{"id":"https://openalex.org/W1994320122","doi":"https://doi.org/10.1111/j.1464-410x.2006.06054.x","title":"A comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinoma","display_name":"A comparison of p21 and p27 immunoexpression in benign glands, prostatic intraepithelial neoplasia and prostate adenocarcinoma","publication_year":2006,"publication_date":"2006-02-10","ids":{"openalex":"https://openalex.org/W1994320122","doi":"https://doi.org/10.1111/j.1464-410x.2006.06054.x","mag":"1994320122","pmid":"https://pubmed.ncbi.nlm.nih.gov/16469041"},"language":"en","primary_location":{"id":"doi:10.1111/j.1464-410x.2006.06054.x","doi":"https://doi.org/10.1111/j.1464-410x.2006.06054.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.2006.06054.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058935013","display_name":"Ba\u015fak Do\u011fanav\u015farg\u0131l","orcid":"https://orcid.org/0000-0002-4738-4350","observed_orcids":["https://orcid.org/0000-0002-4738-4350"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"BASAK DOGANAVSARGIL","raw_affiliation_strings":["Department of Pathology, Ege University, Faculty of Medicine, Izmir, Turkey. bdoganavsargil@yahoo.com","Department of Pathology Ege University Faculty of Medicine Izmir Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Ege University, Faculty of Medicine, Izmir, Turkey. bdoganavsargil@yahoo.com","institution_ids":["https://openalex.org/I41641357"]},{"raw_affiliation_string":"Department of Pathology Ege University Faculty of Medicine Izmir Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023045235","display_name":"Adnan \u015eim\u015fir","orcid":"https://orcid.org/0000-0003-1519-5333","observed_orcids":["https://orcid.org/0000-0003-1519-5333","https://orcid.org/0000-0002-0681-0325"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"ADNAN SIMSIR","raw_affiliation_strings":["Departments of Pathology and Urology, Ege University Faculty of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Urology, Ege University Faculty of Medicine, and","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081564924","display_name":"Hayal Boyac\u0131o\u011flu","orcid":"https://orcid.org/0000-0003-0887-0302","observed_orcids":["https://orcid.org/0000-0003-0887-0302"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"HAYAL BOYACIOGLU","raw_affiliation_strings":["Department of Statistics, Ege University Faculty of Science, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Ege University Faculty of Science, Izmir, Turkey","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051494024","display_name":"\u00c7a\u011f \u00c7al","orcid":"https://orcid.org/0000-0002-6434-7631","observed_orcids":["https://orcid.org/0000-0002-6434-7631"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"CAG CAL","raw_affiliation_strings":["Departments of Pathology and Urology, Ege University Faculty of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Urology, Ege University Faculty of Medicine, and","institution_ids":["https://openalex.org/I41641357"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041184758","display_name":"Mine Hekimgil","orcid":"https://orcid.org/0000-0002-9454-4521","observed_orcids":["https://orcid.org/0000-0002-9454-4521"]},"institutions":[{"id":"https://openalex.org/I41641357","display_name":"Ege University","ror":"https://ror.org/02eaafc18","country_code":"TR","type":"education","lineage":["https://openalex.org/I41641357"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"MINE HEKIMGIL","raw_affiliation_strings":["Departments of Pathology and Urology, Ege University Faculty of Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pathology and Urology, Ege University Faculty of Medicine, and","institution_ids":["https://openalex.org/I41641357"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5058935013"],"corresponding_institution_ids":["https://openalex.org/I41641357"],"apc_list":{"value":4770,"currency":"USD","value_usd":4770},"apc_paid":null,"fwci":2.6523,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89174453,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"97","issue":"3","first_page":"644","last_page":"648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.6312999725341797,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.3481000065803528,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9919999837875366},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prostatic-intraepithelial-neoplasia","display_name":"prostatic intraepithelial neoplasia","score":0.9210000038146973},{"id":"https://openalex.org/keywords/prostate-adenocarcinoma","display_name":"prostate adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/cell-cycle-regulators","display_name":"cell cycle regulators","score":0.5320000052452087},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.921999990940094},{"id":"https://openalex.org/keywords/extraprostatic-extension","display_name":"extraprostatic extension","score":0.9369999766349792},{"id":"https://openalex.org/keywords/seminal-vesicle-invasion","display_name":"seminal vesicle invasion","score":1.0},{"id":"https://openalex.org/keywords/perineural-invasion","display_name":"perineural invasion","score":0.828000009059906},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.4300000071525574},{"id":"https://openalex.org/keywords/gleason-score","display_name":"Gleason score","score":0.8190000057220459},{"id":"https://openalex.org/keywords/radical-prostatectomy","display_name":"radical prostatectomy","score":0.7900000214576721}],"concepts":[{"id":"https://openalex.org/C2777154038","wikidata":"https://www.wikidata.org/wiki/Q7168585","display_name":"Perineural invasion","level":3,"score":0.8482299447059631},{"id":"https://openalex.org/C2776456063","wikidata":"https://www.wikidata.org/wiki/Q15731388","display_name":"High-grade prostatic intraepithelial neoplasia","level":5,"score":0.7281608581542969},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.7077913880348206},{"id":"https://openalex.org/C2779534503","wikidata":"https://www.wikidata.org/wiki/Q6058399","display_name":"Intraepithelial neoplasia","level":4,"score":0.6824162602424622},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.6695173978805542},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6693217754364014},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6443946957588196},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5530140399932861},{"id":"https://openalex.org/C2781171107","wikidata":"https://www.wikidata.org/wiki/Q217259","display_name":"Seminal vesicle","level":4,"score":0.5473778247833252},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.49903130531311035},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.45063820481300354},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.4441510736942291},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.44237416982650757},{"id":"https://openalex.org/C2778913397","wikidata":"https://www.wikidata.org/wiki/Q7646216","display_name":"Surgical margin","level":3,"score":0.41062426567077637},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3262961804866791},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20071610808372498},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.20044976472854614},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011468","descriptor_name":"Prostatectomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D019048","descriptor_name":"Prostatic Intraepithelial Neoplasia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019048","descriptor_name":"Prostatic Intraepithelial Neoplasia","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D050760","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p27","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1464-410x.2006.06054.x","doi":"https://doi.org/10.1111/j.1464-410x.2006.06054.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1464-410x.2006.06054.x","pdf_url":null,"source":{"id":"https://openalex.org/S191188855","display_name":"British Journal of Urology","issn_l":"1464-4096","issn":["1464-4096","1464-410X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU International","raw_type":"journal-article"},{"id":"pmid:16469041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16469041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BJU international","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1557861529","https://openalex.org/W1677310169","https://openalex.org/W1755574894","https://openalex.org/W1973596168","https://openalex.org/W1974897112","https://openalex.org/W1978052913","https://openalex.org/W1980954186","https://openalex.org/W1982881535","https://openalex.org/W1996413533","https://openalex.org/W1996421417","https://openalex.org/W2006678193","https://openalex.org/W2028485973","https://openalex.org/W2041763256","https://openalex.org/W2047549500","https://openalex.org/W2048961928","https://openalex.org/W2048973341","https://openalex.org/W2068026673","https://openalex.org/W2068099856","https://openalex.org/W2070061120","https://openalex.org/W2079200535","https://openalex.org/W2107053575","https://openalex.org/W2124662269","https://openalex.org/W2124814278","https://openalex.org/W2131954674","https://openalex.org/W2134397011","https://openalex.org/W2150794592","https://openalex.org/W2165805008","https://openalex.org/W2167263709","https://openalex.org/W2430226096","https://openalex.org/W2471247236","https://openalex.org/W6717913622"],"related_works":["https://openalex.org/W2330748252","https://openalex.org/W2384013259","https://openalex.org/W2430226096","https://openalex.org/W2183654578","https://openalex.org/W2339037194","https://openalex.org/W2350982469","https://openalex.org/W2377361282","https://openalex.org/W2002823058","https://openalex.org/W2079724727","https://openalex.org/W2159398973"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"assess":[2],"the":[3,41,109,248],"immunoexpression":[4],"of":[5,13,43,50,142,168,247,251,265],"p21":[6,44,117,143,150,174,219],"and":[7,20,45,54,83,113,132,147,155,186,201,214,220,239],"p27":[8,46,88,188,203,222,233],"proteins":[9],"in":[10,47,90,96,122,130,144,152,178,232,237,254],"consecutive":[11],"areas":[12,49,157,241],"benign":[14,51,97,123,153],"glands,":[15,52,124],"prostatic":[16],"intraepithelial":[17],"neoplasia":[18],"(PIN)":[19],"prostate":[21,55,252],"adenocarcinoma.":[22,56],"PATIENTS":[23],"AND":[24],"METHODS:":[25],"Tissue":[26],"from":[27],"91":[28],"patients":[29,138,163,179],"who":[30],"had":[31,139,148,164],"a":[32,165,244,262],"radical":[33],"prostatectomy":[34],"was":[35,92,104,119,127,176,190,269],"assessed":[36],"by":[37],"immunohistochemistry":[38],"to":[39,206,273],"evaluate":[40],"expression":[42,118,141,189,204,223],"adjacent":[48],"PIN":[53,91,112,131,156,202,240],"The":[57,87,172,230],"results":[58],"were":[59],"correlated":[60,192,225],"with":[61,180,193,208,226,234,261],"various":[62],"clinicopathological":[63],"variables,":[64],"e.g.":[65],"age,":[66],"total":[67],"prostate-specific":[68],"antigen":[69],"level,":[70],"tumour":[71,133,145,173,187,238,259],"stage,":[72],"Gleason":[73],"score,":[74],"surgical":[75],"margin":[76],"involvement,":[77],"extraprostatic":[78,181],"extension,":[79],"seminal":[80,194],"vesicle":[81,195],"invasion,":[82],"perineural":[84],"invasion.":[85],"RESULTS:":[86],"score":[89,175],"lower":[93,149,166,221,263],"than":[94],"that":[95],"glands":[98,154],"(P":[99,134,158,183,197,211],"=":[100,184,198,212],"0.04)":[101],"but":[102],"there":[103,126],"no":[105,140],"significant":[106],"difference":[107],"between":[108],"scores":[110,151],"for":[111],"tumour.":[114],"By":[115],"contrast,":[116],"almost":[120],"undetectable":[121],"although":[125],"substantially":[128],"more":[129],"<":[135,159],"0.01).":[136],"Some":[137],"tissue,":[146],"0.05).":[160],"Interestingly,":[161],"these":[162],"frequency":[167,250,264],"negative":[169],"prognostic":[170,228,267],"variables.":[171],"higher":[177],"extension":[182],"0.045)":[185],"inversely":[191],"invasion":[196],"0.028).":[199],"Tumour":[200],"appeared":[205],"decrease":[207],"advancing":[209,235],"age":[210,236],"0.008":[213],"0.012,":[215],"respectively).":[216],"CONCLUSION:":[217],"Higher":[218],"is":[224],"adverse":[227,266],"factors.":[229],"decline":[231],"may":[242],"be":[243,274],"possible":[245],"explanation":[246],"greater":[249],"adenocarcinoma":[253],"older":[255],"men.":[256],"A":[257],"p21-negative":[258],"subgroup":[260],"factors":[268],"identified,":[270],"which":[271],"needs":[272],"further":[275],"explored.":[276]},"counts_by_year":[{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
