{"id":"https://openalex.org/W1994891003","doi":"https://doi.org/10.1016/j.ejps.2006.10.011","title":"Pharmacokinetic simulation of biowaiver criteria: The effects of gastric emptying, dissolution, absorption and elimination rates","display_name":"Pharmacokinetic simulation of biowaiver criteria: The effects of gastric emptying, dissolution, absorption and elimination rates","publication_year":2006,"publication_date":"2006-11-14","ids":{"openalex":"https://openalex.org/W1994891003","doi":"https://doi.org/10.1016/j.ejps.2006.10.011","mag":"1994891003","pmid":"https://pubmed.ncbi.nlm.nih.gov/17187967"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejps.2006.10.011","doi":"https://doi.org/10.1016/j.ejps.2006.10.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejps.2006.10.011","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111858259","display_name":"Hanna Kortej\u00e4rvi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"H. Kortej\u00e4rvi","raw_affiliation_strings":["Research and Development, Orion Pharma, P.O. Box 65, 02101 Espoo, Finland. hanna.kortejarvi@orionpharma.com <hanna.kortejarvi@orionpharma.com>","Research and Development, Orion Pharma, P.O. Box 65, 02101 Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Orion Pharma, P.O. Box 65, 02101 Espoo, Finland. hanna.kortejarvi@orionpharma.com <hanna.kortejarvi@orionpharma.com>","institution_ids":["https://openalex.org/I4210118237"]},{"raw_affiliation_string":"Research and Development, Orion Pharma, P.O. Box 65, 02101 Espoo, Finland","institution_ids":["https://openalex.org/I4210118237"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065810893","display_name":"Arto O. Urtti","orcid":"https://orcid.org/0000-0001-6064-3102","observed_orcids":["https://orcid.org/0000-0001-6064-3102"]},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"A. Urtti","raw_affiliation_strings":["Drug Discovery and Development Technology Center, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Discovery and Development Technology Center, University of Helsinki, P.O. Box 56, FIN-00014 Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053032683","display_name":"Marjo L. Yliperttula","orcid":"https://orcid.org/0000-0003-0726-5733","observed_orcids":["https://orcid.org/0000-0003-0726-5733"]},"institutions":[{"id":"https://openalex.org/I4210118237","display_name":"Orion Corporation (Finland)","ror":"https://ror.org/0296s4x19","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210118237"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"M. Yliperttula","raw_affiliation_strings":["Research and Development, Orion Pharma, P.O. Box 65, 02101 Espoo, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, Orion Pharma, P.O. Box 65, 02101 Espoo, Finland","institution_ids":["https://openalex.org/I4210118237"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111858259"],"corresponding_institution_ids":["https://openalex.org/I4210118237"],"apc_list":{"value":3070,"currency":"USD","value_usd":3070},"apc_paid":null,"fwci":2.857,"has_fulltext":false,"cited_by_count":88,"citation_normalized_percentile":{"value":0.88325261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"30","issue":"2","first_page":"155","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biowaiver","display_name":"biowaiver","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bcs-class-iii-drugs","display_name":"BCS class III drugs","score":0.871999979019165},{"id":"https://openalex.org/keywords/pharmacokinetic-simulation","display_name":"pharmacokinetic simulation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/gastric-emptying","display_name":"gastric emptying","score":0.8679999709129333},{"id":"https://openalex.org/keywords/drug-dissolution-rate","display_name":"drug dissolution rate","score":0.7699999809265137},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.7039999961853027},{"id":"https://openalex.org/keywords/oral-solid-dosage-forms","display_name":"oral solid dosage forms","score":0.6399999856948853},{"id":"https://openalex.org/keywords/oral-solution","display_name":"oral solution","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cmax","display_name":"Cmax","score":0.6309999823570251},{"id":"https://openalex.org/keywords/auc","display_name":"AUC","score":0.9789999723434448},{"id":"https://openalex.org/keywords/dissolution-testing","display_name":"dissolution testing","score":0.5509999990463257},{"id":"https://openalex.org/keywords/gastrointestinal-transit","display_name":"gastrointestinal transit","score":0.5989999771118164}],"concepts":[{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.9087514877319336},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8011729717254639},{"id":"https://openalex.org/C2781430271","wikidata":"https://www.wikidata.org/wiki/Q278760","display_name":"Biopharmaceutics Classification System","level":3,"score":0.7272182703018188},{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.7252548933029175},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6472919583320618},{"id":"https://openalex.org/C2910701995","wikidata":"https://www.wikidata.org/wiki/Q679692","display_name":"Biopharmaceutics","level":5,"score":0.5768972039222717},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.529934823513031},{"id":"https://openalex.org/C14029885","wikidata":"https://www.wikidata.org/wiki/Q5282807","display_name":"Dissolution testing","level":4,"score":0.5253925919532776},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5233078002929688},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.5032040476799011},{"id":"https://openalex.org/C88380143","wikidata":"https://www.wikidata.org/wiki/Q416674","display_name":"Dissolution","level":2,"score":0.49816155433654785},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.49808406829833984},{"id":"https://openalex.org/C125287762","wikidata":"https://www.wikidata.org/wiki/Q1758948","display_name":"Absorption (acoustics)","level":2,"score":0.423306941986084},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.4186326265335083},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.34038305282592773},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29107511043548584},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.18671610951423645},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.053600460290908813},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.05145862698554993},{"id":"https://openalex.org/C160492267","wikidata":"https://www.wikidata.org/wiki/Q319616","display_name":"Pharmacognosy","level":4,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004364","descriptor_name":"Pharmaceutical Preparations","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005746","descriptor_name":"Gastric Emptying","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010599","descriptor_name":"Pharmacokinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012995","descriptor_name":"Solubility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013810","descriptor_name":"Therapeutic Equivalency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.ejps.2006.10.011","doi":"https://doi.org/10.1016/j.ejps.2006.10.011","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejps.2006.10.011","pdf_url":null,"source":{"id":"https://openalex.org/S119477091","display_name":"European Journal of Pharmaceutical Sciences","issn_l":"0928-0987","issn":["0928-0987","1879-0720"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:17187967","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17187967","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W83759074","https://openalex.org/W1485761517","https://openalex.org/W1493470395","https://openalex.org/W1498305210","https://openalex.org/W1520270576","https://openalex.org/W1522767714","https://openalex.org/W1596962878","https://openalex.org/W1779958190","https://openalex.org/W2006661934","https://openalex.org/W2016425824","https://openalex.org/W2019392143","https://openalex.org/W2024362305","https://openalex.org/W2035910944","https://openalex.org/W2071090006","https://openalex.org/W2071925169","https://openalex.org/W2085444179","https://openalex.org/W2085974477","https://openalex.org/W2087703013","https://openalex.org/W2095179999","https://openalex.org/W2098254778","https://openalex.org/W2129827408","https://openalex.org/W2169939486","https://openalex.org/W2478337367"],"related_works":["https://openalex.org/W1978960033","https://openalex.org/W2499274410","https://openalex.org/W650494539","https://openalex.org/W2055421224","https://openalex.org/W1979184433","https://openalex.org/W3136895701","https://openalex.org/W2402716968","https://openalex.org/W2092137244","https://openalex.org/W4322622615","https://openalex.org/W2998610274"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}