{"id":"https://openalex.org/W1994254993","doi":"https://doi.org/10.1111/febs.12810","title":"SIRT 2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors","display_name":"SIRT 2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors","publication_year":2014,"publication_date":"2014-04-08","ids":{"openalex":"https://openalex.org/W1994254993","doi":"https://doi.org/10.1111/febs.12810","mag":"1994254993","pmid":"https://pubmed.ncbi.nlm.nih.gov/24712640"},"language":"en","primary_location":{"id":"doi:10.1111/febs.12810","doi":"https://doi.org/10.1111/febs.12810","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.12810","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110087573","display_name":"Toshiaki Inoue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265336","display_name":"Chromosome Engineering Research Center","ror":"https://ror.org/04gsg8b22","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405265336","https://openalex.org/I4588055"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshiaki Inoue","raw_affiliation_strings":["Chromosome Engineering Research Center, Tottori University, Japan","Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chromosome Engineering Research Center, Tottori University, Japan","institution_ids":["https://openalex.org/I4405265336","https://openalex.org/I4588055"]},{"raw_affiliation_string":"Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yuji Nakayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Nakayama","raw_affiliation_strings":["Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Functional Genomics, Research Center for Bioscience and Technology, Tottori University, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089860490","display_name":"Yanze Li","orcid":"https://orcid.org/0000-0002-8771-7279","observed_orcids":["https://orcid.org/0000-0002-8771-7279"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yanze Li","raw_affiliation_strings":["Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Japan","Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Japan","institution_ids":["https://openalex.org/I4588055"]},{"raw_affiliation_string":"Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037843839","display_name":"Haruka Matsumori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruka Matsumori","raw_affiliation_strings":["Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082442758","display_name":"Haruka Takahashi","orcid":"https://orcid.org/0000-0002-2025-4302","observed_orcids":["https://orcid.org/0000-0002-2025-4302","https://orcid.org/0000-0002-3304-3256"]},"institutions":[{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Haruka Takahashi","raw_affiliation_strings":["Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108725627","display_name":"Hirotada Kojima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotada Kojima","raw_affiliation_strings":["Department of Immunology, Osaka City University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, Osaka City University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085745863","display_name":"Hideki Wanibuchi","orcid":"https://orcid.org/0000-0001-9362-4290","observed_orcids":["https://orcid.org/0000-0001-9362-4290"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideki Wanibuchi","raw_affiliation_strings":["Department of Pathology, Osaka City University Graduate School of Medicine, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Osaka City University Graduate School of Medicine, Japan","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111684857","display_name":"Motonobu Katoh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265336","display_name":"Chromosome Engineering Research Center","ror":"https://ror.org/04gsg8b22","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405265336","https://openalex.org/I4588055"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Motonobu Katoh","raw_affiliation_strings":["Chromosome Engineering Research Center, Tottori University, Japan","Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chromosome Engineering Research Center, Tottori University, Japan","institution_ids":["https://openalex.org/I4405265336","https://openalex.org/I4588055"]},{"raw_affiliation_string":"Division of Human Genome Science, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan","institution_ids":["https://openalex.org/I4588055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108409966","display_name":"Mitsuo Oshimura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265336","display_name":"Chromosome Engineering Research Center","ror":"https://ror.org/04gsg8b22","country_code":"JP","type":"education","lineage":["https://openalex.org/I4405265336","https://openalex.org/I4588055"]},{"id":"https://openalex.org/I4588055","display_name":"Tottori University","ror":"https://ror.org/024yc3q36","country_code":"JP","type":"education","lineage":["https://openalex.org/I4588055"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuo Oshimura","raw_affiliation_strings":["Chromosome Engineering Research Center, Tottori University, Japan","Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chromosome Engineering Research Center, Tottori University, Japan","institution_ids":["https://openalex.org/I4405265336","https://openalex.org/I4588055"]},{"raw_affiliation_string":"Department of Biomedical Science, Institute of Regenerative Medicine and Biofunction, Graduate School of Medical Science, Tottori University, Japan","institution_ids":["https://openalex.org/I4588055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5110087573"],"corresponding_institution_ids":["https://openalex.org/I4405265336","https://openalex.org/I4588055"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":2.2411,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.86690647,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"281","issue":"11","first_page":"2623","last_page":"2637"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.6273999810218811,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.353300005197525,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11051","display_name":"Sirtuins and Resveratrol in Medicine","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirt2","display_name":"SIRT2","score":1.0},{"id":"https://openalex.org/keywords/basal-autophagy","display_name":"basal autophagy","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mitotic-arrest","display_name":"mitotic arrest","score":0.6610000133514404},{"id":"https://openalex.org/keywords/mitotic-slippage","display_name":"mitotic slippage","score":0.7749999761581421},{"id":"https://openalex.org/keywords/mitotic-catastrophe","display_name":"mitotic catastrophe","score":0.7720000147819519},{"id":"https://openalex.org/keywords/microtubule-inhibitors","display_name":"microtubule inhibitors","score":0.9660000205039978},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.9259999990463257},{"id":"https://openalex.org/keywords/tetraploidy","display_name":"tetraploidy","score":0.8790000081062317},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7049999833106995},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.7620000243186951},{"id":"https://openalex.org/keywords/starvation","display_name":"starvation","score":0.6700000166893005},{"id":"https://openalex.org/keywords/cancer-therapy-targets","display_name":"cancer therapy targets","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9312005639076233},{"id":"https://openalex.org/C199848840","wikidata":"https://www.wikidata.org/wiki/Q18036605","display_name":"SIRT2","level":5,"score":0.7933188676834106},{"id":"https://openalex.org/C186000732","wikidata":"https://www.wikidata.org/wiki/Q6881914","display_name":"Mitotic catastrophe","level":4,"score":0.7533837556838989},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7319455146789551},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.6940325498580933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6805013418197632},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5441256165504456},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.48681899905204773},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.44319960474967957},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3615952432155609},{"id":"https://openalex.org/C2780561631","wikidata":"https://www.wikidata.org/wiki/Q421331","display_name":"Sirtuin","level":4,"score":0.2152642011642456},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1676723062992096},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.1145385205745697},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08732753992080688},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045325","descriptor_name":"HCT116 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050257","descriptor_name":"Tubulin Modulators","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D056564","descriptor_name":"Sirtuin 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D056565","descriptor_name":"Sirtuin 2","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D056565","descriptor_name":"Sirtuin 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/febs.12810","doi":"https://doi.org/10.1111/febs.12810","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.12810","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:24712640","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24712640","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W1613698504","https://openalex.org/W1969886832","https://openalex.org/W1976232839","https://openalex.org/W1977345614","https://openalex.org/W1977767269","https://openalex.org/W1982883159","https://openalex.org/W1982973163","https://openalex.org/W1983919608","https://openalex.org/W1989529289","https://openalex.org/W1995176982","https://openalex.org/W1997367417","https://openalex.org/W1997525095","https://openalex.org/W1998192361","https://openalex.org/W1998631287","https://openalex.org/W2003965576","https://openalex.org/W2006201075","https://openalex.org/W2011788275","https://openalex.org/W2018463433","https://openalex.org/W2026143081","https://openalex.org/W2036729837","https://openalex.org/W2040773347","https://openalex.org/W2044819384","https://openalex.org/W2045992894","https://openalex.org/W2046232891","https://openalex.org/W2052268533","https://openalex.org/W2076753965","https://openalex.org/W2079282879","https://openalex.org/W2081057817","https://openalex.org/W2085170551","https://openalex.org/W2097153041","https://openalex.org/W2102614059","https://openalex.org/W2111567059","https://openalex.org/W2117875646","https://openalex.org/W2118964113","https://openalex.org/W2119775441","https://openalex.org/W2129899300","https://openalex.org/W2131817855","https://openalex.org/W2137067692","https://openalex.org/W2142154032","https://openalex.org/W2144554317","https://openalex.org/W2146887271","https://openalex.org/W2147903962","https://openalex.org/W2154603906","https://openalex.org/W2164778558","https://openalex.org/W2167656141","https://openalex.org/W2168702014","https://openalex.org/W2171155178","https://openalex.org/W2314909091","https://openalex.org/W4238843411","https://openalex.org/W7097574187","https://openalex.org/W7099558388"],"related_works":["https://openalex.org/W4282013475","https://openalex.org/W2036729837","https://openalex.org/W2041640995","https://openalex.org/W2402889164","https://openalex.org/W2990726880","https://openalex.org/W2741684534","https://openalex.org/W2957983868","https://openalex.org/W1606024367","https://openalex.org/W7219219486","https://openalex.org/W4361011701"],"abstract_inverted_index":{"Mitotic":[0],"catastrophe,":[1,47],"a":[2,16,42,66,79,86,94,198,226,247],"form":[3],"of":[4,25,69,88,96,136,171,176,212],"cell":[5,27],"death":[6,77],"that":[7,58,110,141],"occurs":[8],"during":[9],"mitosis":[10],"and":[11,48,82,107,139,160,178,218],"after":[12,65,214],"mitotic":[13,34,46,164,205,241],"slippage":[14],"to":[15,53,216,220],"tetraploid":[17,80],"state,":[18,81],"plays":[19],"important":[20],"roles":[21],"in":[22,109,129,173,190],"the":[23,37,89,174],"efficacy":[24],"cancer":[26],"killing":[28],"by":[29,36,114,121,133,149,158,182],"microtubule":[30],"inhibitors":[31],"(MTIs).":[32],"Prolonged":[33],"arrest":[35,165,206],"spindle":[38,61],"assembly":[39,62],"checkpoint":[40,63],"is":[41,71,116],"well-known":[43],"requirement":[44,73],"for":[45,50,74,118,166,207,250],"thus":[49],"conferring":[51],"sensitivity":[52],"MTIs.":[54,221],"We":[55,131],"previously":[56],"reported":[57],"turning":[59],"off":[60],"activation":[64],"defined":[67],"period":[68,170,211],"time":[70,172,213],"another":[72],"efficient":[75],"postslippage":[76,119,184],"from":[78],"we":[83,100],"identified":[84],"SIRT2,":[85,140],"member":[87],"sirtuin":[90],"protein":[91],"family,":[92],"as":[93,225,236],"regulator":[95],"this":[97,144,179,230],"process.":[98],"Here,":[99],"investigated":[101],"whether":[102],"SIRT2":[103,115,142,193,245],"regulates":[104],"basal":[105,151],"autophagy":[106,112,137,152,156,203,223,238],"whether,":[108],"case,":[111],"regulation":[113],"required":[117],"death,":[120,185],"analogy":[122],"with":[123,192],"previous":[124],"insights":[125],"into":[126],"SIRT1":[127],"functions":[128],"autophagy.":[130],"show,":[132],"combined":[134],"knockdown":[135],"genes":[138],"serves":[143],"function":[145],"at":[146],"least":[147],"partially":[148],"suppressing":[150],"levels.":[153],"Notably,":[154],"increased":[155,202,237],"induced":[157],"rapamycin":[159],"mild":[161],"starvation":[162],"caused":[163],"an":[167,208],"abnormally":[168,209],"long":[169,210],"presence":[175],"MTIs,":[177,217],"was":[180,187],"followed":[181],"delayed":[183],"which":[186],"also":[188],"observed":[189],"cells":[191],"knockdown.":[194],"These":[195],"results":[196],"underscore":[197],"causal":[199],"association":[200],"among":[201],"levels,":[204],"exposure":[215],"resistance":[219],"Although":[222],"acts":[224],"tumor":[227,251],"suppressor":[228],"mechanism,":[229],"study":[231],"highlights":[232],"its":[233],"negative":[234],"aspects,":[235],"may":[239],"cause":[240],"catastrophe":[242],"malfunction.":[243],"Thus,":[244],"offers":[246],"novel":[248],"target":[249],"therapy.":[252]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}