{"id":"https://openalex.org/W1994668373","doi":"https://doi.org/10.1182/blood-2011-12-396101","title":"IL-5 promotes induction of antigen-specific CD4+CD25+ T regulatory cells that suppress autoimmunity","display_name":"IL-5 promotes induction of antigen-specific CD4+CD25+ T regulatory cells that suppress autoimmunity","publication_year":2012,"publication_date":"2012-02-07","ids":{"openalex":"https://openalex.org/W1994668373","doi":"https://doi.org/10.1182/blood-2011-12-396101","mag":"1994668373","pmid":"https://pubmed.ncbi.nlm.nih.gov/22310911"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2011-12-396101","doi":"https://doi.org/10.1182/blood-2011-12-396101","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2011-12-396101","pdf_url":"https://ashpublications.org/blood/article-pdf/119/19/4441/1352836/zh801912004441.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/119/19/4441/1352836/zh801912004441.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109179791","display_name":"Giang T. Tran","orcid":"https://orcid.org/0000-0001-7636-7341","observed_orcids":["https://orcid.org/0000-0001-7636-7341"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Giang T. Tran","raw_affiliation_strings":["Departments of Neurology,","Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology,","institution_ids":[]},{"raw_affiliation_string":"Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060950347","display_name":"Suzanne Jean Hodgkinson","orcid":"https://orcid.org/0000-0002-9029-6663","observed_orcids":["https://orcid.org/0000-0002-9029-6663"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Suzanne J. Hodgkinson","raw_affiliation_strings":["Departments of Neurology,","Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology,","institution_ids":[]},{"raw_affiliation_string":"Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101453069","display_name":"Nicole M. Carter","orcid":"https://orcid.org/0000-0003-4453-9027","observed_orcids":["https://orcid.org/0000-0003-4453-9027"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nicole M. Carter","raw_affiliation_strings":["Departments of Neurology,","Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology,","institution_ids":[]},{"raw_affiliation_string":"Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112799896","display_name":"Nirupama Darshan Verma","orcid":"https://orcid.org/0000-0002-7349-1950","observed_orcids":["https://orcid.org/0000-0002-7349-1950"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nirupama D. Verma","raw_affiliation_strings":["Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021399262","display_name":"Karren M. Plain","orcid":"https://orcid.org/0000-0001-7126-9865","observed_orcids":["https://orcid.org/0000-0001-7126-9865"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Karren M. Plain","raw_affiliation_strings":["Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075525937","display_name":"Rochelle A. Boyd","orcid":"https://orcid.org/0000-0001-7535-1815","observed_orcids":["https://orcid.org/0000-0001-7535-1815"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rochelle Boyd","raw_affiliation_strings":["Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","Nephrology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Nephrology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066041781","display_name":"Catherine M. Robinson","orcid":"https://orcid.org/0000-0002-5403-4113","observed_orcids":["https://orcid.org/0000-0002-5403-4113"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Catherine M. Robinson","raw_affiliation_strings":["Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","institution_ids":["https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Masaru Nomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Masaru Nomura","raw_affiliation_strings":["Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","Nephrology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Nephrology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084242177","display_name":"Murray C. Killingsworth","orcid":"https://orcid.org/0000-0002-6125-1183","observed_orcids":["https://orcid.org/0000-0002-6125-1183"]},"institutions":[{"id":"https://openalex.org/I2800849109","display_name":"Liverpool Hospital","ror":"https://ror.org/03zzzks34","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800849109"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Murray Killingsworth","raw_affiliation_strings":["Pathology, Liverpool Hospital, Liverpool, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, Liverpool Hospital, Liverpool, Australia","institution_ids":["https://openalex.org/I2800849109"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020556945","display_name":"Bruce Milne Hall","orcid":"https://orcid.org/0000-0002-0877-3185","observed_orcids":["https://orcid.org/0000-0002-0877-3185"]},"institutions":[{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bruce M. Hall","raw_affiliation_strings":["Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","Nephrology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immune Tolerance Laboratory, Faculty of Medicine, University of New South Wales, Sydney, Australia; and","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Nephrology, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5060950347","https://openalex.org/A5109179791"],"corresponding_institution_ids":["https://openalex.org/I31746571"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":4.0738,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.94560373,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"119","issue":"19","first_page":"4441","last_page":"4450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/il-5","display_name":"IL-5","score":0.8759999871253967},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cd4-cd25-regulatory-t-cells","display_name":"CD4+CD25+ T cells","score":0.8529999852180481},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.8870000243186951},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.7490000128746033},{"id":"https://openalex.org/keywords/experimental-autoimmune-neuritis","display_name":"experimental autoimmune neuritis","score":0.972000002861023},{"id":"https://openalex.org/keywords/il-5-receptor-alpha","display_name":"IL-5 receptor alpha","score":0.7929999828338623},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.8679999709129333},{"id":"https://openalex.org/keywords/antigen-specific-tolerance","display_name":"antigen-specific tolerance","score":0.949999988079071},{"id":"https://openalex.org/keywords/allograft-tolerance","display_name":"allograft tolerance","score":0.8349999785423279},{"id":"https://openalex.org/keywords/th2-response","display_name":"Th2 immune response","score":0.8149999976158142},{"id":"https://openalex.org/keywords/immune-tolerance","display_name":"immune tolerance","score":0.5210000276565552},{"id":"https://openalex.org/keywords/demyelination","display_name":"demyelination","score":0.6520000100135803},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.7246724367141724},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5689395666122437},{"id":"https://openalex.org/C79484868","wikidata":"https://www.wikidata.org/wiki/Q5971673","display_name":"IL-2 receptor","level":4,"score":0.5338835120201111},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4953385889530182},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41266652941703796},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3768981397151947},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.27543455362319946},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25800180435180664}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000945","descriptor_name":"Antigens, Differentiation, T-Lymphocyte","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007108","descriptor_name":"Immune Tolerance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011917","descriptor_name":"Rats, Inbred Lew","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015551","descriptor_name":"Autoimmunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015704","descriptor_name":"CD4 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015848","descriptor_name":"Interleukin-5","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037182","descriptor_name":"T-Cell Antigen Receptor Specificity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050378","descriptor_name":"T-Lymphocytes, Regulatory","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053645","descriptor_name":"Interleukin-2 Receptor alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2011-12-396101","doi":"https://doi.org/10.1182/blood-2011-12-396101","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2011-12-396101","pdf_url":"https://ashpublications.org/blood/article-pdf/119/19/4441/1352836/zh801912004441.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:22310911","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22310911","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.994.5536","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.994.5536","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.bloodjournal.org/content/bloodjournal/119/19/4441.full.pdf?sso-checked%3Dtrue","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1182/blood-2011-12-396101","doi":"https://doi.org/10.1182/blood-2011-12-396101","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2011-12-396101","pdf_url":"https://ashpublications.org/blood/article-pdf/119/19/4441/1352836/zh801912004441.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320368","display_name":"Multiple Sclerosis Australia","ror":"https://ror.org/02caat392"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994668373.pdf","grobid_xml":"https://content.openalex.org/works/W1994668373.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W148138716","https://openalex.org/W160775263","https://openalex.org/W1525143304","https://openalex.org/W1567420244","https://openalex.org/W1580932873","https://openalex.org/W1668943367","https://openalex.org/W1883223948","https://openalex.org/W1891651069","https://openalex.org/W1969576545","https://openalex.org/W1971459512","https://openalex.org/W1973648078","https://openalex.org/W1977913178","https://openalex.org/W1983367810","https://openalex.org/W1986922509","https://openalex.org/W1991232823","https://openalex.org/W1995778103","https://openalex.org/W1997534025","https://openalex.org/W2001360021","https://openalex.org/W2002726823","https://openalex.org/W2004708987","https://openalex.org/W2009390908","https://openalex.org/W2010453211","https://openalex.org/W2011930819","https://openalex.org/W2012628829","https://openalex.org/W2014804480","https://openalex.org/W2014915517","https://openalex.org/W2029146247","https://openalex.org/W2045346081","https://openalex.org/W2046075122","https://openalex.org/W2049757251","https://openalex.org/W2050615631","https://openalex.org/W2062794300","https://openalex.org/W2063579960","https://openalex.org/W2067515152","https://openalex.org/W2067752500","https://openalex.org/W2073505343","https://openalex.org/W2094528973","https://openalex.org/W2101230909","https://openalex.org/W2116082836","https://openalex.org/W2118102164","https://openalex.org/W2118803877","https://openalex.org/W2120101415","https://openalex.org/W2130924672","https://openalex.org/W2137159296","https://openalex.org/W2141664407","https://openalex.org/W2147098499","https://openalex.org/W2147858215","https://openalex.org/W2315609995","https://openalex.org/W2416187487","https://openalex.org/W2564152524","https://openalex.org/W4313324526","https://openalex.org/W6650687451"],"related_works":["https://openalex.org/W7095992366","https://openalex.org/W4313358789","https://openalex.org/W3214944304","https://openalex.org/W1971459512","https://openalex.org/W2155987496","https://openalex.org/W4313365913","https://openalex.org/W2063579960","https://openalex.org/W2006756076","https://openalex.org/W4243947421","https://openalex.org/W2176109478"],"abstract_inverted_index":{"Immune":[0],"responses":[1],"to":[2,24,66,84,144,175,186,197],"foreign":[3],"and":[4,16,47,59,96,115,120,125,141,173],"self-Ags":[5],"can":[6],"be":[7,195],"controlled":[8],"by":[9,38,150,171],"regulatory":[10],"T":[11,40,123],"cells":[12,124],"(Tregs)":[13],"expressing":[14],"CD4":[15],"IL-2R\u03b1":[17],"chain":[18],"(CD25).":[19],"Defects":[20],"in":[21,60,127,201],"Tregs":[22,31,54,83,92,137,155],"lead":[23],"autoimmunity,":[25],"whereas":[26],"induction":[27],"of":[28,63,102,117,135,153,158,163],"Ag-specific":[29,34,82,168,199],"CD4+CD25+":[30,35,91],"restores":[32],"tolerance.":[33,52,86,191],"FOXP3+Tregs":[36],"activated":[37,170],"the":[39,56,61,161],"helper":[41],"type":[42],"2":[43],"(Th2)":[44],"cytokine,":[45],"IL-4,":[46,174],"specific":[48,57,67,145],"alloantigen":[49],"promote":[50,81],"allograft":[51],"These":[53,72,178],"expressed":[55,99,139],"IL-5R\u03b1":[58],"presence":[62],"IL-5":[64,77],"proliferate":[65],"but":[68],"not":[69],"third-party":[70],"Ag.":[71],"findings":[73,179],"suggest":[74],"that":[75,138,147],"recombinant":[76],"(rIL-5)":[78],"therapy":[79,193],"may":[80,180,194],"mediate":[85],"This":[87],"study":[88],"showed":[89],"normal":[90],"cultured":[93],"with":[94,106,133],"IL-4":[95,159],"an":[97],"autoantigen":[98,146,172],"Il-5r\u03b1.":[100],"Treatment":[101],"experimental":[103],"autoimmune":[104],"neuritis":[105],"rIL-5":[107,166,192],"markedly":[108],"reduced":[109],"clinical":[110],"paralysis,":[111],"weight":[112],"loss,":[113],"demyelination,":[114],"infiltration":[116],"CD4+":[118],"(Th1":[119],"Th17)":[121],"CD8+":[122],"macrophages":[126],"nerves.":[128],"Clinical":[129],"improvement":[130],"was":[131,148],"associated":[132],"expansion":[134],"CD4+CD25+FOXP3+":[136],"Il-5r\u03b1":[140],"proliferated":[142],"only":[143],"enhanced":[149],"rIL-5.":[151,164],"Depletion":[152],"CD25+":[154],"or":[156],"blocking":[157],"abolished":[160],"benefits":[162],"Thus,":[165],"promoted":[167],"Tregs,":[169],"control":[176],"autoimmunity.":[177,202],"explain":[181],"how":[182],"Th2":[183],"responses,":[184],"especially":[185],"parasitic":[187],"infestation,":[188],"induce":[189,198],"immune":[190],"able":[196],"tolerance":[200]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}