{"id":"https://openalex.org/W1994075309","doi":"https://doi.org/10.1371/journal.pone.0014117","title":"Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression","display_name":"Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression","publication_year":2010,"publication_date":"2010-11-29","ids":{"openalex":"https://openalex.org/W1994075309","doi":"https://doi.org/10.1371/journal.pone.0014117","mag":"1994075309","pmid":"https://pubmed.ncbi.nlm.nih.gov/21152424","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2994708"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0014117","doi":"https://doi.org/10.1371/journal.pone.0014117","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0014117","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014117&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014117&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110967064","display_name":"Kathryn E. Ware","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kathryn E. Ware","raw_affiliation_strings":["Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America. Kathryn.ware@ucdenver.edu","Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America. Kathryn.ware@ucdenver.edu","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057405011","display_name":"Marianne E. Marshall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marianne E. Marshall","raw_affiliation_strings":["Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040457991","display_name":"Lydia R. Heasley","orcid":"https://orcid.org/0000-0002-8973-1496","observed_orcids":["https://orcid.org/0000-0002-8973-1496"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lydia R. Heasley","raw_affiliation_strings":["Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089346786","display_name":"Lindsay A. Marek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay Marek","raw_affiliation_strings":["Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001135447","display_name":"Trista K. Hinz","orcid":"https://orcid.org/0009-0009-8674-3529","observed_orcids":["https://orcid.org/0009-0009-8674-3529"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trista K. Hinz","raw_affiliation_strings":["Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072910965","display_name":"Paula Hercule","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Hercule","raw_affiliation_strings":["Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110210280","display_name":"Barbara A. Helfrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara A. Helfrich","raw_affiliation_strings":["Department of Medicine, University of Colorado at Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Colorado at Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034705456","display_name":"Robert Charles Doebele","orcid":"https://orcid.org/0000-0001-6728-6857","observed_orcids":["https://orcid.org/0000-0001-6728-6857"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert C. Doebele","raw_affiliation_strings":["Department of Medicine, University of Colorado at Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Colorado at Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057844697","display_name":"Lynn E. Heasley","orcid":"https://orcid.org/0000-0001-8056-0208","observed_orcids":["https://orcid.org/0000-0001-8056-0208"]},"institutions":[{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn E. Heasley","raw_affiliation_strings":["Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Craniofacial Biology, University of Colorado at Denver, Aurora, Colorado, United States of America","institution_ids":["https://openalex.org/I921990950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110967064"],"corresponding_institution_ids":["https://openalex.org/I921990950"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":9.8339,"has_fulltext":true,"cited_by_count":146,"citation_normalized_percentile":{"value":0.98464068,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"5","issue":"11","first_page":"e14117","last_page":"e14117"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr-tyrosine-kinase-inhibitors","display_name":"EGFR tyrosine kinase inhibitors","score":0.9210000038146973},{"id":"https://openalex.org/keywords/gefitinib","display_name":"gefitinib","score":0.9539999961853027},{"id":"https://openalex.org/keywords/acquired-drug-resistance","display_name":"acquired drug resistance","score":0.9300000071525574},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9440000057220459},{"id":"https://openalex.org/keywords/fgfr2","display_name":"FGFR2","score":0.9850000143051147},{"id":"https://openalex.org/keywords/fgfr3","display_name":"FGFR3","score":1.0},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.5960000157356262},{"id":"https://openalex.org/keywords/mek","display_name":"MEK","score":0.9089999794960022},{"id":"https://openalex.org/keywords/erk-activation","display_name":"ERK activation","score":0.9549999833106995},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.921999990940094},{"id":"https://openalex.org/keywords/fgf7","display_name":"FGF7","score":0.9950000047683716},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.9267946481704712},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6902331113815308},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.564468502998352},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5330820083618164},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.5163863301277161},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5016744136810303},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.47068363428115845},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.4625979959964752},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.4595645070075989},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4469072222709656},{"id":"https://openalex.org/C147708747","wikidata":"https://www.wikidata.org/wiki/Q14914358","display_name":"Fibroblast growth factor receptor 3","level":4,"score":0.4225667715072632},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4178179204463959},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3954658806324005},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3311980962753296},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2367183268070221},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2052454650402069},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08267518877983093},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06708985567092896}],"mesh":[{"descriptor_ui":"D000077156","descriptor_name":"Gefitinib","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016222","descriptor_name":"Fibroblast Growth Factor 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D048049","descriptor_name":"Extracellular Signal-Regulated MAP Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051497","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051497","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051523","descriptor_name":"Fibroblast Growth Factor 7","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0014117","doi":"https://doi.org/10.1371/journal.pone.0014117","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0014117","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014117&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2994708","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2994708","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:21152424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21152424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:46fcf9c01b6b4995a8fad7b7b0c4e4d2","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/46fcf9c01b6b4995a8fad7b7b0c4e4d2","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 11, p e14117 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/140392","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Rapidly_Acquired_Resistance_to_EGFR_Tyrosine_Kinase_Inhibitors_in_NSCLC_Cell_Lines_through_De_Repression_of_FGFR2_and_FGFR3_Expression/140392","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0014117","doi":"https://doi.org/10.1371/journal.pone.0014117","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0014117","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0014117&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1086770554","display_name":"FGF-2 Autocrine Signaling in Lung Cancer","funder_award_id":"R01CA127105","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2988872836","display_name":null,"funder_award_id":"P50 CA058187","funder_id":"https://openalex.org/F4320333552","funder_display_name":"Cancer Center, University of Colorado"},{"id":"https://openalex.org/G8447659275","display_name":"SPORE in Lung Cancer","funder_award_id":"P50CA058187","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000891461","display_name":"University of Colorado Cancer Center Support Grant","funder_award_id":"P30CA046934","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333552","display_name":"Cancer Center, University of Colorado","ror":"https://ror.org/04cqn7d42"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1994075309.pdf","grobid_xml":"https://content.openalex.org/works/W1994075309.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1980738750","https://openalex.org/W1998971866","https://openalex.org/W1999614615","https://openalex.org/W1999909760","https://openalex.org/W2001521752","https://openalex.org/W2023781626","https://openalex.org/W2029967426","https://openalex.org/W2048258225","https://openalex.org/W2051037476","https://openalex.org/W2054720651","https://openalex.org/W2056940735","https://openalex.org/W2056983875","https://openalex.org/W2058522541","https://openalex.org/W2058923462","https://openalex.org/W2089417149","https://openalex.org/W2093107932","https://openalex.org/W2103098489","https://openalex.org/W2103514020","https://openalex.org/W2106391833","https://openalex.org/W2107706859","https://openalex.org/W2123027432","https://openalex.org/W2127766722","https://openalex.org/W2127779265","https://openalex.org/W2132074747","https://openalex.org/W2132834292","https://openalex.org/W2135422811","https://openalex.org/W2138297714","https://openalex.org/W2138604360","https://openalex.org/W2138939757","https://openalex.org/W2140334822","https://openalex.org/W2141448895","https://openalex.org/W2150852167","https://openalex.org/W2168691181","https://openalex.org/W2169154218","https://openalex.org/W2171313739","https://openalex.org/W2331822798"],"related_works":["https://openalex.org/W7098285293","https://openalex.org/W2049076276","https://openalex.org/W7098937731","https://openalex.org/W3178280348","https://openalex.org/W2122442582","https://openalex.org/W2022177003","https://openalex.org/W2904931316","https://openalex.org/W2099858549","https://openalex.org/W2988896392","https://openalex.org/W2063874384"],"abstract_inverted_index":{"Despite":[0],"initial":[1],"and":[2,18,38,56,64,120,141,162,172,179,204,210,219,230],"sometimes":[3],"dramatic":[4],"responses":[5],"of":[6,23,36,42,49,96,118,139,160,176,193,213,223,228,241],"specific":[7,232],"NSCLC":[8,24,50,68,224],"tumors":[9],"to":[10,146,216,238],"EGFR":[11,30,74,86,169,194,201,217,229,243],"TKIs,":[12],"nearly":[13],"all":[14],"will":[15],"develop":[16],"resistance":[17,215],"relapse.":[19],"Gene":[20],"expression":[21,58],"analysis":[22],"cell":[25,51,69,83],"lines":[26,52,70,84],"treated":[27],"with":[28,131,226],"the":[29,62,73,191],"TKI,":[31],"gefitinib,":[32,151],"revealed":[33],"increased":[34,60,114],"levels":[35],"FGFR2":[37,55,115,119,161,171,203],"FGFR3":[39,57,121,173,205],"mRNA.":[40],"Analysis":[41],"gefitinib":[43,104],"action":[44],"on":[45],"a":[46,110,147,208,236],"larger":[47],"panel":[48],"verified":[53],"that":[54,153,168,221],"is":[59,75,88],"at":[61],"mRNA":[63],"protein":[65,122],"level":[66],"in":[67,71,82,190],"which":[72],"dominant":[76],"for":[77],"growth":[78,189],"signaling,":[79],"but":[80],"not":[81],"where":[85],"signaling":[87,206],"absent.":[89],"A":[90],"luciferase":[91],"reporter":[92],"containing":[93],"2.5":[94],"kilobases":[95],"fgfr2":[97],"5'":[98],"flanking":[99],"sequence":[100],"was":[101,128],"activated":[102],"after":[103],"treatment,":[105],"indicating":[106],"transcriptional":[107],"regulation":[108],"as":[109,123,125,150,184,186,207],"contributing":[111],"mechanism":[112,212],"controlling":[113],"expression.":[116],"Induction":[117],"well":[124,185],"fgfr2-luc":[126,144],"activity":[127,145],"also":[129],"observed":[130],"Erbitux,":[132],"an":[133],"EGFR-specific":[134],"monoclonal":[135],"antibody.":[136],"Moreover,":[137],"inhibitors":[138],"c-Src":[140],"MEK":[142],"stimulated":[143,181],"similar":[148],"degree":[149],"suggesting":[152],"these":[154],"pathways":[155],"may":[156,234],"mediate":[157],"EGFR-dependent":[158],"repression":[159],"FGFR3.":[163],"Importantly,":[164],"our":[165],"studies":[166],"demonstrate":[167],"TKI-induced":[170,202],"are":[174],"capable":[175],"mediating":[177],"FGF2":[178],"FGF7":[180],"ERK":[182],"activation":[183],"FGF-stimulated":[187],"transformed":[188],"setting":[192],"TKIs.":[195],"In":[196],"conclusion,":[197],"this":[198],"study":[199],"highlights":[200],"novel":[209],"rapid":[211],"acquired":[214],"TKIs":[218,233],"suggests":[220],"treatment":[222],"patients":[225],"combinations":[227],"FGFR":[231],"be":[235],"strategy":[237],"enhance":[239],"efficacy":[240],"single":[242],"inhibitors.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":18},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}