{"id":"https://openalex.org/W1994752087","doi":"https://doi.org/10.1111/jcmm.12378","title":"Mesenchymal stem\u2010cell potential in cartilage repair: an update","display_name":"Mesenchymal stem\u2010cell potential in cartilage repair: an update","publication_year":2014,"publication_date":"2014-10-29","ids":{"openalex":"https://openalex.org/W1994752087","doi":"https://doi.org/10.1111/jcmm.12378","mag":"1994752087","pmid":"https://pubmed.ncbi.nlm.nih.gov/25353372","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4302639"},"language":"en","primary_location":{"id":"doi:10.1111/jcmm.12378","doi":"https://doi.org/10.1111/jcmm.12378","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.12378","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.12378","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.12378","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066021937","display_name":"Marija Mazor","orcid":"https://orcid.org/0000-0002-3670-6334","observed_orcids":["https://orcid.org/0000-0002-3670-6334"]},"institutions":[{"id":"https://openalex.org/I4210144652","display_name":"Centre hospitalier universitaire d'Orl\u00e9ans","ror":"https://ror.org/04yvax419","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210144652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M. Mazor","raw_affiliation_strings":["IPROS, CHRO, EA4708 Orleans University, Orleans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPROS, CHRO, EA4708 Orleans University, Orleans, France","institution_ids":["https://openalex.org/I4210144652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010199500","display_name":"\u00c9ric Lespessailles","orcid":"https://orcid.org/0000-0003-1009-8518","observed_orcids":["https://orcid.org/0000-0003-1009-8518"]},"institutions":[{"id":"https://openalex.org/I4210144652","display_name":"Centre hospitalier universitaire d'Orl\u00e9ans","ror":"https://ror.org/04yvax419","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210144652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Lespessailles","raw_affiliation_strings":["IPROS, CHRO, EA4708 Orleans University, Orleans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPROS, CHRO, EA4708 Orleans University, Orleans, France","institution_ids":["https://openalex.org/I4210144652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072080756","display_name":"Rapha\u00ebl Coursier","orcid":"https://orcid.org/0000-0001-6509-750X","observed_orcids":["https://orcid.org/0000-0001-6509-750X"]},"institutions":[{"id":"https://openalex.org/I4210137780","display_name":"Groupe Hospitalier de l'Institut Catholique de Lille","ror":"https://ror.org/03wr2ty35","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I181827316","https://openalex.org/I4210137780"]},{"id":"https://openalex.org/I4210144652","display_name":"Centre hospitalier universitaire d'Orl\u00e9ans","ror":"https://ror.org/04yvax419","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210144652"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R. Coursier","raw_affiliation_strings":["D\u00e9partement de traumatologie\u2010orthop\u00e9die France UCLille Lille France","Groupement des H\u00f4pitaux de l'Institut Catholique de Lillie (GHICL)/Facult\u00e9 Libre de M\u00e9decine Lille France","IPROS, CHRO, EA4708 Orleans University, Orleans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D\u00e9partement de traumatologie\u2010orthop\u00e9die France UCLille Lille France","institution_ids":[]},{"raw_affiliation_string":"Groupement des H\u00f4pitaux de l'Institut Catholique de Lillie (GHICL)/Facult\u00e9 Libre de M\u00e9decine Lille France","institution_ids":["https://openalex.org/I4210137780"]},{"raw_affiliation_string":"IPROS, CHRO, EA4708 Orleans University, Orleans, France","institution_ids":["https://openalex.org/I4210144652"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084190595","display_name":"Richard Daniellou","orcid":"https://orcid.org/0000-0001-7296-3736","observed_orcids":["https://orcid.org/0000-0001-7296-3736"]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210141565","display_name":"Institut de Chimie Organique et Analytique","ror":"https://ror.org/03ywn7d79","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210128300","https://openalex.org/I4210141565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R. Daniellou","raw_affiliation_strings":["CNRS ICOA UMR 7311 Universit\u00e9 Orl\u00e9ans Orleans France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CNRS ICOA UMR 7311 Universit\u00e9 Orl\u00e9ans Orleans France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040279086","display_name":"Thomas Michael Best","orcid":"https://orcid.org/0000-0003-2836-161X","observed_orcids":["https://orcid.org/0000-0003-2836-161X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T. M. Best","raw_affiliation_strings":["Division of Sports Medicine, Department of Family Medicine, Sports Health And Performance Institute, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Sports Medicine, Department of Family Medicine, Sports Health And Performance Institute, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090270022","display_name":"Hechmi Toumi","orcid":"https://orcid.org/0000-0003-4589-7731","observed_orcids":["https://orcid.org/0000-0003-4589-7731"]},"institutions":[{"id":"https://openalex.org/I4210144652","display_name":"Centre hospitalier universitaire d'Orl\u00e9ans","ror":"https://ror.org/04yvax419","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210144652"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"H. Toumi","raw_affiliation_strings":["IPROS, CHRO, EA4708 Orleans University, Orleans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPROS, CHRO, EA4708 Orleans University, Orleans, France","institution_ids":["https://openalex.org/I4210144652"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5090270022"],"corresponding_institution_ids":["https://openalex.org/I4210144652"],"apc_list":{"value":5210,"currency":"USD","value_usd":5210},"apc_paid":{"value":5210,"currency":"USD","value_usd":5210},"fwci":0.9328,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.64081062,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"18","issue":"12","first_page":"2340","last_page":"2350"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.9940000176429749},{"id":"https://openalex.org/keywords/articular-cartilage-repair","display_name":"articular cartilage repair","score":0.8970000147819519},{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cartilage-degeneration","display_name":"cartilage degeneration","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.9240000247955322},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cartilage-regeneration","display_name":"cartilage regeneration","score":0.8980000019073486},{"id":"https://openalex.org/keywords/conservative-treatment","display_name":"conservative treatment","score":0.6079999804496765},{"id":"https://openalex.org/keywords/intra-articular-hyaluronic-acid","display_name":"viscosupplementation","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.7460793256759644},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.7272325754165649},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6972510814666748},{"id":"https://openalex.org/C2909830753","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Viscosupplementation","level":5,"score":0.6390997171401978},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6269118785858154},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5461696982383728},{"id":"https://openalex.org/C2777564180","wikidata":"https://www.wikidata.org/wiki/Q3109230","display_name":"Articular cartilage repair","level":5,"score":0.5438450574874878},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.45002537965774536},{"id":"https://openalex.org/C3020332539","wikidata":"https://www.wikidata.org/wiki/Q2014564","display_name":"Articular cartilage","level":4,"score":0.44174590706825256},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.429074227809906},{"id":"https://openalex.org/C2779354088","wikidata":"https://www.wikidata.org/wiki/Q15467261","display_name":"Degeneration (medical)","level":2,"score":0.4184281527996063},{"id":"https://openalex.org/C2781032047","wikidata":"https://www.wikidata.org/wiki/Q938793","display_name":"Articular cartilage damage","level":5,"score":0.4145180583000183},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38183820247650146},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.367637574672699},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.36503681540489197},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.22960150241851807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15560325980186462},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.15260803699493408},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14241665601730347},{"id":"https://openalex.org/C3019843197","wikidata":"https://www.wikidata.org/wiki/Q9644","display_name":"Intra articular","level":4,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002358","descriptor_name":"Cartilage, Articular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010003","descriptor_name":"Osteoarthritis","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D019902","descriptor_name":"Chondrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020219","descriptor_name":"Chondrogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059630","descriptor_name":"Mesenchymal Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D064987","descriptor_name":"Cell- and Tissue-Based Therapy","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jcmm.12378","doi":"https://doi.org/10.1111/jcmm.12378","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.12378","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.12378","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4302639","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4302639","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Mol Med","raw_type":"Text"},{"id":"pmid:25353372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25353372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cellular and molecular medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/jcmm.12378","doi":"https://doi.org/10.1111/jcmm.12378","is_oa":true,"landing_page_url":"https://doi.org/10.1111/jcmm.12378","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jcmm.12378","source":{"id":"https://openalex.org/S76698325","display_name":"Journal of Cellular and Molecular Medicine","issn_l":"1582-1838","issn":["1582-1838","1582-4934"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cellular and Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W1994752087.pdf"},"referenced_works_count":143,"referenced_works":["https://openalex.org/W11305555","https://openalex.org/W110475937","https://openalex.org/W151869475","https://openalex.org/W176795339","https://openalex.org/W1522229466","https://openalex.org/W1530921588","https://openalex.org/W1546584312","https://openalex.org/W1554947160","https://openalex.org/W1555330200","https://openalex.org/W1586814698","https://openalex.org/W1592803379","https://openalex.org/W1607875640","https://openalex.org/W1859919406","https://openalex.org/W1894541755","https://openalex.org/W1918057567","https://openalex.org/W1952701339","https://openalex.org/W1957489746","https://openalex.org/W1966852966","https://openalex.org/W1967494982","https://openalex.org/W1968746947","https://openalex.org/W1973411875","https://openalex.org/W1977537144","https://openalex.org/W1978135541","https://openalex.org/W1979731706","https://openalex.org/W1979738387","https://openalex.org/W1979972616","https://openalex.org/W1983529894","https://openalex.org/W1985460230","https://openalex.org/W1988036581","https://openalex.org/W1988509972","https://openalex.org/W1988722238","https://openalex.org/W1988735267","https://openalex.org/W1988904745","https://openalex.org/W1988924807","https://openalex.org/W1989073601","https://openalex.org/W1989444744","https://openalex.org/W1989856361","https://openalex.org/W1990226086","https://openalex.org/W1995122819","https://openalex.org/W1995529601","https://openalex.org/W1995577585","https://openalex.org/W1996499844","https://openalex.org/W1998562433","https://openalex.org/W1999013968","https://openalex.org/W2005832407","https://openalex.org/W2007982185","https://openalex.org/W2011227409","https://openalex.org/W2011318200","https://openalex.org/W2012899141","https://openalex.org/W2013868307","https://openalex.org/W2015680789","https://openalex.org/W2016417501","https://openalex.org/W2017180228","https://openalex.org/W2017506406","https://openalex.org/W2017786610","https://openalex.org/W2018028722","https://openalex.org/W2019055276","https://openalex.org/W2021331319","https://openalex.org/W2022495001","https://openalex.org/W2022586945","https://openalex.org/W2022731821","https://openalex.org/W2023436570","https://openalex.org/W2023714013","https://openalex.org/W2024452130","https://openalex.org/W2025371271","https://openalex.org/W2025945197","https://openalex.org/W2026101620","https://openalex.org/W2026344537","https://openalex.org/W2027600661","https://openalex.org/W2027831505","https://openalex.org/W2032806251","https://openalex.org/W2035141079","https://openalex.org/W2036839600","https://openalex.org/W2038043656","https://openalex.org/W2038243239","https://openalex.org/W2039829008","https://openalex.org/W2041325252","https://openalex.org/W2049751449","https://openalex.org/W2055374048","https://openalex.org/W2057315313","https://openalex.org/W2065429808","https://openalex.org/W2070565156","https://openalex.org/W2070698616","https://openalex.org/W2071536607","https://openalex.org/W2071823815","https://openalex.org/W2075490088","https://openalex.org/W2076062177","https://openalex.org/W2076642520","https://openalex.org/W2076865425","https://openalex.org/W2077836832","https://openalex.org/W2079782844","https://openalex.org/W2081771171","https://openalex.org/W2082661008","https://openalex.org/W2083882414","https://openalex.org/W2084936927","https://openalex.org/W2087751018","https://openalex.org/W2087958138","https://openalex.org/W2089012863","https://openalex.org/W2089536489","https://openalex.org/W2092771822","https://openalex.org/W2095643785","https://openalex.org/W2100287997","https://openalex.org/W2100387661","https://openalex.org/W2101361529","https://openalex.org/W2101471525","https://openalex.org/W2102308673","https://openalex.org/W2103116859","https://openalex.org/W2104468246","https://openalex.org/W2105350898","https://openalex.org/W2107503723","https://openalex.org/W2108434819","https://openalex.org/W2108725095","https://openalex.org/W2110143857","https://openalex.org/W2111222524","https://openalex.org/W2112540399","https://openalex.org/W2113587361","https://openalex.org/W2116660289","https://openalex.org/W2122764374","https://openalex.org/W2122892477","https://openalex.org/W2125578520","https://openalex.org/W2127056741","https://openalex.org/W2127293878","https://openalex.org/W2129106281","https://openalex.org/W2133985629","https://openalex.org/W2135903352","https://openalex.org/W2138007542","https://openalex.org/W2140034839","https://openalex.org/W2143669904","https://openalex.org/W2144268541","https://openalex.org/W2147673404","https://openalex.org/W2150134228","https://openalex.org/W2150488245","https://openalex.org/W2151224463","https://openalex.org/W2152217106","https://openalex.org/W2159999899","https://openalex.org/W2161915238","https://openalex.org/W2162515752","https://openalex.org/W2188194996","https://openalex.org/W2287771163","https://openalex.org/W2352947026","https://openalex.org/W2977720020","https://openalex.org/W4232900352","https://openalex.org/W4300790656"],"related_works":["https://openalex.org/W7101174428","https://openalex.org/W2113223971","https://openalex.org/W4383959292","https://openalex.org/W2402191419","https://openalex.org/W124350502","https://openalex.org/W2095894799","https://openalex.org/W2990285790","https://openalex.org/W2774106158","https://openalex.org/W2295524313","https://openalex.org/W1972911118"],"abstract_inverted_index":{"Articular":[0],"cartilage":[1,55,90,134],"damage":[2],"and":[3,40,47,64,66,82,92,123,136],"subsequent":[4],"degeneration":[5],"are":[6,57,84],"a":[7,18,99,117],"frequent":[8],"occurrence":[9],"in":[10,60,67,126,139],"synovial":[11],"joints.":[12],"Treatment":[13],"of":[14,25,102,110,120,129],"these":[15],"lesions":[16,56],"is":[17,23,116],"challenge":[19],"because":[20],"this":[21],"tissue":[22,103],"incapable":[24],"quality":[26],"repair":[27],"and/or":[28],"regeneration":[29],"to":[30,37,75,106],"its":[31],"native":[32],"state.":[33],"Non-operative":[34],"treatments":[35],"endeavour":[36],"control":[38],"symptoms":[39],"include":[41],"anti-inflammatory":[42],"medications,":[43],"viscosupplementation,":[44],"bracing,":[45],"orthotics":[46],"activity":[48],"modification.":[49],"Classical":[50],"surgical":[51],"techniques":[52],"for":[53,89],"articular":[54,111,133],"frequently":[58],"insufficient":[59],"restoring":[61],"normal":[62],"anatomy":[63],"function":[65],"many":[68],"cases,":[69],"it":[70],"has":[71,97],"not":[72],"been":[73],"possible":[74],"achieve":[76,107],"the":[77,127,140],"desired":[78],"results.":[79],"Consequently,":[80],"researchers":[81],"clinicians":[83],"focusing":[85],"on":[86],"alternative":[87],"methods":[88],"preservation":[91],"repair.":[93],"Recently,":[94],"cell-based":[95],"therapy":[96],"become":[98],"key":[100],"focus":[101],"engineering":[104],"research":[105],"functional":[108],"replacement":[109],"cartilage.":[112],"The":[113],"present":[114],"manuscript":[115],"brief":[118],"review":[119],"stem":[121],"cells":[122],"their":[124],"potential":[125],"treatment":[128],"early":[130],"OA":[131],"(i.e.":[132],"pathology)":[135],"recent":[137],"progress":[138],"field.":[141]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}