{"id":"https://openalex.org/W1994082151","doi":"https://doi.org/10.1016/j.tet.2008.02.079","title":"Synthesis and anti-HIV activity of 5-haloethynyl and 5-(1,2-dihalo)vinyl analogues of AZT and FLT","display_name":"Synthesis and anti-HIV activity of 5-haloethynyl and 5-(1,2-dihalo)vinyl analogues of AZT and FLT","publication_year":2008,"publication_date":"2008-03-03","ids":{"openalex":"https://openalex.org/W1994082151","doi":"https://doi.org/10.1016/j.tet.2008.02.079","mag":"1994082151","pmid":"https://pubmed.ncbi.nlm.nih.gov/34321697","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8315093"},"language":"en","primary_location":{"id":"doi:10.1016/j.tet.2008.02.079","doi":"https://doi.org/10.1016/j.tet.2008.02.079","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tet.2008.02.079","pdf_url":null,"source":{"id":"https://openalex.org/S205754296","display_name":"Tetrahedron","issn_l":"0040-4020","issn":["0040-4020","1464-5416"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8315093","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069378986","display_name":"Nicolas Joubert","orcid":"https://orcid.org/0000-0002-7335-4921","observed_orcids":["https://orcid.org/0000-0002-7335-4921"]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210141565","display_name":"Institut de Chimie Organique et Analytique","ror":"https://ror.org/03ywn7d79","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210128300","https://openalex.org/I4210141565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas Joubert","raw_affiliation_strings":["Institut de Chimie Organique et Analytique, Universit\u00e9 d'Orl\u00e9ans, UMR CNRS 6005, BP 6759, 45067 Orl\u00e9ans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Chimie Organique et Analytique, Universit\u00e9 d'Orl\u00e9ans, UMR CNRS 6005, BP 6759, 45067 Orl\u00e9ans, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029361950","display_name":"Franck Amblard","orcid":"https://orcid.org/0009-0002-6235-4050","observed_orcids":["https://orcid.org/0009-0002-6235-4050"]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210141565","display_name":"Institut de Chimie Organique et Analytique","ror":"https://ror.org/03ywn7d79","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210128300","https://openalex.org/I4210141565"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Franck Amblard","raw_affiliation_strings":["Institut de Chimie Organique et Analytique, Universit\u00e9 d'Orl\u00e9ans, UMR CNRS 6005, BP 6759, 45067 Orl\u00e9ans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Chimie Organique et Analytique, Universit\u00e9 d'Orl\u00e9ans, UMR CNRS 6005, BP 6759, 45067 Orl\u00e9ans, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113582335","display_name":"Kimberly L. Rapp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kimberly L. Rapp","raw_affiliation_strings":["Veterans Affairs Medical Center and Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center and Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30033, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087052821","display_name":"Raymond F. Schinazi","orcid":"https://orcid.org/0000-0002-6688-3614","observed_orcids":["https://orcid.org/0000-0002-6688-3614"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond F. Schinazi","raw_affiliation_strings":["Veterans Affairs Medical Center and Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs Medical Center and Laboratory of Biochemical Pharmacology, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30033, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065114035","display_name":"Luigi Andr\u00e9 Agrofoglio","orcid":"https://orcid.org/0000-0002-6083-0810","observed_orcids":["https://orcid.org/0000-0002-6083-0810"]},"institutions":[{"id":"https://openalex.org/I12449238","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76","country_code":"FR","type":"education","lineage":["https://openalex.org/I12449238"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210141565","display_name":"Institut de Chimie Organique et Analytique","ror":"https://ror.org/03ywn7d79","country_code":"FR","type":"facility","lineage":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I2738703131","https://openalex.org/I4210128300","https://openalex.org/I4210141565"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Luigi A. Agrofoglio","raw_affiliation_strings":["Institut de Chimie Organique et Analytique, Universit\u00e9 d'Orl\u00e9ans, UMR CNRS 6005, BP 6759, 45067 Orl\u00e9ans, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Chimie Organique et Analytique, Universit\u00e9 d'Orl\u00e9ans, UMR CNRS 6005, BP 6759, 45067 Orl\u00e9ans, France","institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065114035"],"corresponding_institution_ids":["https://openalex.org/I12449238","https://openalex.org/I1294671590","https://openalex.org/I4210141565"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":0.8617,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.75319822,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"64","issue":"19","first_page":"4444","last_page":"4452"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10548","display_name":"Catalytic Cross-Coupling Reactions","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-reverse-transcriptase-inhibitors","display_name":"HIV-1 reverse transcriptase inhibitors","score":0.7009999752044678},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.8859999775886536},{"id":"https://openalex.org/keywords/zidovudine","display_name":"zidovudine","score":0.6589999794960022},{"id":"https://openalex.org/keywords/zalcitabine","display_name":"zalcitabine","score":0.875},{"id":"https://openalex.org/keywords/sonogashira-coupling","display_name":"Sonogashira coupling","score":0.8920000195503235},{"id":"https://openalex.org/keywords/anti-hiv-activity","display_name":"anti-HIV activity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9710000157356262}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9276893734931946},{"id":"https://openalex.org/C61442700","wikidata":"https://www.wikidata.org/wiki/Q900334","display_name":"Sonogashira coupling","level":4,"score":0.8523725867271423},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.6674978733062744},{"id":"https://openalex.org/C2776543447","wikidata":"https://www.wikidata.org/wiki/Q28734","display_name":"Nucleoside","level":2,"score":0.6016218662261963},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5550310611724854},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5413032174110413},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5086475610733032},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.5026259422302246},{"id":"https://openalex.org/C2777333352","wikidata":"https://www.wikidata.org/wiki/Q2689559","display_name":"Nucleoside analogue","level":3,"score":0.46525388956069946},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.45625975728034973},{"id":"https://openalex.org/C96529984","wikidata":"https://www.wikidata.org/wiki/Q286136","display_name":"EC50","level":3,"score":0.42604780197143555},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3017187714576721},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2074512243270874},{"id":"https://openalex.org/C502130503","wikidata":"https://www.wikidata.org/wiki/Q1089","display_name":"Palladium","level":3,"score":0.16315382719039917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1383851170539856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1016/j.tet.2008.02.079","doi":"https://doi.org/10.1016/j.tet.2008.02.079","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tet.2008.02.079","pdf_url":null,"source":{"id":"https://openalex.org/S205754296","display_name":"Tetrahedron","issn_l":"0040-4020","issn":["0040-4020","1464-5416"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron","raw_type":"journal-article"},{"id":"pmid:34321697","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34321697","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tetrahedron","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8315093","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8315093","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Tetrahedron","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-05588773v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-05588773","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Tetrahedron, 2008, 64 (19), pp.4444-4452. ⟨10.1016/j.tet.2008.02.079⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8315093","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8315093","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Tetrahedron","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8303019769","display_name":"NUCLEOSIDES WITH DUAL ANTI-HIV AND HBV ACTIVITY","funder_award_id":"R37AI041980","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320323373","display_name":"Universit\u00e9 d'Orl\u00e9ans","ror":"https://ror.org/014zrew76"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W280137907","https://openalex.org/W567352712","https://openalex.org/W1589344673","https://openalex.org/W1932783741","https://openalex.org/W1966866013","https://openalex.org/W1980163204","https://openalex.org/W1982713805","https://openalex.org/W1987212163","https://openalex.org/W1987767749","https://openalex.org/W1992384606","https://openalex.org/W1993814964","https://openalex.org/W1997945421","https://openalex.org/W2020093839","https://openalex.org/W2024536147","https://openalex.org/W2024682383","https://openalex.org/W2058831749","https://openalex.org/W2059963764","https://openalex.org/W2061242953","https://openalex.org/W2064639805","https://openalex.org/W2072982389","https://openalex.org/W2086186867","https://openalex.org/W2097515246","https://openalex.org/W2122072514","https://openalex.org/W2129769595","https://openalex.org/W2148925357","https://openalex.org/W2159818060","https://openalex.org/W2162658079","https://openalex.org/W2316912275","https://openalex.org/W2330220433","https://openalex.org/W2414160161","https://openalex.org/W2897585953","https://openalex.org/W2949714870","https://openalex.org/W2949723190","https://openalex.org/W2950033875","https://openalex.org/W2950136008","https://openalex.org/W2950385685","https://openalex.org/W2952585487","https://openalex.org/W4233213384","https://openalex.org/W4236729606"],"related_works":["https://openalex.org/W1985352714","https://openalex.org/W1992043747","https://openalex.org/W2064696682","https://openalex.org/W2108805007","https://openalex.org/W4388786165","https://openalex.org/W2312902309","https://openalex.org/W2949649780","https://openalex.org/W2057628218","https://openalex.org/W2517623451","https://openalex.org/W1988626614"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}