{"id":"https://openalex.org/W1994539860","doi":"https://doi.org/10.1158/1538-7445.am2011-1214","title":"Abstract 1214: Single nucleotide polymorphism in HER family members increases susceptibility to human invasive cervical cancer","display_name":"Abstract 1214: Single nucleotide polymorphism in HER family members increases susceptibility to human invasive cervical cancer","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W1994539860","doi":"https://doi.org/10.1158/1538-7445.am2011-1214","mag":"1994539860"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-1214","doi":"https://doi.org/10.1158/1538-7445.am2011-1214","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1214","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109079025","display_name":"Duanduan Ma","orcid":"https://orcid.org/0000-0002-4753-0813","observed_orcids":["https://orcid.org/0000-0002-4753-0813"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duanduan Ma","raw_affiliation_strings":["1Washington University, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Washington University, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043327784","display_name":"Raymond Hovey","orcid":"https://orcid.org/0000-0001-6099-2871","observed_orcids":["https://orcid.org/0000-0001-6099-2871"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond Hovey","raw_affiliation_strings":["2Medical College of Wisconsin, Milwaukee, WI","#N#2Medical College of Wisconsin, MIlwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"#N#2Medical College of Wisconsin, MIlwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027367137","display_name":"Zhengyan Zhang","orcid":"https://orcid.org/0000-0002-4906-4481","observed_orcids":["https://orcid.org/0000-0002-4906-4481","https://orcid.org/0000-0002-5074-6826"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengyan Zhang","raw_affiliation_strings":["1Washington University, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Washington University, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Loan Nguyen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loan Nguyen","raw_affiliation_strings":["1Washington University, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Washington University, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108223133","display_name":"Ingrid B. Borecki","orcid":"https://orcid.org/0000-0002-8657-7964","observed_orcids":["https://orcid.org/0000-0002-8657-7964"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ingrid Borecki","raw_affiliation_strings":["1Washington University, St. Louis, MO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Washington University, St. Louis, MO","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017254635","display_name":"Janet Sue Rader","orcid":"https://orcid.org/0000-0001-7031-3385","observed_orcids":["https://orcid.org/0000-0001-7031-3385"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Rader","raw_affiliation_strings":["2Medical College of Wisconsin, Milwaukee, WI","#N#2Medical College of Wisconsin, MIlwaukee, WI"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Medical College of Wisconsin, Milwaukee, WI","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"#N#2Medical College of Wisconsin, MIlwaukee, WI","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"1214","last_page":"1214"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.032099999487400055,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/invasive-cervical-cancer","display_name":"invasive cervical cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cervical-intraepithelial-neoplasia-grade-3","display_name":"cervical intraepithelial neoplasia grade 3","score":0.9649999737739563},{"id":"https://openalex.org/keywords/her-family","display_name":"HER family","score":0.6209999918937683},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8370000123977661},{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.7860000133514404},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.9300000071525574},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":1.0},{"id":"https://openalex.org/keywords/erbb4","display_name":"ErbB4","score":1.0},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.7210000157356262},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7039999961853027},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"linkage disequilibrium","score":0.8679999709129333},{"id":"https://openalex.org/keywords/early-detection","display_name":"early detection","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.7301403284072876},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6521905660629272},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6407598853111267},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6395735740661621},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.501539945602417},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.45915523171424866},{"id":"https://openalex.org/C2777343196","wikidata":"https://www.wikidata.org/wiki/Q196788","display_name":"Cervical intraepithelial neoplasia","level":4,"score":0.42669856548309326},{"id":"https://openalex.org/C2778580637","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"HPV infection","level":4,"score":0.4111612141132355},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35743260383605957},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.33642667531967163},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.27270665764808655},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25744426250457764},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2467406690120697}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-1214","doi":"https://doi.org/10.1158/1538-7445.am2011-1214","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-1214","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2000540427","https://openalex.org/W627634223","https://openalex.org/W4313948723","https://openalex.org/W3203741105","https://openalex.org/W4411635372","https://openalex.org/W3207378909","https://openalex.org/W2807815171","https://openalex.org/W2385259417","https://openalex.org/W2614391934","https://openalex.org/W2606406766"],"abstract_inverted_index":{"Abstract":[0],"Cervical":[1],"cancer":[2,7,49,149],"is":[3,32,65,174],"the":[4,25,75,101,108,116,194,202,221,226],"second-most":[5],"common":[6],"among":[8],"women":[9,94],"worldwide":[10],"(Parkin":[11],"et":[12],"al.":[13],"1999).":[14],"Some":[15],"studies":[16,36,55],"address":[17],"prognostic":[18],"roles":[19],"that":[20,44,67],"different":[21],"genes":[22,40],"play":[23,112],"after":[24],"development":[26,203],"of":[27,35,41,92,103,119,133,146,178,196,204,207,220,225],"cervical":[28,48,80,96,148,152],"cancer.":[29,97],"However,":[30],"there":[31,128],"a":[33,90,113,166],"lack":[34],"addressing":[37],"polymorphisms":[38],"in":[39,59,115,138,144,181,209],"normal":[42],"tissues":[43],"influence":[45],"susceptibility":[46],"to":[47,51,73],"prior":[50],"malignant":[52],"transformation.":[53,123],"Such":[54],"could":[56],"be":[57,74,86],"pivotal":[58],"prevention":[60],"and":[61,107,142,171,180,199],"timely":[62],"diagnosis.":[63],"It":[64],"well-known":[66],"Human":[68],"Papillomavirus":[69],"(HPV)":[70],"infection":[71,121],"appears":[72],"primary":[76],"causative":[77],"factor":[78],"for":[79,193,229],"cancer,":[81],"but":[82],"host":[83],"factors":[84],"must":[85],"crucial":[87],"since":[88],"only":[89],"fraction":[91],"HPV-infected":[93],"develop":[95],"HPV":[98,120],"antigens":[99],"are":[100,129],"ligands":[102],"HER":[104,135],"family":[105],"members,":[106],"E5":[109],"protein":[110],"may":[111],"role":[114],"early":[117,205],"stage":[118],"before":[122],"Thus,":[124],"we":[125,164],"studied":[126],"whether":[127],"excessive":[130],"parent-to-offspring":[131],"transmissions":[132],"specific":[134],"SNP":[136,161],"variants":[137],"EGFR,":[139],"ERBB2,":[140],"ERBB3":[141],"ERBB4,":[143],"cases":[145],"invasive":[147],"(ICC)":[150],"or":[151],"intraepithelial":[153],"neoplasia":[154],"grade":[155],"3":[156],"(CIN3).":[157],"Based":[158],"on":[159],"single":[160],"TDT":[162],"tests,":[163],"identified":[165],"significant":[167],"association":[168],"between":[169],"ICC/CIN3":[170],"rs11770506,":[172],"which":[173],"located":[175],"at":[176],"intron1":[177],"EGFR":[179],"high":[182],"linkage":[183],"disequilibrium":[184],"(LD)":[185],"with":[186],"multiple":[187],"enhancers.":[188],"Our":[189],"study":[190],"provides":[191],"clues":[192],"identification":[195],"vulnerable":[197],"populations":[198],"will":[200],"advance":[201],"detection":[206],"ICC":[208],"appropriate":[210],"populations.":[211],"Citation":[212],"Format:":[213],"{Authors}.":[214],"{Abstract":[215],"title}":[216],"[abstract].":[217],"In:":[218],"Proceedings":[219],"102nd":[222],"Annual":[223],"Meeting":[224],"American":[227],"Association":[228],"Cancer":[230,240],"Research;":[231],"2011":[232],"Apr":[233],"2-6;":[234],"Orlando,":[235],"FL.":[236],"Philadelphia":[237],"(PA):":[238],"AACR;":[239],"Res":[241],"2011;71(8":[242],"Suppl):Abstract":[243],"nr":[244],"1214.":[245],"doi:10.1158/1538-7445.AM2011-1214":[246]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2016-06-24T00:00:00"}
