{"id":"https://openalex.org/W1994863530","doi":"https://doi.org/10.1002/jps.2600821221","title":"Evaluation of the Bioequivalence of Tablet and Capsule Formulations of Granisetron in Patients Undergoing Cytotoxic Chemotherapy for Malignant Disease","display_name":"Evaluation of the Bioequivalence of Tablet and Capsule Formulations of Granisetron in Patients Undergoing Cytotoxic Chemotherapy for Malignant Disease","publication_year":1993,"publication_date":"1993-12-01","ids":{"openalex":"https://openalex.org/W1994863530","doi":"https://doi.org/10.1002/jps.2600821221","mag":"1994863530","pmid":"https://pubmed.ncbi.nlm.nih.gov/8308713"},"language":"en","primary_location":{"id":"doi:10.1002/jps.2600821221","doi":"https://doi.org/10.1002/jps.2600821221","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600821221","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085647218","display_name":"Didier Cupissol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Didier Cupissol","raw_affiliation_strings":["Centre Val-d'Aurelle II, Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Val-d'Aurelle II, Montpellier, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108390764","display_name":"Franqoise Bressolle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19894307","display_name":"Universit\u00e9 de Montpellier","ror":"https://ror.org/051escj72","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307"]},{"id":"https://openalex.org/I4387153574","display_name":"Universit\u00e9 Montpellier 1","ror":"https://ror.org/0227fbx80","country_code":"FR","type":"education","lineage":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franqoise Bressolle","raw_affiliation_strings":["Centre Val-d\u2019Aurelle II, Montpellier, France","D\u00e9partement de Pharmacocindtique, Facultd de Pharmacie, University de Montpellier I, Avenue Ch.Flahault, 34060 Montpellier Cedex 01, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Val-d\u2019Aurelle II, Montpellier, France","institution_ids":[]},{"raw_affiliation_string":"D\u00e9partement de Pharmacocindtique, Facultd de Pharmacie, University de Montpellier I, Avenue Ch.Flahault, 34060 Montpellier Cedex 01, France","institution_ids":["https://openalex.org/I19894307","https://openalex.org/I4387153574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008521069","display_name":"Lucien Adenis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131356","display_name":"Centre Oscar Lambret","ror":"https://ror.org/03xfq7a50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210131356","https://openalex.org/I4210141925"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lucien Adenis","raw_affiliation_strings":["Centre Oscar-Lambret, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre Oscar-Lambret, Lille, France","institution_ids":["https://openalex.org/I4210131356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109902403","display_name":"James Carmichael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801179840","display_name":"Churchill Hospital","ror":"https://ror.org/009vheq40","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801179840","https://openalex.org/I4210147381"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"James Carmichael","raw_affiliation_strings":["Churchill Hospital, Oxford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Churchill Hospital, Oxford, United Kingdom","institution_ids":["https://openalex.org/I2801179840"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036848123","display_name":"Eric M. Bessell","orcid":"https://orcid.org/0000-0003-2957-289X","observed_orcids":["https://orcid.org/0000-0003-2957-289X"]},"institutions":[{"id":"https://openalex.org/I2801978711","display_name":"Nottingham General Hospital","ror":"https://ror.org/02cqyyd50","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801978711"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eric Bessell","raw_affiliation_strings":["Nottingham General Hospital, Nottingham, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nottingham General Hospital, Nottingham, United Kingdom","institution_ids":["https://openalex.org/I2801978711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108569823","display_name":"Ann Allen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann Allen","raw_affiliation_strings":["Research Division, SmithKIine Beecham Pharmaceuticals, The Frythe, Welwyn, Hertfordshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, SmithKIine Beecham Pharmaceuticals, The Frythe, Welwyn, Hertfordshire, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051510974","display_name":"Manfred Wargenau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manfred Wargenau","raw_affiliation_strings":["Statistics Unit, Clinical Pharmacology Operations, SmithKIine Beecham Pharmaceuticals, Neuss, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics Unit, Clinical Pharmacology Operations, SmithKIine Beecham Pharmaceuticals, Neuss, Germany","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074350819","display_name":"Didier Romain","orcid":"https://orcid.org/0000-0001-6214-7612","observed_orcids":["https://orcid.org/0000-0001-6214-7612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Didier Romain","raw_affiliation_strings":["Research Division, SmithKIine Beecham Pharmaceuticals, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, SmithKIine Beecham Pharmaceuticals, Paris, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3620,"currency":"USD","value_usd":3620},"apc_paid":null,"fwci":4.5635,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.94208506,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"82","issue":"12","first_page":"1281","last_page":"1284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.05510000139474869,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.026399999856948853,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/granisetron","display_name":"granisetron","score":1.0},{"id":"https://openalex.org/keywords/bioequivalence","display_name":"bioequivalence","score":0.9779999852180481},{"id":"https://openalex.org/keywords/5-ht3-receptor-antagonists","display_name":"5-HT3 receptor antagonists","score":0.8019999861717224},{"id":"https://openalex.org/keywords/conventional-chemotherapy","display_name":"cytotoxic chemotherapy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9309999942779541},{"id":"https://openalex.org/keywords/area-under-the-curve","display_name":"area under the curve","score":0.8320000171661377},{"id":"https://openalex.org/keywords/maximum-concentration","display_name":"maximum concentration","score":0.8460000157356262},{"id":"https://openalex.org/keywords/interpatient-variability","display_name":"interpatient variability","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C42404028","wikidata":"https://www.wikidata.org/wiki/Q864940","display_name":"Bioequivalence","level":3,"score":0.9102778434753418},{"id":"https://openalex.org/C22979827","wikidata":"https://www.wikidata.org/wiki/Q5137311","display_name":"Cmax","level":3,"score":0.8403681516647339},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.7687750458717346},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.6901560425758362},{"id":"https://openalex.org/C2778778583","wikidata":"https://www.wikidata.org/wiki/Q147768","display_name":"Capsule","level":2,"score":0.6841696500778198},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6292483806610107},{"id":"https://openalex.org/C2777452722","wikidata":"https://www.wikidata.org/wiki/Q596708","display_name":"Granisetron","level":4,"score":0.5853685140609741},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.5637136101722717},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.49775150418281555},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4953431189060211},{"id":"https://openalex.org/C40222840","wikidata":"https://www.wikidata.org/wiki/Q185049","display_name":"Geometric mean","level":2,"score":0.48565614223480225},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4563915431499481},{"id":"https://openalex.org/C76318530","wikidata":"https://www.wikidata.org/wiki/Q16833590","display_name":"Area under the curve","level":2,"score":0.4494001865386963},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3976496458053589},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2813381552696228},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1251741647720337},{"id":"https://openalex.org/C2780884295","wikidata":"https://www.wikidata.org/wiki/Q575136","display_name":"Antiemetic","level":3,"score":0.07383251190185547},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0661126971244812},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.06572556495666504},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002626","descriptor_name":"Chemistry, Pharmaceutical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D009325","descriptor_name":"Nausea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D013607","descriptor_name":"Tablets","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013810","descriptor_name":"Therapeutic Equivalency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017829","descriptor_name":"Granisetron","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017829","descriptor_name":"Granisetron","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017829","descriptor_name":"Granisetron","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jps.2600821221","doi":"https://doi.org/10.1002/jps.2600821221","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jps.2600821221","pdf_url":null,"source":{"id":"https://openalex.org/S130661733","display_name":"Journal of Pharmaceutical Sciences","issn_l":"0022-3549","issn":["0022-3549","1520-6017"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:8308713","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8308713","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical sciences","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1969836247","https://openalex.org/W1980894454","https://openalex.org/W2006998103","https://openalex.org/W2012005071","https://openalex.org/W2024940361","https://openalex.org/W2037698344","https://openalex.org/W2066515069","https://openalex.org/W2324055461","https://openalex.org/W6812008558"],"related_works":["https://openalex.org/W2348625363","https://openalex.org/W2382448163","https://openalex.org/W2357068258","https://openalex.org/W2353384994","https://openalex.org/W2153473127","https://openalex.org/W2288891601","https://openalex.org/W2229799543","https://openalex.org/W2389176539","https://openalex.org/W2045610727","https://openalex.org/W1972070725"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}