{"id":"https://openalex.org/W1994556689","doi":"https://doi.org/10.1369/jhc.2008.951251","title":"Histone Modifications and Nuclear Architecture: A Review","display_name":"Histone Modifications and Nuclear Architecture: A Review","publication_year":2008,"publication_date":"2008-04-14","ids":{"openalex":"https://openalex.org/W1994556689","doi":"https://doi.org/10.1369/jhc.2008.951251","mag":"1994556689","pmid":"https://pubmed.ncbi.nlm.nih.gov/18474937","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2443610"},"language":"en","primary_location":{"id":"doi:10.1369/jhc.2008.951251","doi":"https://doi.org/10.1369/jhc.2008.951251","is_oa":true,"landing_page_url":"https://doi.org/10.1369/jhc.2008.951251","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1369/jhc.2008.951251","source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry & Cytochemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1994556689"],"child_works_count":0,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1369/jhc.2008.951251","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038544882","display_name":"Eva B\u00e1rtov\u00e1","orcid":"https://orcid.org/0000-0003-1299-0470","observed_orcids":["https://orcid.org/0000-0003-1299-0470"]},"institutions":[{"id":"https://openalex.org/I4210089928","display_name":"Czech Academy of Sciences, Institute of Biophysics","ror":"https://ror.org/00angvn73","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Eva B\u00e1rtov\u00e1","raw_affiliation_strings":["Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210089928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080367058","display_name":"Jana Krej\u010d\u00ed","orcid":"https://orcid.org/0000-0001-5204-0723","observed_orcids":["https://orcid.org/0000-0001-5204-0723"]},"institutions":[{"id":"https://openalex.org/I4210089928","display_name":"Czech Academy of Sciences, Institute of Biophysics","ror":"https://ror.org/00angvn73","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jana Krej\u010d\u00ed","raw_affiliation_strings":["Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210089928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109161162","display_name":"Andrea Harni\u010darov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089928","display_name":"Czech Academy of Sciences, Institute of Biophysics","ror":"https://ror.org/00angvn73","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Andrea Harni\u010darov\u00e1","raw_affiliation_strings":["Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210089928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046785563","display_name":"Gabriela Galiov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089928","display_name":"Czech Academy of Sciences, Institute of Biophysics","ror":"https://ror.org/00angvn73","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Gabriela Galiov\u00e1","raw_affiliation_strings":["Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210089928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111683682","display_name":"Stanislav Kozubek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210089928","display_name":"Czech Academy of Sciences, Institute of Biophysics","ror":"https://ror.org/00angvn73","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210089928"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Stanislav Kozubek","raw_affiliation_strings":["Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Cytology and Cytometry, Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic","institution_ids":["https://openalex.org/I4210089928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5038544882"],"corresponding_institution_ids":["https://openalex.org/I4210089928"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":1.7138,"has_fulltext":true,"cited_by_count":383,"citation_normalized_percentile":{"value":0.85588235,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"56","issue":"8","first_page":"711","last_page":"721"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histone-modifications","display_name":"histone modifications","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nuclear-organization","display_name":"nuclear organization","score":0.7570000290870667},{"id":"https://openalex.org/keywords/chromatin-organization","display_name":"chromatin organization","score":0.6809999942779541},{"id":"https://openalex.org/keywords/heterochromatin","display_name":"heterochromatin","score":0.8299999833106995},{"id":"https://openalex.org/keywords/euchromatin","display_name":"euchromatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/histone-acetylation","display_name":"histone acetylation","score":0.9279999732971191},{"id":"https://openalex.org/keywords/histone-methylation","display_name":"histone methylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/histone-phosphorylation","display_name":"histone phosphorylation","score":0.8140000104904175},{"id":"https://openalex.org/keywords/histone-ubiquitination","display_name":"histone ubiquitination","score":0.9800000190734863},{"id":"https://openalex.org/keywords/adp-ribosylation","display_name":"ADP-ribosylation","score":0.9520000219345093},{"id":"https://openalex.org/keywords/core-histones","display_name":"core histones","score":0.7620000243186951},{"id":"https://openalex.org/keywords/interphase-nucleus","display_name":"interphase nuclei","score":0.7440000176429749},{"id":"https://openalex.org/keywords/epigenetic-modifications","display_name":"epigenetic modifications","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6111417412757874},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.6089233756065369},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.595824658870697},{"id":"https://openalex.org/C100924687","wikidata":"https://www.wikidata.org/wiki/Q910324","display_name":"Euchromatin","level":5,"score":0.571617841720581},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5578634142875671},{"id":"https://openalex.org/C10058791","wikidata":"https://www.wikidata.org/wiki/Q910897","display_name":"Histone code","level":5,"score":0.5431647896766663},{"id":"https://openalex.org/C56952853","wikidata":"https://www.wikidata.org/wiki/Q5773144","display_name":"Histone-modifying enzymes","level":5,"score":0.5237895250320435},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.4913007616996765},{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.48361459374427795},{"id":"https://openalex.org/C150425827","wikidata":"https://www.wikidata.org/wiki/Q2560317","display_name":"Histone methyltransferase","level":4,"score":0.4591943025588989},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.44773808121681213},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44749119877815247},{"id":"https://openalex.org/C22709980","wikidata":"https://www.wikidata.org/wiki/Q4117777","display_name":"Histone methylation","level":5,"score":0.4444960057735443},{"id":"https://openalex.org/C101152365","wikidata":"https://www.wikidata.org/wiki/Q838135","display_name":"Histone H1","level":4,"score":0.44431164860725403},{"id":"https://openalex.org/C167227067","wikidata":"https://www.wikidata.org/wiki/Q5113739","display_name":"Chromatin remodeling","level":4,"score":0.4390501379966736},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.27454984188079834},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.2448742389678955},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.17302286624908447},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06588625907897949},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.052965760231018066}],"mesh":[{"descriptor_ui":"D000090266","descriptor_name":"Chromobox Protein Homolog 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000107","descriptor_name":"Acetylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007399","descriptor_name":"Interphase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008745","descriptor_name":"Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041321","descriptor_name":"Chromosomes, Human, X","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056572","descriptor_name":"Histone Deacetylase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1369/jhc.2008.951251","doi":"https://doi.org/10.1369/jhc.2008.951251","is_oa":true,"landing_page_url":"https://doi.org/10.1369/jhc.2008.951251","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1369/jhc.2008.951251","source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry & Cytochemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1487786","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2443610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:18474937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18474937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2443610","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2443610/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Histochem Cytochem","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1369/jhc.2008.951251","doi":"https://doi.org/10.1369/jhc.2008.951251","is_oa":true,"landing_page_url":"https://doi.org/10.1369/jhc.2008.951251","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1369/jhc.2008.951251","source":{"id":"https://openalex.org/S30841621","display_name":"Journal of Histochemistry & Cytochemistry","issn_l":"0022-1554","issn":["0022-1554","1551-5044"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Histochemistry & Cytochemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3351655343","display_name":"Postranslational modifications of histones after cell treatment by inhibitors of histone deacetylases and during induction of cell differentiation","funder_award_id":"GA204/06/0978","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G8500326015","display_name":null,"funder_award_id":"AVOZ50040507","funder_id":"https://openalex.org/F4320321006","funder_display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky"}],"funders":[{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994556689.pdf","grobid_xml":"https://content.openalex.org/works/W1994556689.grobid-xml"},"referenced_works_count":104,"referenced_works":["https://openalex.org/W20935937","https://openalex.org/W53120938","https://openalex.org/W1487239999","https://openalex.org/W1491536683","https://openalex.org/W1520128939","https://openalex.org/W1528082486","https://openalex.org/W1703665345","https://openalex.org/W1757349669","https://openalex.org/W1841489266","https://openalex.org/W1877359570","https://openalex.org/W1964801370","https://openalex.org/W1968398910","https://openalex.org/W1976060096","https://openalex.org/W1977256676","https://openalex.org/W1978493564","https://openalex.org/W1979838381","https://openalex.org/W1985092753","https://openalex.org/W1985180051","https://openalex.org/W1986801877","https://openalex.org/W1991667131","https://openalex.org/W1993765638","https://openalex.org/W1999155341","https://openalex.org/W2000580034","https://openalex.org/W2002781605","https://openalex.org/W2004499293","https://openalex.org/W2004611593","https://openalex.org/W2005046853","https://openalex.org/W2006095114","https://openalex.org/W2006693058","https://openalex.org/W2009121506","https://openalex.org/W2010487837","https://openalex.org/W2013997481","https://openalex.org/W2014286894","https://openalex.org/W2015757633","https://openalex.org/W2015878902","https://openalex.org/W2020956187","https://openalex.org/W2024952704","https://openalex.org/W2026556151","https://openalex.org/W2031310237","https://openalex.org/W2032464841","https://openalex.org/W2032737065","https://openalex.org/W2032794324","https://openalex.org/W2035659472","https://openalex.org/W2038657349","https://openalex.org/W2040285686","https://openalex.org/W2052011655","https://openalex.org/W2054621094","https://openalex.org/W2057341073","https://openalex.org/W2058162240","https://openalex.org/W2060863780","https://openalex.org/W2061015334","https://openalex.org/W2063982921","https://openalex.org/W2070948501","https://openalex.org/W2071393652","https://openalex.org/W2071949364","https://openalex.org/W2072638557","https://openalex.org/W2072810104","https://openalex.org/W2072933764","https://openalex.org/W2072975087","https://openalex.org/W2073127919","https://openalex.org/W2076142853","https://openalex.org/W2077653776","https://openalex.org/W2077981176","https://openalex.org/W2093332176","https://openalex.org/W2096083625","https://openalex.org/W2100805144","https://openalex.org/W2101645956","https://openalex.org/W2104870341","https://openalex.org/W2105314245","https://openalex.org/W2108757615","https://openalex.org/W2109802732","https://openalex.org/W2111424853","https://openalex.org/W2111868960","https://openalex.org/W2116622696","https://openalex.org/W2118474157","https://openalex.org/W2119143930","https://openalex.org/W2127517570","https://openalex.org/W2137202489","https://openalex.org/W2139893790","https://openalex.org/W2142325700","https://openalex.org/W2142928043","https://openalex.org/W2144710552","https://openalex.org/W2146427646","https://openalex.org/W2150960435","https://openalex.org/W2151150138","https://openalex.org/W2152853425","https://openalex.org/W2154026141","https://openalex.org/W2154855808","https://openalex.org/W2155235554","https://openalex.org/W2159479483","https://openalex.org/W2160931305","https://openalex.org/W2162316859","https://openalex.org/W2162633623","https://openalex.org/W2162917230","https://openalex.org/W2163470930","https://openalex.org/W2164412227","https://openalex.org/W2166647372","https://openalex.org/W2168863460","https://openalex.org/W2170177242","https://openalex.org/W2188480055","https://openalex.org/W2408883812","https://openalex.org/W4212766227","https://openalex.org/W4231760255","https://openalex.org/W7096805262"],"related_works":["https://openalex.org/W2188480055","https://openalex.org/W1970496013","https://openalex.org/W2163730646","https://openalex.org/W2117002684","https://openalex.org/W1559360124","https://openalex.org/W2033607377","https://openalex.org/W4233539371","https://openalex.org/W4403532538","https://openalex.org/W3138667484"],"abstract_inverted_index":{"Epigenetic":[0],"modifications,":[1],"such":[2,75],"as":[3,76,100],"acetylation,":[4],"phosphorylation,":[5],"methylation,":[6],"ubiquitination,":[7],"and":[8,20,57,78,80,121],"ADP":[9],"ribosylation,":[10],"of":[11,26,32,41,53,59,72,87,93,125],"the":[12,23,38,46,50,70,85,116,122],"highly":[13],"conserved":[14],"core":[15],"histones,":[16],"H2A,":[17],"H2B,":[18],"H3,":[19],"H4,":[21],"influence":[22],"genetic":[24],"potential":[25,31],"DNA.":[27],"The":[28],"enormous":[29],"regulatory":[30],"histone":[33,54,65],"modification":[34,86],"is":[35],"illustrated":[36],"in":[37],"vast":[39],"array":[40],"epigenetic":[42,103,119],"markers":[43,104],"found":[44],"throughout":[45],"genome.":[47],"More":[48],"than":[49],"other":[51],"types":[52],"modification,":[55],"acetylation":[56],"methylation":[58],"specific":[60,102],"lysine":[61],"residues":[62],"on":[63],"N-terminal":[64],"tails":[66],"are":[67,105],"fundamental":[68],"for":[69],"formation":[71],"chromatin":[73,94,126],"domains,":[74],"euchromatin,":[77],"facultative":[79],"constitutive":[81],"heterochromatin.":[82],"In":[83,111],"addition,":[84],"histones":[88],"can":[89],"cause":[90],"a":[91],"region":[92],"to":[95],"undergo":[96],"nuclear":[97],"compartmentalization":[98,120],"and,":[99],"such,":[101],"non-randomly":[106],"distributed":[107],"within":[108,128],"interphase":[109,129],"nuclei.":[110,130],"this":[112],"review,":[113],"we":[114],"summarize":[115],"principles":[117],"behind":[118],"functional":[123],"consequences":[124],"arrangement":[127]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":33},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":26},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":34}],"updated_date":"2026-11-15T12:55:33.944570","created_date":"2016-06-24T00:00:00"}