{"id":"https://openalex.org/W1994739010","doi":"https://doi.org/10.1210/jcem-43-5-1101","title":"The Effect of ACTH and Cortisol on Aldosterone and Cortisol Clearance and Distribution in Plasma and Whole Blood","display_name":"The Effect of ACTH and Cortisol on Aldosterone and Cortisol Clearance and Distribution in Plasma and Whole Blood","publication_year":1976,"publication_date":"1976-11-01","ids":{"openalex":"https://openalex.org/W1994739010","doi":"https://doi.org/10.1210/jcem-43-5-1101","mag":"1994739010","pmid":"https://pubmed.ncbi.nlm.nih.gov/186476"},"language":"en","primary_location":{"id":"doi:10.1210/jcem-43-5-1101","doi":"https://doi.org/10.1210/jcem-43-5-1101","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-43-5-1101","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021881035","display_name":"Robert D. Zipser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT D. ZIPSER","raw_affiliation_strings":["Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088570874","display_name":"P. Speckart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PAUL F. SPECKART","raw_affiliation_strings":["Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057213925","display_name":"PRISCILLA K. ZIA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"PRISCILLA K. ZIA","raw_affiliation_strings":["Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111607427","display_name":"W.Allan Edmiston","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. ALLAN EDMISTON","raw_affiliation_strings":["Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":null,"display_name":"FRANCIS Y. K. LAU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"FRANCIS Y. K. LAU","raw_affiliation_strings":["Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106922528","display_name":"Richard Horton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RICHARD HORTON","raw_affiliation_strings":["Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sections of Endocrinology and Cardiology, Department of Medicine, Los Angeles C ounty-University of Southern California Medical Center Los Angeles, California 90033","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":3.3595,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.91371959,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"43","issue":"5","first_page":"1101","last_page":"1109"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.5342000126838684,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12421","display_name":"Adrenal Hormones and Disorders","score":0.5342000126838684,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":0.45239999890327454,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldosterone","display_name":"aldosterone","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.9950000047683716},{"id":"https://openalex.org/keywords/acth","display_name":"ACTH","score":0.8899999856948853},{"id":"https://openalex.org/keywords/metabolic-clearance-rate","display_name":"metabolic clearance rate","score":0.9079999923706055},{"id":"https://openalex.org/keywords/hepatic-extraction","display_name":"hepatic extraction","score":0.6830000281333923},{"id":"https://openalex.org/keywords/glucocorticoid-feedback","display_name":"glucocorticoid feedback","score":0.5920000076293945}],"concepts":[{"id":"https://openalex.org/C2778525890","wikidata":"https://www.wikidata.org/wiki/Q184564","display_name":"Aldosterone","level":2,"score":0.7962130904197693},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.746113657951355},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7414360046386719},{"id":"https://openalex.org/C2778709874","wikidata":"https://www.wikidata.org/wiki/Q190875","display_name":"Hydrocortisone","level":2,"score":0.5818691253662109},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.46474167704582214},{"id":"https://openalex.org/C1621761","wikidata":"https://www.wikidata.org/wiki/Q7997549","display_name":"Whole blood","level":2,"score":0.41132447123527527},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4072304964065552},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000324","descriptor_name":"Adrenocorticotropic Hormone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000450","descriptor_name":"Aldosterone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014156","descriptor_name":"Transcortin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/jcem-43-5-1101","doi":"https://doi.org/10.1210/jcem-43-5-1101","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem-43-5-1101","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology & Metabolism","raw_type":"journal-article"},{"id":"pmid:186476","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/186476","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W179909892","https://openalex.org/W1960704614","https://openalex.org/W1970549198","https://openalex.org/W1971802234","https://openalex.org/W1972738780","https://openalex.org/W1975169958","https://openalex.org/W1986855990","https://openalex.org/W2006358282","https://openalex.org/W2006427807","https://openalex.org/W2012465611","https://openalex.org/W2065254008","https://openalex.org/W2078864708","https://openalex.org/W2102231551","https://openalex.org/W2104584127","https://openalex.org/W2133024613","https://openalex.org/W2155800638","https://openalex.org/W2171210829","https://openalex.org/W2395040466"],"related_works":["https://openalex.org/W2172137920","https://openalex.org/W2012465611","https://openalex.org/W2083592067","https://openalex.org/W2050327106","https://openalex.org/W2099587124","https://openalex.org/W1978121868","https://openalex.org/W1986771020","https://openalex.org/W2065863754","https://openalex.org/W2016672720","https://openalex.org/W1999483401"],"abstract_inverted_index":{"The":[0,220,264],"mechanisms":[1],"of":[2,35,120,198,226],"increased":[3,38,155,170,242,274],"aldosterone":[4,89,121,200,227,243,255],"and":[5,24,72,75,142,164,191,204,232,261,283],"cortisol":[6,14,79,99,140,187,218,235,267],"metabolic":[7],"clearance":[8],"rates":[9],"(MCR)":[10],"following":[11],"ACTH":[12,64,97,147,185],"or":[13,98,186],"administration":[15,100],"were":[16],"studied":[17],"in":[18,25,192,202,205,211,230,266],"13":[19],"subjects":[20],"undergoing":[21],"cardiac":[22],"catheterization":[23],"9":[26],"healthy":[27],"controls.":[28],"In":[29,87,189],"control":[30],"subjects,":[31],"the":[32,112,152,165,252],"MCR":[33,90,114,166,268],"(plasma)":[34,269],"both":[36,259,272],"steroids":[37],"by":[39,73,171,234],"29%":[40],"(aldosterone:":[41],"from":[42,52,117,122,156,258,271],"936":[43],"+/-":[44,48,54,58,61,103,107,132,158,162,177,181],"57":[45,104],"to":[46,56,69,84,105,124,160,173,179,213],"1204":[47],"55":[49],"l/day/m2,":[50],"cortisol:":[51],"205":[53],"12":[55],"264":[57],"17":[59],"l/day/m2":[60],"SE)":[62],"after":[63,78,146,184],"(12":[65,80],"units/h)":[66],"for":[67,82],"1":[68,83],"4":[70],"h,":[71],"20":[74],"32%,":[76],"respectively,":[77],"mg/h)":[81],"2":[85],"h.":[86],"contrast,":[88],"(whole":[91,167],"blood)":[92,168],"did":[93],"not":[94],"change":[95],"with":[96,137,216],"(from":[101,175],"1276":[102],"1330":[106],"59":[108],"l/day/m2),":[109,183],"indicating":[110],"that":[111,223],"plasma":[113,123,203,231,244,260,278],"increase":[115,210,265],"results":[116,221,270],"a":[118,224,284],"redistribution":[119,285],"red":[125,206,214,237,262,287],"cells.":[126,238,263,288],"Aldosterone":[127],"splanchnic":[128,153,275],"extraction":[129,143,154,276],"was":[130,144],"92":[131],"1%":[133],"(n":[134],"=":[135],"12)":[136],"normal":[138],"morning":[139],"levels,":[141],"unchanged":[145],"administration.":[148,188],"For":[149],"cortisol,":[150],"however,":[151],"8":[157],"0.8%":[159],"17.8":[161],"5.0%,":[163],"likewise":[169],"15":[172],"31%":[174],"295":[176],"23":[178],"357":[180],"30":[182],"vivo":[190],"vitro":[193],"measurements":[194],"(at":[195],"37":[196],"C)":[197],"tracer":[199],"concentration":[201],"cells":[207,215],"showed":[208],"an":[209,241,273],"distribution":[212],"increasing":[217],"concentrations.":[219],"suggest":[222],"fraction":[225],"is":[228,240],"bound":[229],"displaced":[233],"into":[236,286],"There":[239],"MCR,":[245,250],"but":[246],"unaltered":[247],"whole":[248],"blood":[249],"since":[251],"liver":[253],"extracts":[254],"almost":[256],"completely":[257],"as":[277],"binding":[279],"sites":[280],"approach":[281],"saturation":[282]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}