{"id":"https://openalex.org/W1994843752","doi":"https://doi.org/10.5339/qproc.2012.mutagens.3.27","title":"Mechanisms of Liver Carcinogenesis: Studies of Co-morbidity Factors Using Animal Models","display_name":"Mechanisms of Liver Carcinogenesis: Studies of Co-morbidity Factors Using Animal Models","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W1994843752","doi":"https://doi.org/10.5339/qproc.2012.mutagens.3.27","mag":"1994843752"},"language":"en","primary_location":{"id":"doi:10.5339/qproc.2012.mutagens.3.27","doi":"https://doi.org/10.5339/qproc.2012.mutagens.3.27","is_oa":false,"landing_page_url":"https://doi.org/10.5339/qproc.2012.mutagens.3.27","pdf_url":null,"source":{"id":"https://openalex.org/S4210184479","display_name":"QScience Proceedings","issn_l":"2226-9649","issn":["2226-9649"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320064","host_organization_name":"HBKU Press","host_organization_lineage":["https://openalex.org/P4310320064"],"host_organization_lineage_names":["HBKU Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"QScience Proceedings","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019868317","display_name":"Ivan Rusyn","orcid":"https://orcid.org/0000-0001-9340-7384","observed_orcids":["https://orcid.org/0000-0001-9340-7384","https://orcid.org/0000-0002-4865-9491"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ivan Rusyn","raw_affiliation_strings":["University of North Carolina, Chapel Hill, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019868317"],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.09957924,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2012","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5199999809265137,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.5199999809265137,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.42500001192092896,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.972000002861023},{"id":"https://openalex.org/keywords/hepatitis-c-virus","display_name":"hepatitis C virus","score":0.9810000061988831},{"id":"https://openalex.org/keywords/aflatoxin-b1","display_name":"aflatoxin B1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diethylnitrosamine","display_name":"diethylnitrosamine","score":0.9399999976158142},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/liver-cirrhosis","display_name":"liver cirrhosis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/synergistic-carcinogenesis","display_name":"synergistic carcinogenesis","score":0.6830000281333923},{"id":"https://openalex.org/keywords/carcinogenesis-mechanisms","display_name":"carcinogenesis mechanisms","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8448723554611206},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.772247314453125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6776479482650757},{"id":"https://openalex.org/C2777214474","wikidata":"https://www.wikidata.org/wiki/Q147778","display_name":"Cirrhosis","level":2,"score":0.6476382613182068},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.5331023931503296},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5308588147163391},{"id":"https://openalex.org/C2777575235","wikidata":"https://www.wikidata.org/wiki/Q558404","display_name":"Alcoholic liver disease","level":3,"score":0.49177029728889465},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.49002397060394287},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.4832971394062042},{"id":"https://openalex.org/C2777382497","wikidata":"https://www.wikidata.org/wiki/Q6853","display_name":"Hepatitis B","level":2,"score":0.4778182804584503},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47732430696487427},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4672379791736603},{"id":"https://openalex.org/C2780732942","wikidata":"https://www.wikidata.org/wiki/Q3144986","display_name":"Alcoholic hepatitis","level":4,"score":0.46045711636543274},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4295836091041565},{"id":"https://openalex.org/C2776455275","wikidata":"https://www.wikidata.org/wiki/Q154869","display_name":"Hepatitis C","level":2,"score":0.42828524112701416},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.41677579283714294},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2866891026496887},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.18949472904205322}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.5339/qproc.2012.mutagens.3.27","doi":"https://doi.org/10.5339/qproc.2012.mutagens.3.27","is_oa":false,"landing_page_url":"https://doi.org/10.5339/qproc.2012.mutagens.3.27","pdf_url":null,"source":{"id":"https://openalex.org/S4210184479","display_name":"QScience Proceedings","issn_l":"2226-9649","issn":["2226-9649"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320064","host_organization_name":"HBKU Press","host_organization_lineage":["https://openalex.org/P4310320064"],"host_organization_lineage_names":["HBKU Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"QScience Proceedings","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1979585194","https://openalex.org/W2051772532","https://openalex.org/W2034992482","https://openalex.org/W2077311317","https://openalex.org/W2037700816","https://openalex.org/W2018844505","https://openalex.org/W2470164809","https://openalex.org/W2167210859","https://openalex.org/W4303942519","https://openalex.org/W4253894275"],"abstract_inverted_index":{"Abstract":[0],"Hepatocellular":[1],"carcinoma":[2],"(HCC)":[3],"is":[4,85],"the":[5,13,52,59,88,120,123,177,184],"most":[6],"common":[7],"type":[8],"of":[9,18,56,114,119,122,153,157],"primary":[10],"malignancy":[11],"in":[12,54,58,67,72,87,108,145],"liver.":[14],"Main":[15],"risk":[16],"factors":[17,32,137,161],"HCC":[19,57,107,115,144,158],"are":[20,98,139,181],"well-defined":[21],"and":[22,30,39,42,48,78,90,96,131],"include":[23],"hepatitis":[24,73],"B":[25],"virus":[26,75],"(HBV);":[27],"lifestyle,":[28],"diet":[29],"environmental":[31],"(e.g.,":[33,45],"alcoholic":[34],"beverages,":[35],"aflatoxin":[36],"B1":[37],"(AFB1),":[38],"tobacco":[40],"smoking);":[41],"metabolic":[43],"diseases":[44],"obesity,":[46],"diabetes":[47],"non-alcoholic":[49,79],"steatohepatitis).":[50],"Importantly,":[51],"rise":[53],"incidence":[55],"developed":[60],"countries":[61],"has":[62],"been":[63],"attributed,":[64],"at":[65],"least":[66],"part,":[68],"to":[69,127,141,143,175],"an":[70,173],"increase":[71],"C":[74],"(HCV)":[76],"infections":[77],"steatohepatitis,":[80],"pathological":[81],"states":[82,104],"whose":[83],"prevalence":[84],"growing":[86],"US":[89],"Europe.":[91],"In":[92],"addition,":[93],"liver":[94,102],"fibrosis":[95],"cirrhosis":[97],"well":[99],"known":[100,140],"precursor":[101],"disease":[103,128],"for":[105,183],"hepatocellular":[106],"humans.":[109,146],"While":[110],"animal":[111,155],"model":[112],"studies":[113,171],"have":[116],"contributed":[117],"much":[118],"understanding":[121],"molecular":[124,178],"events":[125],"leading":[126],"initiation,":[129],"progression":[130],"promotion,":[132],"few":[133],"publications":[134],"examined":[135],"co-morbidity":[136,160,187],"that":[138,180],"contribute":[142],"This":[147],"presentation":[148],"will":[149],"describe":[150],"two":[151],"examples":[152],"experimental":[154],"models":[156],"where":[159],"(HCV+AFB1,":[162],"or":[163],"genotoxic":[164],"carcinogen":[165],"diethylnitrosamine+liver":[166],"fibrosis)":[167],"were":[168],"explored.":[169],"These":[170],"afford":[172],"opportunity":[174],"examine":[176],"mechanisms":[179],"crucial":[182],"synergy":[185],"between":[186],"factors.":[188]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}