{"id":"https://openalex.org/W1994577418","doi":"https://doi.org/10.1042/bj20030672","title":"Modulation of NAADP (nicotinic acid\u2013adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations","display_name":"Modulation of NAADP (nicotinic acid\u2013adenine dinucleotide phosphate) receptors by K+ ions: evidence for multiple NAADP receptor conformations","publication_year":2003,"publication_date":"2003-10-24","ids":{"openalex":"https://openalex.org/W1994577418","doi":"https://doi.org/10.1042/bj20030672","mag":"1994577418","pmid":"https://pubmed.ncbi.nlm.nih.gov/12914540","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1223729"},"language":"en","primary_location":{"id":"doi:10.1042/bj20030672","doi":"https://doi.org/10.1042/bj20030672","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20030672","pdf_url":"https://portlandpress.com/biochemj/article-pdf/375/3/805/712831/bj3750805.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/375/3/805/712831/bj3750805.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017767446","display_name":"George David Dickinson","orcid":"https://orcid.org/0000-0001-7711-0388","observed_orcids":["https://orcid.org/0000-0001-7711-0388"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"George D. DICKINSON","raw_affiliation_strings":["The Old Squash Courts, Department of Physiology, University College London, Gower Street, London WC1E 6BT, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Old Squash Courts, Department of Physiology, University College London, Gower Street, London WC1E 6BT, U.K","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086481218","display_name":"Sandip Patel","orcid":"https://orcid.org/0000-0001-7247-2013","observed_orcids":["https://orcid.org/0000-0001-7247-2013"]},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sandip PATEL","raw_affiliation_strings":["The Old Squash Courts, Department of Physiology, University College London, Gower Street, London WC1E 6BT, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Old Squash Courts, Department of Physiology, University College London, Gower Street, London WC1E 6BT, U.K","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":null,"apc_paid":null,"fwci":2.5027,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.87494572,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"375","issue":"3","first_page":"805","last_page":"812"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/naadp-receptor","display_name":"NAADP receptor","score":0.9620000123977661},{"id":"https://openalex.org/keywords/naadp","display_name":"NAADP","score":0.9259999990463257},{"id":"https://openalex.org/keywords/potassium-ions","display_name":"potassium ions","score":0.9409999847412109},{"id":"https://openalex.org/keywords/receptor-conformation","display_name":"receptor conformation","score":0.6579999923706055},{"id":"https://openalex.org/keywords/ligand-dissociation","display_name":"ligand dissociation","score":0.8209999799728394},{"id":"https://openalex.org/keywords/intracellular-calcium-release","display_name":"intracellular calcium release","score":0.7929999828338623},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.7789999842643738},{"id":"https://openalex.org/keywords/sea-urchin-eggs","display_name":"sea urchin eggs","score":0.9509999752044678},{"id":"https://openalex.org/keywords/receptor-inactivation","display_name":"receptor inactivation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/ligand-binding","display_name":"ligand binding","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.641569972038269},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.6389309763908386},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5566365718841553},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5246646404266357},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5110553503036499},{"id":"https://openalex.org/C2776908312","wikidata":"https://www.wikidata.org/wiki/Q83483","display_name":"Sea urchin","level":2,"score":0.43168479204177856},{"id":"https://openalex.org/C102931765","wikidata":"https://www.wikidata.org/wiki/Q189673","display_name":"Dissociation (chemistry)","level":2,"score":0.418011873960495},{"id":"https://openalex.org/C74998103","wikidata":"https://www.wikidata.org/wiki/Q898254","display_name":"Dissociation constant","level":3,"score":0.4150935709476471},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3523353934288025},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2307617962360382},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.11688578128814697},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010063","descriptor_name":"Ovum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010063","descriptor_name":"Ovum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010761","descriptor_name":"Phosphorus Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012617","descriptor_name":"Sea Urchins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018160","descriptor_name":"Receptors, Cytoplasmic and Nuclear","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1042/bj20030672","doi":"https://doi.org/10.1042/bj20030672","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20030672","pdf_url":"https://portlandpress.com/biochemj/article-pdf/375/3/805/712831/bj3750805.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1223729","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1223729","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:12914540","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12914540","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1014.7579","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1014.7579","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://www.researchgate.net/profile/Sandip_Patel16/publication/10616240_Modulation_of_NAADP_receptors_by_K_ions_evidence_for_multiple_NAADP_receptor_conformations/links/0fcfd5093b7e6825a1000000.pdf","raw_type":"text"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:185562","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/185562/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BIOCHEM J , 375 805 - 812. (2003)","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1042/bj20030672","doi":"https://doi.org/10.1042/bj20030672","is_oa":true,"landing_page_url":"https://doi.org/10.1042/bj20030672","pdf_url":"https://portlandpress.com/biochemj/article-pdf/375/3/805/712831/bj3750805.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320286","display_name":"University College London","ror":"https://ror.org/02jx3x895"},{"id":"https://openalex.org/F4320323381","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994577418.pdf","grobid_xml":"https://content.openalex.org/works/W1994577418.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W946217739","https://openalex.org/W1570648636","https://openalex.org/W1599277155","https://openalex.org/W1615545200","https://openalex.org/W1768196376","https://openalex.org/W1853732393","https://openalex.org/W1895963467","https://openalex.org/W1963403501","https://openalex.org/W1963869670","https://openalex.org/W1967329828","https://openalex.org/W1967940275","https://openalex.org/W1969637387","https://openalex.org/W1971881864","https://openalex.org/W1975992025","https://openalex.org/W1980166477","https://openalex.org/W1980615710","https://openalex.org/W1980828399","https://openalex.org/W1987163070","https://openalex.org/W1988859074","https://openalex.org/W1997223430","https://openalex.org/W2003064423","https://openalex.org/W2007522723","https://openalex.org/W2013951701","https://openalex.org/W2015426350","https://openalex.org/W2015807826","https://openalex.org/W2018449719","https://openalex.org/W2019890971","https://openalex.org/W2039043166","https://openalex.org/W2041740826","https://openalex.org/W2043206126","https://openalex.org/W2043767569","https://openalex.org/W2043790677","https://openalex.org/W2045399399","https://openalex.org/W2045959731","https://openalex.org/W2046985049","https://openalex.org/W2052347872","https://openalex.org/W2055221223","https://openalex.org/W2057872722","https://openalex.org/W2063327869","https://openalex.org/W2065368005","https://openalex.org/W2069579599","https://openalex.org/W2070347001","https://openalex.org/W2070908828","https://openalex.org/W2088421990","https://openalex.org/W2089033487","https://openalex.org/W2093716452","https://openalex.org/W2137283585","https://openalex.org/W2146447679","https://openalex.org/W4232372297"],"related_works":["https://openalex.org/W7097362522","https://openalex.org/W1986212634","https://openalex.org/W2009306425","https://openalex.org/W2055221223","https://openalex.org/W1967940275","https://openalex.org/W2066342307","https://openalex.org/W2070405143","https://openalex.org/W2002557150","https://openalex.org/W2063327869","https://openalex.org/W4238996218"],"abstract_inverted_index":{"NAADP":[0,26,69,84,105,124,160],"(nicotinic":[1],"acid-adenine":[2],"dinucleotide":[3],"phosphate)":[4],"mediates":[5],"Ca2+":[6,10,33,131,141],"release":[7,142],"from":[8,70],"intracellular":[9],"stores":[11],"in":[12,52,129,166],"a":[13],"wide":[14],"variety":[15],"of":[16,25,31,44,68,81,91,100,104,117,123,139,146,155,158],"cell":[17],"types.":[18],"In":[19,57,75],"sea":[20,71],"urchin":[21,72],"eggs,":[22],"subthreshold":[23,144],"concentrations":[24,145],"can":[27],"cause":[28],"full":[29],"inactivation":[30,138],"NAADP-induced":[32,140],"release,":[34,132],"an":[35,53,79],"effect":[36],"that":[37,63,162],"may":[38],"be":[39],"related":[40],"to":[41,48],"the":[42,45,58,118,121,153,159],"ability":[43],"target":[46],"protein":[47],"bind":[49],"its":[50],"ligand":[51,128],"essentially":[54],"irreversible":[55],"manner.":[56],"present":[59],"study,":[60],"we":[61],"found":[62],"K+":[64,101],"ions":[65],"inhibit":[66],"dissociation":[67,103],"egg":[73],"homogenates.":[74],"low":[76,167],"K+-containing":[77,168],"media,":[78],"addition":[80],"excess":[82],"unlabelled":[83],"effectively":[85],"displaced":[86],"bound":[87],"radioligand":[88,92],"whereas":[89],"dilution":[90],"initiated":[93],"only":[94],"partial":[95],"dissociation.":[96],"The":[97],"inhibitory":[98],"effects":[99],"on":[102],"were":[106],"concentration":[107],"dependent,":[108],"reversible":[109],"and":[110],"persisted":[111],"after":[112],"detergent":[113],"solubilization.":[114],"Lowering":[115],"[K+]":[116],"medium":[119],"decreased":[120],"sensitivity":[122],"receptors":[125],"for":[126],"their":[127],"stimulating":[130],"but":[133],"it":[134],"did":[135],"not":[136],"affect":[137],"by":[143],"NAADP.":[147],"Our":[148],"results":[149],"are":[150,163],"consistent":[151],"with":[152],"observation":[154],"multiple":[156],"conformations":[157],"receptor":[161],"readily":[164],"revealed":[165],"media.":[169]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}