{"id":"https://openalex.org/W1994575708","doi":"https://doi.org/10.1097/00007691-199406000-00005","title":"Pharmacokinetics of Sulthiame in Epileptic Patients","display_name":"Pharmacokinetics of Sulthiame in Epileptic Patients","publication_year":1994,"publication_date":"1994-06-01","ids":{"openalex":"https://openalex.org/W1994575708","doi":"https://doi.org/10.1097/00007691-199406000-00005","mag":"1994575708","pmid":"https://pubmed.ncbi.nlm.nih.gov/7916169"},"language":"en","primary_location":{"id":"doi:10.1097/00007691-199406000-00005","doi":"https://doi.org/10.1097/00007691-199406000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007691-199406000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111662482","display_name":"Th. May","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268133","display_name":"Gesellschaft f\u00fcr Epilepsieforschung e.V.","ror":"https://ror.org/000ayt557","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405268133"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"T. W. May","raw_affiliation_strings":["Department of Biochemistry, Gesellschaft f\u00fcr Epilepsieforschung e.V., Bethel, Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Gesellschaft f\u00fcr Epilepsieforschung e.V., Bethel, Bielefeld, Germany","institution_ids":["https://openalex.org/I4405268133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044176238","display_name":"Elisabeth Korn\u2010Merker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268133","display_name":"Gesellschaft f\u00fcr Epilepsieforschung e.V.","ror":"https://ror.org/000ayt557","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405268133"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"E. Korn-Merker","raw_affiliation_strings":["Department of Biochemistry, Gesellschaft f\u00fcr Epilepsieforschung e.V., Bethel, Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Gesellschaft f\u00fcr Epilepsieforschung e.V., Bethel, Bielefeld, Germany","institution_ids":["https://openalex.org/I4405268133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113521331","display_name":"Bernhard Rambeck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268133","display_name":"Gesellschaft f\u00fcr Epilepsieforschung e.V.","ror":"https://ror.org/000ayt557","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405268133"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"B. Rambeck","raw_affiliation_strings":["Department of Biochemistry, Gesellschaft f\u00fcr Epilepsieforschung e.V., Bethel, Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Gesellschaft f\u00fcr Epilepsieforschung e.V., Bethel, Bielefeld, Germany","institution_ids":["https://openalex.org/I4405268133"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113758844","display_name":"H. E. Boenigk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268133","display_name":"Gesellschaft f\u00fcr Epilepsieforschung e.V.","ror":"https://ror.org/000ayt557","country_code":"DE","type":"nonprofit","lineage":["https://openalex.org/I4405268133"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H. E. Boenigk","raw_affiliation_strings":["Department of Biochemistry, Gesellschaft f\u00fcr Epilepsieforschung e.V., Bethel, Bielefeld, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Gesellschaft f\u00fcr Epilepsieforschung e.V., Bethel, Bielefeld, Germany","institution_ids":["https://openalex.org/I4405268133"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405268133"],"apc_list":null,"apc_paid":null,"fwci":0.6026,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.6519945,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"3","first_page":"251","last_page":"257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9804999828338623,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sulthiame","display_name":"sulthiame","score":0.9769999980926514},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9750000238418579},{"id":"https://openalex.org/keywords/epilepsy","display_name":"epilepsy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.7950000166893005},{"id":"https://openalex.org/keywords/elimination-half-life","display_name":"elimination half-life","score":0.9779999852180481},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.5509999990463257},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.46299999952316284},{"id":"https://openalex.org/keywords/carbamazepine","display_name":"carbamazepine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":0.984000027179718},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.48399999737739563},{"id":"https://openalex.org/keywords/adults","display_name":"adults","score":0.7670000195503235},{"id":"https://openalex.org/keywords/focal-epilepsy","display_name":"focal epilepsy","score":0.5410000085830688},{"id":"https://openalex.org/keywords/drug-clearance","display_name":"drug clearance","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9152650237083435},{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.5301511883735657},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.48562636971473694},{"id":"https://openalex.org/C2777172819","wikidata":"https://www.wikidata.org/wiki/Q240642","display_name":"Valproic Acid","level":3,"score":0.42677950859069824},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37852752208709717},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.36164963245391846},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3583068251609802},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.15758398175239563}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001827","descriptor_name":"Body Height","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012727","descriptor_name":"Sex Characteristics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013843","descriptor_name":"Thiazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013843","descriptor_name":"Thiazines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D013843","descriptor_name":"Thiazines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007691-199406000-00005","doi":"https://doi.org/10.1097/00007691-199406000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007691-199406000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S179268941","display_name":"Therapeutic Drug Monitoring","issn_l":"0163-4356","issn":["0163-4356","1536-3694"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic Drug Monitoring","raw_type":"journal-article"},{"id":"pmid:7916169","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7916169","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Therapeutic drug monitoring","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4390449421","https://openalex.org/W4234790074","https://openalex.org/W3200304224","https://openalex.org/W2158596044","https://openalex.org/W2518822513","https://openalex.org/W4313192199","https://openalex.org/W4394605846","https://openalex.org/W4398777851","https://openalex.org/W2013826078","https://openalex.org/W4399235583"],"abstract_inverted_index":{"Sulthiame":[0],"is":[1,19],"an":[2],"antiepileptic":[3,131],"drug":[4],"that":[5],"was":[6,184],"introduced":[7],"approximately":[8],"30":[9],"years":[10],"ago":[11],"for":[12],"the":[13,30,50,53,57,61,74,94,99,150,188,193,201],"treatment":[14,31],"of":[15,32,44,63,73,78,149,155,169,200,218],"epilepsy.":[16,70],"Currently":[17],"it":[18],"rarely":[20],"used,":[21],"but":[22],"recent":[23],"studies":[24,43],"show":[25],"its":[26],"efficacy,":[27],"especially":[28],"in":[29,35,46,60,127,139,159,171,185,192,212],"focal":[33],"epilepsies":[34],"children.":[36,221],"Because":[37],"there":[38],"are":[39],"hardly":[40],"any":[41],"pharmacokinetic":[42],"sulthiame":[45,64,75,95,100,107,114,121,134,152,170,194,219],"humans,":[47],"we":[48],"studied":[49],"dose-level":[51,153],"relationship,":[52],"elimination":[54,175],"half-life,":[55],"and":[56,67,84,98,164,208],"daily":[58,190,210],"fluctuations":[59,191,211],"concentration":[62],"among":[65,220],"children":[66,213],"adults":[68],"with":[69,123,129,141,144,187],"The":[71,133,147,205],"evaluation":[72,148],"serum":[76,101,135],"concentrations":[77,115,136,195],"86":[79],"patients":[80,157,203],"gave,":[81],"considering":[82],"age":[83],"comedication,":[85],"a":[86,105,162,215],"relatively":[87],"high":[88],"correlation":[89],"(r":[90],"=":[91],"0.82)":[92],"between":[93],"dose/body":[96],"weight":[97,111],"concentration.":[102],"Children":[103],"on":[104],"comparable":[106],"dose":[108],"per":[109],"body":[110],"have":[112],"lower":[113,138],"than":[116,143],"adults.":[117],"In":[118],"our":[119],"study":[120],"was,":[122],"few":[124],"exceptions,":[125],"administered":[126],"combination":[128],"other":[130],"drugs.":[132],"were":[137,181],"comedication":[140],"carbamazepine":[142],"valproic":[145],"acid.":[146],"individual":[151],"relationship":[154],"8":[156],"showed":[158],"most":[160],"cases":[161],"close":[163],"linear":[165],"relationship.":[166],"After":[167],"withdrawal":[168],"11":[172],"patients,":[173],"short":[174],"half-lives":[176,207],"(8.65":[177],"+/-":[178,198],"3.10":[179],"h)":[180],"estimated.":[182],"This":[183],"accordance":[186],"large":[189],"(swing:":[196],"103.9":[197],"59.3%)":[199],"nine":[202],"examined.":[204],"shorter":[206],"higher":[209,216],"indicate":[214],"clearance":[217]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
