{"id":"https://openalex.org/W1994766366","doi":"https://doi.org/10.1073/pnas.1101818108","title":"Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses","display_name":"Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses","publication_year":2011,"publication_date":"2011-08-15","ids":{"openalex":"https://openalex.org/W1994766366","doi":"https://doi.org/10.1073/pnas.1101818108","mag":"1994766366","pmid":"https://pubmed.ncbi.nlm.nih.gov/21844343","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3161593"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1101818108","doi":"https://doi.org/10.1073/pnas.1101818108","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1101818108","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1994766366"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3161593/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087739263","display_name":"Raunak Sinha","orcid":"https://orcid.org/0000-0002-7553-1274","observed_orcids":["https://orcid.org/0000-0002-7553-1274"]},"institutions":[{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]},{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Raunak Sinha","raw_affiliation_strings":["Department of Cellular Biophysics, Institute for Medical Physics and Biophysics, University of Muenster, 48149 Muenster, Germany","Departments of aMembrane Biophysics and","Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biophysics, Institute for Medical Physics and Biophysics, University of Muenster, 48149 Muenster, Germany","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Departments of aMembrane Biophysics and","institution_ids":[]},{"raw_affiliation_string":"Department of Membrane Biophysics, MPI for biophysical chemistry, Max Planck Society","institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049140429","display_name":"Saheeb Ahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Saheeb Ahmed","raw_affiliation_strings":["Neurobiology, Max-Planck Institute for Biophysical Chemistry, 37077 G\u00f6ttingen, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurobiology, Max-Planck Institute for Biophysical Chemistry, 37077 G\u00f6ttingen, Germany; and","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077214003","display_name":"Reinhard Jahn","orcid":"https://orcid.org/0000-0003-1542-3498","observed_orcids":["https://orcid.org/0000-0003-1542-3498"]},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661","https://openalex.org/I4387154714"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhard Jahn","raw_affiliation_strings":["Neurobiology, Max-Planck Institute for Biophysical Chemistry, 37077 G\u00f6ttingen, Germany; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurobiology, Max-Planck Institute for Biophysical Chemistry, 37077 G\u00f6ttingen, Germany; and","institution_ids":["https://openalex.org/I4210131661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111385251","display_name":"J\u00fcrgen Klingauf","orcid":"https://orcid.org/0009-0003-2762-7938","observed_orcids":["https://orcid.org/0009-0003-2762-7938"]},"institutions":[{"id":"https://openalex.org/I22465464","display_name":"University of M\u00fcnster","ror":"https://ror.org/00pd74e08","country_code":"DE","type":"education","lineage":["https://openalex.org/I22465464"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Jurgen Klingauf","raw_affiliation_strings":["Department of Cellular Biophysics, Institute for Medical Physics and Biophysics, University of Muenster, 48149 Muenster, Germany","Departments of aMembrane Biophysics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Biophysics, Institute for Medical Physics and Biophysics, University of Muenster, 48149 Muenster, Germany","institution_ids":["https://openalex.org/I22465464"]},{"raw_affiliation_string":"Departments of aMembrane Biophysics and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111385251"],"corresponding_institution_ids":["https://openalex.org/I22465464"],"apc_list":null,"apc_paid":null,"fwci":4.6145,"has_fulltext":false,"cited_by_count":196,"citation_normalized_percentile":{"value":0.95774828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"108","issue":"34","first_page":"14318","last_page":"14323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synaptobrevin-2","display_name":"synaptobrevin 2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/snare-complex","display_name":"SNARE complex","score":0.753000020980835},{"id":"https://openalex.org/keywords/synaptic-vesicle-fusion","display_name":"synaptic vesicle fusion","score":0.9779999852180481},{"id":"https://openalex.org/keywords/exocytosis","display_name":"exocytosis","score":0.9520000219345093},{"id":"https://openalex.org/keywords/fast-synaptic-transmission","display_name":"fast synaptic transmission","score":0.7689999938011169},{"id":"https://openalex.org/keywords/vesicle-priming","display_name":"vesicle priming","score":0.7549999952316284},{"id":"https://openalex.org/keywords/phluorin","display_name":"pHluorin","score":0.8180000185966492},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8220000267028809},{"id":"https://openalex.org/keywords/syntaxin-1a","display_name":"syntaxin 1A","score":0.921999990940094},{"id":"https://openalex.org/keywords/snap-25","display_name":"SNAP-25","score":0.9670000076293945},{"id":"https://openalex.org/keywords/single-molecule-fluorescence","display_name":"single-molecule fluorescence","score":0.38199999928474426}],"concepts":[{"id":"https://openalex.org/C2777029164","wikidata":"https://www.wikidata.org/wiki/Q82452579","display_name":"Synaptobrevin","level":5,"score":0.8338836431503296},{"id":"https://openalex.org/C134499376","wikidata":"https://www.wikidata.org/wiki/Q14897641","display_name":"SNAP25","level":5,"score":0.6691374778747559},{"id":"https://openalex.org/C196330066","wikidata":"https://www.wikidata.org/wiki/Q7923216","display_name":"Vesicle fusion","level":5,"score":0.6290984153747559},{"id":"https://openalex.org/C148785051","wikidata":"https://www.wikidata.org/wiki/Q671136","display_name":"Synaptic vesicle","level":4,"score":0.618762195110321},{"id":"https://openalex.org/C175969161","wikidata":"https://www.wikidata.org/wiki/Q323426","display_name":"Exocytosis","level":3,"score":0.6083245873451233},{"id":"https://openalex.org/C2908790754","wikidata":"https://www.wikidata.org/wiki/Q279694","display_name":"SNARE complex","level":4,"score":0.5847001075744629},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.5508168935775757},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5255485773086548},{"id":"https://openalex.org/C200170125","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neurotransmission","level":3,"score":0.5241444706916809},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5184390544891357},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4435787796974182},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.4207102358341217},{"id":"https://openalex.org/C53728453","wikidata":"https://www.wikidata.org/wiki/Q18031771","display_name":"STX1A","level":5,"score":0.42016810178756714},{"id":"https://openalex.org/C165254790","wikidata":"https://www.wikidata.org/wiki/Q6416872","display_name":"Kiss-and-run fusion","level":5,"score":0.4121294617652893},{"id":"https://openalex.org/C65972015","wikidata":"https://www.wikidata.org/wiki/Q6935634","display_name":"Munc-18","level":5,"score":0.4106637239456177},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3534345328807831},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2702443301677704},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22396960854530334},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.10385605692863464}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005089","descriptor_name":"Exocytosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005453","descriptor_name":"Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008561","descriptor_name":"Membrane Fusion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013572","descriptor_name":"Synaptic Vesicles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018628","descriptor_name":"Gene Dosage","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050988","descriptor_name":"Vesicle-Associated Membrane Protein 2","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D050988","descriptor_name":"Vesicle-Associated Membrane Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051040","descriptor_name":"Vesicle-Associated Membrane Protein 3","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051040","descriptor_name":"Vesicle-Associated Membrane Protein 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1101818108","doi":"https://doi.org/10.1073/pnas.1101818108","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1101818108","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:21844343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21844343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3161593","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3161593/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:edoc.mpg.de:571760","doi":null,"is_oa":false,"landing_page_url":"http://edoc.mpg.de/571760","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America, v.108, 14318-14323 (2011)","raw_type":"Article"},{"id":"pmh:oai:pure.mpg.de:item_1291698","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-000F-019B-E","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3161593","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3161593/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1524901037","https://openalex.org/W1534237617","https://openalex.org/W1562455864","https://openalex.org/W1967302106","https://openalex.org/W1968306435","https://openalex.org/W1971016259","https://openalex.org/W1975642381","https://openalex.org/W1978842225","https://openalex.org/W1980886488","https://openalex.org/W1983009379","https://openalex.org/W1988488160","https://openalex.org/W1990646890","https://openalex.org/W1995300675","https://openalex.org/W1998597563","https://openalex.org/W2000302106","https://openalex.org/W2008643711","https://openalex.org/W2015737472","https://openalex.org/W2016166286","https://openalex.org/W2017488713","https://openalex.org/W2019594298","https://openalex.org/W2027775552","https://openalex.org/W2034468530","https://openalex.org/W2038275015","https://openalex.org/W2043843325","https://openalex.org/W2052999464","https://openalex.org/W2056526910","https://openalex.org/W2068323391","https://openalex.org/W2069500280","https://openalex.org/W2069586859","https://openalex.org/W2069655536","https://openalex.org/W2072108954","https://openalex.org/W2085680244","https://openalex.org/W2088526766","https://openalex.org/W2104270687","https://openalex.org/W2117602113","https://openalex.org/W2120405274","https://openalex.org/W2135719485","https://openalex.org/W2140717014","https://openalex.org/W2144447780","https://openalex.org/W2150822049","https://openalex.org/W2154649008","https://openalex.org/W2157189708","https://openalex.org/W2161367731","https://openalex.org/W2169997464"],"related_works":["https://openalex.org/W1544033985","https://openalex.org/W2019594298","https://openalex.org/W2015737472","https://openalex.org/W2752330218","https://openalex.org/W2164846159","https://openalex.org/W2170250764","https://openalex.org/W2104270687","https://openalex.org/W2092557601","https://openalex.org/W2138689772","https://openalex.org/W2052923338"],"abstract_inverted_index":{"Exocytosis":[0],"of":[1,25,28,83,90,125],"synaptic":[2,7,164],"vesicles":[3,76],"(SVs)":[4],"during":[5,162],"fast":[6,163],"transmission":[8],"is":[9,48],"mediated":[10],"by":[11,22],"soluble":[12],"N-ethylmaleimide-sensitive":[13],"factor":[14],"attachment":[15],"protein":[16,30],"receptor":[17],"(SNARE)":[18],"complex":[19],"assembly":[20],"formed":[21],"the":[23,39,70,87,91,108],"coil-coiling":[24],"three":[26],"members":[27],"this":[29,65,118],"family:":[31],"vesicle":[32],"SNARE":[33,53,93,153],"protein,":[34],"synaptobrevin":[35],"2":[36],"(syb2),":[37],"and":[38,44,61,150,157],"presynaptic":[40],"membrane":[41],"SNAREs":[42],"syntaxin-1A":[43],"SNAP-25.":[45],"However,":[46],"it":[47],"controversially":[49],"debated":[50],"how":[51],"many":[52],"complexes":[54,154],"are":[55,155],"minimally":[56],"needed":[57],"for":[58,159],"SV":[59,128,160],"priming":[60],"fusion.":[62],"To":[63],"quantify":[64],"effective":[66],"number,":[67],"we":[68,120],"measured":[69],"fluorescence":[71],"responses":[72,104],"from":[73],"single":[74,114],"fusing":[75],"expressing":[77,135],"pHluorin":[78,115],"(pHl),":[79],"a":[80],"pH-sensitive":[81],"variant":[82],"GFP,":[84],"fused":[85],"to":[86,113,141],"luminal":[88],"domain":[89],"vesicular":[92],"syb2":[94,148],"(spH)":[95],"in":[96],"cultured":[97],"hippocampal":[98],"neurons":[99],"lacking":[100],"endogenous":[101],"syb2.":[102],"Fluorescence":[103],"were":[105,139],"quantal,":[106],"with":[107],"unitary":[109],"signals":[110],"precisely":[111],"corresponding":[112],"molecules.":[116],"Using":[117],"approach":[119],"found":[121],"that":[122],"two":[123,147,152],"copies":[124],"spH":[126,138],"per":[127],"fully":[129],"rescued":[130],"evoked":[131],"fusion":[132,161],"whereas":[133],"SVs":[134],"only":[136],"one":[137],"unable":[140],"rapidly":[142],"fuse":[143],"upon":[144],"stimulation.":[145],"Thus,":[146],"molecules":[149],"likely":[151],"necessary":[156],"sufficient":[158],"transmission.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":17}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}