{"id":"https://openalex.org/W1994719199","doi":"https://doi.org/10.1016/s0531-5565(00)00190-x","title":"Structural brain aging in inbred mice: potential for genetic linkage","display_name":"Structural brain aging in inbred mice: potential for genetic linkage","publication_year":2000,"publication_date":"2000-12-01","ids":{"openalex":"https://openalex.org/W1994719199","doi":"https://doi.org/10.1016/s0531-5565(00)00190-x","mag":"1994719199","pmid":"https://pubmed.ncbi.nlm.nih.gov/11113616"},"language":"en","primary_location":{"id":"doi:10.1016/s0531-5565(00)00190-x","doi":"https://doi.org/10.1016/s0531-5565(00)00190-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0531-5565(00)00190-x","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010409175","display_name":"Mathias Jucker","orcid":"https://orcid.org/0000-0001-9045-1072","observed_orcids":["https://orcid.org/0000-0001-9045-1072"]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"M. Jucker","raw_affiliation_strings":["Neuropathology, Institute of Pathology, University of Basel, Sch\u00f6nbeinstrasse 40, CH-4003, Basel, Switzerland. mjucker@uhbs.ch","Neuropathology, Institute of Pathology, University of Basel, Sch\u00f6nbeinstrasse 40, CH-4003, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropathology, Institute of Pathology, University of Basel, Sch\u00f6nbeinstrasse 40, CH-4003, Basel, Switzerland. mjucker@uhbs.ch","institution_ids":["https://openalex.org/I1850255"]},{"raw_affiliation_string":"Neuropathology, Institute of Pathology, University of Basel, Sch\u00f6nbeinstrasse 40, CH-4003, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036785169","display_name":"Luca Bondolfi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"L. Bondolfi","raw_affiliation_strings":["Neuropathology, Institute of Pathology, University of Basel, Sch\u00f6nbeinstrasse 40, CH-4003, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuropathology, Institute of Pathology, University of Basel, Sch\u00f6nbeinstrasse 40, CH-4003, Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026382005","display_name":"Michael E. Calhoun","orcid":"https://orcid.org/0000-0003-4323-4053","observed_orcids":["https://orcid.org/0000-0003-4323-4053"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M.E. Calhoun","raw_affiliation_strings":["Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072569917","display_name":"Jeffrey M. Long","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J.M. Long","raw_affiliation_strings":["Behavioral Neuroscience Section, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Neuroscience Section, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044264789","display_name":"Donald K. Ingram","orcid":"https://orcid.org/0000-0001-6509-6910","observed_orcids":["https://orcid.org/0000-0001-6509-6910"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D.K. Ingram","raw_affiliation_strings":["Behavioral Neuroscience Section, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Neuroscience Section, Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010409175"],"corresponding_institution_ids":["https://openalex.org/I1850255"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.7919,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.71707317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"35","issue":"9-10","first_page":"1383","last_page":"1388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.8852999806404114,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11265","display_name":"Aging and Gerontology Research","score":0.023399999365210533,"subfield":{"id":"https://openalex.org/subfields/3204","display_name":"Developmental and Educational Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.021800000220537186,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.996999979019165},{"id":"https://openalex.org/keywords/inbred-mouse-strains","display_name":"inbred mouse strains","score":0.9700000286102295},{"id":"https://openalex.org/keywords/genetic-linkage","display_name":"genetic linkage","score":0.8880000114440918},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.8209999799728394},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.703000009059906},{"id":"https://openalex.org/keywords/synaptic-boutons","display_name":"synaptic boutons","score":0.7480000257492065},{"id":"https://openalex.org/keywords/glial-cells","display_name":"glial cells","score":0.7099999785423279},{"id":"https://openalex.org/keywords/cholinergic-basal-forebrain","display_name":"basal forebrain cholinergic system","score":0.8289999961853027},{"id":"https://openalex.org/keywords/age-related-cognitive-decline","display_name":"age-related cognitive decline","score":0.8740000128746033},{"id":"https://openalex.org/keywords/polyglucosan-bodies","display_name":"polyglucosan bodies","score":0.9359999895095825},{"id":"https://openalex.org/keywords/neurogenesis","display_name":"neurogenesis","score":0.6769999861717224},{"id":"https://openalex.org/keywords/stereology","display_name":"stereology","score":0.7509999871253967}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.7421677708625793},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6572791337966919},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6467055678367615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6431311964988708},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6296551823616028},{"id":"https://openalex.org/C76725341","wikidata":"https://www.wikidata.org/wiki/Q1893126","display_name":"Inbred strain","level":3,"score":0.5990964770317078},{"id":"https://openalex.org/C2778794669","wikidata":"https://www.wikidata.org/wiki/Q43054","display_name":"Neuron","level":2,"score":0.5729953050613403},{"id":"https://openalex.org/C2776287375","wikidata":"https://www.wikidata.org/wiki/Q3407681","display_name":"Basal forebrain","level":3,"score":0.556523859500885},{"id":"https://openalex.org/C104966671","wikidata":"https://www.wikidata.org/wiki/Q12167532","display_name":"Cholinergic neuron","level":3,"score":0.4806153178215027},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.4727512300014496},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.43121880292892456},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.4110000431537628},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.21954742074012756},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18638703227043152},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12581214308738708},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09288275241851807},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019636","descriptor_name":"Neurodegenerative Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0531-5565(00)00190-x","doi":"https://doi.org/10.1016/s0531-5565(00)00190-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0531-5565(00)00190-x","pdf_url":null,"source":{"id":"https://openalex.org/S122591147","display_name":"Experimental Gerontology","issn_l":"0531-5565","issn":["0531-5565","1873-6815"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Gerontology","raw_type":"journal-article"},{"id":"pmid:11113616","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11113616","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental gerontology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W103672796","https://openalex.org/W261893250","https://openalex.org/W1525464385","https://openalex.org/W1592665312","https://openalex.org/W1969970154","https://openalex.org/W1980485998","https://openalex.org/W1986991051","https://openalex.org/W1988042413","https://openalex.org/W1998005675","https://openalex.org/W2004782459","https://openalex.org/W2007735166","https://openalex.org/W2020676496","https://openalex.org/W2025922492","https://openalex.org/W2028893665","https://openalex.org/W2031373538","https://openalex.org/W2037701234","https://openalex.org/W2048809344","https://openalex.org/W2049521887","https://openalex.org/W2062610934","https://openalex.org/W2079416180","https://openalex.org/W2079456989","https://openalex.org/W2080239815","https://openalex.org/W2081485190","https://openalex.org/W2084652820","https://openalex.org/W2089646436","https://openalex.org/W2089715790","https://openalex.org/W2101341993","https://openalex.org/W2105382539","https://openalex.org/W2141820578","https://openalex.org/W2154022915","https://openalex.org/W2154908600","https://openalex.org/W2975803268"],"related_works":["https://openalex.org/W2028893665","https://openalex.org/W2081485190","https://openalex.org/W2033914175","https://openalex.org/W2089715790","https://openalex.org/W4292056900","https://openalex.org/W4403083621","https://openalex.org/W2920728968","https://openalex.org/W3106778440","https://openalex.org/W1969358264","https://openalex.org/W70921817"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}