{"id":"https://openalex.org/W1994931346","doi":"https://doi.org/10.1136/heartjnl-2014-306118.231","title":"C Development of Whole Body and Intravascular Near-infrared Optical Molecular Imaging of Markers of Plaque Vulnerablity in Atherosclerosis","display_name":"C Development of Whole Body and Intravascular Near-infrared Optical Molecular Imaging of Markers of Plaque Vulnerablity in Atherosclerosis","publication_year":2014,"publication_date":"2014-05-31","ids":{"openalex":"https://openalex.org/W1994931346","doi":"https://doi.org/10.1136/heartjnl-2014-306118.231","mag":"1994931346"},"language":"en","primary_location":{"id":"doi:10.1136/heartjnl-2014-306118.231","doi":"https://doi.org/10.1136/heartjnl-2014-306118.231","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2014-306118.231","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058435909","display_name":"Ramzi Khamis","orcid":"https://orcid.org/0000-0003-4119-5193","observed_orcids":["https://orcid.org/0000-0003-4119-5193"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ramzi Y Khamis","raw_affiliation_strings":["Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","1Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"1Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084089745","display_name":"Kevin J. Woollard","orcid":"https://orcid.org/0000-0002-9839-5463","observed_orcids":["https://orcid.org/0000-0002-9839-5463"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kevin J Woollard","raw_affiliation_strings":["Department of Medicine, Imperial College London","2Department of Medicine, Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Imperial College London","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"2Department of Medicine, Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015740311","display_name":"Gareth D. Hyde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gareth D Hyde","raw_affiliation_strings":["Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","1Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"1Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036601248","display_name":"Joseph J. Boyle","orcid":"https://orcid.org/0000-0002-4337-3320","observed_orcids":["https://orcid.org/0000-0002-4337-3320"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph J Boyle","raw_affiliation_strings":["Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","1Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"1Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021655504","display_name":"Colin D. Bicknell","orcid":"https://orcid.org/0000-0003-0158-1831","observed_orcids":["https://orcid.org/0000-0003-0158-1831"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin Bicknell","raw_affiliation_strings":["Department of Surgery and Cancer, Imperial College London","#N#3Department of Surgery and Cancer, Imperial College London#N#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Cancer, Imperial College London","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"#N#3Department of Surgery and Cancer, Imperial College London#N#","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017027780","display_name":"Tetsuya Hara","orcid":"https://orcid.org/0000-0003-2793-1932","observed_orcids":["https://orcid.org/0000-0003-2793-1932"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tetsuya Hara","raw_affiliation_strings":["Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","4Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"4Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010718958","display_name":"Adam Mauskapf","orcid":"https://orcid.org/0009-0009-2470-898X","observed_orcids":["https://orcid.org/0009-0009-2470-898X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam Mauskapf","raw_affiliation_strings":["Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","4Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"4Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009684178","display_name":"David Granger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David W Granger","raw_affiliation_strings":["Biopharm R&D, GlaxoSmithKline, Stevenage, UK","5Biopharm R&D, GlaxoSmithKline, Stevenage, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biopharm R&D, GlaxoSmithKline, Stevenage, UK","institution_ids":["https://openalex.org/I188950975"]},{"raw_affiliation_string":"5Biopharm R&D, GlaxoSmithKline, Stevenage, UK","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059731339","display_name":"Jason Lee Johnson","orcid":"https://orcid.org/0000-0003-0630-9183","observed_orcids":["https://orcid.org/0000-0003-0630-9183"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jason L Johnson","raw_affiliation_strings":["Bristol Heart Institute, University of Bristol, Bristol, UK","6Bristol Heart Institute, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bristol Heart Institute, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"6Bristol Heart Institute, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059881887","display_name":"Vasilis Ntziachristos","orcid":"https://orcid.org/0000-0002-9988-0233","observed_orcids":["https://orcid.org/0000-0002-9988-0233"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vasilis Ntziachristos","raw_affiliation_strings":["Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","4Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"4Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070529061","display_name":"Paul McMahan Matthews","orcid":"https://orcid.org/0000-0002-1619-8328","observed_orcids":["https://orcid.org/0000-0002-1619-8328","https://orcid.org/0009-0004-7086-4303"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Paul M Matthews","raw_affiliation_strings":["Department of Medicine, Imperial College London","2Department of Medicine, Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Imperial College London","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"2Department of Medicine, Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035255903","display_name":"Farouc Amin Jaffer","orcid":"https://orcid.org/0000-0001-7980-384X","observed_orcids":["https://orcid.org/0000-0001-7980-384X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farouc A Jaffer","raw_affiliation_strings":["Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","4Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"4Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Harvard Medical School","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113509100","display_name":"Dorian O. Haskard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dorian O Haskard","raw_affiliation_strings":["Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","1Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"1Vascular Sciences Section, National Hearth and Lung Institute, Imperial College London","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10336872,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"100","issue":"Suppl 3","first_page":"A128.1","last_page":"A128"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.5278000235557556,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.40209999680519104,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.018200000748038292,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.847000002861023},{"id":"https://openalex.org/keywords/unstable-plaque","display_name":"plaque vulnerability","score":0.7990000247955322},{"id":"https://openalex.org/keywords/oxidized-ldl","display_name":"oxidized LDL","score":0.9459999799728394},{"id":"https://openalex.org/keywords/near-infrared-fluorescence-imaging","display_name":"near-infrared fluorescence imaging","score":0.875},{"id":"https://openalex.org/keywords/fluorescence-molecular-tomography","display_name":"fluorescence molecular tomography","score":0.9440000057220459},{"id":"https://openalex.org/keywords/intravascular-imaging","display_name":"intravascular imaging","score":0.6539999842643738},{"id":"https://openalex.org/keywords/ldlr-deficient-mice","display_name":"Ldlr-deficient mice","score":0.7620000243186951},{"id":"https://openalex.org/keywords/rabbit-aorta","display_name":"rabbit aorta","score":0.7519999742507935},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.6140000224113464},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6949999928474426},{"id":"https://openalex.org/keywords/subendothelium","display_name":"subendothelium","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6442875862121582},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.5415695905685425},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.48692142963409424},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.4757532775402069},{"id":"https://openalex.org/C136339569","wikidata":"https://www.wikidata.org/wiki/Q1142297","display_name":"Molecular imaging","level":3,"score":0.4735017418861389},{"id":"https://openalex.org/C2779179121","wikidata":"https://www.wikidata.org/wiki/Q559362","display_name":"Fibrous cap","level":2,"score":0.44521456956863403},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.43529942631721497},{"id":"https://openalex.org/C2781285907","wikidata":"https://www.wikidata.org/wiki/Q616032","display_name":"Aortic arch","level":3,"score":0.41909411549568176},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.32976263761520386},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.2959948480129242},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.2636529207229614},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2626578211784363},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.18659955263137817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14208140969276428},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1136/heartjnl-2014-306118.231","doi":"https://doi.org/10.1136/heartjnl-2014-306118.231","is_oa":false,"landing_page_url":"https://doi.org/10.1136/heartjnl-2014-306118.231","pdf_url":null,"source":{"id":"https://openalex.org/S191565391","display_name":"Heart","issn_l":"1355-6037","issn":["1355-6037","1468-201X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Heart","raw_type":"journal-article"},{"id":"pmh:oai:open-archive.highwire.org:heartjnl:100/Suppl_3/A128-a","doi":null,"is_oa":false,"landing_page_url":"http://heart.bmj.com/cgi/content/short/100/Suppl_3/A128-a","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/6f84730e-78c6-4e89-9884-f9df36542560","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1983/6f84730e-78c6-4e89-9884-f9df36542560","pdf_url":null,"source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Khamis, R Y, Woollard, K J, Hyde, G D, Boyle, J J, Bicknell, C, Hara, T, Mauskapf, A, Granger, D W, Johnson, J L, Ntziachristos, V, Matthews, P M, Jaffer, F A & Haskard, D O 2014, 'C\u2005Development of Whole Body and Intravascular Near-infrared Optical Molecular Imaging of Markers of Plaque Vulnerablity in Atherosclerosis', Heart, vol. 100 Suppl 3, pp. A128. https://doi.org/10.1136/heartjnl-2014-306118.231","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6499999761581421}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2335315106","https://openalex.org/W2281915502","https://openalex.org/W2011526170","https://openalex.org/W2032897350","https://openalex.org/W2352391885","https://openalex.org/W6908280815","https://openalex.org/W3170675143","https://openalex.org/W2057976027","https://openalex.org/W7097762949","https://openalex.org/W1971269746"],"abstract_inverted_index":{"Background":[0],"We":[1,89,223],"aimed":[2],"to":[3,44,50,56,118,140,144,162,208,218],"study":[4],"oxidised":[5],"low":[6],"density":[7],"lipoprotein":[8],"(oxLDL)":[9],"as":[10,241],"a":[11,20,41,57,79,94,101,123,182,215],"near":[12],"infrared":[13],"fluorescence":[14],"(NIRF)":[15],"molecular":[16],"imaging":[17,244],"target,":[18],"using":[19,84],"monoclonal":[21],"anti-oxLDL":[22],"autoantibody":[23],"(LO1)":[24],"in":[25,52,158,197,210,214,236],"mouse":[26,212],"and":[27,33,47,131,142,151,165,229],"rabbit":[28,74],"atherosclerosis":[29,51,209],"models.":[30],"Methods":[31],"LO1":[32,92,228],"an":[34],"IgG3k":[35],"control":[36],"antibody":[37],"were":[38],"labelled":[39],"with":[40,70,78,100,200,238],"NIRF":[42,82],"dye":[43],"give":[45],"LO1\u2013750":[46,107,138,150,193],"IgG3\u2013750.":[48],"Targeting":[49],"mice":[53,116],"was":[54,76,177,195],"compared":[55],"reporter":[58,154],"of":[59,106,125,167,188,227,249],"matrix-metalloproteinase":[60],"activity":[61],"(MMPSense":[62],"FAST)":[63],"by":[64,73],"Fluorescence":[65],"Molecular":[66],"Tomography":[67],"(FMT)":[68],"combined":[69],"micro-CT.":[71],"Uptake":[72],"aorta":[75],"detected":[77],"custom-built":[80],"intra-arterial":[81,202],"catheter,":[83],"IVUS":[85],"for":[86,246],"morphological":[87],"assessment.":[88],"further":[90],"developed":[91],"into":[93,108],"molecularly":[95],"expressed":[96],"humanised":[97],"Fab":[98],"construct":[99,206],"cysteine-tag":[102],"(LO1-Fab-Cys).":[103],"Results":[104],"Injection":[105],"high":[109],"fat":[110],"(HF)":[111],"fed":[112],"Ldlr":[113],"-/-":[114],"atherosclerotic":[115,147],"led":[117],"specific":[119],"focal":[120],"localization":[121,194],"within":[122,146],"region":[124],"interest":[126],"enclosing":[127],"the":[128,152,191,201,211,219,225,247],"aortic":[129,198],"arch":[130],"its":[132],"branches.":[133],"Ex":[134],"vivo":[135],"studies":[136],"confirmed":[137],"localisation":[139],"subendothelium":[141],"partially":[143],"macrophages":[145],"lesions.":[148],"Both":[149],"MMP":[153],"quantified":[155],"significant":[156],"increases":[157],"arterial":[159],"targeting":[160,176],"related":[161],"genotype,":[163],"age,":[164],"duration":[166],"HF":[168,171],"diet.":[169],"Following":[170],"diet":[172],"withdrawal,":[173],"MMPSense":[174],"FAST":[175],"affected":[178],"more":[179],"dramatically,":[180],"exhibiting":[181],"lower":[183],"intermediate":[184],"signal":[185],"than":[186],"that":[187],"LO1\u2013750.":[189],"In":[190],"rabbit,":[192],"identified":[196],"lesions":[199],"catheter.":[203],"The":[204],"LO1-Fab-Cys":[205],"localised":[207],"model":[213],"similar":[216],"fashion":[217],"parent":[220],"antibody.":[221],"Conclusion":[222],"demonstrated":[224],"utility":[226],"derivative":[230],"molecularly-expressed":[231],"constructs,":[232],"either":[233],"alone":[234],"or":[235],"combination":[237],"other":[239],"reporters":[240],"multi-modality":[242],"optical":[243],"agents":[245],"evaluation":[248],"atherosclerosis.":[250]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}
