{"id":"https://openalex.org/W1994700466","doi":"https://doi.org/10.1210/en.135.5.2168","title":"Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts","display_name":"Recombinant human insulin-like growth factor (IGF)-binding protein-6 inhibits IGF-II-induced differentiation of L6A1 myoblasts","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W1994700466","doi":"https://doi.org/10.1210/en.135.5.2168","mag":"1994700466","pmid":"https://pubmed.ncbi.nlm.nih.gov/7525263"},"language":"en","primary_location":{"id":"doi:10.1210/en.135.5.2168","doi":"https://doi.org/10.1210/en.135.5.2168","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.135.5.2168","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086610862","display_name":"Leon A. Bach","orcid":"https://orcid.org/0000-0002-9062-1518","observed_orcids":["https://orcid.org/0000-0002-9062-1518"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L A Bach","raw_affiliation_strings":["Growth and Development Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth and Development Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091859452","display_name":"Susan Hsieh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Hsieh","raw_affiliation_strings":["Growth and Development Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth and Development Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045227186","display_name":"Alexandra Lynne Brown","orcid":"https://orcid.org/0000-0001-7022-5342","observed_orcids":["https://orcid.org/0000-0001-7022-5342"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A L Brown","raw_affiliation_strings":["Growth and Development Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth and Development Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084959996","display_name":"Matthew M. Rechler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090567","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M M Rechler","raw_affiliation_strings":["Growth and Development Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Growth and Development Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090567"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":5.8551,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.9659583,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"135","issue":"5","first_page":"2168","last_page":"2176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igfbp-6","display_name":"IGFBP-6","score":0.9660000205039978},{"id":"https://openalex.org/keywords/igf-ii","display_name":"insulin-like growth factor II","score":0.8930000066757202},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.8309999704360962},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8479999899864197},{"id":"https://openalex.org/keywords/igf-binding","display_name":"IGF binding","score":0.4779999852180481},{"id":"https://openalex.org/keywords/o-glycosylation","display_name":"O-glycosylation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/recombinant-protein-expression","display_name":"recombinant protein expression","score":0.8769999742507935},{"id":"https://openalex.org/keywords/creatine-kinase","display_name":"creatine kinase","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cell-association","display_name":"cell association","score":0.4020000100135803},{"id":"https://openalex.org/keywords/proteolysis","display_name":"proteolysis","score":0.8730000257492065},{"id":"https://openalex.org/keywords/growth-factor-modulation","display_name":"growth factor modulation","score":0.4950000047683716}],"concepts":[{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.6384338140487671},{"id":"https://openalex.org/C60278653","wikidata":"https://www.wikidata.org/wiki/Q5008075","display_name":"C2C12","level":4,"score":0.6256047487258911},{"id":"https://openalex.org/C2780378035","wikidata":"https://www.wikidata.org/wiki/Q17143674","display_name":"Insulin-like growth factor-binding protein","level":5,"score":0.618658721446991},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.5429397225379944},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.542719841003418},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5036751627922058},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47541695833206177},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42923659086227417},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.4181775450706482},{"id":"https://openalex.org/C553089730","wikidata":"https://www.wikidata.org/wiki/Q4914021","display_name":"Binding protein","level":3,"score":0.4120236337184906},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.39319273829460144},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36160337924957275},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2655258774757385},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.19606086611747742},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11655190587043762},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0867379903793335},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.06874984502792358},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000882","descriptor_name":"Haplorhini","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007335","descriptor_name":"Insulin-Like Growth Factor II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018976","descriptor_name":"Insulin-Like Growth Factor Binding Protein 6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/en.135.5.2168","doi":"https://doi.org/10.1210/en.135.5.2168","is_oa":false,"landing_page_url":"https://doi.org/10.1210/en.135.5.2168","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"doi:10.1210/endo.135.5.7525263","doi":"https://doi.org/10.1210/endo.135.5.7525263","is_oa":false,"landing_page_url":"https://doi.org/10.1210/endo.135.5.7525263","pdf_url":null,"source":{"id":"https://openalex.org/S157527038","display_name":"Endocrinology","issn_l":"0013-7227","issn":["0013-7227","1945-7170"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"journal-article"},{"id":"pmid:7525263","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7525263","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Endocrinology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W130038521","https://openalex.org/W292398390","https://openalex.org/W1489237025","https://openalex.org/W1571404318","https://openalex.org/W1579811372","https://openalex.org/W1602528313","https://openalex.org/W1821344948","https://openalex.org/W1986877280","https://openalex.org/W2002841462","https://openalex.org/W2007006137","https://openalex.org/W2010230690","https://openalex.org/W2013701819","https://openalex.org/W2015843482","https://openalex.org/W2023974760","https://openalex.org/W2043576320","https://openalex.org/W2043813981","https://openalex.org/W2056820558","https://openalex.org/W2060577528","https://openalex.org/W2063049842","https://openalex.org/W2065842356","https://openalex.org/W2071624463","https://openalex.org/W2071757792","https://openalex.org/W2090277249","https://openalex.org/W2102476333","https://openalex.org/W2133725782","https://openalex.org/W2137870151","https://openalex.org/W2154049094","https://openalex.org/W2161742302","https://openalex.org/W2414189003","https://openalex.org/W2439060150"],"related_works":["https://openalex.org/W2024217920","https://openalex.org/W2060652151","https://openalex.org/W2096748462","https://openalex.org/W2154049094","https://openalex.org/W2094406140","https://openalex.org/W2000978272","https://openalex.org/W2439060150","https://openalex.org/W1966504364","https://openalex.org/W2105606006","https://openalex.org/W7037862460"],"abstract_inverted_index":{"Insulin-like":[0],"growth":[1,12],"factor-binding":[2],"protein-6":[3],"(IGFBP-6)":[4],"is":[5],"an":[6,88],"O-linked":[7],"glycoprotein":[8],"that":[9,32,208,216],"binds":[10],"insulin-like":[11],"factor-II":[13],"(IGF-II)":[14],"with":[15,36,65,135,151,178],"marked":[16],"preferential":[17,137],"affinity":[18,138],"over":[19],"IGF-I.":[20],"Recombinant":[21],"human":[22,62],"IGFBP-6":[23,47,59,140,180,231],"(rhIGFBP-6)":[24],"was":[25,56,81,103,107,181,205],"synthesized":[26],"by":[27,96,161,259],"COS-7":[28],"monkey":[29],"kidney":[30],"cells":[31],"were":[33],"transiently":[34],"transfected":[35],"a":[37,43,99,110,127],"eukaryotic":[38],"expression":[39,232],"vector":[40],"into":[41],"which":[42],"complementary":[44],"DNA":[45],"for":[46,49,141,235],"modified":[48],"optimal":[50],"translation":[51],"had":[52,117,210],"been":[53,149],"inserted.":[54],"rhIGFBP-6":[55,75,92,106,116,217],"similar":[57],"to":[58,67,200,241,245],"purified":[60],"from":[61,183,188],"cerebrospinal":[63],"fluid":[64],"respect":[66],"IGF":[68,159,257],"binding":[69],"and":[70,146,203,220],"O-glycosylation.":[71],"The":[72,227],"effect":[73,119],"of":[74,90,139,158,175,229,250,256],"on":[76,120],"IGF-induced":[77],"L6A1":[78,170,176],"myoblast":[79,171,201],"differentiation":[80,94],"studied":[82],"using":[83],"creatine":[84],"kinase":[85],"activity":[86],"as":[87],"index":[89],"differentiation.":[91,226],"inhibited":[93],"initiated":[95],"IGF-II":[97],"in":[98,109,126,168],"dose-dependent":[100],"manner,":[101],"inhibition":[102],"complete":[104],"when":[105,124],"present":[108],"slight":[111],"molar":[112,129],"excess.":[113,130],"In":[114,194],"contrast,":[115],"no":[118,206],"IGF-I-induced":[121],"differentiation,":[122],"even":[123],"coincubated":[125],"5-fold":[128],"These":[131],"results":[132,214],"are":[133],"consistent":[134],"the":[136,152,156,169,184,230,251,254],"IGF-II.":[142],"As":[143],"cell":[144,189],"association":[145],"proteolysis":[147,209],"have":[148],"associated":[150],"potentiation,":[153],"rather":[154],"than":[155],"inhibition,":[157],"action":[160,258],"IGFBPs,":[162],"we":[163],"investigated":[164],"whether":[165],"they":[166],"occurred":[167],"system.":[172],"After":[173],"incubation":[174],"myoblasts":[177],"rhIGFBP-6,":[179],"recovered":[182],"medium,":[185],"but":[186],"not":[187,198],"lysates":[190],"or":[191],"extracellular":[192],"matrix.":[193],"addition,":[195],"[125I]IGFBP-6":[196],"did":[197],"bind":[199],"monolayers,":[202],"there":[204],"evidence":[207],"occurred.":[211],"Together,":[212],"these":[213,236],"indicate":[215],"remains":[218],"intact":[219],"soluble":[221],"and,":[222],"hence,":[223],"inhibits":[224],"IGF-II-induced":[225],"fidelity":[228],"system":[233,244],"used":[234],"studies":[237],"will":[238],"enable":[239],"us":[240],"use":[242],"this":[243],"determine":[246],"how":[247],"structural":[248],"modifications":[249],"protein":[252],"affect":[253],"modulation":[255],"IGFBP-6.":[260]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}