{"id":"https://openalex.org/W1994699754","doi":"https://doi.org/10.1159/000074229","title":"Pharmacogenetics of Gemtuzumab-Associated Hepatic Sinusoidal Occlusion Syndrome after Hematopoietic Stem Cell Transplant","display_name":"Pharmacogenetics of Gemtuzumab-Associated Hepatic Sinusoidal Occlusion Syndrome after Hematopoietic Stem Cell Transplant","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1994699754","doi":"https://doi.org/10.1159/000074229","mag":"1994699754","pmid":"https://pubmed.ncbi.nlm.nih.gov/14663169"},"language":"en","primary_location":{"id":"doi:10.1159/000074229","doi":"https://doi.org/10.1159/000074229","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000074229","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037359116","display_name":"Richard Aplenc","orcid":"https://orcid.org/0000-0001-7482-5644","observed_orcids":["https://orcid.org/0000-0001-7482-5644"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Aplenc","raw_affiliation_strings":["Pediatric Oncology, Children's Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA. raplenc@cceb.med.upenn.edu","Pediatric Oncology, Children's Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Children's Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA. raplenc@cceb.med.upenn.edu","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]},{"raw_affiliation_string":"Pediatric Oncology, Children's Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037072010","display_name":"Anil Vachani","orcid":"https://orcid.org/0000-0002-3871-8697","observed_orcids":["https://orcid.org/0000-0002-3871-8697"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anil Vachani","raw_affiliation_strings":["Pediatric Oncology, Children\u2019s Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Children\u2019s Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080775982","display_name":"Peggy P. Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peggy Han","raw_affiliation_strings":["Pediatric Oncology, Children\u2019s Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Children\u2019s Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000904186","display_name":"Wendy Glatfelter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Glatfelter","raw_affiliation_strings":["Pediatric Oncology, Children\u2019s Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Children\u2019s Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031662456","display_name":"Eric L. Sievers","orcid":"https://orcid.org/0000-0002-0794-9441","observed_orcids":["https://orcid.org/0000-0002-0794-9441"]},"institutions":[{"id":"https://openalex.org/I1335321130","display_name":"Children's Hospital of Philadelphia","ror":"https://ror.org/01z7r7q48","country_code":"US","type":"funder","lineage":["https://openalex.org/I1335321130"]},{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric L. Sievers","raw_affiliation_strings":["Pediatric Oncology, Children\u2019s Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Oncology, Children\u2019s Hospital of Philadelphia, and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., ZymoGenetics, Inc., Seattle, Wash., USA","institution_ids":["https://openalex.org/I1335321130","https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2566,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.61081081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"110","issue":"4","first_page":"207","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.4011000096797943,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.4011000096797943,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.39750000834465027,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.052400000393390656,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-veno-occlusive-disease","display_name":"veno-occlusive disease","score":0.996999979019165},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.8709999918937683},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.8360000252723694},{"id":"https://openalex.org/keywords/glutathione-s-transferase","display_name":"glutathione S-transferase","score":0.8320000171661377},{"id":"https://openalex.org/keywords/gstt1","display_name":"GSTT1","score":0.4659999907016754},{"id":"https://openalex.org/keywords/gstp1","display_name":"GSTP1","score":0.6869999766349792},{"id":"https://openalex.org/keywords/gsto1","display_name":"GSTO1","score":0.6029999852180481},{"id":"https://openalex.org/keywords/gstm1","display_name":"GSTM1","score":0.49399998784065247},{"id":"https://openalex.org/keywords/gsta1","display_name":"GSTA1","score":0.3540000021457672},{"id":"https://openalex.org/keywords/gstm2","display_name":"GSTM2","score":0.5090000033378601},{"id":"https://openalex.org/keywords/gstm3","display_name":"GSTM3","score":0.5139999985694885},{"id":"https://openalex.org/keywords/gstm4","display_name":"GSTM4","score":0.453000009059906},{"id":"https://openalex.org/keywords/gstm5","display_name":"GSTM5","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2778623314","wikidata":"https://www.wikidata.org/wiki/Q412685","display_name":"Gemtuzumab ozogamicin","level":5,"score":0.9750543236732483},{"id":"https://openalex.org/C2778245361","wikidata":"https://www.wikidata.org/wiki/Q409744","display_name":"Calicheamicin","level":3,"score":0.9370009899139404},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6648701429367065},{"id":"https://openalex.org/C2780895475","wikidata":"https://www.wikidata.org/wiki/Q5731687","display_name":"Hepatic veno-occlusive disease","level":4,"score":0.6178213953971863},{"id":"https://openalex.org/C2777408962","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Hematopoietic stem cell transplantation","level":3,"score":0.5409681797027588},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.48701196908950806},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43921688199043274},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43441301584243774},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3526262044906616},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34544289112091064},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3404729962348938},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3223336935043335},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3216778635978699},{"id":"https://openalex.org/C10205521","wikidata":"https://www.wikidata.org/wiki/Q4035578","display_name":"CD34","level":3,"score":0.21258941292762756},{"id":"https://openalex.org/C176290653","wikidata":"https://www.wikidata.org/wiki/Q21114013","display_name":"CD33","level":4,"score":0.18509525060653687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14246615767478943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000079982","descriptor_name":"Gemtuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006504","descriptor_name":"Hepatic Veno-Occlusive Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010597","descriptor_name":"Pharmacogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000074229","doi":"https://doi.org/10.1159/000074229","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000074229","pdf_url":null,"source":{"id":"https://openalex.org/S182948766","display_name":"Acta Haematologica","issn_l":"0001-5792","issn":["0001-5792","1421-9662"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Haematologica","raw_type":"journal-article"},{"id":"pmid:14663169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14663169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta haematologica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1658221551","https://openalex.org/W1821781403","https://openalex.org/W1842764967","https://openalex.org/W1971677598","https://openalex.org/W2018917611","https://openalex.org/W2024913341","https://openalex.org/W2076106584","https://openalex.org/W2112710602","https://openalex.org/W2124840583","https://openalex.org/W2153591132","https://openalex.org/W2167881633","https://openalex.org/W2187396559","https://openalex.org/W2332389332","https://openalex.org/W2335612101"],"related_works":["https://openalex.org/W2552007511","https://openalex.org/W2577279609","https://openalex.org/W2010760749","https://openalex.org/W7075315561","https://openalex.org/W2011280229","https://openalex.org/W2167766650","https://openalex.org/W2911715819","https://openalex.org/W7096366554","https://openalex.org/W2998104581","https://openalex.org/W2004459801"],"abstract_inverted_index":{"Gemtuzumab":[0],"ozogamicin":[1],"(Mylotarg)":[2],"consists":[3],"of":[4,18,27,44,87,104,114,158,179,219,230,261,282,318,328,347,356,392,497,501,506,597,673,680,698,705,714,721,738,749,764,772,790,813,837,868,874,883,888,931,952,963,977,995,1016,1025,1052,1058],"a":[5,42,164,326,515,694,810,929,1034,1049],"monoclonal":[6],"antibody":[7],"linked":[8],"to":[9,62,102,123,126,185,301,787,923,934],"calicheamicin":[10,124],"that":[11,193,203,273,289,358,550,865,974,1033,1060,1065],"has":[12,52,890],"been":[13,53,153,174,892],"approved":[14,382],"for":[15,36,91,298,354,366,373,425,572,587,724,758,767],"the":[16,63,130,156,217,228,276,280,293,316,339,384,389,395,415,476,539,548,551,594,614,628,658,662,674,678,687,736,746,762,770,780,788,817,842,863,872,881,886,907,940,949,953,959,975,990,996,1006,1022,1041,1074,1080],"treatment":[17,355],"relapsed":[19,359],"acute":[20,93],"myeloid":[21,94],"leukemia":[22,95],"in":[23,59,84,129,137,143,155,182,205,275,292,308,325,464,599,644,793,858,885,1002,1009,1013,1043],"patients":[24,45,60,88,105,183,329,337,521,529,580,598,794,802,818,831,1026],"60":[25],"years":[26],"age":[28],"and":[29,97,135,146,209,232,258,305,345,394,435,448,469,484,508,526,545,619,623,627,633,647,677,776,779,901,914,965,1068,1079,1082],"over":[30],"who":[31,330,351,522,530,708],"are":[32,462,473,642,648],"not":[33,172,532,590,666,684,731,784,799,848,891,945,1038],"considered":[34],"candidates":[35],"further":[37,1056],"cytotoxic":[38],"therapy":[39,51],"[1].":[40],"Although":[41,161,222,798,880],"quarter":[43],"receiving":[46,89,106,832],"gemtuzumab":[47,50,81,90,107,117,186,332,353,602,634,838,878,889,981,1067],"achieve":[48],"remission,":[49],"associated":[54,692],"with":[55,406,547,581,584,650,693,701,735,796,803,819,850,862,958,1048],"hepatic":[56,131,220,237,319,524,681,699,739,759,791,814,875,978],"damage,":[57,928],"especially":[58],"exposed":[61,184],"agent":[64],"after":[65,80,108,118,187,333,360,877,980],"hematopoietic":[66],"stem":[67],"cell":[68],"transplant":[69],"(HSCT)":[70],"[2].":[71],"Hepatic":[72],"sinusoidal":[73,138,485,502,509],"occlusion":[74,486,503],"syndrome":[75,99,487,511],"(SOS),":[76],"or":[77,235,606,854,1001],"veno-occlusive":[78],"disease,":[79],"administration":[82],"occurs":[83],"approximately":[85],"12%":[86],"refractory":[92],"(AML)":[96],"myelodysplastic":[98],"[3]and":[100],"up":[101],"30%":[103],"HSCT":[109,119,162,188,363,632],"transplantation":[110],"[4].":[111,141,493],"The":[112,176,494,535],"etiology":[113,157],"SOS":[115,159,180,199,525,792,815,876,936,979,1010,1044],"from":[116,404,420,475,593,841,926],"may":[120,197,241,870,983,1054,1061],"be":[121,242,984],"due":[122],"toxicity":[125,240,284],"CD33+":[127],"cells":[128,140],"sinusoids":[132],"(Kupffer":[133],"cells)":[134],"perhaps":[136],"endothelial":[139],"Alterations":[142],"glutathione":[144,299],"levels":[145,913],"damage":[147],"by":[148,244,383,414,442,453,657,986,1021,1073],"oxygen":[149,211,310,751,1070],"free":[150],"radicals":[151],"have":[152,171,250,271,910],"implicated":[154],"[5].":[160],"is":[163,189,745,860,921,956],"well-defined":[165],"risk":[166,169,178,195,218,281,317,697,756,789,812,859,873,976,1007],"factor,":[167],"other":[168,269],"factors":[170,196,246,757],"yet":[173],"defined.":[175],"variable":[177],"development":[181,500,679,737,1011],"indirect":[190],"evidence":[191,1032],"suggesting":[192],"genetic":[194,245,560,987],"modify":[198,279,871],"risk.":[200,1045],"We":[201,321],"hypothesized":[202,288],"mutations":[204,291],"drug":[206,294],"metabolizing":[207,213,295,312,753],"enzymes":[208,214,296,313,1064],"reactive":[210,309,750,1069],"species":[212,311,752],"would":[215,314],"alter":[216],"SOS.":[221,320,534,582,682,740,760],"no":[223],"data":[224,480],"presently":[225],"exists":[226],"regarding":[227],"role":[229,882],"polymorphisms":[231,256],"either":[233,851,999],"HSCT-associated":[234],"calicheamicin-associated":[236],"SOS,":[238,700],"chemotherapy":[239,262],"modified":[243,985],"[6].":[247],"Multiple":[248],"studies":[249,1047],"shown":[251,463],"associations":[252,670,734],"between":[253,543,631,671,726,1063],"simple":[254],"nucleotide":[255,470],"(SNPs)":[257],"altered":[259],"risks":[260],"toxicity.":[263],"Specifically,":[264],"Davies":[265,443],"et":[266,444],"al.":[267,445],"[7]and":[268],"authors":[270],"demonstrated":[272],"deletions":[274,778],"glutathione-S-transferase":[277],"gene":[278],"AML":[283,357],"[8].":[285],"Thus":[286],"we":[287],"deactivating":[290,306],"responsible":[297],"conjugation":[300],"phase":[302],"I":[303],"metabolites":[304],"variants":[307],"increase":[315,857],"tested":[322],"these":[323,612],"hypotheses":[324],"group":[327,596,1015],"received":[331,352,709],"HSCT.":[334],"All":[335],"21":[336],"at":[338,388,804],"Fred":[340,396],"Hutchinson":[341,397],"Cancer":[342,398],"Research":[343,399],"Center":[344,350],"University":[346],"Washington":[348],"Medical":[349],"myeloablative":[361],"allogenic":[362],"were":[364,371,438,451,481,520,528,621,839],"eligible":[365],"inclusion.":[367],"Bone":[368],"marrow":[369],"aspirates":[370],"available":[372,474,565,766],"evaluation":[374],"on":[375],"19":[376,564],"patients.":[377,1017],"This":[378,576,856],"research":[379],"study":[380,1029],"was":[381,402,423,488,499,512,636,691,847],"Institutional":[385],"Review":[386],"Boards":[387],"Children\u2019s":[390],"Hospital":[391],"Philadelphia":[393],"Center.":[400],"DNA":[401,408,412,417,427,569,925],"extracted":[403],"slides":[405,422],"Puregene":[407,416],"Tissue":[409,418],"Extraction":[410],"Kit.":[411],"extraction":[413],"Kit":[419],"archived":[421],"optimized":[424],"maximal":[426],"yields":[428,570],"as":[429,440,490,514,755,899],"previously":[430,491,651],"described":[431,441,492],"[9].":[432],"GST":[433,727,852],"mu":[434,853],"theta":[436],"assays":[437,455],"performed":[439,513],"[7].":[446],"GSTP":[447,822,884,894,912,920,964],"NQ01":[449],"genotypes":[450,728,754],"determined":[452],"pyrosequencing":[454],"[10,":[456],"11].":[457],"Representative":[458],"multiplex":[459],"GSTP1":[460],"pyrograms":[461],"figure":[465],"1.":[466],"Primer":[467],"sequences":[468],"dispensation":[471],"orders":[472],"corresponding":[477],"author.":[478],"Clinical":[479],"gathered":[482],"prospectively":[483],"defined":[489],"primary":[495],"outcome":[496],"interest":[498],"syndrome.":[504],"Analysis":[505],"genotype":[507],"injury":[510,932],"case":[516],"control":[517],"analysis.":[518,843],"Cases":[519],"experienced":[523],"controls":[527,546],"did":[531,589,665,730,783,944],"experience":[533],"case-control":[536,663],"analysis":[537,664,748],"compared":[538],"variant":[540,675,689,967],"allele":[541,653,690,808,909,955,968],"frequency":[542],"cases":[544],"understanding":[549],"small":[552,659,1023],"sample":[553,577,660],"sizes":[554],"prevented":[555],"definitive":[556],"conclusions":[557],"about":[558],"modest":[559],"effect":[561,826,846,951],"sizes.":[562],"Of":[563],"specimens,":[566],"18":[567],"had":[568,716,809],"adequate":[571,586],"consistent":[573,649,861,957],"PCR-based":[574],"genotyping.":[575],"included":[578],"9":[579],"Patients":[583,707],"samples":[585,765],"genotyping":[588,768],"differ":[591],"significantly":[592,786],"entire":[595],"age,":[600],"gender,":[601],"dose,":[603],"conditioning":[604],"regimen,":[605],"donor":[607],"type":[608],"(table":[609],"1).":[610],"For":[611],"patients,":[613],"mean":[615,629],"pregemtuzumab":[616],"total":[617],"bilirubin":[618],"AST":[620],"0.6":[622],"39":[624],"mg/dl,":[625],"respectively,":[626],"time":[630],"dose":[635],"195":[637],"days.":[638],"Allele":[639],"frequencies":[640],"obtained":[641],"noted":[643],"table":[645],"2":[646],"published":[652],"frequencies.":[654],"While":[655,683,761,1018],"limited":[656,769,1020],"size,":[661],"demonstrate":[667,732],"statistically":[668,685,800],"significant":[669],"any":[672,733],"alleles":[676],"significant,":[686,801],"GSTP*B":[688,807,869,908,954,991],"substantially":[695],"increased":[696,718],"an":[702,717],"odds":[703,719,942],"ratio":[704,720,943],"4.":[706],"more":[710,828],"than":[711,816,834],"1":[712,835],"mg/m2":[713,836],"Mylotarg":[715],"5.":[722],"Tests":[723],"interaction":[725],"also":[729],"To":[741],"our":[742],"knowledge,":[743],"this":[744,773,825,1014,1028],"first":[747],"number":[763,1024,1051],"power":[771],"study,":[774],"GSTT1":[775],"GSTM1":[777],"NQ01*2":[781],"polymorphism":[782],"contribute":[785],"treated":[795],"gemtuzumab.":[797],"least":[805],"one":[806],"higher":[811],"two":[820],"wild-type":[821],"alleles.":[823],"Interestingly,":[824],"became":[827],"pronounced":[829],"when":[830],"less":[833],"excluded":[840],"A":[844],"similar":[845],"seen":[849,1012],"theta.":[855],"hypothesis":[864],"decreased":[866,915],"function":[867,962],"exposure.":[879],"detoxification":[887,916],"elucidated,":[893],"detoxifies":[895],"electrophilic":[896],"compounds":[897],"such":[898],"carcinogens":[900],"chemotherapeutic":[902],"agents":[903],"[12].":[904],"Individuals":[905],"carrying":[906],"lower":[911],"capability":[917],"[13].":[918],"Moreover,":[919],"thought":[922],"protect":[924],"oxidative":[927],"mechanism":[930],"relevant":[933],"gemtuzumab-induced":[935],"[14].":[937],"Thus,":[938],"although":[939],"observed":[941,950],"reach":[946],"statistical":[947],"significance,":[948],"known":[960],"biologic":[961],"its":[966],"GSTP*B.":[969],"These":[970],"preliminary":[971],"results":[972],"suggest":[973],"exposure":[982],"factors,":[988],"specifically":[989],"polymorphism.":[992],"However,":[993],"none":[994],"examined":[997],"polymorphisms,":[998],"alone":[1000],"combination,":[1003],"fully":[1004,1039],"explains":[1005],"differences":[1008],"clearly":[1019],"evaluated,":[1027],"does":[1030,1037],"provide":[1031],"single":[1035],"SNP":[1036],"explain":[1040],"variation":[1042],"Further":[1046],"greater":[1050],"subjects":[1053],"enable":[1055],"elucidation":[1057],"interactions":[1059],"exist":[1062],"metabolize":[1066],"species.":[1071],"Supported":[1072],"Doris":[1075],"Duke":[1076],"Charitable":[1077],"Foundation":[1078],"Leonard":[1081],"Madilyn":[1083],"Abramson":[1084],"Endowed":[1085],"Chair.":[1086]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}