{"id":"https://openalex.org/W1994555744","doi":"https://doi.org/10.1182/blood.v98.3.834","title":"DNA damage\u2013induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway","display_name":"DNA damage\u2013induced cell-cycle arrest of hematopoietic cells is overridden by activation of the PI-3 kinase/Akt signaling pathway","publication_year":2001,"publication_date":"2001-08-01","ids":{"openalex":"https://openalex.org/W1994555744","doi":"https://doi.org/10.1182/blood.v98.3.834","mag":"1994555744","pmid":"https://pubmed.ncbi.nlm.nih.gov/11468186"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v98.3.834","doi":"https://doi.org/10.1182/blood.v98.3.834","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v98.3.834","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Matthew K. Henry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew K. Henry","raw_affiliation_strings":["From the Department of Pharmacology and the Immunology Graduate Program, The University of Iowa College of Medicine, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology and the Immunology Graduate Program, The University of Iowa College of Medicine, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001622604","display_name":"Jeffrey T. Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey T. Lynch","raw_affiliation_strings":["From the Department of Pharmacology and the Immunology Graduate Program, The University of Iowa College of Medicine, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology and the Immunology Graduate Program, The University of Iowa College of Medicine, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063205252","display_name":"Alex K. Eapen","orcid":"https://orcid.org/0000-0002-0482-9858","observed_orcids":["https://orcid.org/0000-0002-0482-9858"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alex K. Eapen","raw_affiliation_strings":["From the Department of Pharmacology and the Immunology Graduate Program, The University of Iowa College of Medicine, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology and the Immunology Graduate Program, The University of Iowa College of Medicine, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085327021","display_name":"Frederick W. Quelle","orcid":"https://orcid.org/0000-0002-1184-6170","observed_orcids":["https://orcid.org/0000-0002-1184-6170"]},"institutions":[{"id":"https://openalex.org/I126307644","display_name":"University of Iowa","ror":"https://ror.org/036jqmy94","country_code":"US","type":"education","lineage":["https://openalex.org/I126307644"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick W. Quelle","raw_affiliation_strings":["From the Department of Pharmacology and the Immunology Graduate Program, The University of Iowa College of Medicine, Iowa City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Department of Pharmacology and the Immunology Graduate Program, The University of Iowa College of Medicine, Iowa City","institution_ids":["https://openalex.org/I126307644"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I126307644"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":1.1637,"has_fulltext":false,"cited_by_count":81,"citation_normalized_percentile":{"value":0.75712236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"98","issue":"3","first_page":"834","last_page":"841"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.5609999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.30250000953674316,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.03909999877214432,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.8529999852180481},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hematopoietic-cells","display_name":"hematopoietic cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.8519999980926514},{"id":"https://openalex.org/keywords/erythropoietin-receptor","display_name":"erythropoietin receptor","score":0.8659999966621399},{"id":"https://openalex.org/keywords/gamma-irradiation","display_name":"gamma irradiation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/g1-s-checkpoint","display_name":"G1/S checkpoint","score":0.8560000061988831},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.6600000262260437},{"id":"https://openalex.org/keywords/dominant-negative-akt","display_name":"dominant-negative Akt","score":0.7870000004768372},{"id":"https://openalex.org/keywords/ly294002","display_name":"LY294002","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7128672003746033},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5903599858283997},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5588581562042236},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5013906955718994},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.48222458362579346},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.476787805557251},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.46523919701576233},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46364039182662964},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4470604360103607},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4308066964149475},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2884892225265503},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.281340628862381},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1828080415725708},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.15443935990333557}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017467","descriptor_name":"Receptors, Erythropoietin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051057","descriptor_name":"Proto-Oncogene Proteins c-akt","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood.v98.3.834","doi":"https://doi.org/10.1182/blood.v98.3.834","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v98.3.834","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:11468186","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11468186","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2005494393","display_name":"CYTOKINE SIGNALING PATHWAYS REGULATING A G1 CHECKPOINT","funder_award_id":"R01CA079889","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4217493267","display_name":null,"funder_award_id":"CA-79889","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W75111957","https://openalex.org/W1222674504","https://openalex.org/W1554526298","https://openalex.org/W1564510779","https://openalex.org/W1574698301","https://openalex.org/W1751978888","https://openalex.org/W1835174359","https://openalex.org/W1964617786","https://openalex.org/W1964815717","https://openalex.org/W1969308341","https://openalex.org/W1972927903","https://openalex.org/W1991494214","https://openalex.org/W1992393431","https://openalex.org/W1993205500","https://openalex.org/W1993664053","https://openalex.org/W2002127663","https://openalex.org/W2004078164","https://openalex.org/W2009857536","https://openalex.org/W2014453564","https://openalex.org/W2029080338","https://openalex.org/W2030573603","https://openalex.org/W2032361307","https://openalex.org/W2033950216","https://openalex.org/W2037127929","https://openalex.org/W2043217342","https://openalex.org/W2058184498","https://openalex.org/W2059956556","https://openalex.org/W2065549220","https://openalex.org/W2068564200","https://openalex.org/W2070395474","https://openalex.org/W2075515257","https://openalex.org/W2096657295","https://openalex.org/W2105592350","https://openalex.org/W2108958930","https://openalex.org/W2111125738","https://openalex.org/W2144808732","https://openalex.org/W2156138425","https://openalex.org/W2157721629","https://openalex.org/W2168674846","https://openalex.org/W2188651990","https://openalex.org/W4237306139","https://openalex.org/W6634256360"],"related_works":["https://openalex.org/W2011926693","https://openalex.org/W2038762172","https://openalex.org/W2168674846","https://openalex.org/W2110740846","https://openalex.org/W2108366592","https://openalex.org/W1983976301","https://openalex.org/W2022881023","https://openalex.org/W2037068607","https://openalex.org/W2586010660","https://openalex.org/W2037683055"],"abstract_inverted_index":{"Exposure":[0],"of":[1,24,76,87,97,108,114,120,137,144,154,171],"hematopoietic":[2,25,179],"cells":[3,26,64,127],"to":[4,49,89,99,122,175],"DNA-damaging":[5],"agents":[6],"induces":[7],"cell-cycle":[8,92],"arrest":[9,23,102,173],"at":[10],"G1":[11,51],"and":[12,52],"G2/M":[13,53],"checkpoints.":[14,157],"Previously,":[15],"it":[16,71],"was":[17,103],"shown":[18,73],"that":[19,74],"DNA":[20,176],"damage-induced":[21],"growth":[22,34,172],"can":[27],"be":[28,133],"overridden":[29],"by":[30,56,105,112,135],"treatment":[31],"with":[32],"cytokine":[33],"factors,":[35],"such":[36],"as":[37],"erythropoietin":[38],"(EPO)":[39],"or":[40,111],"interleukin-3":[41],"(IL-3).":[42],"Here,":[43],"the":[44,85,95,118,169],"cytokine-activated":[45],"signaling":[46,83,147],"pathways":[47,167],"required":[48,80,150],"override":[50,90,100,123],"checkpoints":[54,125],"induced":[55,156],"gamma-irradiation":[57],"(gamma-IR)":[58],"are":[59],"characterized.":[60],"Using":[61],"factor-dependent":[62],"myeloid":[63],"stably":[65],"expressing":[66,128],"EPO":[67,88,121],"receptor":[68],"(EPO-R)":[69],"mutants,":[70],"is":[72,149],"removal":[75],"a":[77,138,145,162],"minimal":[78],"domain":[79],"for":[81,151,165],"PI-3K":[82,109],"abrogated":[84],"ability":[86,96,119],"gamma-IR-induced":[91,101],"arrest.":[93],"Similarly,":[94],"cytokines":[98],"abolished":[104],"an":[106],"inhibitor":[107],"(LY294002)":[110],"overexpression":[113,136],"dominant-negative":[115],"Akt.":[116,141],"Moreover,":[117],"these":[124,159],"in":[126,168,178],"defective":[129],"EPO-R":[130],"mutants":[131],"could":[132],"restored":[134],"constitutively":[139],"active":[140],"Thus,":[142],"activation":[143],"PI-3K/Akt":[146,166],"pathway":[148],"cytokine-dependent":[152],"suppression":[153],"DNA-damage":[155],"Together,":[158],"findings":[160],"suggest":[161],"novel":[163],"role":[164],"modulation":[170],"responses":[174],"damage":[177],"cells.":[180],"(Blood.":[181],"2001;98:834-841)":[182]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}