{"id":"https://openalex.org/W1994136236","doi":"https://doi.org/10.1113/jphysiol.2007.129288","title":"It takes two to tango: the coherence of cardiac output and sympathetic nerve activity","display_name":"It takes two to tango: the coherence of cardiac output and sympathetic nerve activity","publication_year":2007,"publication_date":"2007-02-09","ids":{"openalex":"https://openalex.org/W1994136236","doi":"https://doi.org/10.1113/jphysiol.2007.129288","mag":"1994136236","pmid":"https://pubmed.ncbi.nlm.nih.gov/17289779","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2075431"},"language":"en","primary_location":{"id":"doi:10.1113/jphysiol.2007.129288","doi":"https://doi.org/10.1113/jphysiol.2007.129288","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2007.129288","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2075431","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029356323","display_name":"C. T. Paul Krediet","orcid":"https://orcid.org/0000-0002-3433-6907","observed_orcids":["https://orcid.org/0000-0002-3433-6907"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]},{"id":"https://openalex.org/I2802928900","display_name":"Amsterdam UMC Location University of Amsterdam","ror":"https://ror.org/03t4gr691","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802928900","https://openalex.org/I4210151833"]},{"id":"https://openalex.org/I887064364","display_name":"University of Amsterdam","ror":"https://ror.org/04dkp9463","country_code":"NL","type":"education","lineage":["https://openalex.org/I887064364"]}],"countries":["NL","US"],"is_corresponding":true,"raw_author_name":"C. T. Paul Krediet","raw_affiliation_strings":["Mayo Clinic, Human and Integrative Physiology, Department of Anaesthesiology, 200 First Street SW, Rochester, MN 55905, USA. c.t.krediet@amc.nl","Mayo Clinic, Human and Integrative Physiology, Department of Anaesthesiology, 200 First Street SW, Rochester, MN 55905, USA","University of Amsterdam, Department of Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Human and Integrative Physiology, Department of Anaesthesiology, 200 First Street SW, Rochester, MN 55905, USA. c.t.krediet@amc.nl","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Human and Integrative Physiology, Department of Anaesthesiology, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"University of Amsterdam, Department of Internal Medicine, Academic Medical Center, Meibergdreef 9, 1105AZ, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I2802928900","https://openalex.org/I887064364"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069789159","display_name":"Maile L. Ceridon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maile L. Ceridon","raw_affiliation_strings":["Mayo Clinic, Human and Integrative Physiology, Department of Anaesthesiology, 200 First Street SW, Rochester, MN 55905, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Human and Integrative Physiology, Department of Anaesthesiology, 200 First Street SW, Rochester, MN 55905, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5029356323"],"corresponding_institution_ids":["https://openalex.org/I1330342723","https://openalex.org/I2802928900","https://openalex.org/I887064364"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":null,"fwci":0.7012,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.75934591,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":96},"biblio":{"volume":"580","issue":"1","first_page":"9","last_page":"11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.7339000105857849,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.21529999375343323,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.03660000115633011,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.8820000290870667},{"id":"https://openalex.org/keywords/sympathetic-nerve-activity","display_name":"sympathetic activity","score":0.8769999742507935},{"id":"https://openalex.org/keywords/muscle-sympathetic-nerve-activity","display_name":"muscle sympathetic nerve activity","score":0.949999988079071},{"id":"https://openalex.org/keywords/blood-pressure-control","display_name":"blood pressure control","score":0.6769999861717224},{"id":"https://openalex.org/keywords/baroreflex","display_name":"baroreflex","score":0.8370000123977661},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.9419999718666077},{"id":"https://openalex.org/keywords/sympathetic-vasoconstriction","display_name":"sympathetic vasoconstriction","score":0.6489999890327454},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.375},{"id":"https://openalex.org/keywords/autonomic-nervous-system","display_name":"autonomic nervous system","score":0.4569999873638153},{"id":"https://openalex.org/keywords/microneurography","display_name":"microneurography","score":0.7049999833106995},{"id":"https://openalex.org/keywords/beat-to-beat-variability","display_name":"beat-to-beat variability","score":0.4950000047683716},{"id":"https://openalex.org/keywords/heart-rate-variability","display_name":"heart rate variability","score":0.45399999618530273},{"id":"https://openalex.org/keywords/baroreflex-sensitivity","display_name":"baroreflex sensitivity","score":0.5540000200271606}],"concepts":[{"id":"https://openalex.org/C2775898464","wikidata":"https://www.wikidata.org/wiki/Q3312240","display_name":"Microneurography","level":5,"score":0.8337490558624268},{"id":"https://openalex.org/C191237925","wikidata":"https://www.wikidata.org/wiki/Q808725","display_name":"Baroreflex","level":4,"score":0.7660616636276245},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.6312520503997803},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6199996471405029},{"id":"https://openalex.org/C2777372248","wikidata":"https://www.wikidata.org/wiki/Q171064","display_name":"Autonomic nervous system","level":4,"score":0.5690263509750366},{"id":"https://openalex.org/C2776533406","wikidata":"https://www.wikidata.org/wiki/Q187215","display_name":"Sympathetic nervous system","level":3,"score":0.5620288252830505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5213955044746399},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5084449052810669},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48058104515075684},{"id":"https://openalex.org/C33114225","wikidata":"https://www.wikidata.org/wiki/Q7370060","display_name":"Rostral ventrolateral medulla","level":4,"score":0.46891745924949646},{"id":"https://openalex.org/C2780761756","wikidata":"https://www.wikidata.org/wiki/Q185589","display_name":"Parasympathetic nervous system","level":5,"score":0.4212665259838104},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3281710743904114}],"mesh":[{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013564","descriptor_name":"Sympathetic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016683","descriptor_name":"Supine Position","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017704","descriptor_name":"Baroreflex","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D018667","descriptor_name":"Tilt-Table Test","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1113/jphysiol.2007.129288","doi":"https://doi.org/10.1113/jphysiol.2007.129288","is_oa":false,"landing_page_url":"https://doi.org/10.1113/jphysiol.2007.129288","pdf_url":null,"source":{"id":"https://openalex.org/S2090548","display_name":"The Journal of Physiology","issn_l":"0022-3751","issn":["0022-3751","1469-7793"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Physiology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2075431","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2075431","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},{"id":"pmid:17289779","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17289779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of physiology","raw_type":"Comment"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire_cris_publications/9239a9f3-4a9f-4309-8d51-85c14c29f574","doi":null,"is_oa":false,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/9239a9f3-4a9f-4309-8d51-85c14c29f574","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Krediet, C T P & Ceridon, A L 2007, 'It takes two to tango: the coherence of cardiac output and sympathetic nerve activity', Journal of physiology, vol. 580, no. 1, pp. 9-11. https://doi.org/10.1113/jphysiol.2007.129288","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:amcpub:oai:pure.amc.nl:publications/3122769c-26aa-4473-8551-5ea882892132","doi":null,"is_oa":false,"landing_page_url":"https://pure.amc.nl/en/publications/it-takes-two-to-tango-the-coherence-of-cardiac-output-and-sympathetic-nerve-activity(3122769c-26aa-4473-8551-5ea882892132).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of physiology, 580(1), 9 - 11. Wiley-Blackwell","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2075431","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2075431","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Physiol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":5,"referenced_works":["https://openalex.org/W1575064221","https://openalex.org/W1613720875","https://openalex.org/W1987270666","https://openalex.org/W1998275628","https://openalex.org/W2140374409"],"related_works":["https://openalex.org/W1613720875","https://openalex.org/W4409137215","https://openalex.org/W2323659401","https://openalex.org/W105995870","https://openalex.org/W1973131576","https://openalex.org/W2129953181","https://openalex.org/W1182342941","https://openalex.org/W1985716586","https://openalex.org/W2010767102","https://openalex.org/W2071690730"],"abstract_inverted_index":{"One":[0],"of":[1,14,48,67,84,138,187,264,290,307,415,455,466,524,557,584,597,614,621,646,658,754,816,846,955,997,1017,1125,1132,1151,1169,1196,1200,1230,1267,1274,1287,1336,1452,1467,1488,1515,1528,1562,1586,1614],"the":[2,10,65,90,99,102,113,123,136,139,182,254,262,296,411,516,529,543,547,589,594,609,619,622,655,684,690,740,743,820,837,842,853,901,913,953,976,995,998,1001,1049,1055,1065,1096,1123,1126,1129,1133,1170,1174,1178,1182,1186,1194,1241,1246,1254,1263,1271,1275,1279,1285,1288,1324,1350,1399,1418,1468,1516,1537,1542,1615,1621,1625],"current":[3,1179],"challenges":[4],"in":[5,24,45,175,190,274,316,542,654,925,994,1008,1034,1095,1122,1156,1173,1177,1212,1221,1296,1333,1344,1421,1427],"human":[6],"physiology":[7],"is":[8,23,64,87,148,286,303,313,375,885,1061,1117,1128,1238,1259,1326,1430,1445,1482,1618,1633],"integrating":[9],"accepted":[11,843],"qualitative":[12,844],"components":[13],"blood":[15,61,85,96,333,356,490,551,567,631,849,1214,1425],"pressure":[16,62,86,97,357,491,552,568,632,850,1051,1215,1426,1523],"control":[17,83,414,443,613],"into":[18,1041,1120],"a":[19,37,56,191,265,287,304,341,389,393,473,477,601,814,906,917,961,988,1014,1079,1085,1149,1197,1209,1224,1298,1309,1382,1407,1414,1448,1472,1526,1551,1568],"coherent":[20],"model":[21,1415],"that":[22,41,94,178,282,367,386,441,856,1031,1053,1077,1116,1142,1327,1405],"agreement":[25,926,1222],"with":[26,246,261,331,354,388,476,852,927,1223],"empirical":[27,39,854],"data.":[28,1026],"For":[29,1560],"this":[30,32,401,981,1143,1480,1546],"purpose,":[31],"Journal":[33,47],"Club":[34],"article":[35],"discusses":[36],"provocative":[38],"study":[40,530,1127,1140,1289,1325],"was":[42,504,600,616,679,687,693,759,774,785],"recently":[43],"published":[44],"The":[46,81,757,826,871,1011,1204,1579],"Physiology":[49],"by":[50,89,144,828,1103,1146,1245,1270,1290,1381,1620],"Fu":[51,403,829,1291],"et":[52,237,278,336,349,363,404,830,950,1111,1162,1292,1457,1461],"al.":[53,238,279,337,350,364,405,831,951,1163,1293,1458,1462],"(2006).":[54],"On":[55],"beat-to-beat":[57],"basis,":[58],"mean":[59,796,1076,1372,1423],"arterial":[60,91,412,489,1373,1424,1522],"(MAP)":[63,1524],"product":[66],"cardiac":[68,146,183,864,1366,1529],"output":[69,865,1367,1530],"(CO)":[70,1435,1531],"and":[71,105,119,122,217,256,272,381,397,431,439,486,495,514,521,629,635,643,683,701,747,752,763,771,809,824,866,877,894,911,1019,1024,1060,1100,1185,1278,1303,1315,1342,1365,1464,1506,1509,1511,1518,1532,1596,1605,1624],"total":[72,487,626,772,800,956,1312],"peripheral":[73,131,192,1313],"resistance":[74,1314],"(TPR)":[75],"(MAP":[76],"=":[77,1434],"CO":[78,143,380,391,503,682,702,919,1508],"\u00d7":[79,697,1436],"TPR).":[80],"short-term":[82,847],"regulated":[88],"baroreflex":[92,413,442,651],"system":[93,115,125,141],"influences":[95],"via":[98],"parasympathetic":[100,114],"(i.e.":[101,161,806,1046,1574],"vagus":[103],"nerve)":[104],"sympathetic":[106,124,140,163,188,247,292,1069],"nervous":[107],"system.":[108],"In":[109,240,932,1283,1477],"general,":[110],"during":[111,371,417,435,448,511,554,636,674,689,705,897,1216,1317],"rest":[112,285,373,751],"regulates":[116,130],"heart":[117,255,496,685,862],"rate,":[118,863],"thereby":[120,1512],"CO,":[121,425,912],"causes":[126],"arteriolar":[127,1056,1469],"vasoconstriction":[128,1101],"which":[129,197,937,1068,1422],"resistance.":[132],"(Under":[133],"resting":[134,241,355,395],"conditions":[135],"influence":[137],"on":[142,472,1202,1236,1339,1398,1610],"augmenting":[145],"contractility":[147],"thought":[149],"to":[150,157,181,250,295,326,409,463,546,563,577,604,664,710,712,716,718,726,728,777,788,836,840,888,895,934,947,958,969,975,1000,1006,1063,1067,1072,1088,1148,1261,1323,1361,1371,1417,1497],"be":[151,168,199,890,924,984,1220,1379,1495],"minor;":[152],"Rowell,":[153],"1993.)":[154],"Sympathetic":[155,650],"outflow":[156,1207],"skeletal":[158],"muscle":[159,162],"vasculature":[160,1057],"nerve":[164,193,1002],"activity,":[165],"MSNA)":[166],"can":[167,198,320,982,1003],"directly":[169],"assessed":[170,617,742],"using":[171,506,618,1406],"microneurography.":[172],"MSNA":[173,243,271,283,308,312,343,382,396,416,445,479,573,615,627,746,762,767,789,867,910,921,940,957,1018,1081,1099,1201,1206,1302,1316,1337,1364,1505,1534],"comes":[174],"surges":[176],"(\u2018bursts\u2019)":[177],"are":[179,433,540,1565],"synchronous":[180],"cycle.":[184],"Multi-unit":[185],"recordings":[186],"neurones":[189,971],"bundle":[194],"yields":[195],"MSNA,":[196,424,878],"expressed":[200],"as":[201,322,324,481,695,879,941,1306,1308,1346,1368,1447,1525,1550],"burst":[202,208,215,218,224,482,484,769,794,942,945,1009],"frequency":[203,216,770,946],"(bursts":[204,210],"per":[205,211,230],"minute)":[206,231,642],"or":[207,346,944],"incidence":[209,219,485,943],"100":[212],"beats).":[213],"Since":[214],"do":[220],"not":[221,570,671,904,1118,1330],"differentiate":[222],"among":[223,328,358,368,868,882,1153],"amplitudes,":[225],"\u2018total":[226],"activity\u2019":[227],"(arbitrary":[228],"units":[229,1592],"may":[232,1144,1166,1494],"give":[233],"additional":[234],"information":[235,835],"(Halliwill":[236,1110,1456],"1996).":[239],"subjects,":[242,318,884,893],"correlates":[244],"well":[245,1307],"vasoconstrictor":[248,293],"traffic":[249,1070],"other":[251],"tissues,":[252],"including":[253,1021],"kidney.":[257],"This":[258,1074,1165,1258,1375,1492,1631],"evidence,":[259],"along":[260],"observation":[263],"significant":[266],"correlation":[267,624],"(r=":[268],"0.61)":[269],"between":[270,379,625,745,874,909,1098,1301,1311],"TPR":[273,432,692,723,782,948,959,1089,1237,1268],"supine":[275,372,456,512,548,634,750,883,1023,1083],"subjects":[276,460,532,537,766,784,803,1155],"(Charkoudian":[277,335,348,949,1161],"2005),":[280,952],"suggests":[281],"at":[284,309,383,515,608,1484,1576],"reliable":[288],"index":[289],"\u2018net\u2019":[291],"activity":[294,628],"whole":[297],"body.":[298],"Among":[299,802],"normotensive":[300,329,369,869],"individuals":[301,330,370,387],"there":[302,374,599],"wide":[305],"variability":[306,993,1131],"baseline.":[310],"Resting":[311],"quite":[314],"reproducible":[315],"individual":[317],"but":[319,669],"vary":[321,1145],"much":[323],"7-":[325],"10-fold":[327],"similar":[332,907,1416],"pressures":[334],"2005,":[338,351],"2006).":[339,1164],"As":[340],"result,":[342],"has":[344,1084],"little":[345],"no":[347],"2006)":[352],"relationship":[353],"healthy":[359,459,1154],"subjects.":[360,870],"Recently":[361],"Charkoudian":[362,1460,1607],"(2005)":[365],"showed":[366,1141],"an":[376,507,928,1157,1234,1391,1611],"inverse":[377,872,929],"relation":[378,744,873,1087,1097,1300,1310],"baseline,":[384],"such":[385,1032],"high":[390],"exhibit":[392],"low":[394],"vice":[398],"versa.":[399],"Against":[400],"background,":[402],"(2006)":[406,832,1294],"set":[407,1540],"out":[408],"assess":[410],"prolonged":[418,449,1318],"orthostatic":[419,450,558,755,898,1183,1217,1319],"stress.":[420,451,899,1320],"They":[421],"studied":[422],"how":[423],"left":[426],"ventricular":[427],"stroke":[428,860,875,1304],"volume":[429,677,876],"(SV)":[430,678],"modulated":[434],"sustained":[436,1299],"upright":[437,1092],"posture":[438,1345],"hypothesized":[440],"over":[444,1567],"would":[446,923,1075,1219,1352],"subside":[447],"After":[452],"30":[453],"min":[454,465,583,596],"rest,":[457,513],"20":[458],"were":[461,500],"subjected":[462],"45":[464,595],"60":[467],"deg":[468],"head":[469,525,659,706],"up":[470,526,660,707,1147],"tilt":[471,474,585,598,661,708],"table":[475],"saddle.":[478],"(expressed":[480],"frequency,":[483],"activity),":[488],"(Finapres,":[492],"Ohmeda,":[493],"USA)":[494],"rate":[497,686],"(from":[498,662],"electrocardiogram)":[499],"continuously":[501],"measured.":[502],"measured":[505,688],"acetylene":[508],"rebreathing":[509],"technique,":[510],"5th,":[517],"10th,":[518],"20th,":[519],"30th":[520],"40th":[522],"minute":[523],"tilt.":[527,675],"During":[528,593],"seven":[531],"developed":[533],"presyncope,":[534],"leaving":[535],"13":[536],"whose":[538],"data":[539,855,914,1042,1539,1564],"included":[541],"paper.":[544,1180],"Compared":[545],"position,":[549],"diastolic":[550,630,1213],"increased":[553,574,653,724,1205],"all":[555],"stages":[556,645,753],"stress":[559,1045,1218],"(mean":[560,779,790],"from":[561,575,588,681,819,1208,1240,1253,1471,1541],"\u223c65":[562],"\u223c78":[564],"mmHg).":[565,1578],"Systolic":[566],"did":[569,670,903],"change":[571,672,1211],"significantly.":[572],"\u223c18":[576],"\u223c36":[578],"bursts":[579,606],"min\u22121":[580,607],"after":[581],"5":[582],"(data":[586],"derived":[587,818,1252],"authors":[590,741,902,1012,1255],"Figure":[591,1256],"2).":[592],"further":[602,673,1355],"increase":[603],"\u223c43":[605],"final":[610],"stage.":[611],"Baroreflex":[612],"slope":[620],"linear":[623,734,1015,1242,1384,1409],"while":[633,920,1082,1091],"early":[637],"(2nd\u20135th":[638],"minute),":[639],"middle":[640],"(17th\u201320th":[641],"late":[644],"tilting":[647],"(42nd\u201345th":[648],"minute).":[649],"sensitivity":[652],"first":[656],"stage":[657],"\u223c\u2212300":[663],"\u223c\u2212700":[665],"a.u.":[666,1598],"beat\u22121":[667],"mmHg\u22121),":[668],"Stroke":[676],"calculated":[680,694],"rebreathing.":[691],"MAP":[696,1433,1572],"CO\u22121.":[698],"Both":[699],"SV":[700,748,778],"decreased":[703],"progressively":[704],"(103":[709],"75":[711],"55":[713],"ml;":[714],"7.74":[715],"6.31":[717],"4.91":[719],"l":[720],"min\u22121),":[721],"whereas":[722],"(873":[725],"1247":[727],"1541":[729],"dyn":[730,1249],"s":[731,1250],"cm\u22125).":[732],"Using":[733],"regression":[735,908,954,1016,1385,1410],"analysis":[736,1386],"for":[737,761,793,799,1377,1394,1554,1608],"each":[738],"subject":[739],"(combining":[749],"stress).":[756],"same":[758],"done":[760,986,1380],"TPR.":[764,1203],"Within":[765],"(both":[768],"activity)":[773],"inversely":[775],"related":[776,787,939],"r=":[780,791,797],"0.88).":[781],"within":[783,892,987],"positively":[786],"0.82":[792],"incidence,":[795],"0.75":[798],"activity).":[801],"both":[804,1022],"relations":[805],"\u0394MSNA":[807],"\u00d7\u0394SV\u22121":[808],"\u0394TPR":[810],"\u00d7\u0394MSNA\u22121)":[811],"varied":[812],"(by":[813],"factor":[815,1115,1150,1450],"\u223c2\u20135,":[817],"authors'":[821,1247],"Figures":[822],"3":[823,1556],"5).":[825],"paper":[827,1351,1544],"contributes":[833],"important":[834],"ongoing":[838],"efforts":[839],"unify":[841],"mechanisms":[845],"(efferent)":[848],"regulation":[851],"show":[857],"widely":[858],"varying":[859],"volume,":[861,1305],"earlier":[880,1612],"described":[881],"now":[886],"shown":[887],"also":[889,1004],"present":[891],"persist":[896],"Although":[900],"include":[905],"provided":[915],"showing":[916],"declining":[918],"increases":[922,1048],"CO\u2013MSNA":[930],"relation.":[931],"contrast":[933],"previous":[935,1139],"studies,":[936],"only":[938,983],"provides":[960],"potentially":[962],"more":[963,1499,1514],"\u2018physiological\u2019":[964],"approach,":[965],"since":[966,991],"arterioles":[967,1281],"respond":[968],"single":[970],"firing":[972],"rather":[973],"than":[974,1090,1500,1570],"integrated":[977],"variable":[978],"\u2018burst\u2019.":[979],"However,":[980,1027],"reliably":[985],"given":[989,1198,1210,1431],"subject,":[990],"intersubject":[992],"proximity":[996],"electrode":[999],"contribute":[1005],"differences":[1007],"size.":[1010],"make":[1013],"TPR,":[1020],"head-up-tilt":[1025],"one":[1028,1402,1419],"could":[1029,1037,1376,1403,1412],"argue":[1030],"variation":[1033,1172],"gravitational":[1035,1465],"stresses":[1036,1054],"introduce":[1038],"potential":[1039,1232],"confounds":[1040],"interpretation.":[1043],"Orthostatic":[1044],"tilt)":[1047],"hydrostatic":[1050,1473],"column":[1052,1474],"(Rowell,":[1058,1475],"1993)":[1059],"likely":[1062,1260],"affect":[1064],"extent":[1066],"leads":[1071],"vasoconstriction.":[1073],"(within":[1078],"subject)":[1080],"different":[1086,1486,1584],"(Intra-individual":[1093],"changes":[1094,1343],"caused":[1102],"experimental":[1104],"procedures":[1105],"have":[1106,1353],"been":[1107],"documented":[1108],"before":[1109],"al.,":[1112],"1996).).":[1113],"Another":[1114],"taken":[1119],"account":[1121],"design":[1124],"interindividual":[1130,1171,1517],"intrinsic":[1134],"vascular":[1135,1159,1191,1227,1334,1439,1443,1453,1490,1588],"adrenergic":[1136,1187,1340,1454],"responsiveness.":[1137,1228,1491],"A":[1138,1321],"2\u20133":[1152],"isolated":[1158],"bed":[1160,1470],"explain":[1167,1513],"some":[1168],"MSNA\u2013TPR":[1175],"relationships":[1176],"Together,":[1181],"load":[1184],"responsiveness":[1188,1341,1444,1455],"(the":[1189],"\u2018combined":[1190,1587],"responsiveness\u2019)":[1192],"determine":[1193],"effect":[1195],"amount":[1199],"lower":[1225,1599],"combined":[1226,1489],"Irrespective":[1229],"these":[1231],"limitations,":[1233],"off-set":[1235],"evident":[1239],"regressions":[1243],"made":[1244],"(\u223c400\u2013700":[1248],"cm\u22125,":[1251],"3).":[1257],"represent":[1262,1582],"non-sympathetically":[1264],"mediated":[1265],"portion":[1266],"determined":[1269],"mechanical":[1272],"properties":[1273],"conduit":[1276],"vessels":[1277],"relaxed":[1280],"(TPRoffset).":[1282],"summary":[1284],"novelty":[1286],"lies":[1295,1390],"documenting":[1297],"limitation":[1322],"it":[1328,1358],"does":[1329],"consider":[1331],"variations":[1332],"transduction":[1335],"depending":[1338],"discussed":[1347,1543],"above.":[1348],"Furthermore,":[1349],"gained":[1354],"prominence":[1356],"if":[1357],"had":[1359],"tried":[1360],"bring":[1362],"together":[1363],"independent":[1369],"contributors":[1370],"pressure.":[1374],"example":[1378],"multiple":[1383,1408],"(see":[1387],"Appendix).":[1388],"Herein":[1389],"apparent":[1392],"challenge":[1393],"future":[1395],"research.":[1396],"Based":[1397],"considerations":[1400],"above,":[1401],"speculate":[1404],"approach":[1411,1493],"produce":[1413],"below":[1420],"steady":[1428],"state":[1429],"as:":[1432],"(TPRoffset+":[1437],"((\u2018combined":[1438],"responsiveness\u2019\u00d7":[1440],"MSNA)).":[1441],"Combined":[1442],"suggested":[1446],"composite":[1449],"consisting":[1451],"1996;":[1459],"2005)":[1463],"loading":[1466],"1993).":[1476],"Fig.":[1478],"1":[1479],"function":[1481,1527],"plotted":[1483,1566],"two":[1485,1501,1580,1583],"levels":[1487,1585],"able":[1496],"relate":[1498],"cardiovascular":[1502],"parameters":[1503],"(e.g.":[1504],"CO;":[1507],"MAP)":[1510],"intraindividual":[1519],"variations.":[1520],"Mean":[1521],"Total":[1533],"Not":[1535],"having":[1536],"complete":[1538],"available,":[1545],"surface":[1547],"plot":[1548],"takes":[1549],"hypothetical":[1552],"value":[1553],"TPRoffset":[1555],"mmHg":[1557],"l\u22121":[1558],"min\u22121.":[1559],"reasons":[1561],"clarity":[1563],"wider":[1569],"physiological":[1571],"range":[1573],"starting":[1575],"0":[1577],"planes":[1581],"responsiveness\u2019":[1589],"(0.8":[1590],"arbitrary":[1591],"(a.u.)":[1593],"upper":[1594],"plane;":[1595],"0.2":[1597],"plane).":[1600],"We":[1601],"thank":[1602],"Christiane":[1603],"Hesse":[1604],"Nisha":[1606],"commenting":[1609],"version":[1613],"manuscript.":[1616],"C.T.P.K.":[1617],"supported":[1619],"Fulbright":[1622],"Program":[1623],"Netherlands":[1626],"Heart":[1627],"Foundation":[1628],"(no.":[1629],"2004T007).":[1630],"support":[1632],"gratefully":[1634],"acknowledged.":[1635]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
