{"id":"https://openalex.org/W1994863571","doi":"https://doi.org/10.1002/syn.20544","title":"Kinetic brain analysis and whole\u2010body imaging in monkey of [11C]MNPA: A dopamine agonist radioligand","display_name":"Kinetic brain analysis and whole\u2010body imaging in monkey of [11C]MNPA: A dopamine agonist radioligand","publication_year":2008,"publication_date":"2008-06-24","ids":{"openalex":"https://openalex.org/W1994863571","doi":"https://doi.org/10.1002/syn.20544","mag":"1994863571","pmid":"https://pubmed.ncbi.nlm.nih.gov/18566975","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2786063"},"language":"en","primary_location":{"id":"doi:10.1002/syn.20544","doi":"https://doi.org/10.1002/syn.20544","is_oa":false,"landing_page_url":"https://doi.org/10.1002/syn.20544","pdf_url":null,"source":{"id":"https://openalex.org/S158211696","display_name":"Synapse","issn_l":"0887-4476","issn":["0887-4476","1098-2396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2786063","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001422614","display_name":"Nicholas M. Seneca","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["SE","US"],"is_corresponding":true,"raw_author_name":"Nicholas Seneca","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, Building 31, Bethesda, MD 20892, USA. nicholasseneca@mail.nih.gov","Department of Clinical Neuroscience, Section of Psychiatry, Karolinska Institutet, Stockholm, Sweden","Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Building 31, Bethesda, MD 20892, USA. nicholasseneca@mail.nih.gov","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Department of Clinical Neuroscience, Section of Psychiatry, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077391375","display_name":"Mette Skinbjerg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["SE","US"],"is_corresponding":false,"raw_author_name":"Mette Skinbjerg","raw_affiliation_strings":["Department of Clinical Neuroscience, Section of Psychiatry, Karolinska Institutet, Stockholm, Sweden","Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Section of Psychiatry, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]},{"raw_affiliation_string":"Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039918144","display_name":"Sami S. Zoghbi","orcid":"https://orcid.org/0000-0001-5613-8314","observed_orcids":["https://orcid.org/0000-0001-5613-8314","https://orcid.org/0009-0001-4145-7029"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sami S. Zoghbi","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035586136","display_name":"Jeih\u2010San Liow","orcid":"https://orcid.org/0000-0002-7878-1076","observed_orcids":["https://orcid.org/0000-0002-7878-1076"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeih\u2010San Liow","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061688680","display_name":"Robert L. Gladding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Gladding","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103525133","display_name":"Jinsoo S. Hong","orcid":"https://orcid.org/0000-0002-0450-6258","observed_orcids":["https://orcid.org/0000-0002-0450-6258"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jinsoo Hong","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034856451","display_name":"Pavitra Kannan","orcid":"https://orcid.org/0000-0002-9170-6062","observed_orcids":["https://orcid.org/0000-0002-9170-6062"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavitra Kannan","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109847895","display_name":"Edward W. Tuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward Tuan","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076880355","display_name":"David R. Sibley","orcid":"https://orcid.org/0000-0002-0624-962X","observed_orcids":["https://orcid.org/0000-0002-0624-962X"]},"institutions":[{"id":"https://openalex.org/I4210110767","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210110767"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Sibley","raw_affiliation_strings":["Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland","institution_ids":["https://openalex.org/I4210110767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081327813","display_name":"Christer Halldin","orcid":"https://orcid.org/0000-0002-7681-1104","observed_orcids":["https://orcid.org/0000-0002-7681-1104"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Christer Halldin","raw_affiliation_strings":["Department of Clinical Neuroscience, Section of Psychiatry, Karolinska Institutet, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Neuroscience, Section of Psychiatry, Karolinska Institutet, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048937067","display_name":"Victor William Pike","orcid":"https://orcid.org/0000-0001-9032-2553","observed_orcids":["https://orcid.org/0000-0001-9032-2553"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor W. Pike","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079125204","display_name":"Robert B. Innis","orcid":"https://orcid.org/0000-0003-1238-7209","observed_orcids":["https://orcid.org/0000-0003-1238-7209"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Innis","raw_affiliation_strings":["Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Imaging Branch, National Institute of Mental Health, Bethesda, Maryland","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5001422614"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I28166907","https://openalex.org/I4210158500"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":1.0236,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.76876355,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"62","issue":"9","first_page":"700","last_page":"709"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.490200012922287,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.4494999945163727,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/d2-d3-dopamine-receptors","display_name":"D2/D3 dopamine receptors","score":0.7979999780654907},{"id":"https://openalex.org/keywords/compartmental-modeling","display_name":"compartmental modeling","score":0.8619999885559082},{"id":"https://openalex.org/keywords/whole-body-imaging","display_name":"whole-body imaging","score":0.5820000171661377},{"id":"https://openalex.org/keywords/radiation-exposure","display_name":"radiation exposure","score":0.7670000195503235},{"id":"https://openalex.org/keywords/effective-dose","display_name":"effective dose","score":0.8500000238418579},{"id":"https://openalex.org/keywords/bladder","display_name":"urinary bladder","score":0.7350000143051147},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.6489999890327454},{"id":"https://openalex.org/keywords/cerebellum","display_name":"cerebellum","score":0.921999990940094},{"id":"https://openalex.org/keywords/reference-tissue-model","display_name":"reference tissue model","score":0.7160000205039978},{"id":"https://openalex.org/keywords/volume-of-distribution","display_name":"volume of distribution","score":0.8230000138282776},{"id":"https://openalex.org/keywords/nonhuman-primate-model","display_name":"nonhuman primate model","score":0.4699999988079071},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C67847695","wikidata":"https://www.wikidata.org/wiki/Q626478","display_name":"Radioligand","level":3,"score":0.7814257740974426},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6723207235336304},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.6406149864196777},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.5567464828491211},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.5275477766990662},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4367883801460266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36739861965179443},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.268684059381485},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.24506136775016785},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1690237820148468}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002250","descriptor_name":"Carbon Radioisotopes","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009288","descriptor_name":"Naproxen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009288","descriptor_name":"Naproxen","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011874","descriptor_name":"Radiometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017448","descriptor_name":"Receptors, Dopamine D2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D050637","descriptor_name":"Receptors, Dopamine D3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051598","descriptor_name":"Whole Body Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/syn.20544","doi":"https://doi.org/10.1002/syn.20544","is_oa":false,"landing_page_url":"https://doi.org/10.1002/syn.20544","pdf_url":null,"source":{"id":"https://openalex.org/S158211696","display_name":"Synapse","issn_l":"0887-4476","issn":["0887-4476","1098-2396"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse","raw_type":"journal-article"},{"id":"pmid:18566975","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18566975","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Synapse (New York, N.Y.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2786063","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2786063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Synapse","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2786063","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2786063","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Synapse","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4562775012","display_name":"Preclinical Evaluation Of PET Radiotracers","funder_award_id":"Z01MH002795","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1585488465","https://openalex.org/W1817176777","https://openalex.org/W1946923111","https://openalex.org/W1966092598","https://openalex.org/W1969866636","https://openalex.org/W1973200478","https://openalex.org/W1981420707","https://openalex.org/W1993647063","https://openalex.org/W1996065499","https://openalex.org/W1998454579","https://openalex.org/W2001859804","https://openalex.org/W2016678309","https://openalex.org/W2017040809","https://openalex.org/W2017409452","https://openalex.org/W2030773481","https://openalex.org/W2033964055","https://openalex.org/W2034135634","https://openalex.org/W2039634418","https://openalex.org/W2042331277","https://openalex.org/W2048246008","https://openalex.org/W2048458184","https://openalex.org/W2053445747","https://openalex.org/W2064671909","https://openalex.org/W2067722023","https://openalex.org/W2091088809","https://openalex.org/W2112278807","https://openalex.org/W2117891587","https://openalex.org/W2126262208","https://openalex.org/W2127499858","https://openalex.org/W2127534961","https://openalex.org/W2135747349","https://openalex.org/W2142635246","https://openalex.org/W2148296362","https://openalex.org/W2155177235","https://openalex.org/W2158166289","https://openalex.org/W2165387697","https://openalex.org/W2172273738","https://openalex.org/W2322398337","https://openalex.org/W2327894624","https://openalex.org/W2332676550","https://openalex.org/W2397150142","https://openalex.org/W2412039226"],"related_works":["https://openalex.org/W2165387697","https://openalex.org/W1988255117","https://openalex.org/W7033736632","https://openalex.org/W2150181075","https://openalex.org/W2065639039","https://openalex.org/W1968481114","https://openalex.org/W1817176777","https://openalex.org/W2006209509","https://openalex.org/W2119368143","https://openalex.org/W2030465821"],"abstract_inverted_index":{"With":[0,200],"a":[1,91,158,201],"view":[2],"to":[3,17,34,52,112,125,168,227,234],"future":[4],"extension":[5],"of":[6,9,39,50,73,77,116,135,140,217,222],"the":[7,10,32,36,47,74,129,137,175,178,184,205,220],"use":[8],"agonist":[11],"radioligand":[12],"[(11)C]MNPA":[13,40,51,218],"([O-methyl-(11)C]2-methoxy-N-propylnorapomorphine)":[14],"from":[15,82,110,166],"animals":[16],"humans,":[18],"we":[19,30,45],"performed":[20],"two":[21,89],"positron":[22],"emission":[23],"tomography":[24],"(PET)":[25],"studies":[26],"in":[27,59,142,145,150],"monkeys.":[28,60],"First,":[29],"assessed":[31],"ability":[33],"quantify":[35],"brain":[37,143,215],"uptake":[38,216],"with":[41,88,128,147,157,177],"compartmental":[42,160],"modeling.":[43],"Second,":[44],"estimated":[46],"radiation":[48,131,180,236],"exposure":[49],"human":[53],"subjects":[54],"based":[55],"on":[56,120],"whole-body":[57,123],"imaging":[58],"Brain":[61],"PET":[62,99,172],"scans":[63,100,173],"were":[64,86,101,118],"acquired":[65,102],"for":[66,103],"90":[67,169],"min":[68,105],"and":[69,84,95,162,196,231],"included":[70],"concurrent":[71],"measurements":[72],"plasma":[75],"concentration":[76,139],"unchanged":[78],"radioligand.":[79],"Time-activity":[80],"data":[81],"striatum":[83],"cerebellum":[85],"quantified":[87,225],"methods,":[90],"reference":[92],"tissue":[93],"model":[94,161],"distribution":[96],"volume.":[97],"Whole-body":[98,171],"120":[104],"using":[106],"four":[107],"bed":[108],"positions":[109],"head":[111],"mid":[113],"thigh.":[114],"Regions":[115],"interest":[117],"drawn":[119],"compressed":[121],"planar":[122],"images":[124],"identify":[126],"organs":[127],"highest":[130,138,179],"exposures.":[132],"After":[133],"injection":[134],"[(11)C]MNPA,":[136],"radioactivity":[141],"was":[144,154,163,183,208],"striatum,":[146],"lowest":[148],"levels":[149],"cerebellum.":[151],"Distribution":[152],"volume":[153],"well":[155],"identified":[156],"two-tissue":[159],"quite":[164],"stable":[165],"60":[167],"min.":[170],"showed":[174],"organ":[176],"burden":[181],"(muSv/MBq)":[182],"urinary":[185],"bladder":[186],"wall":[187,194,198],"(26.0),":[188],"followed":[189],"by":[190],"lungs":[191],"(22.5),":[192],"gallbladder":[193],"(21.9),":[195],"heart":[197],"(16.1).":[199],"2.4-h":[202],"voiding":[203],"interval,":[204],"effective":[206],"dose":[207],"6.4":[209],"muSv/MBq":[210],"(23.5":[211],"mrem/mCi).":[212],"In":[213],"conclusion,":[214],"reflected":[219],"density":[221],"D(2/3)":[223],"receptors,":[224],"relative":[226],"serial":[228],"arterial":[229],"measurements,":[230],"caused":[232],"moderate":[233],"low":[235],"exposure.":[237]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}