{"id":"https://openalex.org/W1994528279","doi":"https://doi.org/10.1016/0014-4827(85)90272-1","title":"Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin","display_name":"Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectin","publication_year":1985,"publication_date":"1985-01-01","ids":{"openalex":"https://openalex.org/W1994528279","doi":"https://doi.org/10.1016/0014-4827(85)90272-1","mag":"1994528279","pmid":"https://pubmed.ncbi.nlm.nih.gov/2981173"},"language":"en","primary_location":{"id":"doi:10.1016/0014-4827(85)90272-1","doi":"https://doi.org/10.1016/0014-4827(85)90272-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-4827(85)90272-1","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070827614","display_name":"Filippo G. Giancotti","orcid":"https://orcid.org/0000-0002-0541-9519","observed_orcids":["https://orcid.org/0000-0002-0541-9519"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo G. Giancotti","raw_affiliation_strings":["Department of Histology, School of Medicine, University of Turin, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050840654","display_name":"Guido Tarone","orcid":"https://orcid.org/0000-0003-4805-086X","observed_orcids":["https://orcid.org/0000-0003-4805-086X"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Guido Tarone","raw_affiliation_strings":["Department of Histology, School of Medicine, University of Turin, Turin, Italy","University of Turin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"University of Turin","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111559684","display_name":"Karen A. Knudsen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen Knudsen","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, USA","Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114260710","display_name":"Caroline H. Damsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322052","display_name":"The Wistar Institute","ror":"https://ror.org/04wncat98","country_code":"US","type":"facility","lineage":["https://openalex.org/I102322052"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caroline Damsky","raw_affiliation_strings":["The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, USA","Wistar Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104, USA","institution_ids":["https://openalex.org/I102322052"]},{"raw_affiliation_string":"Wistar Institute","institution_ids":["https://openalex.org/I102322052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033662919","display_name":"Paolo Maria Comoglio","orcid":"https://orcid.org/0000-0002-7056-5328","observed_orcids":["https://orcid.org/0000-0002-7056-5328","https://orcid.org/0000-0003-4971-3987"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo M. Comoglio","raw_affiliation_strings":["Department of Histology, School of Medicine, University of Turin, Turin, Italy","University of Turin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology, School of Medicine, University of Turin, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"University of Turin","institution_ids":["https://openalex.org/I55143463"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5050840654"],"corresponding_institution_ids":["https://openalex.org/I55143463"],"apc_list":{"value":3270,"currency":"USD","value_usd":3270},"apc_paid":null,"fwci":11.6493,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.9845397,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"156","issue":"1","first_page":"182","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cell-surface-glycoproteins","display_name":"cell surface glycoproteins","score":0.7799999713897705},{"id":"https://openalex.org/keywords/fibroblast-adhesion","display_name":"fibroblast adhesion","score":0.8849999904632568},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.734000027179718},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.675000011920929},{"id":"https://openalex.org/keywords/reducing-agents","display_name":"reducing agents","score":0.47600001096725464},{"id":"https://openalex.org/keywords/trypsin-resistance","display_name":"trypsin resistance","score":0.8610000014305115},{"id":"https://openalex.org/keywords/bhk-cells","display_name":"BHK cells","score":0.5630000233650208},{"id":"https://openalex.org/keywords/glycoprotein-conformation","display_name":"glycoprotein conformation","score":0.7749999761581421},{"id":"https://openalex.org/keywords/cell-adhesion-molecules","display_name":"adhesion molecules","score":0.39100000262260437}],"concepts":[{"id":"https://openalex.org/C86492073","wikidata":"https://www.wikidata.org/wiki/Q413766","display_name":"Fibronectin","level":3,"score":0.8849034309387207},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.7917259335517883},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.7020170092582703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.633365273475647},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.6279692649841309},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.621301531791687},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.6080654859542847},{"id":"https://openalex.org/C33263850","wikidata":"https://www.wikidata.org/wiki/Q4838438","display_name":"Baby hamster kidney cell","level":3,"score":0.5668541789054871},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.5555383563041687},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.49006330966949463},{"id":"https://openalex.org/C38240268","wikidata":"https://www.wikidata.org/wiki/Q17125118","display_name":"Trypsinization","level":4,"score":0.444476455450058},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.44053179025650024},{"id":"https://openalex.org/C91523082","wikidata":"https://www.wikidata.org/wiki/Q420496","display_name":"Antiserum","level":3,"score":0.4283912777900696},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4196479618549347},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4093533754348755},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.40813392400741577},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.28208956122398376},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2254335880279541},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.18189075589179993},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15774625539779663},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.078093022108078},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001358","descriptor_name":"Avian Sarcoma Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005353","descriptor_name":"Fibronectins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/0014-4827(85)90272-1","doi":"https://doi.org/10.1016/0014-4827(85)90272-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0014-4827(85)90272-1","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},{"id":"pmid:2981173","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2981173","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental cell research","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unito.it:2318/30061","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/30061","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4811468502","display_name":null,"funder_award_id":"CA 32311","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5363403851","display_name":null,"funder_award_id":"CA32311","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6619427741","display_name":null,"funder_award_id":"CA 19144","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000270500","display_name":null,"funder_award_id":"CA19144","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320321408","display_name":"Ministry of Education","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322651","display_name":"Consiglio Nazionale delle Ricerche","ror":"https://ror.org/04zaypm56"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W653324489","https://openalex.org/W1489040242","https://openalex.org/W1514659744","https://openalex.org/W1531769687","https://openalex.org/W1892388442","https://openalex.org/W1965126364","https://openalex.org/W1991825604","https://openalex.org/W1992643804","https://openalex.org/W1997257050","https://openalex.org/W2008883939","https://openalex.org/W2024373128","https://openalex.org/W2028518884","https://openalex.org/W2042305430","https://openalex.org/W2047764972","https://openalex.org/W2050871655","https://openalex.org/W2055146463","https://openalex.org/W2063639703","https://openalex.org/W2063753069","https://openalex.org/W2076300996","https://openalex.org/W2082438371","https://openalex.org/W2083507408","https://openalex.org/W2100837269","https://openalex.org/W2105023791","https://openalex.org/W2125579324","https://openalex.org/W2128690724","https://openalex.org/W2148329395","https://openalex.org/W2167071561"],"related_works":["https://openalex.org/W2042305430","https://openalex.org/W6685396","https://openalex.org/W1872623971","https://openalex.org/W2086155704","https://openalex.org/W2041706219","https://openalex.org/W1875235011","https://openalex.org/W2171181498","https://openalex.org/W427938826","https://openalex.org/W2123426218","https://openalex.org/W2035954117"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}