{"id":"https://openalex.org/W1994190865","doi":"https://doi.org/10.1021/bi901669q","title":"A Thiolate Anion Buried within the Hydrocarbon Ruler Perturbs PagP Lipid Acyl Chain Selection","display_name":"A Thiolate Anion Buried within the Hydrocarbon Ruler Perturbs PagP Lipid Acyl Chain Selection","publication_year":2010,"publication_date":"2010-02-23","ids":{"openalex":"https://openalex.org/W1994190865","doi":"https://doi.org/10.1021/bi901669q","mag":"1994190865","pmid":"https://pubmed.ncbi.nlm.nih.gov/20175558","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5007130"},"language":"en","primary_location":{"id":"doi:10.1021/bi901669q","doi":"https://doi.org/10.1021/bi901669q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi901669q","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5007130/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114084922","display_name":"M. Adil Khan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287412","display_name":"Michael G. DeGroote Institute for Infectious Disease Research","ror":"https://ror.org/053905274","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405287412","https://openalex.org/I98251732"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"M. Adil Khan","raw_affiliation_strings":["Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I4405287412","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020517655","display_name":"Joel Moktar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405287412","display_name":"Michael G. DeGroote Institute for Infectious Disease Research","ror":"https://ror.org/053905274","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405287412","https://openalex.org/I98251732"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Joel Moktar","raw_affiliation_strings":["Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I4405287412","https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036713634","display_name":"Patrick J. Mott","orcid":"https://orcid.org/0000-0003-4687-251X","observed_orcids":["https://orcid.org/0000-0003-4687-251X"]},"institutions":[{"id":"https://openalex.org/I4405287412","display_name":"Michael G. DeGroote Institute for Infectious Disease Research","ror":"https://ror.org/053905274","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405287412","https://openalex.org/I98251732"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Patrick J. Mott","raw_affiliation_strings":["Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I4405287412","https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004854655","display_name":"Russell E. Bishop","orcid":"https://orcid.org/0000-0002-5043-0784","observed_orcids":["https://orcid.org/0000-0002-5043-0784"]},"institutions":[{"id":"https://openalex.org/I4405287412","display_name":"Michael G. DeGroote Institute for Infectious Disease Research","ror":"https://ror.org/053905274","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4405287412","https://openalex.org/I98251732"]},{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Russell E. Bishop","raw_affiliation_strings":["Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada L8N 3Z5"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada L8N 3Z5","institution_ids":["https://openalex.org/I4405287412","https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004854655"],"corresponding_institution_ids":["https://openalex.org/I4405287412","https://openalex.org/I98251732"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6372,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.6184449,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"49","issue":"11","first_page":"2368","last_page":"2379"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.8163999915122986,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.12890000641345978,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.019099999219179153,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pagp","display_name":"PagP","score":0.9860000014305115},{"id":"https://openalex.org/keywords/thiolate-anion","display_name":"thiolate anion","score":0.902999997138977},{"id":"https://openalex.org/keywords/cysteine-pka","display_name":"cysteine pKa","score":0.703000009059906},{"id":"https://openalex.org/keywords/exciton-interactions","display_name":"exciton interactions","score":0.6349999904632568},{"id":"https://openalex.org/keywords/beta-barrel-proteins","display_name":"beta-barrel proteins","score":0.6119999885559082},{"id":"https://openalex.org/keywords/thermal-stability","display_name":"thermal stability","score":0.6899999976158142},{"id":"https://openalex.org/keywords/escherichia-coli-outer-membrane","display_name":"Escherichia coli outer membrane","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6632822751998901},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3868853747844696},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3657721281051636},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.33933764696121216},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.32698503136634827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.08425876498222351}],"mesh":[{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000217","descriptor_name":"Acyltransferases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003902","descriptor_name":"Detergents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004795","descriptor_name":"Enzyme Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005960","descriptor_name":"Glucosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006838","descriptor_name":"Hydrocarbons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011489","descriptor_name":"Protein Denaturation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011522","descriptor_name":"Protons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013438","descriptor_name":"Sulfhydryl Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019791","descriptor_name":"Guanidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D050356","descriptor_name":"Lipid Metabolism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/bi901669q","doi":"https://doi.org/10.1021/bi901669q","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi901669q","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:20175558","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20175558","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5007130","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5007130/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5007130","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5007130/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochemistry","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4608644166","display_name":"Enzymatic modification of endotoxins","funder_award_id":"84329_1","funder_id":"https://openalex.org/F4320334506","funder_display_name":"Canadian Institutes of Health Research"}],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W652646270","https://openalex.org/W1510619113","https://openalex.org/W1512374553","https://openalex.org/W1522802334","https://openalex.org/W1532387244","https://openalex.org/W1541838625","https://openalex.org/W1552944091","https://openalex.org/W1934130920","https://openalex.org/W1967725603","https://openalex.org/W1975722845","https://openalex.org/W1978955250","https://openalex.org/W1982308521","https://openalex.org/W1986704124","https://openalex.org/W1991358290","https://openalex.org/W2003112779","https://openalex.org/W2006979726","https://openalex.org/W2010519412","https://openalex.org/W2014361215","https://openalex.org/W2029224565","https://openalex.org/W2034541624","https://openalex.org/W2036032390","https://openalex.org/W2042290438","https://openalex.org/W2042814467","https://openalex.org/W2047376279","https://openalex.org/W2053843767","https://openalex.org/W2063968553","https://openalex.org/W2070144513","https://openalex.org/W2072494970","https://openalex.org/W2073578515","https://openalex.org/W2078481695","https://openalex.org/W2091664813","https://openalex.org/W2098933865","https://openalex.org/W2102746809","https://openalex.org/W2111967267","https://openalex.org/W2119586900","https://openalex.org/W2121372091","https://openalex.org/W2122698861","https://openalex.org/W2124530114","https://openalex.org/W2125102406","https://openalex.org/W2129093332","https://openalex.org/W2151980911","https://openalex.org/W2152490783","https://openalex.org/W2156961003","https://openalex.org/W2160084442","https://openalex.org/W2171780940","https://openalex.org/W2314225431","https://openalex.org/W3192085238","https://openalex.org/W4232534952"],"related_works":["https://openalex.org/W2047376279","https://openalex.org/W2113860584","https://openalex.org/W7020999488","https://openalex.org/W2125102406","https://openalex.org/W7132996814","https://openalex.org/W2053843767","https://openalex.org/W7097294329","https://openalex.org/W2018593287","https://openalex.org/W782438281","https://openalex.org/W2102746809"],"abstract_inverted_index":{"The":[0,89,161],"Escherichia":[1],"coli":[2],"outer":[3],"membrane":[4],"phospholipid:lipid":[5],"A":[6,231],"palmitoyltransferase":[7],"PagP":[8,91,224,239],"exhibits":[9],"remarkable":[10],"selectivity":[11],"because":[12],"its":[13,58],"binding":[14,54],"pocket":[15,36,55,188],"for":[16,246],"lipid":[17,230,248],"acyl":[18,52,69,249],"chains":[19],"excludes":[20],"those":[21],"differing":[22],"in":[23,124,151,156,226,233,238],"length":[24],"from":[25,135,149],"palmitate":[26],"by":[27,201],"a":[28,98,119,136,170,173,217,242],"solitary":[29],"methylene":[30],"unit.":[31],"This":[32],"narrow":[33],"detergent-binding":[34],"hydrophobic":[35,185],"buried":[37,137],"within":[38],"the":[39,46,51,62,67,102,115,131,144,157,167,183,192,197],"eight-strand":[40],"antiparallel":[41],"beta-barrel":[42,175],"is":[43,164],"known":[44],"as":[45,97,216],"hydrocarbon":[47,158,186],"ruler.":[48],"Gly88":[49],"lines":[50],"chain":[53,250],"floor,":[56],"and":[57,77,109,117,172,206],"substitution":[59],"can":[60],"raise":[61],"floor":[63],"to":[64,87,95,141,154,190,210],"correspondingly":[65],"shorten":[66],"selected":[68,106],"chain.":[70],"An":[71],"aromatic":[72],"exciton":[73,205],"interaction":[74],"between":[75,169],"Tyr26":[76],"Trp66":[78],"provides":[79],"an":[80],"intrinsic":[81],"spectroscopic":[82],"probe":[83],"located":[84],"immediately":[85],"adjacent":[86],"Gly88.":[88],"Gly88Cys":[90,211,223],"enzyme":[92,104],"was":[93,112],"engineered":[94],"function":[96],"dedicated":[99,218],"myristoyltransferase,":[100],"but":[101],"mutant":[103],"instead":[105],"both":[107],"myristoyl":[108],"pentadecanoyl":[110],"groups,":[111],"devoid":[113],"of":[114,143,196],"exciton,":[116],"displayed":[118],"21":[120],"degrees":[121],"C":[122],"reduction":[123],"thermal":[125,207],"stability.":[126],"We":[127],"now":[128],"demonstrate":[129],"that":[130,179],"structural":[132],"perturbation":[133],"results":[134],"thiolate":[138,199],"anion":[139,200],"attributed":[140],"suppression":[142],"Cys":[145,162,198],"sulfhydryl":[146],"group":[147],"pK(a)":[148],"9.4":[150],"aqueous":[152],"solvent":[153],"7.5":[155],"ruler":[159,187],"microenvironment.":[160],"thiol":[163,193],"sandwiched":[165],"at":[166,220],"interface":[168],"nonpolar":[171],"polar":[174],"interior":[176],"milieu,":[177],"suggesting":[178],"local":[180],"electrostatics":[181],"near":[182],"otherwise":[184],"serve":[189],"perturb":[191],"pK(a).":[194],"Neutralization":[195],"protonation":[202],"restores":[203],"wild-type":[204],"stability":[208],"signatures":[209],"PagP,":[212],"which":[213],"then":[214],"functions":[215],"myristoyltransferase":[219],"pH":[221],"7.":[222],"assembled":[225],"bacterial":[227],"membranes":[228],"recapitulates":[229],"myristoylation":[232],"vivo.":[234],"Hydrocarbon":[235],"ruler-exciton":[236],"coupling":[237],"thus":[240],"reveals":[241],"thiol-thiolate":[243],"ionization":[244],"mechanism":[245],"modulating":[247],"selection.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
