{"id":"https://openalex.org/W1994098506","doi":"https://doi.org/10.1159/000057842","title":"Latest Industry Information on the Safety Profile of Levofloxacin in the US","display_name":"Latest Industry Information on the Safety Profile of Levofloxacin in the US","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W1994098506","doi":"https://doi.org/10.1159/000057842","mag":"1994098506","pmid":"https://pubmed.ncbi.nlm.nih.gov/11549787"},"language":"en","primary_location":{"id":"doi:10.1159/000057842","doi":"https://doi.org/10.1159/000057842","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000057842","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074687160","display_name":"James B. Kahn","orcid":"https://orcid.org/0000-0002-8546-6293","observed_orcids":["https://orcid.org/0000-0002-8546-6293"]},"institutions":[{"id":"https://openalex.org/I4405271437","display_name":"Ortho-McNeil Pharmaceutical (United States)","ror":"https://ror.org/02e7e3t27","country_code":"US","type":"company","lineage":["https://openalex.org/I4405271437"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James B. Kahn","raw_affiliation_strings":["Infectious Disease Research, Ortho-McNeil Pharmaceutical Inc, Raritan, NJ 08869-0602, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infectious Disease Research, Ortho-McNeil Pharmaceutical Inc, Raritan, NJ 08869-0602, USA","institution_ids":["https://openalex.org/I4405271437"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074687160"],"corresponding_institution_ids":["https://openalex.org/I4405271437"],"apc_list":null,"apc_paid":null,"fwci":4.1631,"has_fulltext":false,"cited_by_count":57,"citation_normalized_percentile":{"value":0.93125427,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"47","issue":"3","first_page":"32","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10654","display_name":"Pneumonia and Respiratory Infections","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/levofloxacin","display_name":"levofloxacin","score":1.0},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7210000157356262},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.8669999837875366},{"id":"https://openalex.org/keywords/post-marketing-surveillance","display_name":"post-marketing surveillance","score":0.9359999895095825},{"id":"https://openalex.org/keywords/clinical-trials","display_name":"clinical trials","score":0.6620000004768372},{"id":"https://openalex.org/keywords/community-acquired-pneumonia","display_name":"community-acquired pneumonia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ceftriaxone","display_name":"ceftriaxone","score":0.7929999828338623},{"id":"https://openalex.org/keywords/azithromycin","display_name":"azithromycin","score":0.9430000185966492},{"id":"https://openalex.org/keywords/tendon-rupture","display_name":"tendon rupture","score":0.8370000123977661},{"id":"https://openalex.org/keywords/qt-interval-prolongation","display_name":"QT prolongation","score":0.8220000267028809},{"id":"https://openalex.org/keywords/photosensitivity","display_name":"photosensitivity","score":0.7739999890327454},{"id":"https://openalex.org/keywords/nausea","display_name":"nausea","score":0.48899999260902405},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.4269999861717224}],"concepts":[{"id":"https://openalex.org/C2781276175","wikidata":"https://www.wikidata.org/wiki/Q424193","display_name":"Levofloxacin","level":3,"score":0.9369378089904785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8439919948577881},{"id":"https://openalex.org/C2780580376","wikidata":"https://www.wikidata.org/wiki/Q186889","display_name":"Nausea","level":2,"score":0.7035776972770691},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.5382151007652283},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5326452255249023},{"id":"https://openalex.org/C2780852908","wikidata":"https://www.wikidata.org/wiki/Q127076","display_name":"Vomiting","level":2,"score":0.5050652623176575},{"id":"https://openalex.org/C2779001537","wikidata":"https://www.wikidata.org/wiki/Q182155","display_name":"Shingles","level":3,"score":0.4320872724056244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38049232959747314},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3545873761177063},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.12908050417900085},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004345","descriptor_name":"Drug Industry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014486","descriptor_name":"United States Food and Drug Administration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015242","descriptor_name":"Ofloxacin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D015242","descriptor_name":"Ofloxacin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016907","descriptor_name":"Adverse Drug Reaction Reporting Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017277","descriptor_name":"Drug Approval","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064704","descriptor_name":"Levofloxacin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1159/000057842","doi":"https://doi.org/10.1159/000057842","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000057842","pdf_url":null,"source":{"id":"https://openalex.org/S92531173","display_name":"Chemotherapy","issn_l":"0009-3157","issn":["0009-3157","1421-9794"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"journal-article"},{"id":"pmid:11549787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11549787","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1970001731","https://openalex.org/W2060696060","https://openalex.org/W2471893896","https://openalex.org/W2362247931","https://openalex.org/W2393790540","https://openalex.org/W2393730373","https://openalex.org/W7001867042","https://openalex.org/W2436576931","https://openalex.org/W2041855547","https://openalex.org/W7154479245"],"abstract_inverted_index":{"This":[0],"paper":[1],"reviews":[2],"the":[3,95],"safety":[4],"data":[5,115,139],"for":[6,23,26,29,33,120],"levofloxacin":[7,80,86,102],"utilizing":[8],"reports":[9],"from":[10],"clinical":[11,52,59],"and":[12,31,47,60,67,108,129,132,136,165],"post-marketing":[13],"surveillance":[14,138],"trials.":[15],"The":[16],"side":[17],"effect":[18],"incidence":[19],"rates":[20,119],"are":[21],"1.3%":[22],"nausea,":[24],"0.1%":[25,32],"anxiety,":[27],"0.3%":[28],"insomnia,":[30],"headache.":[34],"No":[35],"levofloxacin-related":[36],"adverse":[37,91],"events":[38,92],"were":[39,49,54],"reported":[40,116],"at":[41],"a":[42],"rate":[43],"higher":[44],"than":[45,147,156,180],"1.3%,":[46],"most":[48],"lower.":[50],"Four":[51],"trials":[53],"reported.":[55],"Levofloxacin":[56],"achieved":[57],"superior":[58],"microbiological":[61],"results":[62],"compared":[63],"to":[64,110],"ceftriaxone/macrolide":[65],"combination,":[66],"was":[68,105],"better":[69],"tolerated.":[70,113],"Results":[71],"comparing":[72],"IV":[73],"azithromycin":[74],"plus":[75],"ceftriaxone":[76],"versus":[77],"500":[78],"mg":[79],"in":[81,145,154,161,178],"hospitalised":[82],"CAP":[83],"demonstrated":[84],"that":[85,141],"performed":[87],"better,":[88],"with":[89,94],"more":[90],"associated":[93],"comparators":[96,99],"(levofloxacin":[97],"5.3%,":[98],"9.3%).":[100],"High-dose":[101],"(750":[103],"mg)":[104],"also":[106],"evaluated":[107],"found":[109],"be":[111],"well":[112],"Surveillance":[114],"low":[117],"ADR":[118],"levofloxacin:":[121],"nausea":[122],"0.8%,":[123],"rash":[124],"0.5%,":[125],"abdominal":[126],"pain":[127],"0.4%,":[128],"diarrhoea,":[130],"dizziness,":[131],"vomiting":[133],"0.3%.":[134],"Worldwide":[135],"US":[137],"confirmed":[140],"tendon":[142],"rupture":[143],"occurred":[144],"less":[146,155,179],"4":[148],"per":[149,158,163,182],"million":[150],"prescriptions,":[151],"taste":[152],"perversion":[153],"3":[157],"million,":[159,164],"convulsions":[160],"2":[162],"photosensitivity,":[166],"hepatitis,":[167],"hepatic":[168],"failure,":[169],"QT":[170],"prolongation,":[171],"torsade":[172],"de":[173],"pointes":[174],"or":[175],"empyema":[176],"all":[177],"1":[181],"million.":[183]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
