{"id":"https://openalex.org/W1994071925","doi":"https://doi.org/10.1097/00007890-200112270-00006","title":"CYTOMEGALOVIRUS EARLY PROMOTER INDUCED EXPRESSION OF hCD59 IN PORCINE ORGANS PROVIDES PROTECTION AGAINST HYPERACUTE REJECTION1","display_name":"CYTOMEGALOVIRUS EARLY PROMOTER INDUCED EXPRESSION OF hCD59 IN PORCINE ORGANS PROVIDES PROTECTION AGAINST HYPERACUTE REJECTION1","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W1994071925","doi":"https://doi.org/10.1097/00007890-200112270-00006","mag":"1994071925","pmid":"https://pubmed.ncbi.nlm.nih.gov/11773886"},"language":"en","primary_location":{"id":"doi:10.1097/00007890-200112270-00006","doi":"https://doi.org/10.1097/00007890-200112270-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200112270-00006","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071612299","display_name":"Heiner Niemann","orcid":"https://orcid.org/0000-0003-0282-9704","observed_orcids":["https://orcid.org/0000-0003-0282-9704"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Heiner Niemann","raw_affiliation_strings":["Department of Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten, Mariensee, 31535 Neustadt, Germany","Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee","Heiner Niemann, Department of Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten, Mariensee, 31535 Neustadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten, Mariensee, 31535 Neustadt, Germany","institution_ids":[]},{"raw_affiliation_string":"Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee","institution_ids":[]},{"raw_affiliation_string":"Heiner Niemann, Department of Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten, Mariensee, 31535 Neustadt, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002265683","display_name":"Els Verhoeyen","orcid":"https://orcid.org/0000-0001-9224-5491","observed_orcids":["https://orcid.org/0000-0001-9224-5491"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Els Verhoeyen","raw_affiliation_strings":["Molecular Biotechnology, GBF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biotechnology, GBF","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111803324","display_name":"K Wonigeit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kurt Wonigeit","raw_affiliation_strings":["Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047757604","display_name":"Ralf Lorenz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralf Lorenz","raw_affiliation_strings":["Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045410911","display_name":"Jens Hecker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jens Hecker","raw_affiliation_strings":["Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044703287","display_name":"Reinhard Schwinzer","orcid":"https://orcid.org/0000-0002-9226-4796","observed_orcids":["https://orcid.org/0000-0002-9226-4796"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reinhard Schwinzer","raw_affiliation_strings":["Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091704443","display_name":"H. H\u00e4user","orcid":"https://orcid.org/0000-0002-4418-9859","observed_orcids":["https://orcid.org/0000-0002-4418-9859"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hansj??rg Hauser","raw_affiliation_strings":["Molecular Biotechnology, GBF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biotechnology, GBF","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056220165","display_name":"Wilfried A. Kues","orcid":"https://orcid.org/0000-0002-0850-8103","observed_orcids":["https://orcid.org/0000-0002-0850-8103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wilfried A. Kues","raw_affiliation_strings":["Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087576541","display_name":"Roman Halter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111966","display_name":"Fraunhofer Institute for Toxicology and Experimental Medicine","ror":"https://ror.org/02byjcr11","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]},{"id":"https://openalex.org/I4923324","display_name":"Fraunhofer-Gesellschaft","ror":"https://ror.org/05hkkdn48","country_code":"DE","type":"government","lineage":["https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Roman Halter","raw_affiliation_strings":["Center for Medical Biotechnology, Fraunhofer Institut f\u00fcr Toxikologie und Aerosolforschung"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Medical Biotechnology, Fraunhofer Institut f\u00fcr Toxikologie und Aerosolforschung","institution_ids":["https://openalex.org/I4210111966","https://openalex.org/I4923324"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Erika Lemme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erika Lemme","raw_affiliation_strings":["Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109382722","display_name":"Doris Herrmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Doris Herrmann","raw_affiliation_strings":["Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Winkler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Winkler","raw_affiliation_strings":["Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr Viszeral- und Transplantationschirurgie, D-30625 Medizinische Hochschule","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065508051","display_name":"Dagmar Wirth","orcid":"https://orcid.org/0000-0002-2541-6251","observed_orcids":["https://orcid.org/0000-0002-2541-6251"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dagmar Wirth","raw_affiliation_strings":["Molecular Biotechnology, GBF"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biotechnology, GBF","institution_ids":["https://openalex.org/I4210124929"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110024681","display_name":"Dieter Paul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4923324","display_name":"Fraunhofer-Gesellschaft","ror":"https://ror.org/05hkkdn48","country_code":"DE","type":"government","lineage":["https://openalex.org/I4923324"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dieter Paul","raw_affiliation_strings":["Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee, D-31535 Neustadt","Molecular Biotechnology, GBF, D-38124 Braunschweig","and Center for Medical Biotechnology, Fraunhofer Institut f\u00fcr Toxikologie und Aerosolforschung, D-30625 Hannover, Germany","Braunschweig","Germany","Neustadt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Biotechnology, Institut f\u00fcr Tierzucht und Tierverhalten (FAL) Mariensee, D-31535 Neustadt","institution_ids":[]},{"raw_affiliation_string":"Molecular Biotechnology, GBF, D-38124 Braunschweig","institution_ids":["https://openalex.org/I4210124929"]},{"raw_affiliation_string":"and Center for Medical Biotechnology, Fraunhofer Institut f\u00fcr Toxikologie und Aerosolforschung, D-30625 Hannover, Germany","institution_ids":["https://openalex.org/I4923324"]},{"raw_affiliation_string":"Braunschweig","institution_ids":[]},{"raw_affiliation_string":"Germany","institution_ids":[]},{"raw_affiliation_string":"Neustadt","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071612299"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.1259,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.9382695,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"72","issue":"12","first_page":"1898","last_page":"1906"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12654","display_name":"Xenotransplantation and immune response","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12900","display_name":"Organ and Tissue Transplantation Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd59","display_name":"CD59","score":0.7239999771118164},{"id":"https://openalex.org/keywords/complement-regulatory-proteins","display_name":"complement regulatory proteins","score":0.7910000085830688},{"id":"https://openalex.org/keywords/hyperacute-rejection","display_name":"hyperacute rejection","score":0.8579999804496765},{"id":"https://openalex.org/keywords/porcine-xenotransplantation","display_name":"porcine xenotransplantation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/transgenic-pigs","display_name":"transgenic pigs","score":0.8109999895095825},{"id":"https://openalex.org/keywords/xenoreactive-antibodies","display_name":"xenoreactive antibodies","score":0.7509999871253967},{"id":"https://openalex.org/keywords/complement-mediated-cell-lysis","display_name":"complement-mediated lysis","score":0.9430000185966492},{"id":"https://openalex.org/keywords/kidney-xenotransplantation","display_name":"kidney xenotransplantation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.5630000233650208},{"id":"https://openalex.org/keywords/cell-specific-expression","display_name":"cell-specific expression","score":0.46399998664855957},{"id":"https://openalex.org/keywords/xenotransplantation-immunology","display_name":"xenotransplantation immunology","score":0.6110000014305115}],"concepts":[{"id":"https://openalex.org/C2778442404","wikidata":"https://www.wikidata.org/wiki/Q55505","display_name":"Xenotransplantation","level":3,"score":0.9041932821273804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7083292007446289},{"id":"https://openalex.org/C184404459","wikidata":"https://www.wikidata.org/wiki/Q5009828","display_name":"CD59","level":4,"score":0.6692014336585999},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6662018299102783},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.5906927585601807},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4954015016555786},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.4754997193813324},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.46259039640426636},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4515393078327179},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.3787720799446106},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35256439447402954},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3335835635662079},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.3228040337562561},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12126097083091736},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12019917368888855},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11850297451019287},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001790","descriptor_name":"Blood Physiological Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010477","descriptor_name":"Perfusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016377","descriptor_name":"Organ Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018957","descriptor_name":"CD59 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D030801","descriptor_name":"Animals, Genetically Modified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1097/00007890-200112270-00006","doi":"https://doi.org/10.1097/00007890-200112270-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007890-200112270-00006","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},{"id":"pmid:11773886","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11773886","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"Journal Article"},{"id":"pmh:oai:fraunhofer.de:N-8350","doi":null,"is_oa":false,"landing_page_url":"http://publica.fraunhofer.de/documents/N-8350.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306400801","display_name":"Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Fraunhofer ITA","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/199980","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/199980","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:www.openagrar.de:timport_mods_00036540","doi":null,"is_oa":false,"landing_page_url":"https://www.openagrar.de/receive/timport_mods_00036540","pdf_url":null,"source":{"id":"https://openalex.org/S7407055137","display_name":"OpenAgrar","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W18814673","https://openalex.org/W167429615","https://openalex.org/W1513170871","https://openalex.org/W1522961018","https://openalex.org/W1549680994","https://openalex.org/W1826783215","https://openalex.org/W1916885428","https://openalex.org/W1969345130","https://openalex.org/W1970966609","https://openalex.org/W1974582505","https://openalex.org/W1980900674","https://openalex.org/W1981275517","https://openalex.org/W1992251016","https://openalex.org/W2004933260","https://openalex.org/W2006203423","https://openalex.org/W2007516625","https://openalex.org/W2019799031","https://openalex.org/W2048581545","https://openalex.org/W2054090966","https://openalex.org/W2057235597","https://openalex.org/W2059171126","https://openalex.org/W2065519715","https://openalex.org/W2068608804","https://openalex.org/W2075581948","https://openalex.org/W2078337051","https://openalex.org/W2082359168","https://openalex.org/W2085307337","https://openalex.org/W2086669698","https://openalex.org/W2088549741","https://openalex.org/W2090122012","https://openalex.org/W2092819012","https://openalex.org/W2117539939","https://openalex.org/W2121542842","https://openalex.org/W2134812217","https://openalex.org/W2138009608","https://openalex.org/W2142337841","https://openalex.org/W2147028712","https://openalex.org/W2152232578","https://openalex.org/W2155898643","https://openalex.org/W2167928355","https://openalex.org/W2170234372","https://openalex.org/W2176031043","https://openalex.org/W2342214969","https://openalex.org/W2396126481","https://openalex.org/W4213314525"],"related_works":["https://openalex.org/W2943347759","https://openalex.org/W2067599992","https://openalex.org/W2059171126","https://openalex.org/W1985195336","https://openalex.org/W1973489195","https://openalex.org/W2037732765","https://openalex.org/W1970966609","https://openalex.org/W1998499070","https://openalex.org/W2037565502","https://openalex.org/W2085379066"],"abstract_inverted_index":{"The":[0,16,211],"critical":[1],"shortage":[2],"of":[3,48,68,81,105,116,127,132,147,165,196,207,214,260,286],"human":[4,14,49,60,70,178,200,239],"donor":[5,246],"organs":[6,271],"has":[7],"generated":[8],"growing":[9],"interest":[10],"for":[11,249,273,294],"porcine":[12],"to":[13,20,40,65,189],"xenotransplantation.":[15,258],"major":[17],"immunological":[18],"barrier":[19],"xenotransplantation":[21,274],"is":[22,29,45],"the":[23,42,46,59,69,125,163,174,231,284,287,291],"hyperacute":[24],"rejection":[25],"(HAR)":[26],"response":[27],"that":[28,233,245,283],"mediated":[30,191,241],"by":[31,136],"preformed":[32],"xenoreactive":[33,177],"antibodies":[34,179],"and":[35,99,112,119,144,151,157,180,243,275],"complement.":[36],"A":[37,79,139],"promising":[38],"strategy":[39],"control":[41,184],"complement":[43,50,71,181,190,240],"activation,":[44],"expression":[47,67,104,133,141,268],"regulatory":[51,72],"proteins":[52],"in":[53,76,107,114,124,142,256,269],"transgenic":[54,77,84,92,148,166,215,248,263],"animals.":[55],"We":[56],"have":[57],"used":[58],"early":[61],"cytomegalovirus":[62],"(CMV)":[63],"promoter":[64],"drive":[66],"protein":[73],"CD59":[74],"(hCD59)":[75],"pigs.":[78],"total":[80],"eight":[82],"live":[83],"founder":[85],"animals":[86,115],"was":[87,134,153,217],"born":[88],"from":[89,162],"which":[90],"five":[91,261],"lines":[93,117,149,264],"could":[94,251],"be":[95],"established.":[96],"mRNA":[97],"analysis":[98],"Western":[100],"blotting":[101],"revealed":[102,202],"high":[103],"hCD59":[106,208,234,250,262,267],"heart,":[108],"kidney,":[109],"skeletal":[110],"muscle,":[111],"skin":[113],"1":[118,150],"5,":[120],"as":[121,123],"well":[122],"pancreas":[126],"four":[128],"lines.":[129],"This":[130,281],"pattern":[131],"confirmed":[135],"immunhistological":[137],"staining.":[138],"cell-specific":[140],"heart":[143],"kidney":[145],"tissue":[146],"5":[152],"determined.":[154],"Primary":[155],"fibroblasts":[156],"endothelial":[158],"cell":[159],"cultures":[160],"derived":[161],"aorta":[164],"pigs":[167,247],"showed":[168,265],"a":[169,203,253,276],"significantly":[170,218],"diminished":[171],"sensitivity":[172],"against":[173,209,238,279],"challenge":[175],"with":[176,198],"whereas":[182],"non-transgenic":[183],"cells":[185,237],"were":[186],"highly":[187],"susceptible":[188],"lysis.":[192],"Ex":[193],"vivo":[194],"perfusion":[195],"kidneys":[197,216],"pooled":[199],"blood":[201],"significant":[204],"protective":[205,277],"effect":[206,278],"HAR.":[210,280],"average":[212],"survival":[213],"extended":[219],"(P<0.05)":[220],"over":[221],"nontransgenic":[222],"controls":[223],"(207.5+/-54.6":[224],"vs.":[225],"57.5+/-64.5":[226],"min).":[227],"These":[228],"data":[229],"support":[230],"concept":[232],"protects":[235],"nonprimate":[236],"lysis":[242],"suggest":[244],"play":[252],"crucial":[254],"role":[255],"clinical":[257],"Two":[259],"strong":[266],"several":[270],"relevant":[272],"indicates":[282],"use":[285],"CMV-promoter":[288],"can":[289],"facilitate":[290],"selection":[292],"process":[293],"optimized":[295],"transgene":[296],"expression.":[297]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
