{"id":"https://openalex.org/W1994051782","doi":"https://doi.org/10.1037//0735-7044.97.5.759","title":"Anticipatory hyperexcitability and tolerance to the narcotizing effect of morphine in the rat.","display_name":"Anticipatory hyperexcitability and tolerance to the narcotizing effect of morphine in the rat.","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W1994051782","doi":"https://doi.org/10.1037//0735-7044.97.5.759","mag":"1994051782","pmid":"https://pubmed.ncbi.nlm.nih.gov/6685524"},"language":"en","primary_location":{"id":"doi:10.1037//0735-7044.97.5.759","doi":"https://doi.org/10.1037//0735-7044.97.5.759","is_oa":false,"landing_page_url":"https://doi.org/10.1037//0735-7044.97.5.759","pdf_url":null,"source":{"id":"https://openalex.org/S25269534","display_name":"Behavioral Neuroscience","issn_l":"0735-7044","issn":["0735-7044","1939-0084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320262","host_organization_name":"American Psychological Association","host_organization_lineage":["https://openalex.org/P4310320262"],"host_organization_lineage_names":["American Psychological Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioral Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037764642","display_name":"Riley E. Hinson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Riley E. Hinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074692242","display_name":"Shepard Siegel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shepard Siegel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2577,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.75331272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"97","issue":"5","first_page":"759","last_page":"767"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9404000043869019,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.027499999850988388,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/morphine-tolerance","display_name":"morphine tolerance","score":0.9319999814033508},{"id":"https://openalex.org/keywords/classical-conditioning","display_name":"classical conditioning","score":0.9549999833106995},{"id":"https://openalex.org/keywords/withdrawal-symptoms","display_name":"withdrawal symptoms","score":0.7739999890327454},{"id":"https://openalex.org/keywords/opioid-tolerance","display_name":"opioid tolerance","score":0.3580000102519989}],"concepts":[{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.8887002468109131},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6114098429679871},{"id":"https://openalex.org/C45262634","wikidata":"https://www.wikidata.org/wiki/Q5159291","display_name":"Conditioning","level":2,"score":0.5927980542182922},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4620164632797241},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4583247900009155},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.4536144733428955},{"id":"https://openalex.org/C39617858","wikidata":"https://www.wikidata.org/wiki/Q212737","display_name":"Classical conditioning","level":3,"score":0.44444137811660767},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4063189625740051},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3134470582008362},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003214","descriptor_name":"Conditioning, Classical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003463","descriptor_name":"Cues","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004361","descriptor_name":"Drug Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004644","descriptor_name":"Emotions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009021","descriptor_name":"Morphine Dependence","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":true},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013375","descriptor_name":"Substance Withdrawal Syndrome","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1037//0735-7044.97.5.759","doi":"https://doi.org/10.1037//0735-7044.97.5.759","is_oa":false,"landing_page_url":"https://doi.org/10.1037//0735-7044.97.5.759","pdf_url":null,"source":{"id":"https://openalex.org/S25269534","display_name":"Behavioral Neuroscience","issn_l":"0735-7044","issn":["0735-7044","1939-0084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320262","host_organization_name":"American Psychological Association","host_organization_lineage":["https://openalex.org/P4310320262"],"host_organization_lineage_names":["American Psychological Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioral Neuroscience","raw_type":"journal-article"},{"id":"doi:10.1037/0735-7044.97.5.759","doi":"https://doi.org/10.1037/0735-7044.97.5.759","is_oa":false,"landing_page_url":"https://doi.org/10.1037/0735-7044.97.5.759","pdf_url":null,"source":{"id":"https://openalex.org/S25269534","display_name":"Behavioral Neuroscience","issn_l":"0735-7044","issn":["0735-7044","1939-0084"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320262","host_organization_name":"American Psychological Association","host_organization_lineage":["https://openalex.org/P4310320262"],"host_organization_lineage_names":["American Psychological Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioral Neuroscience","raw_type":"journal-article"},{"id":"pmid:6685524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6685524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Behavioral neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W81951410","https://openalex.org/W1932021207","https://openalex.org/W1966606339","https://openalex.org/W2006503862","https://openalex.org/W2027918721","https://openalex.org/W2031380954","https://openalex.org/W2053322498","https://openalex.org/W2053759256","https://openalex.org/W2084670192","https://openalex.org/W2084870626","https://openalex.org/W2501139372","https://openalex.org/W2892983187","https://openalex.org/W2909517775"],"related_works":["https://openalex.org/W2114733914","https://openalex.org/W1979992848","https://openalex.org/W7213634781","https://openalex.org/W1586422649","https://openalex.org/W2063918049","https://openalex.org/W7115809913","https://openalex.org/W2031380954","https://openalex.org/W2008101913","https://openalex.org/W2002632297","https://openalex.org/W2045105543"],"abstract_inverted_index":{"The":[0],"role":[1],"of":[2,11,15,28,38,49,74,77,87,99,133],"Pavlovian":[3],"conditioning":[4],"in":[5,17,47,62,69,84,130],"tolerance":[6],"to":[7,95,159],"the":[8,18,53,70,85,88,96,118,131,134],"narcotizing":[9,97],"effect":[10,98],"a":[12,57],"high":[13],"dose":[14],"morphine":[16,29,67,100],"rat":[19],"was":[20,45],"examined.":[21],"Initially,":[22],"two":[23,33,50],"groups":[24,34,64],"received":[25,35,65],"nine":[26,36],"injections":[27,37,68],"(40":[30],"mg/kg),":[31],"and":[32,151],"saline.":[39],"One":[40],"group":[41],"administered":[42],"each":[43],"substance":[44],"injected":[46],"one":[48],"distinctive":[51,58,71],"environments:":[52],"animal":[54],"colony":[55],"or":[56],"room.":[59,72],"Subsequently,":[60],"rats":[61,82,102,115,128],"all":[63],"five":[66],"Analyses":[73],"videotape":[75],"records":[76],"postinjection":[78],"behavior":[79,126],"indicated":[80],"that":[81,143,154],"tested":[83,103,116,129],"presence":[86],"usual":[89,119,135],"predrug":[90,120,136],"cues":[91,105,121],"were":[92],"more":[93,123],"tolerant":[94],"than":[101,127],"with":[104,111,117],"different":[106],"from":[107],"those":[108],"previously":[109],"associated":[110],"morphine.":[112],"In":[113],"addition,":[114],"exhibited":[122],"anticipatory":[124],"\"hyperexcitable\"":[125],"absence":[132],"cues.":[137],"These":[138],"results":[139],"provide":[140],"further":[141],"evidence":[142],"compensatory":[144],"pharmacological":[145],"conditional":[146],"responses":[147,157],"partially":[148],"mediate":[149],"tolerance,":[150],"they":[152],"suggest":[153],"these":[155],"drug-anticipatory":[156],"contribute":[158],"so-called":[160],"\"withdrawal":[161],"symptoms.\"":[162]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}