{"id":"https://openalex.org/W1994766987","doi":"https://doi.org/10.1371/journal.pone.0100985","title":"7-Ketocholesterol-Induced Inflammation Signals Mostly through the TLR4 Receptor Both In Vitro and In Vivo","display_name":"7-Ketocholesterol-Induced Inflammation Signals Mostly through the TLR4 Receptor Both In Vitro and In Vivo","publication_year":2014,"publication_date":"2014-07-18","ids":{"openalex":"https://openalex.org/W1994766987","doi":"https://doi.org/10.1371/journal.pone.0100985","mag":"1994766987","pmid":"https://pubmed.ncbi.nlm.nih.gov/25036103","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4103802"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0100985","doi":"https://doi.org/10.1371/journal.pone.0100985","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0100985","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100985&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100985&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101019162","display_name":"Jiahn-Dar Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiahn-Dar Huang","raw_affiliation_strings":["Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023776852","display_name":"Juan Amaral","orcid":"https://orcid.org/0000-0001-8755-9170","observed_orcids":["https://orcid.org/0000-0001-8755-9170"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Juan Amaral","raw_affiliation_strings":["Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113313914","display_name":"Jung Wha Lee","orcid":"https://orcid.org/0000-0002-7068-6760","observed_orcids":["https://orcid.org/0000-0002-7068-6760"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jung Wha Lee","raw_affiliation_strings":["Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021429317","display_name":"Ignacio R. Rodr\u00edguez","orcid":"https://orcid.org/0009-0004-7522-8947","observed_orcids":["https://orcid.org/0009-0004-7522-8947"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210139686","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ignacio R. Rodriguez","raw_affiliation_strings":["Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanisms of Retinal Diseases Section, Laboratory of Retinal Cell and Molecular Biology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5021429317"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210139686"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":1.6923,"has_fulltext":true,"cited_by_count":73,"citation_normalized_percentile":{"value":0.82971645,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"9","issue":"7","first_page":"e100985","last_page":"e100985"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.01489999983459711,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/7-ketocholesterol","display_name":"7-ketocholesterol","score":1.0},{"id":"https://openalex.org/keywords/cholesterol-oxidation","display_name":"cholesterol oxidation","score":0.6309999823570251},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5839999914169312},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.824999988079071},{"id":"https://openalex.org/keywords/er-stress-response","display_name":"ER stress response","score":0.843999981880188},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.953000009059906},{"id":"https://openalex.org/keywords/egfr-signaling","display_name":"EGFR signaling","score":0.6859999895095825},{"id":"https://openalex.org/keywords/cytokine-induction","display_name":"cytokine induction","score":0.7110000252723694},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8619999885559082},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.8360000252723694},{"id":"https://openalex.org/keywords/arpe-19-cells","display_name":"ARPE-19 cells","score":0.7310000061988831}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.7693915367126465},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.657090961933136},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.5936375856399536},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.548057496547699},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5207833647727966},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5144124627113342},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4604983329772949},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4604083001613617},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4490512013435364},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.42320123314857483},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41898080706596375},{"id":"https://openalex.org/C43929388","wikidata":"https://www.wikidata.org/wiki/Q4050587","display_name":"TRIF","level":5,"score":0.4186924993991852},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3990784287452698},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37996238470077515},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3515167236328125},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2733928859233856},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2708224952220917},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.18048986792564392},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.0998285710811615},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002867","descriptor_name":"Chromones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005110","descriptor_name":"Extracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005229","descriptor_name":"Fatty Acids, Monounsaturated","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007653","descriptor_name":"Ketocholesterols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058847","descriptor_name":"Inflammasomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059865","descriptor_name":"Endoplasmic Reticulum Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0100985","doi":"https://doi.org/10.1371/journal.pone.0100985","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0100985","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100985&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3074325","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4103802","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4103802","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4103802","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:25036103","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25036103","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.797.9898","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.797.9898","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/e5/92/pone.0100985.PMC4103802.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:95b8afc335554272beb8e15d89357581","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/95b8afc335554272beb8e15d89357581","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 7, p e100985 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0100985","doi":"https://doi.org/10.1371/journal.pone.0100985","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0100985","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0100985&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994766987.pdf","grobid_xml":"https://content.openalex.org/works/W1994766987.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W1625702540","https://openalex.org/W1878897522","https://openalex.org/W1959223184","https://openalex.org/W1966766618","https://openalex.org/W1966778168","https://openalex.org/W1971144696","https://openalex.org/W1971263149","https://openalex.org/W1971915082","https://openalex.org/W1973078232","https://openalex.org/W1984230217","https://openalex.org/W1985139053","https://openalex.org/W1986060457","https://openalex.org/W1987642183","https://openalex.org/W1988280690","https://openalex.org/W1990398272","https://openalex.org/W1993849420","https://openalex.org/W1994348637","https://openalex.org/W2006404179","https://openalex.org/W2006801592","https://openalex.org/W2014913652","https://openalex.org/W2016231119","https://openalex.org/W2018956263","https://openalex.org/W2023817080","https://openalex.org/W2025677435","https://openalex.org/W2029678644","https://openalex.org/W2033414404","https://openalex.org/W2035721831","https://openalex.org/W2039179842","https://openalex.org/W2046335519","https://openalex.org/W2046822015","https://openalex.org/W2049645198","https://openalex.org/W2049685849","https://openalex.org/W2052615604","https://openalex.org/W2052983274","https://openalex.org/W2054226501","https://openalex.org/W2056993355","https://openalex.org/W2073220467","https://openalex.org/W2074966907","https://openalex.org/W2079332279","https://openalex.org/W2079568800","https://openalex.org/W2080592193","https://openalex.org/W2083000129","https://openalex.org/W2085933321","https://openalex.org/W2087289608","https://openalex.org/W2089910376","https://openalex.org/W2094114923","https://openalex.org/W2096931514","https://openalex.org/W2100852463","https://openalex.org/W2101935191","https://openalex.org/W2104041621","https://openalex.org/W2107495112","https://openalex.org/W2108040405","https://openalex.org/W2113574245","https://openalex.org/W2119424783","https://openalex.org/W2123898358","https://openalex.org/W2124962639","https://openalex.org/W2128003689","https://openalex.org/W2129881449","https://openalex.org/W2134887638","https://openalex.org/W2135185526","https://openalex.org/W2141954135","https://openalex.org/W2149071811","https://openalex.org/W2155502203","https://openalex.org/W2156275792","https://openalex.org/W2158591358","https://openalex.org/W2161682775","https://openalex.org/W2161791643","https://openalex.org/W2346096088"],"related_works":["https://openalex.org/W1988280690","https://openalex.org/W2033414404","https://openalex.org/W4414307963","https://openalex.org/W940500347","https://openalex.org/W2058491905","https://openalex.org/W4400724386","https://openalex.org/W3159135285","https://openalex.org/W2150277507","https://openalex.org/W2531601161","https://openalex.org/W2194510606"],"abstract_inverted_index":{"The":[0,119,136,144],"cholesterol":[1,31],"oxide":[2],"7-ketocholesterol":[3],"(7KCh)":[4],"has":[5],"been":[6],"implicated":[7],"in":[8,38,49,52,61,81,86,213],"numerous":[9],"age-related":[10,21],"diseases":[11],"such":[12],"as":[13],"atherosclerosis,":[14],"Alzheimer's":[15],"disease,":[16,18],"Parkinson's":[17],"cancer":[19],"and":[20,32,45,51,85,201],"macular":[22],"degeneration.":[23],"It":[24,54],"is":[25,55,106],"formed":[26],"by":[27,78,177],"the":[28,74,93,97,110,122,129,133,169,183,188,192,198,202,214],"autooxidation":[29],"of":[30,57,96,116,121,132,187],"especially":[33],"cholesterol-fatty":[34],"acid":[35],"esters":[36],"found":[37],"lipoprotein":[39,66],"deposits.":[40,67],"This":[41],"molecule":[42],"causes":[43],"complex":[44],"potent":[46],"inflammatory":[47,75],"responses":[48],"vitro":[50],"vivo.":[53],"suspected":[56],"causing":[58],"chronic":[59],"inflammation":[60,105,146],"tissues":[62],"exposed":[63],"to":[64,126,149,162,174,196,210],"oxidized":[65],"In":[68],"this":[69,157],"study":[70],"we":[71],"have":[72],"examined":[73],"pathways":[76],"activated":[77,181],"7KCh":[79],"both":[80],"cultured":[82],"ARPE19":[83],"cells":[84],"vivo":[87],"using":[88],"7KCh-containing":[89],"implants":[90],"inserted":[91],"into":[92],"anterior":[94],"chamber":[95],"rat":[98],"eye.":[99],"Our":[100],"results":[101],"indicate":[102],"that":[103],"7KCh-induced":[104,145],"mediated":[107,176],"mostly":[108],"though":[109],"TLR4":[111,134,184],"receptor":[112],"with":[113],"some":[114],"cross-activation":[115],"EGFR-related":[117],"pathways.":[118],"majority":[120],"cytokine":[123,199],"inductions":[124,200],"seem":[125,161,195,209],"signal":[127],"via":[128],"TRIF/TRAM":[130],"side":[131,138],"receptor.":[135,185],"MyD88/TIRAP":[137],"only":[139],"significantly":[140],"effects":[141],"IL-1\u03b2":[142],"inductions.":[143],"also":[147],"seems":[148,173],"involve":[150,163],"a":[151,164],"robust":[152],"ER":[153,170,215],"stress":[154,171,216],"response.":[155,217],"However,":[156],"response":[158,172],"does":[159],"not":[160,208],"calcium":[165],"efflux-mediated":[166],"UPR.":[167],"Instead":[168],"be":[175,211],"yet":[178],"identified":[179,190],"kinases":[180,189],"through":[182],"Some":[186],"are":[191],"RSKs":[193],"which":[194],"mediate":[197],"cell":[203],"death":[204],"pathway":[205],"but":[206],"do":[207],"involved":[212]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
