{"id":"https://openalex.org/W1994640446","doi":"https://doi.org/10.1002/em.20586","title":"Mitochondrial DNA mutations in disease and aging","display_name":"Mitochondrial DNA mutations in disease and aging","publication_year":2010,"publication_date":"2010-05-14","ids":{"openalex":"https://openalex.org/W1994640446","doi":"https://doi.org/10.1002/em.20586","mag":"1994640446","pmid":"https://pubmed.ncbi.nlm.nih.gov/20544884"},"language":"en","primary_location":{"id":"doi:10.1002/em.20586","doi":"https://doi.org/10.1002/em.20586","is_oa":false,"landing_page_url":"https://doi.org/10.1002/em.20586","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085274471","display_name":"Douglas C. Wallace","orcid":"https://orcid.org/0000-0002-7480-8278","observed_orcids":["https://orcid.org/0000-0002-7480-8278"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Douglas C. Wallace","raw_affiliation_strings":["ORU for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA, USA. dwallace@uci.edu","ORU for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ORU for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA, USA. dwallace@uci.edu","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"ORU for Molecular and Mitochondrial Medicine and Genetics, University of California, Irvine, CA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5085274471"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.4239,"has_fulltext":false,"cited_by_count":623,"citation_normalized_percentile":{"value":0.97396094,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"51","issue":"5","first_page":"440","last_page":"450"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11027","display_name":"Metabolism and Genetic Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.9919999837875366},{"id":"https://openalex.org/keywords/mitochondrial-disease","display_name":"mitochondrial disease","score":0.9729999899864197},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.9079999923706055},{"id":"https://openalex.org/keywords/oxidative-phosphorylation","display_name":"oxidative phosphorylation","score":0.953000009059906},{"id":"https://openalex.org/keywords/mitochondrial-biogenesis","display_name":"mitochondrial biogenesis","score":0.6230000257492065},{"id":"https://openalex.org/keywords/somatic-mtdna-mutations","display_name":"somatic mtDNA mutations","score":0.6970000267028809},{"id":"https://openalex.org/keywords/maternal-inheritance","display_name":"maternal inheritance","score":0.5609999895095825},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.34299999475479126},{"id":"https://openalex.org/keywords/regional-adaptation","display_name":"regional adaptation","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.9165376424789429},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8464486598968506},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.7552188634872437},{"id":"https://openalex.org/C151994961","wikidata":"https://www.wikidata.org/wiki/Q715263","display_name":"Human mitochondrial genetics","level":4,"score":0.604239284992218},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6026837825775146},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5638123750686646},{"id":"https://openalex.org/C20750100","wikidata":"https://www.wikidata.org/wiki/Q7068120","display_name":"Nuclear gene","level":4,"score":0.5478172898292542},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5453625321388245},{"id":"https://openalex.org/C2777229759","wikidata":"https://www.wikidata.org/wiki/Q6881848","display_name":"Mitochondrial biogenesis","level":3,"score":0.5315487384796143},{"id":"https://openalex.org/C2777614518","wikidata":"https://www.wikidata.org/wiki/Q935710","display_name":"Mitochondrial disease","level":4,"score":0.527975857257843},{"id":"https://openalex.org/C13514818","wikidata":"https://www.wikidata.org/wiki/Q5552256","display_name":"Germline mutation","level":4,"score":0.45616230368614197},{"id":"https://openalex.org/C109825262","wikidata":"https://www.wikidata.org/wiki/Q1139164","display_name":"Germline","level":3,"score":0.44909510016441345},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4378580152988434},{"id":"https://openalex.org/C115960442","wikidata":"https://www.wikidata.org/wiki/Q769863","display_name":"Nuclear DNA","level":4,"score":0.4159248173236847},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.4135567247867584}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D024101","descriptor_name":"Mitochondrial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D028361","descriptor_name":"Mitochondrial Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/em.20586","doi":"https://doi.org/10.1002/em.20586","is_oa":false,"landing_page_url":"https://doi.org/10.1002/em.20586","pdf_url":null,"source":{"id":"https://openalex.org/S204663187","display_name":"Environmental and Molecular Mutagenesis","issn_l":"0893-6692","issn":["0893-6692","1098-2280"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and Molecular Mutagenesis","raw_type":"journal-article"},{"id":"pmid:20544884","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20544884","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental and molecular mutagenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/7","display_name":"Affordable and clean energy","score":0.7699999809265137}],"study_designs":[],"awards":[{"id":"https://openalex.org/G322054087","display_name":null,"funder_award_id":"AG 16573","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3376850671","display_name":null,"funder_award_id":"NS 41850","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G3534085635","display_name":null,"funder_award_id":"AG-13154","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3568819","display_name":"Adaptive Physiology of mtDNA Longevity Mutations","funder_award_id":"R01AG024373","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G4346860958","display_name":null,"funder_award_id":"DK-73691","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4358608740","display_name":"The Alzheimer's Disease Research Center at the University of California, Irvine","funder_award_id":"P50AG016573","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5484089957","display_name":null,"funder_award_id":"AG24373","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G6619669572","display_name":"Mitochondrial Diabetes & Manganic Porphyrin Treatment","funder_award_id":"R01DK073691","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6828539183","display_name":"Mitochondrial Inborn Errors in Metabolism","funder_award_id":"R01NS021328","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7792539346","display_name":"ANT Defects in Neurodegenerative Diseases","funder_award_id":"R01NS041850","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G7832375816","display_name":"Mitochondrial Genetics and Aging","funder_award_id":"R01AG013154","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":99,"referenced_works":["https://openalex.org/W1481324524","https://openalex.org/W1535907462","https://openalex.org/W1538214352","https://openalex.org/W1551996591","https://openalex.org/W1569332557","https://openalex.org/W1576093526","https://openalex.org/W1665535554","https://openalex.org/W1889275428","https://openalex.org/W1917926680","https://openalex.org/W1965637094","https://openalex.org/W1966828661","https://openalex.org/W1967511612","https://openalex.org/W1968516838","https://openalex.org/W1972140717","https://openalex.org/W1973780680","https://openalex.org/W1978675778","https://openalex.org/W1981186447","https://openalex.org/W1981831202","https://openalex.org/W1982151076","https://openalex.org/W1986207059","https://openalex.org/W1989669460","https://openalex.org/W1993103503","https://openalex.org/W1998916359","https://openalex.org/W2001702206","https://openalex.org/W2002063846","https://openalex.org/W2003103396","https://openalex.org/W2003318822","https://openalex.org/W2004019018","https://openalex.org/W2007678016","https://openalex.org/W2008523969","https://openalex.org/W2009756075","https://openalex.org/W2010421268","https://openalex.org/W2011809681","https://openalex.org/W2015859699","https://openalex.org/W2017035597","https://openalex.org/W2017347785","https://openalex.org/W2017847012","https://openalex.org/W2019541219","https://openalex.org/W2029777214","https://openalex.org/W2034378072","https://openalex.org/W2037616674","https://openalex.org/W2041596211","https://openalex.org/W2042120426","https://openalex.org/W2044353940","https://openalex.org/W2044897807","https://openalex.org/W2045409504","https://openalex.org/W2046566818","https://openalex.org/W2050502424","https://openalex.org/W2060082206","https://openalex.org/W2061574765","https://openalex.org/W2062957434","https://openalex.org/W2066160429","https://openalex.org/W2068568687","https://openalex.org/W2070143299","https://openalex.org/W2071878964","https://openalex.org/W2077414996","https://openalex.org/W2079092251","https://openalex.org/W2079640584","https://openalex.org/W2081208114","https://openalex.org/W2082557602","https://openalex.org/W2084509816","https://openalex.org/W2084983931","https://openalex.org/W2085666957","https://openalex.org/W2085752695","https://openalex.org/W2086005166","https://openalex.org/W2086369154","https://openalex.org/W2088649670","https://openalex.org/W2090494914","https://openalex.org/W2093682552","https://openalex.org/W2094113524","https://openalex.org/W2094832206","https://openalex.org/W2095566500","https://openalex.org/W2099358791","https://openalex.org/W2104018711","https://openalex.org/W2105754268","https://openalex.org/W2109291482","https://openalex.org/W2110519784","https://openalex.org/W2115372514","https://openalex.org/W2117517043","https://openalex.org/W2118321705","https://openalex.org/W2122380998","https://openalex.org/W2123944789","https://openalex.org/W2127271204","https://openalex.org/W2129526111","https://openalex.org/W2129666171","https://openalex.org/W2138786768","https://openalex.org/W2139699261","https://openalex.org/W2141847223","https://openalex.org/W2147277388","https://openalex.org/W2148536297","https://openalex.org/W2153029275","https://openalex.org/W2155113724","https://openalex.org/W2157840716","https://openalex.org/W2163069284","https://openalex.org/W2164511303","https://openalex.org/W2166743660","https://openalex.org/W2170946953","https://openalex.org/W2171522573","https://openalex.org/W4388364016"],"related_works":["https://openalex.org/W2115668288","https://openalex.org/W2413253424","https://openalex.org/W2137062754","https://openalex.org/W575128618","https://openalex.org/W7096131242","https://openalex.org/W2081208114","https://openalex.org/W195126743","https://openalex.org/W2951423361","https://openalex.org/W2105754268","https://openalex.org/W4231101050"],"abstract_inverted_index":{"The":[0,23,51,154],"human":[1],"mitochondrial":[2,13,35,76,103,120,126],"genome":[3],"involves":[4],"over":[5],"1,000":[6],"genes,":[7],"dispersed":[8],"across":[9],"the":[10,17,31,34,42,49,108,131,158,168,173,194,199,211,214,220],"maternally":[11],"inherited":[12,19],"DNA":[14,21],"(mtDNA)":[15],"and":[16,95,106,122,133,143,151,162,213,217,237],"biparentally":[18],"nuclear":[20],"(nDNA).":[22],"mtDNA":[24,52,67,132,144,160,175,189,202,206],"encodes":[25],"13":[26],"core":[27],"proteins":[28,161],"that":[29,98,193,240],"determine":[30],"efficiency":[32],"of":[33,64,83,157,185],"energy-generating":[36],"system,":[37],"oxidative":[38],"phosphorylation":[39],"(OXPHOS),":[40],"plus":[41],"RNA":[43],"genes":[44,116,128],"for":[45,231],"their":[46,92,163,248],"translation":[47],"within":[48],"mitochondrion.":[50],"has":[53],"a":[54,81,228],"very":[55],"high":[56,164],"mutation":[57,165],"rate,":[58],"which":[59,84],"results":[60],"in":[61,75,91,112,124,181,235,247],"three":[62],"classes":[63],"clinically":[65],"relevant":[66],"mutations:":[68],"recently":[69],"deleterious":[70,188,201],"germline":[71,216],"line":[72],"mutations":[73,97,190,207],"resulting":[74],"disease;":[77],"ancient":[78],"regional":[79,249],"variants,":[80],"subset":[82],"permitted":[85],"humans":[86],"to":[87,89,135,171,243,245],"adapt":[88,244],"differences":[90],"energetic":[93,250],"environments;":[94],"somatic":[96],"accumulate":[99],"with":[100],"age":[101],"eroding":[102],"energy":[104],"production":[105],"providing":[107],"aging":[109],"clock.":[110],"Mutations":[111],"nDNA-encoded":[113],"OXPHOS":[114],"structural":[115],"can":[117,129,147],"also":[118],"cause":[119,152],"disease,":[121],"alterations":[123,246],"nDNA":[125,142],"biogenesis":[127],"destabilize":[130],"lead":[134],"clinical":[136],"phenotypes.":[137],"Finally,":[138],"when":[139],"combined,":[140],"nonpathogenic":[141],"protein":[145],"variants":[146],"be":[148],"functionally":[149],"incompatible":[150],"disease.":[153],"essential":[155],"functions":[156],"conserved":[159],"rate":[166],"raise":[167],"question":[169],"as":[170],"why":[172],"cumulative":[174],"genetic":[176,225,233],"load":[177],"does":[178],"not":[179],"result":[180],"species":[182,242],"extinction.":[183],"Studies":[184],"mice":[186],"harboring":[187],"have":[191],"shown":[192],"mammalian":[195],"ovary":[196,212],"selectively":[197],"eliminates":[198],"most":[200],"mutations.":[203],"However,":[204],"milder":[205],"are":[208],"transmitted":[209],"through":[210],"female":[215],"introduced":[218],"into":[219],"general":[221],"population.":[222],"This":[223],"unique":[224],"system":[226],"provides":[227],"flexible":[229],"method":[230],"generating":[232],"variation":[234],"cellular":[236],"organismal":[238],"energetics":[239],"permits":[241],"environment.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":23},{"year":2025,"cited_by_count":33},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":27},{"year":2021,"cited_by_count":31},{"year":2020,"cited_by_count":33},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":32},{"year":2017,"cited_by_count":51},{"year":2016,"cited_by_count":44},{"year":2015,"cited_by_count":40},{"year":2014,"cited_by_count":54},{"year":2013,"cited_by_count":54},{"year":2012,"cited_by_count":60}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}