{"id":"https://openalex.org/W1994473383","doi":"https://doi.org/10.1111/1574-6976.12048","title":"Yeast: a simple model system to study complex phenomena of aneuploidy","display_name":"Yeast: a simple model system to study complex phenomena of aneuploidy","publication_year":2013,"publication_date":"2013-10-12","ids":{"openalex":"https://openalex.org/W1994473383","doi":"https://doi.org/10.1111/1574-6976.12048","mag":"1994473383","pmid":"https://pubmed.ncbi.nlm.nih.gov/24118136","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3951669"},"language":"en","primary_location":{"id":"doi:10.1111/1574-6976.12048","doi":"https://doi.org/10.1111/1574-6976.12048","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1574-6976.12048","pdf_url":"https://academic.oup.com/femsre/article-pdf/38/2/201/18145783/38-2-201.pdf","source":{"id":"https://openalex.org/S7317325","display_name":"FEMS Microbiology Reviews","issn_l":"0168-6445","issn":["0168-6445","1574-6976"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Reviews","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/femsre/article-pdf/38/2/201/18145783/38-2-201.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020308658","display_name":"Wahid A Mulla","orcid":"https://orcid.org/0000-0003-3356-3902","observed_orcids":["https://orcid.org/0000-0003-3356-3902"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Wahid Mulla","raw_affiliation_strings":["Stowers Institute for Medical Research, Kansas City, MO, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA","Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA","Stowers Institute for Medical Research, Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO, USA; Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I114131015","https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO, USA","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031543598","display_name":"Jin Zhu","orcid":"https://orcid.org/0000-0002-6866-5709","observed_orcids":["https://orcid.org/0000-0002-6866-5709"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jin Zhu","raw_affiliation_strings":["Stowers Institute for Medical Research, Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO, USA","institution_ids":["https://openalex.org/I114131015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100385039","display_name":"Rong Li","orcid":"https://orcid.org/0000-0002-0540-6566","observed_orcids":["https://orcid.org/0000-0002-0540-6566"]},"institutions":[{"id":"https://openalex.org/I114131015","display_name":"Stowers Institute for Medical Research","ror":"https://ror.org/04bgfm609","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I114131015"]},{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rong Li","raw_affiliation_strings":["Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA","Stowers Institute for Medical Research, Kansas City, MO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, USA","institution_ids":["https://openalex.org/I4210128618"]},{"raw_affiliation_string":"Stowers Institute for Medical Research, Kansas City, MO, USA","institution_ids":["https://openalex.org/I114131015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020308658"],"corresponding_institution_ids":["https://openalex.org/I114131015","https://openalex.org/I4210128618"],"apc_list":{"value":2500,"currency":"GBP","value_usd":3297},"apc_paid":null,"fwci":0.2299,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.17622378,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"38","issue":"2","first_page":"201","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9556000232696533,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.03539999946951866,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aneuploidy","display_name":"aneuploidy","score":1.0},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.5920000076293945},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9900000095367432},{"id":"https://openalex.org/keywords/aneuploidy-detection","display_name":"aneuploidy detection","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7129999995231628},{"id":"https://openalex.org/keywords/developmental-disorders","display_name":"developmental disorders","score":0.8379999995231628},{"id":"https://openalex.org/keywords/model-organisms","display_name":"model organisms","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2779672484","wikidata":"https://www.wikidata.org/wiki/Q529622","display_name":"Aneuploidy","level":4,"score":0.9694880247116089},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.806398332118988},{"id":"https://openalex.org/C143191323","wikidata":"https://www.wikidata.org/wiki/Q118406","display_name":"Ploidy","level":3,"score":0.6070185899734497},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5255894660949707},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.5131261944770813},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5084154009819031},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4080212712287903},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13165774941444397}],"mesh":[{"descriptor_ui":"D000782","descriptor_name":"Aneuploidy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":"Q000639","qualifier_name":"trends","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D043171","descriptor_name":"Chromosomal Instability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1111/1574-6976.12048","doi":"https://doi.org/10.1111/1574-6976.12048","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1574-6976.12048","pdf_url":"https://academic.oup.com/femsre/article-pdf/38/2/201/18145783/38-2-201.pdf","source":{"id":"https://openalex.org/S7317325","display_name":"FEMS Microbiology Reviews","issn_l":"0168-6445","issn":["0168-6445","1574-6976"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Reviews","raw_type":"journal-article"},{"id":"pmid:24118136","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24118136","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS microbiology reviews","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3307874","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3951669","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3951669","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3951669/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FEMS Microbiol Rev","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.1019.171","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.1019.171","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://femsre.oxfordjournals.org/content/femsre/38/2/201.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1111/1574-6976.12048","doi":"https://doi.org/10.1111/1574-6976.12048","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1574-6976.12048","pdf_url":"https://academic.oup.com/femsre/article-pdf/38/2/201/18145783/38-2-201.pdf","source":{"id":"https://openalex.org/S7317325","display_name":"FEMS Microbiology Reviews","issn_l":"0168-6445","issn":["0168-6445","1574-6976"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEMS Microbiology Reviews","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6000000238418579,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3072611274","display_name":"The effect of aneuploidy on cellular physiology and adaptation","funder_award_id":"R01GM059964","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994473383.pdf","grobid_xml":"https://content.openalex.org/works/W1994473383.grobid-xml"},"referenced_works_count":99,"referenced_works":["https://openalex.org/W50091167","https://openalex.org/W111444428","https://openalex.org/W148793297","https://openalex.org/W1491750590","https://openalex.org/W1512828086","https://openalex.org/W1535354154","https://openalex.org/W1583265575","https://openalex.org/W1667925774","https://openalex.org/W1884430856","https://openalex.org/W1910331933","https://openalex.org/W1962277119","https://openalex.org/W1967304777","https://openalex.org/W1968423560","https://openalex.org/W1968659469","https://openalex.org/W1969348568","https://openalex.org/W1971013077","https://openalex.org/W1971248187","https://openalex.org/W1973221039","https://openalex.org/W1978005916","https://openalex.org/W1983710766","https://openalex.org/W1983781571","https://openalex.org/W1990144254","https://openalex.org/W1991082065","https://openalex.org/W1994213227","https://openalex.org/W1996152576","https://openalex.org/W1998926042","https://openalex.org/W2002005828","https://openalex.org/W2006141070","https://openalex.org/W2006189750","https://openalex.org/W2011172223","https://openalex.org/W2016991364","https://openalex.org/W2026854486","https://openalex.org/W2028793515","https://openalex.org/W2029971236","https://openalex.org/W2032475954","https://openalex.org/W2032518018","https://openalex.org/W2032866129","https://openalex.org/W2034592203","https://openalex.org/W2035776094","https://openalex.org/W2037012644","https://openalex.org/W2043071112","https://openalex.org/W2047687247","https://openalex.org/W2048411015","https://openalex.org/W2048938594","https://openalex.org/W2052167721","https://openalex.org/W2052931063","https://openalex.org/W2054590265","https://openalex.org/W2055595349","https://openalex.org/W2062214822","https://openalex.org/W2064977507","https://openalex.org/W2066985045","https://openalex.org/W2067466498","https://openalex.org/W2074548008","https://openalex.org/W2075447540","https://openalex.org/W2075601868","https://openalex.org/W2080797446","https://openalex.org/W2083609933","https://openalex.org/W2085755609","https://openalex.org/W2091902964","https://openalex.org/W2092296116","https://openalex.org/W2093002897","https://openalex.org/W2094746916","https://openalex.org/W2096562200","https://openalex.org/W2102381613","https://openalex.org/W2102502996","https://openalex.org/W2105649156","https://openalex.org/W2106942402","https://openalex.org/W2107702258","https://openalex.org/W2111209294","https://openalex.org/W2119565509","https://openalex.org/W2120741544","https://openalex.org/W2123173066","https://openalex.org/W2123558100","https://openalex.org/W2129055445","https://openalex.org/W2129763268","https://openalex.org/W2131213513","https://openalex.org/W2131635397","https://openalex.org/W2133725114","https://openalex.org/W2138122869","https://openalex.org/W2140844543","https://openalex.org/W2143075801","https://openalex.org/W2145329735","https://openalex.org/W2146143136","https://openalex.org/W2147366327","https://openalex.org/W2155012056","https://openalex.org/W2158161949","https://openalex.org/W2159940514","https://openalex.org/W2162714351","https://openalex.org/W2164055391","https://openalex.org/W2164324273","https://openalex.org/W2165317850","https://openalex.org/W2166530712","https://openalex.org/W2169724322","https://openalex.org/W2169773990","https://openalex.org/W2169800519","https://openalex.org/W2170124838","https://openalex.org/W2170568588","https://openalex.org/W2188548307","https://openalex.org/W2332228582"],"related_works":["https://openalex.org/W2206957995","https://openalex.org/W4386253185","https://openalex.org/W1512828086","https://openalex.org/W1550665604","https://openalex.org/W3091274775","https://openalex.org/W4402794881","https://openalex.org/W6945377874","https://openalex.org/W1971013077","https://openalex.org/W4404698989","https://openalex.org/W2129688482"],"abstract_inverted_index":{"Aneuploidy,":[0],"the":[1,13,45,50,54,60,73,90,118,146,150],"state":[2],"of":[3,12,26,39,53,78,82,120,152],"having":[4],"a":[5,10,37,139],"chromosome":[6],"number":[7],"different":[8],"from":[9],"multiple":[11],"haploid":[14],"number,":[15],"has":[16,35,64,84],"been":[17,36,65,85],"associated":[18],"with":[19],"diseases":[20],"and":[21,42,56,75,107,110,141],"developmental":[22],"disorders.":[23],"The":[24,80],"role":[25],"aneuploidy":[27,83],"in":[28,33,122,149],"human":[29],"disease":[30],"pathology,":[31],"especially":[32],"cancer,":[34],"subject":[38],"much":[40],"attention":[41],"debate":[43],"over":[44],"last":[46,61],"century":[47],"due":[48],"to":[49,89,124,144],"intrinsic":[51],"complexity":[52],"phenomena":[55],"experimental":[57,134],"challenges.":[58],"Over":[59],"decade,":[62],"yeast":[63,96,123,138],"an":[66],"invaluable":[67],"model":[68,143],"for":[69,92,104],"driving":[70],"discoveries":[71],"about":[72,127],"genetic":[74,101],"molecular":[76],"aspects":[77],"aneuploidy.":[79,128,153],"understanding":[81],"significantly":[86],"improved":[87],"owing":[88],"methods":[91],"selectively":[93],"generating":[94],"aneuploid":[95],"strains":[97],"without":[98],"causing":[99],"other":[100],"changes,":[102],"techniques":[103],"detecting":[105],"aneuploidy,":[106],"cutting-edge":[108],"genetics":[109],"'omics'":[111],"approaches.":[112],"In":[113],"this":[114],"review,":[115],"we":[116],"discuss":[117],"contribution":[119],"studies":[121],"current":[125],"knowledge":[126],"Special":[129],"emphasis":[130],"is":[131],"placed":[132],"on":[133],"features":[135],"that":[136],"make":[137],"simpler":[140],"efficient":[142],"investigate":[145],"complex":[147],"questions":[148],"field":[151]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}