{"id":"https://openalex.org/W1994130325","doi":"https://doi.org/10.1210/jc.2003-032056","title":"Rate of Production of Plasma and Very-Low-Density Lipoprotein (VLDL) Apolipoprotein C-III Is Strongly Related to the Concentration and Level of Production of VLDL Triglyceride in Male Subjects with Different Body Weights and Levels of Insulin Sensitivity","display_name":"Rate of Production of Plasma and Very-Low-Density Lipoprotein (VLDL) Apolipoprotein C-III Is Strongly Related to the Concentration and Level of Production of VLDL Triglyceride in Male Subjects with Different Body Weights and Levels of Insulin Sensitivity","publication_year":2004,"publication_date":"2004-08-01","ids":{"openalex":"https://openalex.org/W1994130325","doi":"https://doi.org/10.1210/jc.2003-032056","mag":"1994130325","pmid":"https://pubmed.ncbi.nlm.nih.gov/15292332"},"language":"en","primary_location":{"id":"doi:10.1210/jc.2003-032056","doi":"https://doi.org/10.1210/jc.2003-032056","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-032056","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023567192","display_name":"Jeffrey S. Cohn","orcid":"https://orcid.org/0000-0003-3060-1459","observed_orcids":["https://orcid.org/0000-0003-3060-1459"]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Jeffrey S. Cohn","raw_affiliation_strings":["Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montr\u00e9al, Qu\u00e9bec, Canada, H2W 1R7. cohnj@ircm.qc.ca","Clinical Research Institute of Montreal (J.S.C., J.D.), Quebec, Canada, H2W 1R7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montr\u00e9al, Qu\u00e9bec, Canada, H2W 1R7. cohnj@ircm.qc.ca","institution_ids":["https://openalex.org/I4210158752"]},{"raw_affiliation_string":"Clinical Research Institute of Montreal (J.S.C., J.D.), Quebec, Canada, H2W 1R7","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029941147","display_name":"Bruce W. Patterson","orcid":"https://orcid.org/0000-0001-9261-0233","observed_orcids":["https://orcid.org/0000-0001-9261-0233"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce W. Patterson","raw_affiliation_strings":["the Washington University School of Medicine (B.W.P.), St. Louis, Missouri 63110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Washington University School of Medicine (B.W.P.), St. Louis, Missouri 63110","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109191301","display_name":"Kristine D. Uffelman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Kris D. Uffelman","raw_affiliation_strings":["the Toronto General Hospital (K.D.U., G.S.), Ontario, Canada M5G 2C4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Toronto General Hospital (K.D.U., G.S.), Ontario, Canada M5G 2C4","institution_ids":["https://openalex.org/I2801845744"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070770963","display_name":"Jean Davignon","orcid":"https://orcid.org/0000-0002-8365-6552","observed_orcids":["https://orcid.org/0000-0002-8365-6552"]},"institutions":[{"id":"https://openalex.org/I4210158752","display_name":"Montreal Clinical Research Institute","ror":"https://ror.org/05m8pzq90","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210158752","https://openalex.org/I70931966"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jean Davignon","raw_affiliation_strings":["Clinical Research Institute of Montreal (J.S.C., J.D.), Quebec, Canada, H2W 1R7"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Institute of Montreal (J.S.C., J.D.), Quebec, Canada, H2W 1R7","institution_ids":["https://openalex.org/I4210158752"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109176818","display_name":"George A. Steiner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801845744","display_name":"Toronto General Hospital","ror":"https://ror.org/026pg9j08","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2801845744"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"George Steiner","raw_affiliation_strings":["the Toronto General Hospital (K.D.U., G.S.), Ontario, Canada M5G 2C4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Toronto General Hospital (K.D.U., G.S.), Ontario, Canada M5G 2C4","institution_ids":["https://openalex.org/I2801845744"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023567192"],"corresponding_institution_ids":["https://openalex.org/I4210158752"],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":4.7651,"has_fulltext":false,"cited_by_count":172,"citation_normalized_percentile":{"value":0.95201351,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"89","issue":"8","first_page":"3949","last_page":"3955"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apolipoprotein-c-iii","display_name":"apolipoprotein C-III","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vldl-triglycerides","display_name":"VLDL triglycerides","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.8360000252723694},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.8399999737739563},{"id":"https://openalex.org/keywords/overweight","display_name":"overweight","score":0.6930000185966492},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.9340000152587891},{"id":"https://openalex.org/keywords/fractional-catabolic-rate","display_name":"fractional catabolic rate","score":0.8539999723434448}],"concepts":[{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.8817577958106995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8498777747154236},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7919260263442993},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.7241341471672058},{"id":"https://openalex.org/C2776919658","wikidata":"https://www.wikidata.org/wiki/Q1467339","display_name":"Hypertriglyceridemia","level":4,"score":0.6462665796279907},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5542068481445312},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.540210485458374},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.48058652877807617},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.26554834842681885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23946449160575867},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2224506437778473}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001056","descriptor_name":"Apolipoproteins C","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008079","descriptor_name":"Lipoproteins, VLDL","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009994","descriptor_name":"Osmolar Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D053305","descriptor_name":"Apolipoprotein C-III","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jc.2003-032056","doi":"https://doi.org/10.1210/jc.2003-032056","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.2003-032056","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:15292332","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15292332","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.315.2264","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.315.2264","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcem.endojournals.org/content/89/8/3949.full.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W86554116","https://openalex.org/W166215000","https://openalex.org/W1527680278","https://openalex.org/W1607120480","https://openalex.org/W1900613292","https://openalex.org/W1942605285","https://openalex.org/W1963872182","https://openalex.org/W1983914332","https://openalex.org/W1997090264","https://openalex.org/W1997542488","https://openalex.org/W2006819250","https://openalex.org/W2009316979","https://openalex.org/W2020258883","https://openalex.org/W2020885344","https://openalex.org/W2021976026","https://openalex.org/W2026602634","https://openalex.org/W2029164903","https://openalex.org/W2031988119","https://openalex.org/W2033886436","https://openalex.org/W2034202460","https://openalex.org/W2034515512","https://openalex.org/W2034751031","https://openalex.org/W2039250890","https://openalex.org/W2040805488","https://openalex.org/W2046868406","https://openalex.org/W2047589448","https://openalex.org/W2051059551","https://openalex.org/W2052300367","https://openalex.org/W2059589608","https://openalex.org/W2082672996","https://openalex.org/W2083811960","https://openalex.org/W2093287637","https://openalex.org/W2096432979","https://openalex.org/W2100577034","https://openalex.org/W2112770128","https://openalex.org/W2115396555","https://openalex.org/W2123521914","https://openalex.org/W2123782138","https://openalex.org/W2127958304","https://openalex.org/W2129950813","https://openalex.org/W2130377792","https://openalex.org/W2130796675","https://openalex.org/W2133151327","https://openalex.org/W2135922747","https://openalex.org/W2136404492","https://openalex.org/W2142371147","https://openalex.org/W2144970509","https://openalex.org/W2155129096","https://openalex.org/W2160234571","https://openalex.org/W2160942744","https://openalex.org/W2185343095","https://openalex.org/W2327077996","https://openalex.org/W2334791394","https://openalex.org/W2348229247","https://openalex.org/W2403507619","https://openalex.org/W2415615490","https://openalex.org/W2740134755","https://openalex.org/W2911655320"],"related_works":["https://openalex.org/W7097773216","https://openalex.org/W2008281569","https://openalex.org/W7096726331","https://openalex.org/W2017291851","https://openalex.org/W2027083746","https://openalex.org/W1900613292","https://openalex.org/W2470314814","https://openalex.org/W2041953515","https://openalex.org/W2056645421","https://openalex.org/W2017096727"],"abstract_inverted_index":{"Overweight":[0],"individuals":[1],"with":[2,33,69,128,228,239,273],"reduced":[3],"insulin":[4,43,281],"sensitivity":[5,44,282],"often":[6],"have":[7],"mild":[8],"to":[9,192,201,287],"moderate":[10],"hypertriglyceridemia.":[11],"To":[12],"investigate":[13],"the":[14,21,288],"role":[15],"of":[16,23,266,271,280,293,295],"apolipoprotein":[17],"(apo)C-III":[18],"metabolism":[19],"in":[20,25,80],"etiology":[22],"hypertriglyceridemia":[24],"these":[26],"individuals,":[27],"we":[28],"investigated":[29],"10":[30],"male":[31],"subjects":[32,272],"different":[34],"body":[35,129,275],"weights":[36,276],"(body":[37],"mass":[38,130],"index,":[39,131],"24-34":[40],"kg/m(2))":[41],"and":[42,51,63,77,88,113,135,211,277,283,291],"(homeostasis":[45],"model":[46,133],"assessment,":[47,134],"4.7-35.0).":[48],"Total":[49],"plasma":[50,136,162,289],"very-low-density":[52],"lipoprotein":[53],"(VLDL)":[54],"apoC-III":[55,123,163,203,213,222,268],"kinetics,":[56,66],"as":[57,59],"well":[58],"VLDL":[60,64,81,97,105,114,122,195,202,212,221,229,240,244,267,296],"triglyceride":[61],"(TG)":[62],"apoB":[65,78,245],"were":[67,125,159,188,198,224],"measured":[68],"iv":[70],"injected":[71],"stable":[72],"isotopes.":[73],"The":[74],"apoC-III,":[75,98],"TG,":[76,106],"levels":[79,197,204,223,279],"ranged":[82],"from":[83],"2.9-18.2":[84],"mg/dl,":[85,90],"0.49-2.89":[86],"mmol/liter,":[87],"6.7-29.3":[89],"respectively.":[91],"Mean":[92],"production":[93,265,294],"rates":[94,186],"(PRs)":[95],"were:":[96],"20.2":[99],"+/-":[100,108,117],"4.1":[101],"micromol/d":[102,119],"(range,":[103,111,120],"8.0-44.8);":[104],"26.9":[107],"4.6":[109],"mmol/d":[110],"10.2-51.1);":[112],"apoB,":[115],"4.4":[116],"0.8":[118],"1.5-9.1).":[121],"PRs":[124,164,214,231],"significantly":[126,190],"correlated":[127,227],"homeostasis":[132],"TG":[137,196,230,241],"(r":[138,165,205,215,232,247],"=":[139,145,151,166,172,178,206,216,233,248,251,254,257],"0.66,":[140],"P":[141,147,153,168,174,180,208,218,235,250,256],"<":[142,148,154,169,175,181,209,219,236],"0.05;":[143,170,176],"r":[144,150,171,177,253],"0.80,":[146,179],"0.01;":[149],"0.95,":[152],"0.001,":[155],"respectively).":[156,183],"Similar":[157],"correlations":[158],"found":[160],"for":[161],"0.70,":[167],"0.67,":[173],"0.01,":[182],"Fractional":[184],"catabolic":[185],"(FCRs)":[187],"not":[189],"related":[191,200,286],"metabolic":[193],"variables.":[194],"strongly":[199,226,285],"0.99,":[207],"0.001)":[210],"0.94,":[217],"0.001).":[220],"more":[225],"0.81,":[234],"0.01)":[237],"than":[238],"FCRs":[242,246],"or":[243],"-0.53,":[249],"0.12;":[252],"-0.37,":[255],"0.29).":[258],"These":[259],"results":[260],"suggest":[261],"that":[262],"increased":[263],"hepatic":[264],"is":[269,284],"characteristic":[270],"higher":[274],"lower":[278],"concentration":[290],"level":[292],"TG.":[297]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}