{"id":"https://openalex.org/W1994872813","doi":"https://doi.org/10.1042/0264-6021:3400365","title":"Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: requirement for two different tyrosine kinases","display_name":"Signal transduction pathway regulating prostaglandin EP3 receptor-induced neurite retraction: requirement for two different tyrosine kinases","publication_year":1999,"publication_date":"1999-05-25","ids":{"openalex":"https://openalex.org/W1994872813","doi":"https://doi.org/10.1042/0264-6021:3400365","mag":"1994872813","pmid":"https://pubmed.ncbi.nlm.nih.gov/10333476","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1220258"},"language":"en","primary_location":{"id":"doi:10.1042/0264-6021:3400365","doi":"https://doi.org/10.1042/0264-6021:3400365","is_oa":false,"landing_page_url":"https://doi.org/10.1042/0264-6021:3400365","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/340/2/365/633929/bj3400365.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112202561","display_name":"Junko Aoki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Junko AOKI","raw_affiliation_strings":["Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039215121","display_name":"Hironori Katoh","orcid":"https://orcid.org/0000-0002-8191-8117","observed_orcids":["https://orcid.org/0000-0002-8191-8117"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hironori KATOH","raw_affiliation_strings":["Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063810047","display_name":"Hidekazu Yasui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hidekazu YASUI","raw_affiliation_strings":["Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011871848","display_name":"Yoshiaki Yamaguchi","orcid":"https://orcid.org/0000-0003-4126-542X","observed_orcids":["https://orcid.org/0000-0003-4126-542X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshiaki YAMAGUCHI","raw_affiliation_strings":["Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016084389","display_name":"Kazuhiro Nakamura","orcid":"https://orcid.org/0000-0002-6095-8996","observed_orcids":["https://orcid.org/0000-0002-6095-8996"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kazuhiro NAKAMURA","raw_affiliation_strings":["Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101724929","display_name":"Hiroshi Hasegawa","orcid":"https://orcid.org/0000-0002-2014-8737","observed_orcids":["https://orcid.org/0000-0002-2014-8737"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hiroshi HASEGAWA","raw_affiliation_strings":["Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036189941","display_name":"Atsushi Ichikawa","orcid":"https://orcid.org/0009-0000-2175-2963","observed_orcids":["https://orcid.org/0009-0000-2175-2963"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi ICHIKAWA","raw_affiliation_strings":["Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089629096","display_name":"Masahiko Negishi","orcid":"https://orcid.org/0000-0002-2076-8928","observed_orcids":["https://orcid.org/0000-0002-2076-8928"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Manabu NEGISHI","raw_affiliation_strings":["Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Neurobiology, Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan","institution_ids":["https://openalex.org/I22299242"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011871848","https://openalex.org/A5016084389","https://openalex.org/A5039215121","https://openalex.org/A5063810047","https://openalex.org/A5089629096","https://openalex.org/A5101724929","https://openalex.org/A5112202561"],"corresponding_institution_ids":["https://openalex.org/I22299242"],"apc_list":null,"apc_paid":null,"fwci":1.1484,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.75715013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"340","issue":"2","first_page":"365","last_page":"365"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurite-retraction","display_name":"neurite retraction","score":0.996999979019165},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.9049999713897705},{"id":"https://openalex.org/keywords/rhoa","display_name":"RhoA","score":0.8650000095367432},{"id":"https://openalex.org/keywords/genistein","display_name":"genistein","score":0.984000027179718},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7639999985694885},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.828000009059906},{"id":"https://openalex.org/keywords/nerve-growth-factor-differentiation","display_name":"nerve growth factor differentiation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cell-rounding","display_name":"cell rounding","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.6921805143356323},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.6684409976005554},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.6181683540344238},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6119582653045654},{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.5169464945793152},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5050225853919983},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46284979581832886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34148192405700684},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32067418098449707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21784746646881104},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000527","descriptor_name":"Alprostadil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011233","descriptor_name":"Precipitin Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011459","descriptor_name":"Prostaglandins E, Synthetic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018078","descriptor_name":"Receptors, Prostaglandin E","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019833","descriptor_name":"Genistein","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020032","descriptor_name":"Tyrphostins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051419","descriptor_name":"Paxillin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058308","descriptor_name":"Receptors, Prostaglandin E, EP3 Subtype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1042/0264-6021:3400365","doi":"https://doi.org/10.1042/0264-6021:3400365","is_oa":false,"landing_page_url":"https://doi.org/10.1042/0264-6021:3400365","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"doi:10.1042/bj3400365","doi":"https://doi.org/10.1042/bj3400365","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3400365","pdf_url":"https://portlandpress.com/biochemj/article-pdf/340/2/365/633929/bj3400365.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1220258","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1220258","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:10333476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10333476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1042/bj3400365","doi":"https://doi.org/10.1042/bj3400365","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj3400365","pdf_url":"https://portlandpress.com/biochemj/article-pdf/340/2/365/633929/bj3400365.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2086893255","display_name":"Approarch for neuronal functions of prostaglandins","funder_award_id":"10470482","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994872813.pdf","grobid_xml":"https://content.openalex.org/works/W1994872813.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1513979636","https://openalex.org/W1531820450","https://openalex.org/W1597787921","https://openalex.org/W1744354425","https://openalex.org/W1964570827","https://openalex.org/W1983153323","https://openalex.org/W1985074372","https://openalex.org/W1995782272","https://openalex.org/W1997087774","https://openalex.org/W2006678562","https://openalex.org/W2010929645","https://openalex.org/W2020993672","https://openalex.org/W2030051082","https://openalex.org/W2032295238","https://openalex.org/W2033221676","https://openalex.org/W2040393757","https://openalex.org/W2040500793","https://openalex.org/W2078992684","https://openalex.org/W2081245541","https://openalex.org/W2081688069","https://openalex.org/W2096791952","https://openalex.org/W2112634792","https://openalex.org/W2117406052","https://openalex.org/W2121666423","https://openalex.org/W2132052155","https://openalex.org/W2155369806","https://openalex.org/W2155684371","https://openalex.org/W2157441732","https://openalex.org/W2157918194","https://openalex.org/W2170467038","https://openalex.org/W2174324620","https://openalex.org/W2214371436","https://openalex.org/W4206507674","https://openalex.org/W6606442571","https://openalex.org/W6629829920"],"related_works":["https://openalex.org/W1964570827","https://openalex.org/W2030051082","https://openalex.org/W2092464470","https://openalex.org/W2007021147","https://openalex.org/W2034108437","https://openalex.org/W2033221676","https://openalex.org/W2069228549","https://openalex.org/W2030990798","https://openalex.org/W2138795118","https://openalex.org/W2104715092"],"abstract_inverted_index":{"We":[0],"reported":[1],"previously":[2],"that":[3,89,154],"activation":[4,65,124],"of":[5,39,66,83,125,131,144,149,176],"the":[6,16,37,67,97,100,107,126,167],"prostaglandin":[7],"E":[8],"receptor":[9,102,128],"EP3":[10,30,68,101,127,168],"subtype":[11],"triggered":[12],"neurite":[13,58,75,116,170],"retraction":[14,59,76,117,171],"through":[15],"small":[17],"GTPase":[18],"Rho-,":[19],"and":[20,60,77,118,129,161,174],"its":[21],"target,":[22],"RhoA-binding":[23],"kinase":[24,55,93,113],"alpha":[25],"(ROKalpha)-,":[26],"dependent":[27],"pathway":[28,44,98],"in":[29,42,45,96,166],"receptor-expressing":[31],"PC12":[32,49],"cells.":[33,50],"Here":[34],"we":[35],"examined":[36],"involvement":[38],"tyrosine":[40,54,92,112,157],"kinases":[41],"this":[43],"nerve":[46],"growth":[47],"factor-differentiated":[48],"Tyrphostin":[51],"A25,":[52],"a":[53,90,145],"inhibitor,":[56,114],"blocked":[57,115],"cell":[61,78,119],"rounding":[62,79,120],"induced":[63,80,121,141],"by":[64,81,122,142],"receptor,":[69],"however,":[70],"it":[71],"failed":[72],"to":[73,103],"block":[74,137],"microinjection":[82,130,143],"constitutively":[84,146],"active":[85,147],"RhoA,":[86],"RhoAV14,":[87],"indicating":[88],"tyrphostin-sensitive":[91],"was":[94],"involved":[95,165],"from":[99],"Rho":[104],"activation.":[105],"On":[106],"other":[108],"hand,":[109],"genistein,":[110],"another":[111],"both":[123],"RhoAV14.":[132],"However,":[133],"genistein":[134],"did":[135],"not":[136],"neuronal":[138],"morphological":[139],"changes":[140],"mutant":[148],"ROKalpha.":[150],"These":[151],"results":[152],"indicate":[153],"two":[155],"different":[156],"kinases,":[158,163],"tyrphostin":[159],"A25-sensitive":[160],"genistein-sensitive":[162],"are":[164],"receptor-mediated":[169],"acting":[172],"upstream":[173],"downstream":[175],"Rho,":[177],"respectively.":[178]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}