{"id":"https://openalex.org/W1994723744","doi":"https://doi.org/10.1097/pai.0b013e318206d958","title":"Pdx1 Expression in Pancreatic Precursor Lesions and Neoplasms","display_name":"Pdx1 Expression in Pancreatic Precursor Lesions and Neoplasms","publication_year":2011,"publication_date":"2011-02-04","ids":{"openalex":"https://openalex.org/W1994723744","doi":"https://doi.org/10.1097/pai.0b013e318206d958","mag":"1994723744","pmid":"https://pubmed.ncbi.nlm.nih.gov/21297446","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123421"},"language":"en","primary_location":{"id":"doi:10.1097/pai.0b013e318206d958","doi":"https://doi.org/10.1097/pai.0b013e318206d958","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pai.0b013e318206d958","pdf_url":null,"source":{"id":"https://openalex.org/S42732013","display_name":"Applied immunohistochemistry & molecular morphology","issn_l":"1533-4058","issn":["1533-4058","1541-2016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Immunohistochemistry & Molecular Morphology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123421","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100615462","display_name":"Jason Y. Park","orcid":"https://orcid.org/0000-0001-6797-4000","observed_orcids":["https://orcid.org/0000-0001-6797-4000"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jason Y. Park","raw_affiliation_strings":["Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 75235, USA. jaspar@childrens.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 75235, USA. jaspar@childrens.com","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064975394","display_name":"Seung\u2010Mo Hong","orcid":"https://orcid.org/0000-0002-8888-6007","observed_orcids":["https://orcid.org/0000-0002-8888-6007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seung-Mo Hong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016615488","display_name":"David S. Klimstra","orcid":"https://orcid.org/0000-0001-8814-1702","observed_orcids":["https://orcid.org/0000-0001-8814-1702"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David S. Klimstra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090286753","display_name":"Michael Goggins","orcid":"https://orcid.org/0000-0002-4286-2296","observed_orcids":["https://orcid.org/0000-0002-4286-2296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael G. Goggins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048073439","display_name":"Anirban Maitra","orcid":"https://orcid.org/0000-0001-7923-9978","observed_orcids":["https://orcid.org/0000-0001-7923-9978","https://orcid.org/0000-0003-0298-9775"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anirban Maitra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001682484","display_name":"Ralph H. Hruban","orcid":"https://orcid.org/0000-0003-4554-5672","observed_orcids":["https://orcid.org/0000-0003-4554-5672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph H. Hruban","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100615462"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":2.0454,"has_fulltext":false,"cited_by_count":64,"citation_normalized_percentile":{"value":0.86670927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"19","issue":"5","first_page":"444","last_page":"449"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdx1","display_name":"PDX1","score":0.921999990940094},{"id":"https://openalex.org/keywords/pancreatic-precursor-lesions","display_name":"pancreatic precursor lesions","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.8840000033378601},{"id":"https://openalex.org/keywords/intraductal-papillary-mucinous-neoplasm","display_name":"intraductal papillary mucinous neoplasm","score":0.9279999732971191},{"id":"https://openalex.org/keywords/mucinous-cystic-neoplasm","display_name":"mucinous cystic neoplasm","score":0.9589999914169312},{"id":"https://openalex.org/keywords/acinar-cell-carcinoma","display_name":"acinar cell carcinoma","score":0.8650000095367432},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.9789999723434448},{"id":"https://openalex.org/keywords/pancreatoblastoma","display_name":"pancreatoblastoma","score":0.9409999847412109},{"id":"https://openalex.org/keywords/solid-pseudopapillary-tumor","display_name":"solid pseudopapillary neoplasm","score":0.9890000224113464},{"id":"https://openalex.org/keywords/pancreatic-intraepithelial-neoplasia","display_name":"pancreatic intraepithelial neoplasia","score":0.9449999928474426},{"id":"https://openalex.org/keywords/pancreatic-neoplasms","display_name":"pancreatic neoplasms","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C113324615","wikidata":"https://www.wikidata.org/wiki/Q472302","display_name":"Login","level":2,"score":0.7579665184020996},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.646636962890625},{"id":"https://openalex.org/C2779050171","wikidata":"https://www.wikidata.org/wiki/Q18027973","display_name":"PDX1","level":4,"score":0.5541206002235413},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.5502455830574036},{"id":"https://openalex.org/C169093310","wikidata":"https://www.wikidata.org/wiki/Q3702971","display_name":"Personally identifiable information","level":2,"score":0.5100684762001038},{"id":"https://openalex.org/C108827166","wikidata":"https://www.wikidata.org/wiki/Q175975","display_name":"Internet privacy","level":1,"score":0.476842999458313},{"id":"https://openalex.org/C2779235478","wikidata":"https://www.wikidata.org/wiki/Q286576","display_name":"Register (sociolinguistics)","level":2,"score":0.44930508732795715},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27234649658203125},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.2453368902206421},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08017861843109131},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D021441","descriptor_name":"Carcinoma, Pancreatic Ductal","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/pai.0b013e318206d958","doi":"https://doi.org/10.1097/pai.0b013e318206d958","is_oa":false,"landing_page_url":"https://doi.org/10.1097/pai.0b013e318206d958","pdf_url":null,"source":{"id":"https://openalex.org/S42732013","display_name":"Applied immunohistochemistry & molecular morphology","issn_l":"1533-4058","issn":["1533-4058","1541-2016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Immunohistochemistry & Molecular Morphology","raw_type":"journal-article"},{"id":"pmid:21297446","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21297446","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied immunohistochemistry & molecular morphology : AIMM","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3123421","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123421","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Appl Immunohistochem Mol Morphol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3123421","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3123421","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Appl Immunohistochem Mol Morphol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/16","display_name":"Peace, justice, and strong institutions","score":0.41999998688697815}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1386330427","display_name":"Training Program in the Pathobiology of Cancer","funder_award_id":"T32CA067751","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6841957552","display_name":"Pancreatic Cancer Genetic Epidemiology Consortium (PACGENE)","funder_award_id":"R01CA097075","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W1526836724","https://openalex.org/W1967265654","https://openalex.org/W1980447806","https://openalex.org/W1995554477","https://openalex.org/W1996739849","https://openalex.org/W1999873374","https://openalex.org/W2005688198","https://openalex.org/W2017212291","https://openalex.org/W2029167057","https://openalex.org/W2042380860","https://openalex.org/W2048056915","https://openalex.org/W2055737059","https://openalex.org/W2067154687","https://openalex.org/W2067849918","https://openalex.org/W2109681240","https://openalex.org/W2132387165","https://openalex.org/W2137230232","https://openalex.org/W2139315873","https://openalex.org/W2148078342","https://openalex.org/W2155664314"],"related_works":["https://openalex.org/W2080338079","https://openalex.org/W2061425601","https://openalex.org/W2424047845","https://openalex.org/W2042380860","https://openalex.org/W2410427200","https://openalex.org/W1992320746","https://openalex.org/W1577096645","https://openalex.org/W2109681240","https://openalex.org/W1980417198","https://openalex.org/W2159076367"],"abstract_inverted_index":{"Pancreatic":[0],"and":[1,28,41,81,99,121,125,148,178,191,199,208,242,265,277],"duodenal":[2],"homeobox":[3,7],"(Pdx1)":[4],"is":[5,258],"a":[6,243,260],"transcription":[8],"factor":[9],"required":[10],"for":[11,89,114,123],"the":[12,16,144,170,213,248,254,281],"embryonic":[13],"development":[14],"of":[15,127,143,154,169,175,180,194,204,237,245,251,253,280],"pancreas.":[17,282],"Pdx1":[18,34,90,115,134,155,165,183,211,232,256],"expression":[19,36,153,184,218,233,257],"has":[20],"been":[21],"earlier":[22],"identified":[23],"in":[24,37,139,158,173,187,212,219,234,271],"pancreatic":[25,38,44,65,110,132,163],"ductal":[26,78,83,150,189,195,238,266],"adenocarcinomas":[27,196],"endocrine":[29,66],"neoplasms.":[30],"This":[31,229],"study":[32,230],"characterizes":[33],"protein":[35,136],"precursor":[39,192,235,272],"lesions":[40,193,236,273],"neoplasms,":[42,164],"including":[43],"intraepithelial":[45],"neoplasia":[46],"(PanIN,":[47,197,274],"n=32),":[48],"intraductal":[49],"papillary":[50],"mucinous":[51,55],"neoplasm":[52,57,67,75],"(IPMN,":[53],"n=88),":[54],"cystic":[56],"(MCN,":[58],"n=3),":[59],"acinar":[60,160,214],"cell":[61,146],"carcinoma":[62],"(ACC,":[63],"n=8),":[64],"(PEN,":[68],"n=44),":[69],"pancreatoblastoma":[70],"(PB,":[71],"n=1),":[72],"solid":[73],"pseudopapillary":[74,223],"(n=8),":[76],"invasive":[77,188],"adenocarcinoma":[79,190],"(n=67),":[80],"nondysplastic":[82],"epithelium.":[84,151],"A":[85,201],"mouse":[86],"monoclonal":[87],"antibody":[88],"was":[91,116,137,156,185,206],"used":[92],"to":[93,263],"examine":[94],"archived":[95],"surgical":[96],"pathology":[97],"cases":[98,177],"tissue":[100,104],"microarrays":[101],"containing":[102],">655":[103],"cores":[105],"from":[106],"more":[107],"than":[108],"250":[109],"specimens.":[111],"Immunohistochemical":[112],"labeling":[113],"performed":[117],"using":[118],"standard":[119],"methods":[120],"scored":[122],"percentage":[124],"intensity":[126],"nuclear":[128,135],"labeling.":[129],"Among":[130,162],"non-neoplastic":[131,149,159],"tissues,":[133],"expressed":[138],"islet":[140],"cells,":[141],"cells":[142,172],"centroacinar":[145],"compartment,":[147],"No":[152],"seen":[157],"cells.":[161],"consistently":[166],"labeled":[167],">50%":[168],"tumor":[171],"87.5%":[174],"ACC":[176],"38.6%":[179],"PEN":[181],"cases.":[182],"variable":[186],"IPMN,":[198,275],"MCN).":[200],"single":[202],"case":[203,244],"PB":[205],"examined":[207],"it":[209],"showed":[210],"component,":[215],"but":[216,268],"no":[217],"squamoid":[220],"nests.":[221],"Solid":[222],"neoplasms":[224,252,279],"did":[225],"not":[226,259],"express":[227],"Pdx1.":[228],"shows":[231],"adenocarcinomas,":[239,267],"PEN,":[240],"ACC,":[241],"PB.":[246],"In":[247],"immunohistochemical":[249],"evaluation":[250],"pancreas,":[255],"finding":[261],"specific":[262],"PENs":[264],"also":[269],"occurs":[270],"MCN)":[276],"other":[278]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}