{"id":"https://openalex.org/W1994488917","doi":"https://doi.org/10.1016/j.jalz.2009.04.777","title":"P4\u2010109: PICOGEN: A genetic counseling program experience in dementia","display_name":"P4\u2010109: PICOGEN: A genetic counseling program experience in dementia","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W1994488917","doi":"https://doi.org/10.1016/j.jalz.2009.04.777","mag":"1994488917"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2009.04.777","doi":"https://doi.org/10.1016/j.jalz.2009.04.777","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.777","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2009.04.777","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2009.04.777","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010797490","display_name":"Juan Fortea","orcid":"https://orcid.org/0000-0002-1340-638X","observed_orcids":["https://orcid.org/0000-0002-1340-638X"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Juan Fortea","raw_affiliation_strings":["Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025017484","display_name":"Albert Llad\u00f3","orcid":"https://orcid.org/0000-0002-5066-4150","observed_orcids":["https://orcid.org/0000-0002-5066-4150","https://orcid.org/0009-0003-5843-0724"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Albert Llad\u00f3","raw_affiliation_strings":["Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058541347","display_name":"Lu\u00eds Pintor","orcid":"https://orcid.org/0000-0002-8730-7296","observed_orcids":["https://orcid.org/0000-0002-8730-7296"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis Pintor","raw_affiliation_strings":["Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066095411","display_name":"Josep M. Peri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Josep Peri","raw_affiliation_strings":["Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035872689","display_name":"Jordi Clarim\u00f3n","orcid":"https://orcid.org/0000-0002-6824-6942","observed_orcids":["https://orcid.org/0000-0002-6824-6942"]},"institutions":[{"id":"https://openalex.org/I2801795740","display_name":"Hospital de Sant Pau","ror":"https://ror.org/059n1d175","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2801795740"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jordi Clarimon","raw_affiliation_strings":["Hospital de Sant Pau Barcelona Spain","Hospital de Sant Pau, Barcelona, Spain#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital de Sant Pau Barcelona Spain","institution_ids":["https://openalex.org/I2801795740"]},{"raw_affiliation_string":"Hospital de Sant Pau, Barcelona, Spain#TAB#","institution_ids":["https://openalex.org/I2801795740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022634568","display_name":"Jordi Yag\u00fce","orcid":"https://orcid.org/0000-0002-1935-4488","observed_orcids":["https://orcid.org/0000-0002-1935-4488"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yag\u00fce Jordi","raw_affiliation_strings":["Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086020595","display_name":"Rafael Oliva","orcid":"https://orcid.org/0000-0003-4876-2410","observed_orcids":["https://orcid.org/0000-0003-4876-2410"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rafael Oliva","raw_affiliation_strings":["Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027089756","display_name":"Lorena Rami","orcid":"https://orcid.org/0000-0002-7411-1921","observed_orcids":["https://orcid.org/0000-0002-7411-1921"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lorena Rami","raw_affiliation_strings":["Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036068671","display_name":"Jos\u00e9 Lu\u00eds Molinuevo","orcid":"https://orcid.org/0000-0003-0485-6001","observed_orcids":["https://orcid.org/0000-0003-0485-6001"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jose Luis Molinuevo","raw_affiliation_strings":["Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047159861","display_name":"Raquel S\u00e1nchez\u2010Valle","orcid":"https://orcid.org/0000-0001-7750-896X","observed_orcids":["https://orcid.org/0000-0001-7750-896X"]},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Sanchez\u2010Valle","raw_affiliation_strings":["Hospital Clinic, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Clinic, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054762575","display_name":"David Bartr\u00e9s-faz A","orcid":"https://orcid.org/0000-0001-6020-4118","observed_orcids":["https://orcid.org/0000-0001-6020-4118"]},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David Bartr\u00e9s Faz","raw_affiliation_strings":["Universitat de Barcelona, Barcelona , Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitat de Barcelona, Barcelona , Spain","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5010797490"],"corresponding_institution_ids":["https://openalex.org/I4210115097"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.1431603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"4S_Part_15","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.5512999892234802,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.4187000095844269,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genetic-counseling","display_name":"genetic counseling","score":0.7559999823570251},{"id":"https://openalex.org/keywords/early-onset-dementia","display_name":"early-onset dementia","score":0.7979999780654907}],"concepts":[{"id":"https://openalex.org/C80227256","wikidata":"https://www.wikidata.org/wiki/Q1124169","display_name":"Genetic counseling","level":2,"score":0.8776230812072754},{"id":"https://openalex.org/C2780673598","wikidata":"https://www.wikidata.org/wiki/Q285223","display_name":"Genetic testing","level":2,"score":0.7769169807434082},{"id":"https://openalex.org/C2777910003","wikidata":"https://www.wikidata.org/wiki/Q1707292","display_name":"Asymptomatic","level":2,"score":0.7349227070808411},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6581326127052307},{"id":"https://openalex.org/C137916694","wikidata":"https://www.wikidata.org/wiki/Q1549382","display_name":"Asymptomatic carrier","level":3,"score":0.6397224068641663},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6259426474571228},{"id":"https://openalex.org/C68122502","wikidata":"https://www.wikidata.org/wiki/Q764527","display_name":"Informed consent","level":3,"score":0.569245457649231},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5150787234306335},{"id":"https://openalex.org/C2778641062","wikidata":"https://www.wikidata.org/wiki/Q18592","display_name":"Frontotemporal dementia","level":4,"score":0.4737209379673004},{"id":"https://openalex.org/C158951850","wikidata":"https://www.wikidata.org/wiki/Q17004546","display_name":"Carrier testing","level":5,"score":0.44385629892349243},{"id":"https://openalex.org/C2776485563","wikidata":"https://www.wikidata.org/wiki/Q18253272","display_name":"PSEN1","level":5,"score":0.44165700674057007},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.43724074959754944},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.4329102635383606},{"id":"https://openalex.org/C2778258057","wikidata":"https://www.wikidata.org/wiki/Q1136569","display_name":"Prenatal diagnosis","level":4,"score":0.3996677100658417},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3553726077079773},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2448178231716156},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.23789358139038086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2270694077014923},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.19856390357017517},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.12489870190620422},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.10123366117477417},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08470162749290466},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.07674294710159302},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2009.04.777","doi":"https://doi.org/10.1016/j.jalz.2009.04.777","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.777","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2009.04.777","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2009.04.777","doi":"https://doi.org/10.1016/j.jalz.2009.04.777","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.777","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2009.04.777","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's & Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994488917.pdf","grobid_xml":"https://content.openalex.org/works/W1994488917.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011256907","https://openalex.org/W2005249865","https://openalex.org/W3105782967","https://openalex.org/W7097274818","https://openalex.org/W2260434832","https://openalex.org/W1970281209","https://openalex.org/W2133579433","https://openalex.org/W4232882390","https://openalex.org/W2122106431","https://openalex.org/W2038411281"],"abstract_inverted_index":{"Pathogenic":[0],"mutations":[1,162,287,320],"leading":[2],"to":[3,28,123],"familial":[4,8],"Alzheimer's":[5],"disease":[6,39],"(FAD),":[7],"frontotemporal":[9],"dementia":[10],"(fFTD)":[11],"and":[12,31,42,101,104,173,185,219,226,262,325,339],"genetic":[13,80,85,145,183,204,230,299,302],"prion":[14],"diseases":[15],"(gTSE)":[16],"are":[17],"responsible":[18],"for":[19,79,144,241,288,298],"1-15%":[20],"cases":[21],"of":[22,64,129,134,151,187,291,305],"presenile":[23],"dementia.":[24,289],"To":[25],"give":[26],"support":[27,264],"these":[29,294],"patients":[30],"their":[32],"families":[33,159,196,212,284,295],"a":[34,69,74,94,99,102,130],"multidisciplinary":[35],"program":[36],"following":[37],"Huntington's":[38],"counseling":[40,181,300,337],"guidelines":[41],"approved":[43],"by":[44,98,345],"the":[45,60,124,127,138,148,152,246,259,263,267],"local":[46],"ethics":[47],"commitee":[48],"was":[49,110,113],"developed":[50],"in":[51,126,147,163,170,175,200],"Hospital":[52],"Clinic,":[53],"Barcelona:":[54],"The":[55],"PICOGEN":[56],"program.":[57,66,153,270],"We":[58,156,281,314],"describe":[59],"5":[61,236],"year":[62],"experience":[63],"this":[65],"Subjects":[67],"attended":[68],"first":[70,149],"screening":[71,139],"visit":[72,140],"with":[73,160,197,213,217,221,285],"neurologist":[75],"who":[76],"selected":[77],"candidates":[78,83,92,143],"testing.":[81,303],"Symptomatic":[82],"underwent":[84,93,182,203,229,301],"testing":[86,109,146,231,330],"after":[87,115,180],"written":[88,116],"informed":[89,117],"consent.":[90,118],"Asymptomatic":[91],"structured":[95],"clinical":[96],"interview":[97],"psychologist":[100],"psychiatrist":[103],"were":[105,120,141,189,239,275,307],"recounseled":[106],"after.":[107],"If":[108],"recommended,":[111],"blood":[112],"drawn":[114],"Results":[119],"given":[121],"directly":[122],"individual":[125],"presence":[128],"companion.":[131],"-":[132,154,193,209,235,249,280,313,328],"20%":[133],"subjects":[135,179,292],"(59/302)":[136],"at":[137,277],"considered":[142],"phase":[150],"FAD:":[155],"found":[157,315],"4":[158,216,316],"pathogenic":[161,247,286],"PSEN1":[164],"(M139T,":[165],"P264L,":[166],"L286P,":[167],"E120G),":[168],"one":[169,174],"PSEN2":[171,324],"(T430M)":[172],"APP":[176],"(I716F).":[177],"23/31":[178],"analysis":[184,205],"17":[186],"them":[188,306],"carriers":[190,257,308],"(7":[191],"asymptomatic).":[192],"fFTD:":[194],"2":[195,211,220],"P301L":[198],"mutation":[199],"MAPT,":[201],"3/5":[202],"(1/3":[206],"asymptomatic":[207,310],"carrier).":[208],"gTSE:":[210],"E200K":[214],"mutation,":[215],"D178N":[218],"octapeptide":[222],"repeat":[223],"insertions":[224],"(4-OPRI":[225],"9-OPRI)":[227],"16/24":[228],"(3/11":[232],"asymtomatic":[233],"carriers).":[234],"corionic":[237],"biopsies":[238],"perfomed":[240],"prenatal":[242],"diagnosis":[243],"(4/5":[244],"showed":[245],"mutation).":[248],"Psychological":[250],"impact:":[251],"All":[252],"noncarriers":[253],"felt":[254],"relieved.":[255],"Overall":[256],"valued":[258],"information":[260],"received":[261],"obtained":[265],"during":[266],"post-test":[268],"follow-up":[269],"No":[271],"negative":[272],"psychological":[273],"reactions":[274],"observed":[276],"medium-term":[278],"follow-up.":[279],"identified":[282],"14":[283],"70%":[290],"from":[293],"that":[296],"came":[297],"74%":[304],"(32%":[309],"when":[311],"tested).":[312],"non":[317],"previously":[318],"described":[319],"(2":[321],"PSEN1,":[322],"1":[323,326],"APP).":[327],"Predictive":[329],"may":[331],"be":[332],"performed":[333],"safely":[334],"within":[335],"strict":[336],"protocols":[338],"is":[340],"also":[341],"regarded":[342],"as":[343],"beneficial":[344],"at-risk":[346],"individuals.":[347]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}