{"id":"https://openalex.org/W1994729909","doi":"https://doi.org/10.1055/s-0031-1299594","title":"Estrogen Receptor-\u03b2 in the Gonadotropin-Releasing Hormone Neuron","display_name":"Estrogen Receptor-\u03b2 in the Gonadotropin-Releasing Hormone Neuron","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1994729909","doi":"https://doi.org/10.1055/s-0031-1299594","mag":"1994729909","pmid":"https://pubmed.ncbi.nlm.nih.gov/22271291","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9335859"},"language":"en","primary_location":{"id":"doi:10.1055/s-0031-1299594","doi":"https://doi.org/10.1055/s-0031-1299594","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1299594","pdf_url":null,"source":{"id":"https://openalex.org/S19775678","display_name":"Seminars in Reproductive Medicine","issn_l":"1526-4564","issn":["1526-4564","1526-8004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Reproductive Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9335859","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070839835","display_name":"Andrew Wolfe","orcid":"https://orcid.org/0000-0003-1120-1679","observed_orcids":["https://orcid.org/0000-0003-1120-1679"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Wolfe","raw_affiliation_strings":["Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland","Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948"]},{"raw_affiliation_string":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21287, USA","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102002381","display_name":"Sheng Wu","orcid":"https://orcid.org/0000-0003-2944-0475","observed_orcids":["https://orcid.org/0000-0003-2944-0475"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheng Wu","raw_affiliation_strings":["Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2354,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.86272768,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"30","issue":"01","first_page":"23","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10364","display_name":"Reproductive Biology and Fertility","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.9539999961853027},{"id":"https://openalex.org/keywords/gnrh-neurons","display_name":"GnRH neurons","score":0.9559999704360962},{"id":"https://openalex.org/keywords/estrogen-signaling","display_name":"estrogen signaling","score":0.7149999737739563},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-gonadal-axis","display_name":"hypothalamic-pituitary-gonadal axis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/gnrh-surge","display_name":"GnRH surge","score":0.796999990940094},{"id":"https://openalex.org/keywords/ovulation","display_name":"ovulation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/membrane-estrogen-receptor","display_name":"membrane estrogen receptor","score":0.8080000281333923},{"id":"https://openalex.org/keywords/gpr30","display_name":"GPR30","score":0.9760000109672546},{"id":"https://openalex.org/keywords/reproductive-behavior","display_name":"reproductive behavior","score":0.44999998807907104},{"id":"https://openalex.org/keywords/female-reproduction","display_name":"female reproduction","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.6338607668876648},{"id":"https://openalex.org/C2778782382","wikidata":"https://www.wikidata.org/wiki/Q409770","display_name":"Gonadotropin","level":3,"score":0.600006639957428},{"id":"https://openalex.org/C2778894405","wikidata":"https://www.wikidata.org/wiki/Q318896","display_name":"Gonadotropin-releasing hormone","level":4,"score":0.5226454734802246},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5154277086257935},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5105224847793579},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5090858340263367},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.48341286182403564},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.4741078019142151},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.46373406052589417},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4221717119216919},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39171290397644043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3409067690372467},{"id":"https://openalex.org/C2778575703","wikidata":"https://www.wikidata.org/wiki/Q50265477","display_name":"Luteinizing hormone","level":3,"score":0.26790523529052734},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.1731986105442047},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007030","descriptor_name":"Hypothalamo-Hypophyseal System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007987","descriptor_name":"Gonadotropin-Releasing Hormone","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010053","descriptor_name":"Ovary","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D059330","descriptor_name":"GABAergic Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1055/s-0031-1299594","doi":"https://doi.org/10.1055/s-0031-1299594","is_oa":false,"landing_page_url":"https://doi.org/10.1055/s-0031-1299594","pdf_url":null,"source":{"id":"https://openalex.org/S19775678","display_name":"Seminars in Reproductive Medicine","issn_l":"1526-4564","issn":["1526-4564","1526-8004"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320000","host_organization_name":"Thieme Medical Publishers (Germany)","host_organization_lineage":["https://openalex.org/P4310320000"],"host_organization_lineage_names":["Thieme Medical Publishers (Germany)"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in Reproductive Medicine","raw_type":"journal-article"},{"id":"pmid:22271291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22271291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Seminars in reproductive medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9335859","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9335859","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Semin Reprod Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9335859","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9335859","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Semin Reprod Med","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3373186732","display_name":"Insulin and Androgen Interactions in the Infertility of Obesity","funder_award_id":"K99HD068130","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7160525818","display_name":"Insulin and Androgen Interactions in the Infertility of Obesity","funder_award_id":"R00HD068130","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W230394473","https://openalex.org/W1503554255","https://openalex.org/W1519190311","https://openalex.org/W1541234884","https://openalex.org/W1569704074","https://openalex.org/W1749538909","https://openalex.org/W1906546857","https://openalex.org/W1957864102","https://openalex.org/W1969613322","https://openalex.org/W1969883008","https://openalex.org/W1971423810","https://openalex.org/W1973359179","https://openalex.org/W1975140802","https://openalex.org/W1975890243","https://openalex.org/W1976130365","https://openalex.org/W1995075148","https://openalex.org/W1997917613","https://openalex.org/W1998286971","https://openalex.org/W2000117155","https://openalex.org/W2000780044","https://openalex.org/W2000782468","https://openalex.org/W2005701209","https://openalex.org/W2006417886","https://openalex.org/W2006727096","https://openalex.org/W2009302214","https://openalex.org/W2012425172","https://openalex.org/W2014455593","https://openalex.org/W2017886735","https://openalex.org/W2018446899","https://openalex.org/W2018664770","https://openalex.org/W2024788152","https://openalex.org/W2025895459","https://openalex.org/W2027421516","https://openalex.org/W2029134717","https://openalex.org/W2035681673","https://openalex.org/W2037330610","https://openalex.org/W2039698855","https://openalex.org/W2039725741","https://openalex.org/W2040020955","https://openalex.org/W2041165166","https://openalex.org/W2044207030","https://openalex.org/W2045690475","https://openalex.org/W2045949916","https://openalex.org/W2048561091","https://openalex.org/W2055514389","https://openalex.org/W2058341606","https://openalex.org/W2060977606","https://openalex.org/W2061398909","https://openalex.org/W2063807916","https://openalex.org/W2066104572","https://openalex.org/W2070625108","https://openalex.org/W2073353512","https://openalex.org/W2075307470","https://openalex.org/W2076382116","https://openalex.org/W2077525377","https://openalex.org/W2080973676","https://openalex.org/W2089315979","https://openalex.org/W2092411075","https://openalex.org/W2092486725","https://openalex.org/W2095274391","https://openalex.org/W2096509045","https://openalex.org/W2098259195","https://openalex.org/W2101022457","https://openalex.org/W2106279530","https://openalex.org/W2108475046","https://openalex.org/W2111598080","https://openalex.org/W2111851253","https://openalex.org/W2117326208","https://openalex.org/W2118750014","https://openalex.org/W2119788961","https://openalex.org/W2120653485","https://openalex.org/W2121454015","https://openalex.org/W2124443875","https://openalex.org/W2128681733","https://openalex.org/W2129890422","https://openalex.org/W2130134250","https://openalex.org/W2131769837","https://openalex.org/W2133601798","https://openalex.org/W2136581119","https://openalex.org/W2141115613","https://openalex.org/W2142686356","https://openalex.org/W2147785886","https://openalex.org/W2150974178","https://openalex.org/W2152327361","https://openalex.org/W2152840134","https://openalex.org/W2157861204","https://openalex.org/W2161185871","https://openalex.org/W2161623422","https://openalex.org/W2162755691","https://openalex.org/W2170026872","https://openalex.org/W2170093730","https://openalex.org/W2172256092","https://openalex.org/W2410514322","https://openalex.org/W4212936275","https://openalex.org/W4237884234"],"related_works":["https://openalex.org/W2052757541","https://openalex.org/W1987812698","https://openalex.org/W4322703282","https://openalex.org/W2147785886","https://openalex.org/W1749538909","https://openalex.org/W2139348797","https://openalex.org/W2035681673","https://openalex.org/W2136581119","https://openalex.org/W1972057947","https://openalex.org/W2013995127"],"abstract_inverted_index":{"Estrogen":[0,19],"regulation":[1,14,163],"of":[2,15,25,32,38,48,81,99,107,133,144,150,164],"gonadotropin-releasing":[3],"hormone":[4],"(GnRH)":[5],"neuronal":[6,85,166],"activity":[7],"plays":[8],"a":[9,22,30,39,70,159],"crucial":[10],"role":[11,160],"in":[12,102],"homeostatic":[13],"the":[16,43,52,65,75,79,96,105,124,131,134,142,147,151,156],"hypothalamic-pituitary-gonadal":[17],"axis.":[18],"also":[20],"coordinates":[21],"complex":[23],"series":[24],"physiological":[26],"changes":[27],"culminating":[28],"with":[29],"surge":[31],"gonadotropin":[33],"secretion":[34],"that":[35,51],"triggers":[36],"ovulation":[37],"developed":[40],"follicle":[41],"from":[42],"ovary.":[44],"The":[45],"coordinated":[46],"functions":[47],"estrogen":[49,82,100,109,113,145,152],"ensure":[50],"female":[53],"will":[54],"elaborate":[55],"appropriate":[56],"reproductive":[57],"behaviors":[58],"ultimately":[59],"designed":[60],"to":[61,64,68,91,95,140],"deliver":[62],"sperm":[63],"oocyte":[66],"and":[67,116],"provide":[69],"receptive":[71],"uterine":[72],"environment":[73],"for":[74,158,161],"fertilized":[76],"embryo.":[77],"Although":[78],"effects":[80,143],"on":[83,127],"GnRH":[84,103,135,165],"function":[86],"have":[87],"long":[88],"been":[89],"proposed":[90],"be":[92],"indirect":[93],"due":[94],"presumed":[97],"lack":[98],"receptors":[101],"neurons,":[104],"identification":[106],"alternative":[108],"signaling":[110],"pathways,":[111],"including":[112],"receptor":[114],"(ER)\u03b2":[115],"membrane":[117],"ERs":[118],"such":[119],"as":[120],"GPR30,":[121],"has":[122],"put":[123],"focus":[125],"back":[126],"estrogen's":[128],"effect":[129],"at":[130],"level":[132],"neuron":[136],"itself.":[137],"One":[138],"candidate":[139],"mediate":[141],"is":[146],"\u03b2":[148],"isoform":[149],"receptor.":[153],"We":[154],"review":[155],"evidence":[157],"ER\u03b2-mediated":[162],"function.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
