{"id":"https://openalex.org/W1994460564","doi":"https://doi.org/10.1038/labinvest.3780182","title":"Interstitial Fibrosis of Unilateral Ureteral Obstruction is Exacerbated in Kidneys of Mice Lacking the Gene for Inducible Nitric Oxide Synthase","display_name":"Interstitial Fibrosis of Unilateral Ureteral Obstruction is Exacerbated in Kidneys of Mice Lacking the Gene for Inducible Nitric Oxide Synthase","publication_year":2000,"publication_date":"2000-11-01","ids":{"openalex":"https://openalex.org/W1994460564","doi":"https://doi.org/10.1038/labinvest.3780182","mag":"1994460564","pmid":"https://pubmed.ncbi.nlm.nih.gov/11092532"},"language":"en","primary_location":{"id":"doi:10.1038/labinvest.3780182","doi":"https://doi.org/10.1038/labinvest.3780182","is_oa":true,"landing_page_url":"https://doi.org/10.1038/labinvest.3780182","pdf_url":"https://www.nature.com/articles/3780182.pdf","source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/3780182.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050615953","display_name":"David A. Hochberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Hochberg","raw_affiliation_strings":["Center for Pediatric Urology, Department of Urology, Children's Hospital of New York, Weill Medical College of Cornell University, New York 10021, USA","Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Pediatric Urology, Department of Urology, Children's Hospital of New York, Weill Medical College of Cornell University, New York 10021, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Christopher W Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher W Johnson","raw_affiliation_strings":["Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100332866","display_name":"Jie Chen","orcid":"https://orcid.org/0000-0001-9388-2695","observed_orcids":["https://orcid.org/0000-0001-9388-2695"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jie Chen","raw_affiliation_strings":["Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072837703","display_name":"Drorit Cohen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drorit Cohen","raw_affiliation_strings":["Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028828658","display_name":"Joshua M. Stern","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Stern","raw_affiliation_strings":["Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113757334","display_name":"E. Darracott Vaughan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Darracott Vaughan","raw_affiliation_strings":["Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090886190","display_name":"Dix Phillip Poppas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dix Poppas","raw_affiliation_strings":["Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068682755","display_name":"Diane Felsen","orcid":"https://orcid.org/0000-0003-1190-9626","observed_orcids":["https://orcid.org/0000-0003-1190-9626"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Diane Felsen","raw_affiliation_strings":["Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Department of Urology, Center for Pediatric Urology and Laboratory for Minimally Invasive Urologic Surgery, Children's Hospital of New York, Weill Medical College of Cornell University, New York","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5068682755"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":2.9386,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.9039273,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"80","issue":"11","first_page":"1721","last_page":"1728"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.8511000275611877,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0357000008225441,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/unilateral-ureteral-obstruction","display_name":"unilateral ureteral obstruction","score":0.9430000185966492},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9649999737739563},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.6600000262260437},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7919999957084656},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.6899999976158142},{"id":"https://openalex.org/keywords/interstitial-macrophages","display_name":"interstitial macrophages","score":0.8730000257492065},{"id":"https://openalex.org/keywords/inos-knockout-mice","display_name":"iNOS knockout mice","score":0.8169999718666077},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2777622882","wikidata":"https://www.wikidata.org/wiki/Q417619","display_name":"Nitric oxide synthase","level":3,"score":0.8141028881072998},{"id":"https://openalex.org/C2779797417","wikidata":"https://www.wikidata.org/wiki/Q12460151","display_name":"Hydroxyproline","level":2,"score":0.7060734629631042},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.6568313241004944},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.6276768445968628},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5864236354827881},{"id":"https://openalex.org/C2778577996","wikidata":"https://www.wikidata.org/wiki/Q2307492","display_name":"Renal cortex","level":3,"score":0.5809177160263062},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5356215238571167},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5327895283699036},{"id":"https://openalex.org/C2777534427","wikidata":"https://www.wikidata.org/wiki/Q6057165","display_name":"Interstitial cell","level":2,"score":0.49324697256088257},{"id":"https://openalex.org/C2780512574","wikidata":"https://www.wikidata.org/wiki/Q2409399","display_name":"Renal medulla","level":3,"score":0.4348163306713104},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.424974262714386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3640749156475067},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3561859428882599}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014517","descriptor_name":"Ureteral Obstruction","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019001","descriptor_name":"Nitric Oxide Synthase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052247","descriptor_name":"Nitric Oxide Synthase Type II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/labinvest.3780182","doi":"https://doi.org/10.1038/labinvest.3780182","is_oa":true,"landing_page_url":"https://doi.org/10.1038/labinvest.3780182","pdf_url":"https://www.nature.com/articles/3780182.pdf","source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},{"id":"pmid:11092532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11092532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory investigation; a journal of technical methods and pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/labinvest.3780182","doi":"https://doi.org/10.1038/labinvest.3780182","is_oa":true,"landing_page_url":"https://doi.org/10.1038/labinvest.3780182","pdf_url":"https://www.nature.com/articles/3780182.pdf","source":{"id":"https://openalex.org/S137146891","display_name":"Laboratory Investigation","issn_l":"0023-6837","issn":["0023-6837","1530-0307"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Laboratory Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994460564.pdf","grobid_xml":"https://content.openalex.org/works/W1994460564.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W27859160","https://openalex.org/W65050009","https://openalex.org/W85814666","https://openalex.org/W167193934","https://openalex.org/W1967245379","https://openalex.org/W1968002331","https://openalex.org/W1968941811","https://openalex.org/W1972298908","https://openalex.org/W1975715446","https://openalex.org/W1982652863","https://openalex.org/W1985039207","https://openalex.org/W2003777560","https://openalex.org/W2009393201","https://openalex.org/W2011965024","https://openalex.org/W2015996457","https://openalex.org/W2017129200","https://openalex.org/W2032667836","https://openalex.org/W2035718064","https://openalex.org/W2055368734","https://openalex.org/W2055533480","https://openalex.org/W2062674313","https://openalex.org/W2063523864","https://openalex.org/W2064119208","https://openalex.org/W2074563181","https://openalex.org/W2078044852","https://openalex.org/W2078381217","https://openalex.org/W2084528397","https://openalex.org/W2101052864","https://openalex.org/W2103079216","https://openalex.org/W2104486246","https://openalex.org/W2104963688","https://openalex.org/W2113456660","https://openalex.org/W2122515902","https://openalex.org/W2124843985","https://openalex.org/W2126196465","https://openalex.org/W2126880436","https://openalex.org/W2128494605","https://openalex.org/W2145792977","https://openalex.org/W2148365188","https://openalex.org/W2158130822","https://openalex.org/W2229130239","https://openalex.org/W2278308791","https://openalex.org/W2289257592","https://openalex.org/W2335187016","https://openalex.org/W2401589271","https://openalex.org/W2426973307","https://openalex.org/W6630920825","https://openalex.org/W6678862793","https://openalex.org/W6717124287"],"related_works":["https://openalex.org/W1994429374","https://openalex.org/W2078044852","https://openalex.org/W2068886741","https://openalex.org/W2354293111","https://openalex.org/W2018995741","https://openalex.org/W2015721783","https://openalex.org/W2064229667","https://openalex.org/W2027644823","https://openalex.org/W2161954266","https://openalex.org/W2121337176"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}