{"id":"https://openalex.org/W1994123430","doi":"https://doi.org/10.1002/prca.201300044","title":"Old proteins and the A chilles heel of mass spectrometry. The role of proteomics in the etiology of human cataract","display_name":"Old proteins and the A chilles heel of mass spectrometry. The role of proteomics in the etiology of human cataract","publication_year":2014,"publication_date":"2014-01-24","ids":{"openalex":"https://openalex.org/W1994123430","doi":"https://doi.org/10.1002/prca.201300044","mag":"1994123430","pmid":"https://pubmed.ncbi.nlm.nih.gov/24458544"},"language":"en","primary_location":{"id":"doi:10.1002/prca.201300044","doi":"https://doi.org/10.1002/prca.201300044","is_oa":false,"landing_page_url":"https://doi.org/10.1002/prca.201300044","pdf_url":null,"source":{"id":"https://openalex.org/S118886446","display_name":"PROTEOMICS - CLINICAL APPLICATIONS","issn_l":"1862-8346","issn":["1862-8346","1862-8354"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS \u2013 Clinical Applications","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110058663","display_name":"Roger J.W. Truscott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Roger J. W. Truscott","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, University of Wollongong Wollongong, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong Wollongong, NSW, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070664576","display_name":"Michael G. Friedrich","orcid":"https://orcid.org/0000-0002-8274-1552","observed_orcids":["https://orcid.org/0000-0002-8274-1552"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I4210091629","display_name":"Illawarra Health and Medical Research Institute","ror":"https://ror.org/00dt9qb91","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210091629"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Michael G. Friedrich","raw_affiliation_strings":["Illawarra Health and Medical Research Institute, University of Wollongong Wollongong, NSW, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illawarra Health and Medical Research Institute, University of Wollongong Wollongong, NSW, Australia","institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110058663"],"corresponding_institution_ids":["https://openalex.org/I204824540","https://openalex.org/I4210091629"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.1943,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.15706806,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"3-4","first_page":"195","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.8173999786376953,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.0697999969124794,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-related-cataract","display_name":"senile cataract","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lens-crystallins","display_name":"lens crystallins","score":0.6819999814033508},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.4300000071525574},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.8700000047683716},{"id":"https://openalex.org/keywords/racemization","display_name":"racemization","score":0.7889999747276306},{"id":"https://openalex.org/keywords/d-amino-acids","display_name":"D-amino acids","score":0.8550000190734863},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6668625473976135},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4858081340789795},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4423934817314148},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4270833134651184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36533263325691223},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08933860063552856}],"mesh":[{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/prca.201300044","doi":"https://doi.org/10.1002/prca.201300044","is_oa":false,"landing_page_url":"https://doi.org/10.1002/prca.201300044","pdf_url":null,"source":{"id":"https://openalex.org/S118886446","display_name":"PROTEOMICS - CLINICAL APPLICATIONS","issn_l":"1862-8346","issn":["1862-8346","1862-8354"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PROTEOMICS \u2013 Clinical Applications","raw_type":"journal-article"},{"id":"pmid:24458544","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24458544","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proteomics. Clinical applications","raw_type":"Journal Article"},{"id":"pmh:oai:ro.uow.edu.au:ihmri-1453","doi":null,"is_oa":false,"landing_page_url":"https://ro.uow.edu.au/ihmri/436","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Illawarra Health and Medical Research Institute","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W148976868","https://openalex.org/W195618031","https://openalex.org/W592303347","https://openalex.org/W1534259153","https://openalex.org/W1537185729","https://openalex.org/W1563814271","https://openalex.org/W1568231313","https://openalex.org/W1594157888","https://openalex.org/W1815807971","https://openalex.org/W1896619220","https://openalex.org/W1944789189","https://openalex.org/W1964157302","https://openalex.org/W1965488063","https://openalex.org/W1966234811","https://openalex.org/W1970217589","https://openalex.org/W1973100735","https://openalex.org/W1981589118","https://openalex.org/W1987014746","https://openalex.org/W1987305776","https://openalex.org/W1992341964","https://openalex.org/W1996153172","https://openalex.org/W2000758165","https://openalex.org/W2000798225","https://openalex.org/W2001012162","https://openalex.org/W2004015458","https://openalex.org/W2010261765","https://openalex.org/W2020054871","https://openalex.org/W2022301810","https://openalex.org/W2023703673","https://openalex.org/W2031480359","https://openalex.org/W2033781934","https://openalex.org/W2041076448","https://openalex.org/W2044031095","https://openalex.org/W2044754760","https://openalex.org/W2048877651","https://openalex.org/W2052427083","https://openalex.org/W2055230175","https://openalex.org/W2056300299","https://openalex.org/W2058345849","https://openalex.org/W2058834514","https://openalex.org/W2062007365","https://openalex.org/W2064828019","https://openalex.org/W2064868949","https://openalex.org/W2065566934","https://openalex.org/W2066303560","https://openalex.org/W2069520252","https://openalex.org/W2075593072","https://openalex.org/W2079068897","https://openalex.org/W2079811216","https://openalex.org/W2081643248","https://openalex.org/W2082937294","https://openalex.org/W2083368345","https://openalex.org/W2086963517","https://openalex.org/W2088056196","https://openalex.org/W2094272634","https://openalex.org/W2114326373","https://openalex.org/W2115644880","https://openalex.org/W2132345593","https://openalex.org/W2142207652","https://openalex.org/W2151803690","https://openalex.org/W2158366330","https://openalex.org/W4251647708"],"related_works":["https://openalex.org/W1229018818","https://openalex.org/W2083030188","https://openalex.org/W2033213275","https://openalex.org/W6939780140","https://openalex.org/W2883597085","https://openalex.org/W3094018919","https://openalex.org/W2983721232","https://openalex.org/W2990967770","https://openalex.org/W2953830440","https://openalex.org/W2919960127"],"abstract_inverted_index":{"Proteomics":[0],"may":[1,172],"have":[2],"enabled":[3,37],"the":[4,22,29,39,43,91,113,127,183,193],"root":[5],"cause":[6],"of":[7,25,46,57,79,96,116,130,145,159,185],"a":[8,75,142,189],"major":[9],"human-blinding":[10],"condition,":[11],"age-related":[12,177],"cataract,":[13],"to":[14,19,53,161,176],"be":[15,54,110],"established.":[16],"Cataract":[17],"appears":[18],"result":[20],"from":[21,59],"spontaneous":[23,146],"decomposition":[24],"long-lived":[26,186],"macromolecules":[27],"in":[28,126,180,192],"human":[30,178],"lens,":[31],"and":[32,42,118,157],"recent":[33],"proteomic":[34],"analysis":[35],"has":[36,62],"both":[38],"particular":[40,181],"crystallins,":[41],"specific":[44],"sites":[45,68,150],"amino":[47],"acid":[48],"modification":[49,95],"within":[50],"each":[51],"polypeptide,":[52],"identified.":[55],"Analysis":[56],"proteins":[58,72,99,187],"cataract":[60],"lenses":[61],"demonstrated":[63],"that":[64,73,90,140,152,166],"there":[65,119],"are":[66,120,155],"key":[67,149],"on":[69],"some":[70],"structural":[71,107],"show":[74],"consistently":[76],"greater":[77],"degree":[78],"deterioration":[80,184],"than":[81],"age-matched":[82],"normal":[83],"lenses.":[84],"Proteomic":[85],"analysis,":[86],"using":[87],"MS,":[88],"revealed":[89],"most":[92],"abundant":[93],"posttranslational":[94],"aged":[97],"lens":[98],"is":[100,103,138,188],"racemization.":[101],"This":[102],"somewhat":[104],"ironic,":[105],"since":[106],"isomers":[108],"can":[109],"viewed":[111],"as":[112],"\"Achilles":[114],"heel\"":[115],"MS":[117],"typically":[121],"few,":[122],"if":[123],"any,":[124],"differences":[125],"MS/MS":[128],"spectra":[129],"tryptic":[131],"peptides":[132],"containing":[133],"one":[134],"d-amino":[135],"acid.":[136],"It":[137],"proposed":[139],"once":[141],"certain":[143],"level":[144],"PTM":[147],"at":[148],"occurs,":[151],"protein-protein":[153],"interactions":[154],"disrupted,":[156],"binding":[158],"complexes":[160],"cell":[162],"membranes":[163],"takes":[164],"place":[165],"impairs":[167],"cell-to-cell":[168],"communication.":[169],"These":[170],"findings":[171],"apply":[173],"more":[174],"widely":[175],"diseases,":[179],"where":[182],"crucial":[190],"component":[191],"etiology.":[194]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
