{"id":"https://openalex.org/W1994627202","doi":"https://doi.org/10.1046/j.1460-9568.2003.02655.x","title":"Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal\u2010regulating kinase 1 during seizure\u2010induced neuronal death","display_name":"Formation of a tumour necrosis factor receptor 1 molecular scaffolding complex and activation of apoptosis signal\u2010regulating kinase 1 during seizure\u2010induced neuronal death","publication_year":2003,"publication_date":"2003-05-01","ids":{"openalex":"https://openalex.org/W1994627202","doi":"https://doi.org/10.1046/j.1460-9568.2003.02655.x","mag":"1994627202","pmid":"https://pubmed.ncbi.nlm.nih.gov/12786973"},"language":"en","primary_location":{"id":"doi:10.1046/j.1460-9568.2003.02655.x","doi":"https://doi.org/10.1046/j.1460-9568.2003.02655.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.2003.02655.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061026629","display_name":"Sachiko Shinoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163879017","display_name":"Legacy Health","ror":"https://ror.org/04g9xj393","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I163879017"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Sachiko Shinoda","raw_affiliation_strings":["Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA","Department of Neurosurgery, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA","institution_ids":["https://openalex.org/I163879017"]},{"raw_affiliation_string":"Department of Neurosurgery, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003842517","display_name":"Shana L. Skradski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163879017","display_name":"Legacy Health","ror":"https://ror.org/04g9xj393","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I163879017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shana L. Skradski","raw_affiliation_strings":["Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA","institution_ids":["https://openalex.org/I163879017"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Tomohiro Araki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163879017","display_name":"Legacy Health","ror":"https://ror.org/04g9xj393","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I163879017"]},{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Tomohiro Araki","raw_affiliation_strings":["Department of Neurosurgery, Mie University School of Medicine, Tsu, Mie, Japan","Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]},{"raw_affiliation_string":"Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA","institution_ids":["https://openalex.org/I163879017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044394104","display_name":"Clara K. Schindler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163879017","display_name":"Legacy Health","ror":"https://ror.org/04g9xj393","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I163879017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clara K. Schindler","raw_affiliation_strings":["Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA","institution_ids":["https://openalex.org/I163879017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070403963","display_name":"Robert Meller","orcid":"https://orcid.org/0000-0003-3528-8019","observed_orcids":["https://orcid.org/0000-0003-3528-8019"]},"institutions":[{"id":"https://openalex.org/I163879017","display_name":"Legacy Health","ror":"https://ror.org/04g9xj393","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I163879017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Meller","raw_affiliation_strings":["Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA","institution_ids":["https://openalex.org/I163879017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109948699","display_name":"Jing\u2010Quan Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163879017","display_name":"Legacy Health","ror":"https://ror.org/04g9xj393","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I163879017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing\u2010Quan Lan","raw_affiliation_strings":["Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA","institution_ids":["https://openalex.org/I163879017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011179401","display_name":"Waro Taki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I178574317","display_name":"Mie University","ror":"https://ror.org/01529vy56","country_code":"JP","type":"education","lineage":["https://openalex.org/I178574317"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Waro Taki","raw_affiliation_strings":["Department of Neurosurgery, Mie University School of Medicine, Tsu, Mie, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Mie University School of Medicine, Tsu, Mie, Japan","institution_ids":["https://openalex.org/I178574317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069808116","display_name":"Roger Pancoast Simon","orcid":"https://orcid.org/0000-0001-7287-6915","observed_orcids":["https://orcid.org/0000-0001-7287-6915"]},"institutions":[{"id":"https://openalex.org/I163879017","display_name":"Legacy Health","ror":"https://ror.org/04g9xj393","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I163879017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger P. Simon","raw_affiliation_strings":["Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA","institution_ids":["https://openalex.org/I163879017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002978004","display_name":"David Clifford Henshall","orcid":"https://orcid.org/0000-0001-6237-9632","observed_orcids":["https://orcid.org/0000-0001-6237-9632"]},"institutions":[{"id":"https://openalex.org/I163879017","display_name":"Legacy Health","ror":"https://ror.org/04g9xj393","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I163879017"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David C. Henshall","raw_affiliation_strings":["Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA","institution_ids":["https://openalex.org/I163879017"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002978004"],"corresponding_institution_ids":["https://openalex.org/I163879017"],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":2.5461,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.90051145,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"17","issue":"10","first_page":"2065","last_page":"2076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.017500000074505806,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-necrosis-factor-receptor-1","display_name":"tumor necrosis factor receptor 1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ask1","display_name":"ASK1","score":0.9649999737739563},{"id":"https://openalex.org/keywords/seizure-induced-neuronal-death","display_name":"seizure-induced neuronal death","score":0.906000018119812},{"id":"https://openalex.org/keywords/receptor-interacting-protein","display_name":"receptor-interacting protein","score":0.9599999785423279},{"id":"https://openalex.org/keywords/bcl10","display_name":"BCL10","score":0.9340000152587891},{"id":"https://openalex.org/keywords/14-3-3beta","display_name":"14-3-3\u03b2","score":0.902999997138977},{"id":"https://openalex.org/keywords/protein-phosphatase-5","display_name":"protein phosphatase 5","score":0.9789999723434448},{"id":"https://openalex.org/keywords/daxx","display_name":"DAXX","score":0.7870000004768372},{"id":"https://openalex.org/keywords/kainic-acid-induced-seizures","display_name":"kainic acid-induced seizures","score":0.7699999809265137},{"id":"https://openalex.org/keywords/hippocampal-ca3-neurons","display_name":"CA3 neurons","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C124160383","wikidata":"https://www.wikidata.org/wiki/Q14914383","display_name":"ASK1","level":5,"score":0.7905837297439575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6964536905288696},{"id":"https://openalex.org/C2779004061","wikidata":"https://www.wikidata.org/wiki/Q5247322","display_name":"Death domain","level":4,"score":0.584687352180481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.580963671207428},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5727276802062988},{"id":"https://openalex.org/C2776472363","wikidata":"https://www.wikidata.org/wiki/Q14914379","display_name":"TRADD","level":5,"score":0.529816746711731},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5053372979164124},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.47976598143577576},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.4568849205970764},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42299431562423706},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.39323028922080994},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2947852611541748},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12025481462478638}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010749","descriptor_name":"Phosphoprotein Phosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D017966","descriptor_name":"Pyramidal Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018124","descriptor_name":"Receptors, Tumor Necrosis Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047888","descriptor_name":"Receptors, Tumor Necrosis Factor, Type I","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047992","descriptor_name":"TNF Receptor-Associated Factor 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048948","descriptor_name":"14-3-3 Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1046/j.1460-9568.2003.02655.x","doi":"https://doi.org/10.1046/j.1460-9568.2003.02655.x","is_oa":false,"landing_page_url":"https://doi.org/10.1046/j.1460-9568.2003.02655.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:12786973","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12786973","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9074000120162964,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2321063182","display_name":"Caspases mediate seizure-induced brain injury","funder_award_id":"R01NS041935","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4341343528","display_name":"Molecular mechanisms of seizure induced brain injury","funder_award_id":"R01NS039016","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1548862642","https://openalex.org/W1583498507","https://openalex.org/W1615546978","https://openalex.org/W1633015885","https://openalex.org/W1699101563","https://openalex.org/W1724950598","https://openalex.org/W1877363685","https://openalex.org/W1963616049","https://openalex.org/W1968055572","https://openalex.org/W1968982991","https://openalex.org/W1970328728","https://openalex.org/W1978843688","https://openalex.org/W1987110784","https://openalex.org/W1996901446","https://openalex.org/W1998571837","https://openalex.org/W2004398763","https://openalex.org/W2006338784","https://openalex.org/W2006625418","https://openalex.org/W2008376815","https://openalex.org/W2008872627","https://openalex.org/W2012357103","https://openalex.org/W2015805559","https://openalex.org/W2020303700","https://openalex.org/W2022247016","https://openalex.org/W2022378197","https://openalex.org/W2024476573","https://openalex.org/W2024587309","https://openalex.org/W2025128734","https://openalex.org/W2033620246","https://openalex.org/W2034580062","https://openalex.org/W2043884992","https://openalex.org/W2045207504","https://openalex.org/W2048096362","https://openalex.org/W2048399408","https://openalex.org/W2059407857","https://openalex.org/W2060173267","https://openalex.org/W2060426018","https://openalex.org/W2062098209","https://openalex.org/W2063094517","https://openalex.org/W2064122617","https://openalex.org/W2064489771","https://openalex.org/W2069824337","https://openalex.org/W2071055800","https://openalex.org/W2076363178","https://openalex.org/W2084028198","https://openalex.org/W2085109799","https://openalex.org/W2085128427","https://openalex.org/W2087160210","https://openalex.org/W2090609163","https://openalex.org/W2090980940","https://openalex.org/W2114379972","https://openalex.org/W2115205812","https://openalex.org/W2120003285","https://openalex.org/W2123619341","https://openalex.org/W2127789417","https://openalex.org/W2133726754","https://openalex.org/W2137060094","https://openalex.org/W2142850882","https://openalex.org/W2145221831","https://openalex.org/W2147122201","https://openalex.org/W2148209200","https://openalex.org/W2152445095","https://openalex.org/W2155130890","https://openalex.org/W2155868854","https://openalex.org/W2163815564","https://openalex.org/W2329112543","https://openalex.org/W4241091303","https://openalex.org/W4297244290","https://openalex.org/W4300196626"],"related_works":["https://openalex.org/W1597900450","https://openalex.org/W143161349","https://openalex.org/W2057612076","https://openalex.org/W1615546978","https://openalex.org/W2122906925","https://openalex.org/W1979962409","https://openalex.org/W2297816804","https://openalex.org/W1605888494","https://openalex.org/W7096997125","https://openalex.org/W2313592706"],"abstract_inverted_index":{"The":[0,16],"consequences":[1],"of":[2,4,33,40,47,64,82,85,98,118,128,131,161,180,200,211,229,234],"activation":[3],"tumour":[5],"necrosis":[6],"factor":[7,113,120,194],"receptor":[8,108],"1":[9,20,138],"(TNFR1)":[10],"during":[11,49],"neuronal":[12,51,72,231],"injury":[13],"remain":[14],"controversial.":[15],"apoptosis":[17,132],"signal-regulating":[18,136],"kinase":[19,25,26,137,167,168],"(ASK1),":[21],"a":[22,76,95,99,142,235],"mitogen-activated":[23,165],"protein":[24,88,110,133,151,166,173],"kinase,":[27],"can":[28],"mediate":[29],"cell":[30],"death":[31,86,105,232],"downstream":[32,233],"TNFR1.":[34],"Presently,":[35],"we":[36],"examined":[37],"the":[38,41,80,83,146,159,162,178,188,197,209,216,227],"formation":[39],"TNFR1":[42,100,236],"signalling":[43],"cascade":[44],"and":[45,111,150,158,170,192],"response":[46],"ASK1":[48,163,185,222],"seizure-induced":[50,230],"death.":[52,73],"Brief":[53],"(40":[54],"min)":[55],"seizures":[56],"were":[57],"induced":[58],"in":[59,79,141,226],"rats":[60],"by":[61,125],"intra-amygdala":[62],"microinjection":[63],"kainic":[65],"acid,":[66],"which":[67],"elicited":[68],"unilateral":[69],"hippocampal":[70],"CA3":[71,182,202],"Seizures":[74,154],"caused":[75],"rapid":[77],"decline":[78],"expression":[81],"silencer":[84],"domains":[87],"within":[89,215],"injured":[90,201,217],"CA3.":[91],"Co-immunoprecipitation":[92],"analysis":[93],"revealed":[94],"commensurate":[96],"assembly":[97],"scaffold":[101],"complex":[102,143],"containing":[103],"TNFR-associated":[104],"domain":[106],"protein,":[107],"interacting":[109],"TNFR-activating":[112,119,193],"2.":[114,134],"In":[115],"addition,":[116],"recruitment":[117],"2":[121,195],"was":[122,139],"likely":[123],"promoted":[124],"Bcl10-mediated":[126],"sequestering":[127],"cellular":[129],"inhibitor":[130],"Apoptosis":[135],"sequestered":[140],"that":[144],"contained":[145],"molecular":[147],"chaperone":[148],"14-3-3beta":[149],"phosphatase":[152,174],"5.":[153],"triggered":[155],"its":[156],"dissociation,":[157],"phosphorylation":[160],"substrates,":[164],"3/6":[169],"4.":[171],"Subsequently,":[172],"5":[175],"translocated":[176],"into":[177],"nuclei":[179],"degenerating":[181],"neurons,":[183],"while":[184],"colocalized":[186],"with":[187],"adaptor":[189],"proteins":[190],"Daxx":[191],"at":[196],"outer":[198],"membrane":[199],"neurons.":[203],"Neutralizing":[204],"antibodies":[205],"to":[206],"TNFalpha":[207],"reduced":[208],"numbers":[210],"DNA":[212],"damaged":[213],"cells":[214],"hippocampus.":[218],"These":[219],"data":[220],"suggest":[221],"may":[223],"be":[224],"involved":[225],"mechanism":[228],"death-signalling":[237],"complex.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
