{"id":"https://openalex.org/W199479084","doi":null,"title":"Protective effects of amlodipine on mitochondrial injury in ischemic reperfused rat heart.","display_name":"Protective effects of amlodipine on mitochondrial injury in ischemic reperfused rat heart.","publication_year":2012,"publication_date":"2012-05-01","ids":{"openalex":"https://openalex.org/W199479084","mag":"199479084","pmid":"https://pubmed.ncbi.nlm.nih.gov/23029908"},"language":"en","primary_location":{"id":"pmid:23029908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23029908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of environmental biology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077516909","display_name":"Najam Ali Khan","orcid":"https://orcid.org/0000-0002-4698-6819","observed_orcids":["https://orcid.org/0000-0002-4698-6819"]},"institutions":[{"id":"https://openalex.org/I2801192375","display_name":"IFTM University","ror":"https://ror.org/02v2sn747","country_code":"IN","type":"education","lineage":["https://openalex.org/I2801192375"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Najam Ali Khan","raw_affiliation_strings":["Department of Pharmacology and Clinical Research, College of Pharmacy, IFTM University, Moradabad - 244 001, India. alikhan_najam@yahoo.co.in"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Clinical Research, College of Pharmacy, IFTM University, Moradabad - 244 001, India. alikhan_najam@yahoo.co.in","institution_ids":["https://openalex.org/I2801192375"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080050045","display_name":"Pronobesh Chattopadhyay","orcid":"https://orcid.org/0000-0001-7770-6341","observed_orcids":["https://orcid.org/0000-0001-7770-6341"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pronobesh Chattopadhyay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Mohammad Abid","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Abid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035254182","display_name":"Abhijeet Pawdey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abhijeet Pawdey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kamal Kishore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamal Kishore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5108466574","display_name":"Arun Kumar Wahi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arun Kumar Wahi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4127,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.67246842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"33","issue":"3","first_page":"591","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amlodipine","display_name":"amlodipine","score":1.0},{"id":"https://openalex.org/keywords/myocardial-ischemia-reperfusion-injury","display_name":"myocardial ischemia-reperfusion injury","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mitochondrial-injury","display_name":"mitochondrial injury","score":0.7960000038146973},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.8389999866485596},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.9309999942779541},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":1.0},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cardiomyocyte-injury","display_name":"cardiomyocyte injury","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2779646130","wikidata":"https://www.wikidata.org/wiki/Q411347","display_name":"Amlodipine","level":3,"score":0.9378103017807007},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.684930145740509},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6557910442352295},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6482102274894714},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.6182324886322021},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.530593752861023},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.49036645889282227},{"id":"https://openalex.org/C544855455","wikidata":"https://www.wikidata.org/wiki/Q1070952","display_name":"Histopathology","level":2,"score":0.43665772676467896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4267463684082031},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3474166989326477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3241179883480072},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30724698305130005},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17749863862991333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17455080151557922},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.1258353590965271}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003331","descriptor_name":"Coronary Vessels","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008929","descriptor_name":"Mitochondria, Heart","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015428","descriptor_name":"Myocardial Reperfusion Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017311","descriptor_name":"Amlodipine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23029908","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23029908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of environmental biology","raw_type":"Journal Article"},{"id":"mag:199479084","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23029908","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1859822101","https://openalex.org/W1966939913","https://openalex.org/W1967487924","https://openalex.org/W1967629185","https://openalex.org/W1971034264","https://openalex.org/W1986375453","https://openalex.org/W1988291501","https://openalex.org/W1991222876","https://openalex.org/W2002717483","https://openalex.org/W2009163539","https://openalex.org/W2009451441","https://openalex.org/W2043131158","https://openalex.org/W2048547503","https://openalex.org/W2048966030","https://openalex.org/W2063020456","https://openalex.org/W2065622829","https://openalex.org/W2070839245","https://openalex.org/W2073225923","https://openalex.org/W2073690515","https://openalex.org/W2079438155","https://openalex.org/W2088745867","https://openalex.org/W2093055423","https://openalex.org/W2094469939","https://openalex.org/W2130950961","https://openalex.org/W2134907826","https://openalex.org/W2151398790","https://openalex.org/W2158350888","https://openalex.org/W2170347547","https://openalex.org/W2291903346","https://openalex.org/W2300787713","https://openalex.org/W2313326603"],"related_works":["https://openalex.org/W4256579238","https://openalex.org/W2075966415","https://openalex.org/W1993515055","https://openalex.org/W2130149128","https://openalex.org/W2091381853","https://openalex.org/W2326211609","https://openalex.org/W2092036834","https://openalex.org/W2894141299","https://openalex.org/W1968004849","https://openalex.org/W2394399877"],"abstract_inverted_index":{"The":[0,15],"most":[1],"significant":[2,51],"finding":[3],"of":[4,11,17,103,113,121,125,133],"the":[5,9,91,100,111,122,129],"present":[6],"study":[7,98],"was":[8,28,49],"release":[10,130],"nitric":[12],"oxide":[13],"(NO).":[14],"effect":[16],"amlodipine":[18,65,83,104,126],"on":[19],"NO":[20,134],"production":[21],"associated":[22],"with":[23],"ischemic":[24],"reperfused":[25],"(IR)":[26],"injury":[27,89],"investigated":[29],"in":[30,53,64,87],"rat":[31],"heart":[32],"model.":[33],"Cardiac":[34],"tissues":[35],"from":[36],"animal":[37],"groups":[38],"were":[39],"processed":[40],"for":[41],"biochemical,":[42],"histopathological":[43],"and":[44,60,135],"electron":[45,95],"microscopic":[46,96],"studies.":[47],"There":[48],"a":[50,119],"increase":[52],"myocardial":[54],"catalase":[55],"(CAT),":[56],"superoxide":[57],"dismutase":[58],"(SOD)":[59],"glutathione":[61],"(GSH)":[62],"enzymes":[63],"treated":[66],"group":[67,76],"(1.37,":[68],"10.27,":[69],"6.39)":[70],"when":[71],"compared":[72],"to":[73],"IR":[74,106],"injured":[75],"(0.81,":[77],"6.87,":[78],"4.53).":[79],"Histopathology":[80],"studies":[81],"showed":[82],"reduce":[84],"cardiocyte":[85],"damage":[86],"cardiac":[88,92,108],"during":[90],"IR.":[93],"Transmission":[94],"(TEM)":[97],"confirmed":[99],"cardioprotective":[101],"role":[102],"against":[105],"induced":[107],"injury.":[109],"On":[110],"basis":[112],"findings,":[114],"it":[115],"is":[116],"hypothesized":[117],"that":[118],"portion":[120],"beneficial":[123],"actions":[124],"may":[127],"involve":[128],"or":[131],"action":[132],"probably":[136],"by":[137],"its":[138],"antioxidant":[139],"properties.":[140]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
