191868","https://openalex.org/W2564296332","https://openalex.org/W2084235230"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}