{"id":"https://openalex.org/W1994108115","doi":"https://doi.org/10.1038/sj.onc.1206443","title":"Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival","display_name":"Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival","publication_year":2003,"publication_date":"2003-05-19","ids":{"openalex":"https://openalex.org/W1994108115","doi":"https://doi.org/10.1038/sj.onc.1206443","mag":"1994108115","pmid":"https://pubmed.ncbi.nlm.nih.gov/12789278"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1206443","doi":"https://doi.org/10.1038/sj.onc.1206443","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1206443","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022764850","display_name":"Hans R. Widlund","orcid":"https://orcid.org/0000-0002-7506-2447","observed_orcids":["https://orcid.org/0000-0002-7506-2447"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hans R Widlund","raw_affiliation_strings":["Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA","Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078874539","display_name":"David E. Fisher","orcid":"https://orcid.org/0000-0002-5506-0575","observed_orcids":["https://orcid.org/0000-0002-5506-0575"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David E Fisher","raw_affiliation_strings":["Children's Hospital, Harvard Medical School, Boston, 02115, MA, USA","Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital, Harvard Medical School, Boston, 02115, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5078874539"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984","https://openalex.org/I4210117453"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":1.7155,"has_fulltext":false,"cited_by_count":368,"citation_normalized_percentile":{"value":0.85234899,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"22","issue":"20","first_page":"3035","last_page":"3041"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.05050000175833702,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitf","display_name":"MITF","score":0.8960000276565552},{"id":"https://openalex.org/keywords/melanocyte-development","display_name":"melanocyte development","score":0.7879999876022339},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8870000243186951},{"id":"https://openalex.org/keywords/bhlh-transcription-factors","display_name":"bHLH transcription factors","score":0.6299999952316284},{"id":"https://openalex.org/keywords/neural-crest","display_name":"neural crest","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cell-fate-specification","display_name":"cell fate specification","score":0.6299999952316284},{"id":"https://openalex.org/keywords/tyrosinase","display_name":"tyrosinase","score":0.8009999990463257},{"id":"https://openalex.org/keywords/trp-1","display_name":"TRP-1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/discrete-cosine-transform","display_name":"discrete cosine transform","score":0.9589999914169312},{"id":"https://openalex.org/keywords/pigment-cell-differentiation","display_name":"pigment cell differentiation","score":0.7210000157356262},{"id":"https://openalex.org/keywords/melanocyte-survival","display_name":"melanocyte survival","score":0.746999979019165},{"id":"https://openalex.org/keywords/transcriptional-regulatory-networks","display_name":"transcriptional regulatory networks","score":0.7419999837875366},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C177504595","wikidata":"https://www.wikidata.org/wiki/Q336500","display_name":"Microphthalmia-associated transcription factor","level":4,"score":0.9928502440452576},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8924341201782227},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.783517599105835},{"id":"https://openalex.org/C126749454","wikidata":"https://www.wikidata.org/wiki/Q1348455","display_name":"Neural crest","level":3,"score":0.6991226077079773},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.6300802826881409},{"id":"https://openalex.org/C6174537","wikidata":"https://www.wikidata.org/wiki/Q377955","display_name":"Basic helix-loop-helix","level":5,"score":0.6103493571281433},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.6038020253181458},{"id":"https://openalex.org/C2779769559","wikidata":"https://www.wikidata.org/wiki/Q247101","display_name":"Melanocyte","level":3,"score":0.5905352234840393},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5777424573898315},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.5681841969490051},{"id":"https://openalex.org/C202908374","wikidata":"https://www.wikidata.org/wiki/Q4867030","display_name":"Basic helix-loop-helix leucine zipper transcription factors","level":5,"score":0.542759120464325},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4667043685913086},{"id":"https://openalex.org/C2777302934","wikidata":"https://www.wikidata.org/wiki/Q18031655","display_name":"SOX10","level":4,"score":0.4412744343280792},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.4402107298374176},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39230501651763916},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.20695039629936218},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15089017152786255},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.07712531089782715}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009432","descriptor_name":"Neural Crest","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010860","descriptor_name":"Pigments, Biological","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014442","descriptor_name":"Monophenol Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014849","descriptor_name":"Waardenburg Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051739","descriptor_name":"Microphthalmia-Associated Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.onc.1206443","doi":"https://doi.org/10.1038/sj.onc.1206443","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1206443","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:12789278","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12789278","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000877509","display_name":"MITF from control of pigmentation to melanoma risk","funder_award_id":"R01AR043369","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320306550","display_name":"Wenner-Gren Foundation","ror":"https://ror.org/04qvvhf62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":82,"referenced_works":["https://openalex.org/W1484878776","https://openalex.org/W1487917997","https://openalex.org/W1493098692","https://openalex.org/W1548932088","https://openalex.org/W1549618031","https://openalex.org/W1576536426","https://openalex.org/W1598239389","https://openalex.org/W1611895582","https://openalex.org/W1614304853","https://openalex.org/W1667206495","https://openalex.org/W1777743642","https://openalex.org/W1855838475","https://openalex.org/W1861331149","https://openalex.org/W1883936019","https://openalex.org/W1963091570","https://openalex.org/W1963652662","https://openalex.org/W1966566830","https://openalex.org/W1982714302","https://openalex.org/W1984362855","https://openalex.org/W1987047126","https://openalex.org/W1987223451","https://openalex.org/W1997830187","https://openalex.org/W1997889534","https://openalex.org/W2000146676","https://openalex.org/W2002918515","https://openalex.org/W2008735439","https://openalex.org/W2008797552","https://openalex.org/W2010684388","https://openalex.org/W2015721987","https://openalex.org/W2016114470","https://openalex.org/W2019668010","https://openalex.org/W2022083096","https://openalex.org/W2029906374","https://openalex.org/W2031841201","https://openalex.org/W2034030391","https://openalex.org/W2036274324","https://openalex.org/W2037104940","https://openalex.org/W2042419999","https://openalex.org/W2043645272","https://openalex.org/W2045593483","https://openalex.org/W2049669210","https://openalex.org/W2051718122","https://openalex.org/W2059169513","https://openalex.org/W2062595374","https://openalex.org/W2064254523","https://openalex.org/W2070987304","https://openalex.org/W2071478817","https://openalex.org/W2073772356","https://openalex.org/W2075310700","https://openalex.org/W2078002199","https://openalex.org/W2078337982","https://openalex.org/W2081462173","https://openalex.org/W2083061238","https://openalex.org/W2087447340","https://openalex.org/W2088406835","https://openalex.org/W2089293124","https://openalex.org/W2090364563","https://openalex.org/W2090851532","https://openalex.org/W2102763487","https://openalex.org/W2105516543","https://openalex.org/W2107006976","https://openalex.org/W2108175127","https://openalex.org/W2116306988","https://openalex.org/W2117112828","https://openalex.org/W2119239047","https://openalex.org/W2122711551","https://openalex.org/W2125418297","https://openalex.org/W2125842849","https://openalex.org/W2126638912","https://openalex.org/W2128963294","https://openalex.org/W2133608451","https://openalex.org/W2141934953","https://openalex.org/W2145297890","https://openalex.org/W2153649171","https://openalex.org/W2159299286","https://openalex.org/W2159522663","https://openalex.org/W2162497387","https://openalex.org/W2162997202","https://openalex.org/W2165061154","https://openalex.org/W2165685789","https://openalex.org/W4298074190","https://openalex.org/W7097257549"],"related_works":["https://openalex.org/W2085002165","https://openalex.org/W4253998987","https://openalex.org/W1982635732","https://openalex.org/W2055514887","https://openalex.org/W4255729697","https://openalex.org/W3149003612","https://openalex.org/W2103134073","https://openalex.org/W2065989662","https://openalex.org/W2592824004","https://openalex.org/W7167478588"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":24},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}