{"id":"https://openalex.org/W1994346887","doi":"https://doi.org/10.1006/excr.2000.4979","title":"Reactive Oxidizing Species Produced near the Plasma Membrane Induce Apoptosis in Bovine Aorta Endothelial Cells","display_name":"Reactive Oxidizing Species Produced near the Plasma Membrane Induce Apoptosis in Bovine Aorta Endothelial Cells","publication_year":2000,"publication_date":"2000-09-01","ids":{"openalex":"https://openalex.org/W1994346887","doi":"https://doi.org/10.1006/excr.2000.4979","mag":"1994346887","pmid":"https://pubmed.ncbi.nlm.nih.gov/10964502"},"language":"en","primary_location":{"id":"doi:10.1006/excr.2000.4979","doi":"https://doi.org/10.1006/excr.2000.4979","is_oa":false,"landing_page_url":"https://doi.org/10.1006/excr.2000.4979","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054061274","display_name":"Charles P. Lin","orcid":"https://orcid.org/0000-0002-7450-627X","observed_orcids":["https://orcid.org/0000-0002-7450-627X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles P. Lin","raw_affiliation_strings":["Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Laboratories of Photomedicine, Harvard Medical School, Boston, Massachusetts 02114, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101164266","display_name":"Mary C. Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary C. Lynch","raw_affiliation_strings":["Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033699079","display_name":"Irene E. Kochevar","orcid":"https://orcid.org/0000-0002-3763-3923","observed_orcids":["https://orcid.org/0000-0002-3763-3923"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irene E. Kochevar","raw_affiliation_strings":["Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Laboratories of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3270,"currency":"USD","value_usd":3270},"apc_paid":null,"fwci":4.3273,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.93935912,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"259","issue":"2","first_page":"351","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.4368000030517578,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.4368000030517578,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.38449999690055847,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.13819999992847443,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8180000185966492},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.890999972820282},{"id":"https://openalex.org/keywords/singlet-oxygen","display_name":"singlet oxygen","score":0.8830000162124634},{"id":"https://openalex.org/keywords/photosensitization","display_name":"photosensitization","score":0.8489999771118164},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.7350000143051147},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.7463287711143494},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.6712489724159241},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6311177015304565},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5970734357833862},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5492255687713623},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.5093058347702026},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.46784934401512146},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.4429760277271271},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4291006326675415},{"id":"https://openalex.org/C80107235","wikidata":"https://www.wikidata.org/wiki/Q7162625","display_name":"Penetration (warfare)","level":2,"score":0.4130590558052063},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24668645858764648},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.21507707238197327},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.17712938785552979},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C42475967","wikidata":"https://www.wikidata.org/wiki/Q194292","display_name":"Operations research","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001011","descriptor_name":"Aorta","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010777","descriptor_name":"Photochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011419","descriptor_name":"Propidium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012395","descriptor_name":"Rose Bengal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016650","descriptor_name":"Fluorescein-5-isothiocyanate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017304","descriptor_name":"Annexin A5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D055095","descriptor_name":"Optics and Photonics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/excr.2000.4979","doi":"https://doi.org/10.1006/excr.2000.4979","is_oa":false,"landing_page_url":"https://doi.org/10.1006/excr.2000.4979","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},{"id":"pmid:10964502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10964502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental cell research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1530302646","display_name":null,"funder_award_id":"GM 30755","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6174023882","display_name":"Ultraviolet Light Induced Phenomena in Biomembranes","funder_award_id":"R01GM030755","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W185672304","https://openalex.org/W575773148","https://openalex.org/W1491901751","https://openalex.org/W1556700452","https://openalex.org/W1966503640","https://openalex.org/W1971320218","https://openalex.org/W1981289966","https://openalex.org/W1990428058","https://openalex.org/W1998424046","https://openalex.org/W2011342890","https://openalex.org/W2012587770","https://openalex.org/W2020063343","https://openalex.org/W2021749851","https://openalex.org/W2032085425","https://openalex.org/W2032673826","https://openalex.org/W2032970657","https://openalex.org/W2043244974","https://openalex.org/W2045086385","https://openalex.org/W2054955905","https://openalex.org/W2060810889","https://openalex.org/W2064179230","https://openalex.org/W2066597100","https://openalex.org/W2071239471","https://openalex.org/W2072477400","https://openalex.org/W2076660441","https://openalex.org/W2077488483","https://openalex.org/W2077504134","https://openalex.org/W2077628780","https://openalex.org/W2080080873","https://openalex.org/W2082163465","https://openalex.org/W2109673107","https://openalex.org/W2113999599","https://openalex.org/W2124967686","https://openalex.org/W2134080855","https://openalex.org/W2136076136","https://openalex.org/W2143304082","https://openalex.org/W2161990266","https://openalex.org/W2163832837","https://openalex.org/W2288750238","https://openalex.org/W2314469790","https://openalex.org/W2315250335","https://openalex.org/W2315953643","https://openalex.org/W2328643786","https://openalex.org/W2331874435","https://openalex.org/W2413216812","https://openalex.org/W2419566523","https://openalex.org/W4248667766","https://openalex.org/W4256237491","https://openalex.org/W6830501397"],"related_works":["https://openalex.org/W1491901751","https://openalex.org/W2092687265","https://openalex.org/W2077727884","https://openalex.org/W2607362064","https://openalex.org/W3190895573","https://openalex.org/W2018968399","https://openalex.org/W7100345876","https://openalex.org/W2915403125","https://openalex.org/W1975598948","https://openalex.org/W2042160477"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}