{"id":"https://openalex.org/W1994727715","doi":"https://doi.org/10.1107/s0907444904020633","title":"Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase fromTrypanosoma brucei","display_name":"Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase fromTrypanosoma brucei","publication_year":2004,"publication_date":"2004-09-23","ids":{"openalex":"https://openalex.org/W1994727715","doi":"https://doi.org/10.1107/s0907444904020633","mag":"1994727715","pmid":"https://pubmed.ncbi.nlm.nih.gov/15388934"},"language":"en","primary_location":{"id":"doi:10.1107/s0907444904020633","doi":"https://doi.org/10.1107/s0907444904020633","is_oa":false,"landing_page_url":"https://doi.org/10.1107/s0907444904020633","pdf_url":null,"source":{"id":"https://openalex.org/S114502960","display_name":"Acta Crystallographica Section D Biological Crystallography","issn_l":"0907-4449","issn":["0907-4449","1399-0047"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section D Biological Crystallography","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111601485","display_name":"Junhong Mao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junhong Mao","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110167047","display_name":"Yi\u2010Gui Gao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi-Gui Gao","raw_affiliation_strings":["School of Chemical Sciences, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chemical Sciences, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055837867","display_name":"Sarah Odeh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Odeh","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078223433","display_name":"Howard H. Robinson","orcid":"https://orcid.org/0000-0001-7523-4678","observed_orcids":["https://orcid.org/0000-0001-7523-4678"]},"institutions":[{"id":"https://openalex.org/I200870766","display_name":"Brookhaven National Laboratory","ror":"https://ror.org/02ex6cf31","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I200870766","https://openalex.org/I39565521","https://openalex.org/I4210142672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Howard Robinson","raw_affiliation_strings":["Department of Biology, Brookhaven National Laboratory, Upton, NY 11973, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Brookhaven National Laboratory, Upton, NY 11973, USA","institution_ids":["https://openalex.org/I200870766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055584768","display_name":"Andrea Montalvetti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Montalvetti","raw_affiliation_strings":["Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000842323","display_name":"Roberto Docampo","orcid":"https://orcid.org/0000-0003-4229-8784","observed_orcids":["https://orcid.org/0000-0003-4229-8784"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Docampo","raw_affiliation_strings":["Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, Illinois 61802, USA","institution_ids":["https://openalex.org/I157725225"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080397665","display_name":"Eric Oldfield","orcid":"https://orcid.org/0000-0002-0996-7352","observed_orcids":["https://orcid.org/0000-0002-0996-7352"]},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Oldfield","raw_affiliation_strings":["Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA","institution_ids":["https://openalex.org/I157725225"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4740,"currency":"USD","value_usd":4740},"apc_paid":null,"fwci":0.8875,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.67816543,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"60","issue":"10","first_page":"1863","last_page":"1866"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.6381999850273132,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.336899995803833,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11882","display_name":"Plant biochemistry and biosynthesis","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/farnesyl-pyrophosphate-synthase","display_name":"farnesyl diphosphate synthase","score":1.0},{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-crystallization","display_name":"protein crystallization","score":0.7459999918937683},{"id":"https://openalex.org/keywords/minodronate","display_name":"minodronate","score":0.9739999771118164},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6520000100135803},{"id":"https://openalex.org/keywords/human-african-trypanosomiasis","display_name":"sleeping sickness","score":0.8519999980926514},{"id":"https://openalex.org/keywords/homology-model","display_name":"homology model","score":0.7139999866485596},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.5799999833106995},{"id":"https://openalex.org/keywords/dimethylallyl-pyrophosphate","display_name":"dimethylallyl diphosphate","score":0.8209999799728394},{"id":"https://openalex.org/keywords/isopentenyl-pyrophosphate","display_name":"isopentenyl pyrophosphate","score":0.9879999756813049}],"concepts":[{"id":"https://openalex.org/C2775933503","wikidata":"https://www.wikidata.org/wiki/Q25113781","display_name":"Farnesyl diphosphate synthase","level":4,"score":0.9212203025817871},{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.8700115084648132},{"id":"https://openalex.org/C112243037","wikidata":"https://www.wikidata.org/wiki/Q22327117","display_name":"ATP synthase","level":3,"score":0.6231291890144348},{"id":"https://openalex.org/C2777166331","wikidata":"https://www.wikidata.org/wiki/Q17104122","display_name":"Molecular replacement","level":3,"score":0.508787214756012},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.46308666467666626},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44292426109313965},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.43167823553085327},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3731447756290436},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.35408467054367065},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3457191586494446},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019883","descriptor_name":"Alkyl and Aryl Transferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D034622","descriptor_name":"RNA Interference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051228","descriptor_name":"Geranyltranstransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1107/s0907444904020633","doi":"https://doi.org/10.1107/s0907444904020633","is_oa":false,"landing_page_url":"https://doi.org/10.1107/s0907444904020633","pdf_url":null,"source":{"id":"https://openalex.org/S114502960","display_name":"Acta Crystallographica Section D Biological Crystallography","issn_l":"0907-4449","issn":["0907-4449","1399-0047"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Crystallographica Section D Biological Crystallography","raw_type":"journal-article"},{"id":"pmid:15388934","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15388934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta crystallographica. Section D, Biological crystallography","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1030857638","display_name":"Structure, Function and Inhibition of [4Fe-4S] Proteins","funder_award_id":"R01GM065307","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W19504073","https://openalex.org/W60551495","https://openalex.org/W1484185978","https://openalex.org/W1539796472","https://openalex.org/W1948558382","https://openalex.org/W1971661467","https://openalex.org/W1974080719","https://openalex.org/W1987608235","https://openalex.org/W1989825457","https://openalex.org/W2013083986","https://openalex.org/W2014694459","https://openalex.org/W2030292056","https://openalex.org/W2045369683","https://openalex.org/W2060807817","https://openalex.org/W2062028126","https://openalex.org/W2104298626","https://openalex.org/W2128635872","https://openalex.org/W2149852370","https://openalex.org/W2154607635","https://openalex.org/W2156355362","https://openalex.org/W2156714804"],"related_works":["https://openalex.org/W2030292056","https://openalex.org/W7098540358","https://openalex.org/W3048995880","https://openalex.org/W6997036011","https://openalex.org/W2019688167","https://openalex.org/W3035017896","https://openalex.org/W2151191720","https://openalex.org/W2010712548","https://openalex.org/W1978595252","https://openalex.org/W1968027703"],"abstract_inverted_index":{"Farnesyl":[0],"diphosphate":[1,9,12,15,167],"synthase":[2],"(FPPS)":[3],"catalyses":[4],"the":[5,25,46,53,58,79,105,135,146,162,171],"formation":[6],"of":[7,28,57,81,107,134,164,173],"farnesyl":[8,166],"from":[10,72],"dimethylallyl":[11],"and":[13,16,45,55,149,160],"isopentenyl":[14],"is":[17],"an":[18],"RNAi-validated":[19],"drug":[20],"target":[21],"in":[22,42,52,78,104],"Trypanosoma":[23],"brucei,":[24],"causative":[26],"agent":[27],"African":[29],"sleeping":[30],"sickness.":[31],"A":[32,153],"T.":[33],"brucei":[34],"FPPS":[35],"(390":[36],"amino":[37],"acids)":[38],"has":[39,49,138],"been":[40,50,139],"expressed":[41],"Escherichia":[43],"coli":[44],"recombinant":[47],"protein":[48,137],"crystallized":[51],"absence":[54,80],"presence":[56,106],"bisphosphonate":[59],"inhibitor":[60],"minodronate.":[61],"Diffraction":[62],"data":[63],"were":[64],"collected":[65],"at":[66],"100":[67],"K":[68],"using":[69,141],"synchrotron":[70],"radiation":[71],"both":[73],"crystal":[74],"types.":[75],"Crystals":[76],"obtained":[77],"minodronate":[82,108],"belong":[83,109],"to":[84,110,151],"space":[85,111],"group":[86,112],"I222,":[87],"with":[88,114,145,170],"unit-cell":[89,115],"parameters":[90,116],"a":[91,117,142],"=":[92,95,98,118,121,124,128],"61.43,":[93],"b":[94,120],"118.12,":[96],"c":[97,123],"120.04":[99],"A,":[100,126],"while":[101],"crystals":[102],"grown":[103],"C2,":[113],"131.98,":[119],"118.10,":[122],"63.25":[125],"beta":[127],"112.48":[129],"degrees.":[130],"An":[131],"initial":[132],"model":[133,144],"drug-free":[136],"built":[140],"homology":[143],"molecular-replacement":[147],"method":[148],"refined":[150],"3.3":[152],"resolution.":[154],"It":[155],"shows":[156],"mostly":[157],"helical":[158],"structure":[159,163],"resembles":[161],"avian":[165],"synthase,":[168],"but":[169],"addition":[172],"two":[174],"loop":[175],"regions.":[176]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
