{"id":"https://openalex.org/W1994792502","doi":"https://doi.org/10.1111/j.1600-0609.1998.tb01027.x","title":"Characterization of the ETO and AML1\u2013ETO proteins involved in the 8;21 translocation in acute myelogenous leukemia","display_name":"Characterization of the ETO and AML1\u2013ETO proteins involved in the 8;21 translocation in acute myelogenous leukemia","publication_year":1998,"publication_date":"1998-04-01","ids":{"openalex":"https://openalex.org/W1994792502","doi":"https://doi.org/10.1111/j.1600-0609.1998.tb01027.x","mag":"1994792502","pmid":"https://pubmed.ncbi.nlm.nih.gov/9579874"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0609.1998.tb01027.x","doi":"https://doi.org/10.1111/j.1600-0609.1998.tb01027.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.1998.tb01027.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077290971","display_name":"Xiao\u2010Feng Le","orcid":"https://orcid.org/0000-0002-2381-5929","observed_orcids":["https://orcid.org/0000-0002-2381-5929"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiao\u2010Feng Le","raw_affiliation_strings":["Division of Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA","Division of Laboratory Medicine, The University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Division of Laboratory Medicine, The University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004302802","display_name":"David F. Claxton","orcid":"https://orcid.org/0000-0001-9209-2405","observed_orcids":["https://orcid.org/0000-0001-9209-2405"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Claxton","raw_affiliation_strings":["Department of Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108616256","display_name":"Steve M. Kornblau","orcid":"https://orcid.org/0000-0002-5990-9548","observed_orcids":["https://orcid.org/0000-0002-5990-9548"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Kornblau","raw_affiliation_strings":["Department of Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111601660","display_name":"You\u2010Hong Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"You\u2010Hong Fan","raw_affiliation_strings":["Division of Laboratory Medicine, Houston, Texas, USA","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Laboratory Medicine, Houston, Texas, USA","institution_ids":[]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078969035","display_name":"Zhaomei Mu","orcid":"https://orcid.org/0000-0002-0049-5387","observed_orcids":["https://orcid.org/0000-0002-0049-5387"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhao\u2010Mei Mu","raw_affiliation_strings":["Division of Laboratory Medicine, Houston, Texas, USA","University of Texas Health Science Center at Houston"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Laboratory Medicine, Houston, Texas, USA","institution_ids":[]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113603363","display_name":"Kun-Sang Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kun\u2010Sang Chang","raw_affiliation_strings":["Division of Laboratory Medicine, Houston, Texas, USA","University of Texas Health Science Center at Houston","University of Texas MD Anderson Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Laboratory Medicine, Houston, Texas, USA","institution_ids":[]},{"raw_affiliation_string":"University of Texas Health Science Center at Houston","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113603363"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I919571938"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":3.2508,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.91649916,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"60","issue":"4","first_page":"217","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eto","display_name":"ETO","score":0.6740000247955322},{"id":"https://openalex.org/keywords/aml1-eto-fusion-protein","display_name":"AML1-ETO fusion protein","score":0.9779999852180481},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9829999804496765},{"id":"https://openalex.org/keywords/nuclear-matrix","display_name":"nuclear matrix","score":0.5659999847412109},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.7070000171661377},{"id":"https://openalex.org/keywords/kasumi-1-cells","display_name":"Kasumi-1 cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/k562-cells","display_name":"K562 cells","score":0.9369999766349792}],"concepts":[{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.7867214679718018},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.743151068687439},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6674520969390869},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.6081741452217102},{"id":"https://openalex.org/C171122931","wikidata":"https://www.wikidata.org/wiki/Q6324626","display_name":"K562 cells","level":3,"score":0.5995110273361206},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5884630680084229},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5883424878120422},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.5676103830337524},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5425920486450195},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.49864840507507324},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3764825463294983},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3378511667251587},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23206517100334167},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16294142603874207},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12189120054244995},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.10724344849586487},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.07880526781082153}],"mesh":[{"descriptor_ui":"D000075142","descriptor_name":"RUNX1 Translocation Partner 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075142","descriptor_name":"RUNX1 Translocation Partner 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075142","descriptor_name":"RUNX1 Translocation Partner 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002891","descriptor_name":"Chromosomes, Human, Pair 21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002891","descriptor_name":"Chromosomes, Human, Pair 21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002891","descriptor_name":"Chromosomes, Human, Pair 21","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002898","descriptor_name":"Chromosomes, Human, Pair 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015672","descriptor_name":"Erythroid Precursor Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050676","descriptor_name":"Core Binding Factor Alpha 2 Subunit","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0609.1998.tb01027.x","doi":"https://doi.org/10.1111/j.1600-0609.1998.tb01027.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.1998.tb01027.x","pdf_url":null,"source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:9579874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9579874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of haematology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.44999998807907104}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3774884214","display_name":"THE THERAPY OF AML","funder_award_id":"5p01ca055164-19","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6128007255","display_name":null,"funder_award_id":"CA55164-5","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W91818377","https://openalex.org/W109488878","https://openalex.org/W123071911","https://openalex.org/W164903874","https://openalex.org/W221180449","https://openalex.org/W1524671781","https://openalex.org/W1596935560","https://openalex.org/W1829757075","https://openalex.org/W1847881039","https://openalex.org/W1891785401","https://openalex.org/W1945687446","https://openalex.org/W1982721874","https://openalex.org/W1991766825","https://openalex.org/W2011975744","https://openalex.org/W2012160343","https://openalex.org/W2047591593","https://openalex.org/W2051886380","https://openalex.org/W2058468726","https://openalex.org/W2067040747","https://openalex.org/W2068728784","https://openalex.org/W2073374262","https://openalex.org/W2075027785","https://openalex.org/W2080991719","https://openalex.org/W2085033687","https://openalex.org/W2113086962","https://openalex.org/W2116989970","https://openalex.org/W2170425393","https://openalex.org/W2260510793","https://openalex.org/W2280340122","https://openalex.org/W2338753933","https://openalex.org/W2415138605","https://openalex.org/W2419614507","https://openalex.org/W2467957568","https://openalex.org/W6603640516"],"related_works":["https://openalex.org/W1983082628","https://openalex.org/W2048472511","https://openalex.org/W2088238879","https://openalex.org/W2380136365","https://openalex.org/W2356396438","https://openalex.org/W2136658115","https://openalex.org/W1978071048","https://openalex.org/W2368054163","https://openalex.org/W2350704154","https://openalex.org/W2366088680"],"abstract_inverted_index":{"The":[0,134,159],"AML1":[1,20,63],"and":[2,43,56,60,64,79,86,91,125,207],"ETO":[3,34,42,55,65,78],"genes":[4],"are":[5],"disrupted":[6],"by":[7,131,185],"the":[8,19,30,39,46,50,100,106,126,178,196],"nonrandom":[9],"chromosomal":[10],"translocation":[11],"t(8;21)":[12],"in":[13,45,70,142,152,166,209],"acute":[14],"myelogenous":[15],"leukemia":[16,117],"(AML).":[17],"While":[18],"gene":[21],"encodes":[22],"a":[23,110],"transcription":[24],"factor":[25],"indispensable":[26],"for":[27,204],"definitive":[28],"hematopoiesis,":[29],"biological":[31,160],"function":[32],"of":[33,41,48,54,119,162,181,188],"is":[35],"unknown.":[36],"To":[37,103],"understand":[38],"role":[40],"AML1-ETO":[44,57,80,137,163,176,197],"pathogenesis":[47],"AML,":[49],"full":[51],"length":[52],"cDNAs":[53],"were":[58,81,97,129],"cloned":[59],"antibodies":[61],"against":[62],"proteins":[66],"have":[67],"been":[68],"developed":[69],"our":[71],"laboratory.":[72],"Western":[73,132],"blot":[74],"analysis":[75],"showed":[76],"that":[77,92,175],"identified":[82],"as":[83],"70":[84],"kDa":[85,88,136],"94":[87,135],"proteins,":[89,94],"respectively,":[90],"both":[93],"like":[95],"AML1,":[96],"associated":[98],"with":[99,122,156],"nuclear":[101],"matrix.":[102],"examine":[104],"whether":[105],"t(8;21)-positive":[107,123,191],"AMLs":[108,192],"expressed":[109],"94-kDa":[111],"AML1-ETO,":[112],"protein":[113,139,148],"fractions":[114],"isolated":[115],"from":[116],"blasts":[118],"10":[120],"patients":[121,155],"AML":[124],"Kasumi-1":[127],"cells":[128,183],"analyzed":[130],"blotting.":[133],"fusion":[138,147,198],"was":[140,149,164],"detected":[141],"all":[143,153],"samples.":[144],"However,":[145],"this":[146],"not":[150],"detectable":[151],"40":[154],"t(8;21)-negative":[157],"AMLs.":[158],"significance":[161],"examined":[165],"K562":[167,182],"cells,":[168],"which":[169,200],"stably":[170],"overexpress":[171,195],"AML1-ETO.":[172],"We":[173],"found":[174],"blocked":[177],"erythroid":[179],"differentiation":[180,205],"induced":[184],"low":[186],"doses":[187],"Ara-C.":[189],"Thus,":[190],"appear":[193],"to":[194],"protein,":[199],"may":[201],"be":[202],"responsible":[203],"block":[206],"leukemogenesis":[208],"AML.":[210]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}