{"id":"https://openalex.org/W1994606972","doi":"https://doi.org/10.1016/j.ejcsup.2013.07.055","title":"Cancer invasion and resistance","display_name":"Cancer invasion and resistance","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W1994606972","doi":"https://doi.org/10.1016/j.ejcsup.2013.07.055","mag":"1994606972","pmid":"https://pubmed.ncbi.nlm.nih.gov/26217149","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4041189"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejcsup.2013.07.055","doi":"https://doi.org/10.1016/j.ejcsup.2013.07.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejcsup.2013.07.055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1359634913000566/pdf","source":{"id":"https://openalex.org/S13410216","display_name":"European Journal of Cancer Supplements","issn_l":"1359-6349","issn":["1359-6349","1878-1217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","norway-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer Supplements","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S1359634913000566/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109395702","display_name":"Anna H\u00e4ger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Anna H\u00e4ger","raw_affiliation_strings":["Microscopical Imaging of the Cell, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microscopical Imaging of the Cell, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054964176","display_name":"Stephanie Alexander","orcid":"https://orcid.org/0000-0002-8308-3977","observed_orcids":["https://orcid.org/0000-0002-8308-3977"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Alexander","raw_affiliation_strings":["David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026527299","display_name":"Peter Friedl","orcid":"https://orcid.org/0000-0002-0119-4041","observed_orcids":["https://orcid.org/0000-0002-0119-4041"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210127603","display_name":"Cancer Genomics Centre","ror":"https://ror.org/02y9qjz38","country_code":"NL","type":"nonprofit","lineage":["https://openalex.org/I4210127603"]}],"countries":["NL","US"],"is_corresponding":true,"raw_author_name":"Peter Friedl","raw_affiliation_strings":["Microscopical Imaging of the Cell, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands ; David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA ; Cancer Genomics Center, The Netherlands","Cancer Genomics Center, The Netherlands","David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","Microscopical Imaging of the Cell, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microscopical Imaging of the Cell, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands ; David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA ; Cancer Genomics Center, The Netherlands","institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I145872427"]},{"raw_affiliation_string":"Cancer Genomics Center, The Netherlands","institution_ids":["https://openalex.org/I4210127603"]},{"raw_affiliation_string":"David H. Koch Center, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Microscopical Imaging of the Cell, Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, The Netherlands","institution_ids":["https://openalex.org/I145872427"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5026527299"],"corresponding_institution_ids":["https://openalex.org/I1343551460","https://openalex.org/I145872427","https://openalex.org/I4210127603"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":0.7145,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.71707841,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"11","issue":"2","first_page":"291","last_page":"293"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.8550000190734863,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.02319999970495701,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9850000143051147},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9929999709129333},{"id":"https://openalex.org/keywords/collective-invasion","display_name":"collective invasion","score":0.5320000052452087},{"id":"https://openalex.org/keywords/intravital-microscopy","display_name":"intravital microscopy","score":0.8679999709129333},{"id":"https://openalex.org/keywords/organotypic-models","display_name":"organotypic models","score":0.8799999952316284},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.7360000014305115},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"cytoskeleton","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.9750000238418579},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.8769999742507935},{"id":"https://openalex.org/keywords/stroma","display_name":"stroma","score":0.5659999847412109},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tumor-cell-survival","display_name":"tumor cell survival","score":0.9079999923706055}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6540001034736633},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.5865864753723145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43626105785369873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2657797932624817},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23019331693649292},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.1192435622215271}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.ejcsup.2013.07.055","doi":"https://doi.org/10.1016/j.ejcsup.2013.07.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejcsup.2013.07.055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1359634913000566/pdf","source":{"id":"https://openalex.org/S13410216","display_name":"European Journal of Cancer Supplements","issn_l":"1359-6349","issn":["1359-6349","1878-1217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","norway-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer Supplements","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3224044","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4041189","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4041189","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4041189","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJC Suppl","raw_type":"Text"},{"id":"pmid:26217149","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26217149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EJC supplements : EJC : official journal of EORTC, European Organization for Research and Treatment of Cancer ... [et al.]","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.ejcsup.2013.07.055","doi":"https://doi.org/10.1016/j.ejcsup.2013.07.055","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.ejcsup.2013.07.055","pdf_url":"https://www.sciencedirect.com/science/article/pii/S1359634913000566/pdf","source":{"id":"https://openalex.org/S13410216","display_name":"European Journal of Cancer Supplements","issn_l":"1359-6349","issn":["1359-6349","1878-1217"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","norway-1","poland-100","russia-white-list-4"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer Supplements","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994606972.pdf","grobid_xml":"https://content.openalex.org/works/W1994606972.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W2012376126","https://openalex.org/W2062116473","https://openalex.org/W2110024452","https://openalex.org/W2125753081","https://openalex.org/W2132101412","https://openalex.org/W2133054656","https://openalex.org/W2143468862","https://openalex.org/W2145013849","https://openalex.org/W6679412370"],"related_works":["https://openalex.org/W2154536586","https://openalex.org/W2110024452","https://openalex.org/W2520404264","https://openalex.org/W2143468862","https://openalex.org/W904058290","https://openalex.org/W3159846284","https://openalex.org/W1966025692","https://openalex.org/W2657389501","https://openalex.org/W2838855305","https://openalex.org/W2102974965"],"abstract_inverted_index":{"Preclinical":[0],"microscopy":[1,82],"has":[2,47,83],"greatly":[3],"enhanced":[4],"our":[5],"mechanistic":[6],"understanding":[7],"of":[8,15,72,80,130],"cancer":[9,30,87,107,131],"invasion":[10,24,56,88,99,125],"and":[11,22,25,33,52,57,113,122,134],"metastasis,":[12],"the":[13,16,26,63,69,73],"contribution":[14],"tumour":[17],"microenvironment":[18,27],"to":[19,105,115,136],"metastatic":[20],"progression,":[21],"how":[23,49],"jointly":[28],"support":[29],"cell":[31,132],"survival":[32,133],"resistance.":[34],"Using":[35],"organotypic":[36],"models":[37],"in":[38,42,92,100],"vitro,":[39],"live-cell":[40],"imaging":[41],"three-dimensional":[43],"(3D)":[44],"tissue":[45,120],"culture":[46],"identified":[48],"cytoskeletal,":[50],"adhesion":[51],"protease":[53],"systems":[54],"drive":[55],"metastasis":[58],"[1].":[59],"When":[60],"altered":[61],"at":[62],"molecular":[64],"level,":[65],"these":[66],"pathways":[67,126,129],"underlie":[68],"unexpected":[70],"diversity":[71],"invasive":[74],"process":[75],"[2].":[76],"The":[77],"recent":[78],"use":[79],"intravital":[81],"further":[84],"suggested":[85],"that":[86,124],"into":[89],"interstitial":[90],"stroma":[91],"vivo:":[93],"(1)":[94],"occurs":[95],"mostly":[96],"as":[97],"collective":[98],"which":[101],"cells":[102],"remain":[103],"coupled":[104],"neighbouring":[106],"cells,":[108],"(2)":[109],"is":[110],"guided":[111],"by":[112,118],"responsive":[114],"signals":[116],"delivered":[117],"connective":[119],"structures":[121],"(3)":[123],"cross-talk":[127],"with":[128],"resistance":[135],"anticancer":[137],"therapy":[138],"[3].":[139]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
