{"id":"https://openalex.org/W1994288693","doi":"https://doi.org/10.1200/jco.2007.14.1416","title":"Stem-Cell Biology and Cancer Therapy: The More Things Change\u2026","display_name":"Stem-Cell Biology and Cancer Therapy: The More Things Change\u2026","publication_year":2008,"publication_date":"2008-02-16","ids":{"openalex":"https://openalex.org/W1994288693","doi":"https://doi.org/10.1200/jco.2007.14.1416","mag":"1994288693","pmid":"https://pubmed.ncbi.nlm.nih.gov/18281648"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.14.1416","doi":"https://doi.org/10.1200/jco.2007.14.1416","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.14.1416","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068338594","display_name":"Samuel Hellm\u00e4n","orcid":"https://orcid.org/0009-0003-8360-6306","observed_orcids":["https://orcid.org/0009-0003-8360-6306"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samuel Hellman","raw_affiliation_strings":["Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL","Department of Radiation & Cellular Oncology, University of Chicago, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Department of Radiation & Cellular Oncology, University of Chicago, Chicago, IL, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048381122","display_name":"Leslie E. Botnick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leslie Botnick","raw_affiliation_strings":["Valley Radiotherapy Medical Group and Vantage Oncology, Los Angeles, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Valley Radiotherapy Medical Group and Vantage Oncology, Los Angeles, CA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022220719","display_name":"Peter Mauch","orcid":"https://orcid.org/0000-0002-9817-7968","observed_orcids":["https://orcid.org/0000-0002-9817-7968"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Mauch","raw_affiliation_strings":["Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8506,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.75589635,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"26","issue":"6","first_page":"821","last_page":"822"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/founder-cells","display_name":"founder cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/stem-cell-self-renewal","display_name":"stem cell self-renewal","score":0.5709999799728394},{"id":"https://openalex.org/keywords/stem-cell-differentiation","display_name":"stem cell differentiation","score":0.4699999988079071},{"id":"https://openalex.org/keywords/normal-tissue-toxicity","display_name":"normal tissue toxicity","score":0.46000000834465027},{"id":"https://openalex.org/keywords/bone-marrow-stroma","display_name":"bone marrow stroma","score":0.7229999899864197},{"id":"https://openalex.org/keywords/hematopoietic-stem-cell-transplantation","display_name":"hematopoietic stem cell transplantation","score":0.47999998927116394},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.32199999690055847},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.4830000102519989},{"id":"https://openalex.org/keywords/radiation-damage","display_name":"radiation damage","score":0.3230000138282776},{"id":"https://openalex.org/keywords/busulfan","display_name":"busulfan","score":0.7440000176429749},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.760820746421814},{"id":"https://openalex.org/C2983331546","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer therapy","level":3,"score":0.5293033123016357},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.47420576214790344},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4572643041610718},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.42788833379745483},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33999645709991455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27165549993515015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15134596824645996},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11877062916755676}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2007.14.1416","doi":"https://doi.org/10.1200/jco.2007.14.1416","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2007.14.1416","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:18281648","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18281648","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2155175949","https://openalex.org/W2082762764","https://openalex.org/W2400834261","https://openalex.org/W2070733891","https://openalex.org/W2082603775","https://openalex.org/W2064918902","https://openalex.org/W2474210583","https://openalex.org/W1999325683","https://openalex.org/W2419515810","https://openalex.org/W214075742"],"abstract_inverted_index":{"It":[0],"has":[1,10,16,42,206,272],"been":[2,11,43,273],"25":[3],"years":[4,617],"since":[5],"the":[6,20,35,38,46,83,92,101,104,132,152,166,173,186,212,215,221,226,232,239,242,250,265,270,281,297,302,313,320,333,375,401,404,438,442,448,488,498,522,526,542,545,584,589,593,601,605,657,692,718,727],"accompanying":[7],"review":[8,33,79,99,321,453,744],"article":[9,80],"published,":[12],"and":[13,60,131,147,224,236,249,507,548,631,637,644,677,700,703,724,771,783],"although":[14],"much":[15,18,329,678],"changed,":[17],"remains":[19],"same,":[21],"at":[22,352,595,667],"least":[23],"in":[24,103,120,217,220,260,280,316,358,411,451,475,486,497,531,554,664,710,742,769,776],"its":[25,121],"general":[26],"form.":[27],"The":[28,98,291,445],"focus":[29],"of":[30,34,37,49,107,124,214,229,241,267,304,319,332,377,393,403,437,441,528,535,569,571,586,592,604,623,689,691,712,738,760],"our":[31,452,743],"1983":[32],"organization":[36,603],"hematopoietic":[39,84,105,163,298,606,693],"stem-cell":[40,47,136,299,443,529,602,734],"compartment":[41,300],"expanded":[44],"to":[45,64,71,150,202,244,275,295,343,397,407,464,470,521,588,655,659,747,798],"compartments":[48],"other":[50,117,203,261],"cellrenewal":[51,58],"tissues,":[52,59],"normal":[53,96,204,262,341,782],"tissues":[54,205,715],"not":[55,160,509],"formerly":[56],"considered":[57,410],"perhaps":[61,792],"most":[62,93],"pertinently,":[63],"tumors":[65,663,711,770],"themselves.":[66],"This":[67,157],"work":[68],"is":[69,114,158,165,188,198,301,322,326,328,356,369,409,434,454,463,503,525,608,672,745],"continuing":[70],"yield":[72],"important":[73,285,294,461],"potentially":[74],"clinically":[75],"relevant":[76,746],"information.":[77],"Our":[78],"focused":[81],"on":[82,238,505],"system":[85,439,607],"because":[86,432],"it":[87],"was":[88,620],"then,":[89],"as":[90,144,307,395,563,642,717],"now,":[91],"frequent":[94],"dose-limiting":[95],"tissue.":[97],"emphasized":[100],"differences":[102],"damage":[106,201,587],"different":[108,115,756],"cytotoxic":[109],"agents":[110,119],"used":[111],"clinically.":[112],"Cyclophosphamide":[113],"from":[116,457,751],"alkylating":[118],"relative":[122],"sparing":[123],"stem":[125,155,178,247,277,308,380,490,516,537,590,625,683,730,739,762,785,794],"cells,":[126,647],"whereas":[127],"radiation,":[128,235],"busulfan,":[129,230],"L-PAM,":[130],"nitrosoureas":[133],"are":[134,180,284,386,481,492,576,583,780,796],"potent":[135,175],"toxins.":[137],"Drugs":[138],"primarily":[139],"affecting":[140],"dividing":[141,154],"cells":[142,179,248,278,305,351,491,517,538,591,626,651,684,731,740,753,795],"(such":[143],"methotrexate,":[145],"fluorouracil,":[146],"vinblastine)":[148],"tend":[149],"spare":[151],"slowly":[153],"cells.":[156,309,335,763,786],"why":[159],"all":[161,455,653],"iatrogenic":[162],"depression":[164],"same.":[167],"When":[168,787],"caused":[169,189],"by":[170,190,346],"cycle-active":[171],"agents,":[172],"more":[174,181],"proliferatively":[176],"inactive":[177],"likely":[182],"spared":[183],"than":[184,495,758],"when":[185],"cytopenia":[187],"busulfan":[191],"or":[192,385,666,803],"radiation.":[193,565],"Although":[194,633],"bone":[195,222,499,719],"marrow":[196,223,243],"toxicity":[197],"still":[199,323],"important,":[200],"become":[207],"increasingly":[208],"important.":[209],"We":[210,310,483,578],"recognized":[211],"importance":[213],"stroma":[216],"supporting":[218],"hematopoiesis":[219,342],"demonstrated":[225],"detrimental":[227],"effects":[228,255],"L-pam,":[231],"nitrosoureas,":[233],"ionizing":[234,564],"aging":[237],"ability":[240,658],"support":[245,799],"transplanted":[246],"resulting":[251],"hematopoiesis.":[252,800],"Similar":[253],"stromal":[254],"should":[256,551],"be":[257,344,424,429,733,767],"equally":[258],"critical":[259],"tissues.":[263],"Since":[264],"time":[266,355],"this":[268,370,394,502,614],"review,":[269],"CNS":[271],"shown":[274],"have":[276,656,686,755],"present":[279,768],"adult,":[282],"which":[283,476],"for":[286,382,612,628],"cell":[287,381,477,635,713],"renewal":[288,478,714],"after":[289],"injury.":[290],"major":[292],"concept":[293],"understanding":[296,331,436,613],"heterogeneity":[303,737],"classified":[306],"believe":[311],"that":[312,339,485,511,685,775],"model":[314,449,611],"suggested":[315,450],"Figure":[317],"1":[318],"valid.":[324],"What":[325],"needed":[327],"greater":[330],"founder":[334,350,752],"If":[336],"clonal":[337,371],"succession":[338,372,765],"allows":[340],"provided":[345],"only":[347,431],"a":[348,353,378,416,609,668,788],"few":[349],"given":[354],"true":[357,504],"mice,":[359],"what":[360],"can":[361,773],"we":[362],"say":[363],"about":[364],"humans?":[365],"Most":[366,460],"importantly,":[367],"how":[368],"controlled?":[373],"Is":[374,414],"selection":[376,402],"particular":[379,405],"division":[383],"stochastic,":[384],"there":[387,415,433,512,619,779],"determining":[388],"causes?":[389],"One":[390,706],"may":[391,423,428,707,732,754,766],"think":[392],"similar":[396,417],"radioactive":[398],"decay,":[399],"where":[400],"nucleus":[406],"decay":[408],"probabilistic":[412],"terms.":[413],"biologic":[418],"uncertainty":[419],"principle?":[420],"Probabilistic":[421],"notions":[422],"appropriate":[425],"but":[426,501],"these":[427,467,582],"necessary":[430],"insufficient":[435],"biology":[440],"compartment.":[444],"information":[446],"underlying":[447],"derived":[456,750],"murine":[458],"studies.":[459],"today":[462],"ascertain":[465],"whether":[466,581,600,709],"concepts":[468],"pertain":[469],"man":[471],"and,":[472,597],"if":[473,598],"so,":[474,599],"systems":[479],"they":[480],"present.":[482],"know":[484],"mice":[487],"circulating":[489],"less":[493,556],"robust":[494],"those":[496,690,759],"marrow,":[500,720],"average":[506],"does":[508],"mean":[510],"aren\u2019t":[513],"some":[514,674,777],"early":[515],"regularly":[518],"circulating.":[519],"More":[520],"clinical":[523],"point":[524],"nature":[527],"traffic":[530,540,549],"humans.":[532],"Recent":[533],"studies":[534],"neuronal":[536],"suggest":[539],"within":[541],"CNS.":[543],"Knowing":[544],"location,":[546],"robustness,":[547],"dynamics":[550],"greatly":[552],"help":[553],"fashioning":[555],"toxic":[557],"therapies,":[558],"particularly":[559],"regional":[560],"therapies":[561],"such":[562,716],"As":[566],"new":[567,574,662,793],"types":[568],"treatment":[570],"cancer":[572],"emerge,":[573],"toxicities":[575],"produced.":[577],"must":[579],"determine":[580],"result":[585],"organ":[594],"risk":[596],"useful":[610],"toxicity.":[615],"Twenty-five":[616],"ago":[618],"no":[621],"suggestion":[622],"tumor":[624,629,650,682,729],"responsible":[627],"growth":[630],"metastasis.":[632],"appreciable":[634],"death":[636],"terminal":[638,645],"maturation":[639],"were":[640,652],"noted":[641],"necrosis":[643],"differentiated":[646],"respectively,":[648],"viable":[649],"believed":[654],"proliferate":[660],"into":[661],"situ":[665],"distant":[669],"site.":[670],"There":[671],"now":[673],"evidence":[675],"for,":[676],"discussion":[679],"of,":[680],"possible":[681],"properties":[687],"reminiscent":[688],"system:":[694],"slow":[695],"proliferation,":[696],"limited":[697],"differentiation":[698],"markers,":[699],"both":[701,781],"self-renewing":[702],"maturing":[704],"progeny.":[705],"wonder":[708],"lymphatic":[721],"tissue,":[722],"skin,":[723],"GI":[725],"system,":[726],"putative":[728],"deviants.":[735],"Perhaps":[736],"described":[741],"tumors.":[748],"Tumors":[749],"prognoses":[757],"later":[761],"Clonal":[764],"one":[772],"imagine":[774],"leukemias":[778],"malignant":[784],"complete":[789],"remission":[790],"occurs,":[791],"recruited":[797],"Does":[801],"chance":[802],"definable":[804],"JOURNAL":[805],"OF":[806],"CLINICAL":[807],"ONCOLOGY":[808],"C":[809,830],"E":[810,812,823],"L":[811],"B":[813],"R":[814,825],"A":[815,824],"T":[816],"I":[817],"N":[818],"G":[819],"2":[820,837],"5":[821],"Y":[822],"S":[826],"O":[827,831],"F":[828],"J":[829],"VOLUME":[832],"26":[833],"NUMBER":[834],"6":[835],"FEBRUARY":[836]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}