{"id":"https://openalex.org/W1994045265","doi":"https://doi.org/10.1111/j.8755-8920.2001.450404.x","title":"Plasma Antiviral Activity and Interferon\u2010\u03b3 Production by Superantigen\u2010stimulated Lymphocytes during Normal Human Pregnancy","display_name":"Plasma Antiviral Activity and Interferon\u2010\u03b3 Production by Superantigen\u2010stimulated Lymphocytes during Normal Human Pregnancy","publication_year":2001,"publication_date":"2001-04-01","ids":{"openalex":"https://openalex.org/W1994045265","doi":"https://doi.org/10.1111/j.8755-8920.2001.450404.x","mag":"1994045265","pmid":"https://pubmed.ncbi.nlm.nih.gov/11327548"},"language":"en","primary_location":{"id":"doi:10.1111/j.8755-8920.2001.450404.x","doi":"https://doi.org/10.1111/j.8755-8920.2001.450404.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.8755-8920.2001.450404.x","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061049828","display_name":"Giovanni Grasso","orcid":"https://orcid.org/0000-0001-5362-0092","observed_orcids":["https://orcid.org/0000-0001-5362-0092","https://orcid.org/0000-0002-8246-0283"]},"institutions":[{"id":"https://openalex.org/I102064193","display_name":"University of Siena","ror":"https://ror.org/01tevnk56","country_code":"IT","type":"education","lineage":["https://openalex.org/I102064193"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"GIOVANNI GRASSO","raw_affiliation_strings":["Department of Biomedical Science, University of Siena, Italy. grasso@unisi.it","Department of Biomedical Science, University of Siena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Science, University of Siena, Italy. grasso@unisi.it","institution_ids":["https://openalex.org/I102064193"]},{"raw_affiliation_string":"Department of Biomedical Science, University of Siena, Italy","institution_ids":["https://openalex.org/I102064193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003071058","display_name":"Lauretta Massai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"LAURETTA MASSAI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031326001","display_name":"Pierluigi Migliaccio","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"PIERLUIGI MIGLIACCIO","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058699619","display_name":"Enrico Picciolini","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"ENRICO PICCIOLINI","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111836168","display_name":"Michela Muscettola","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MICHELA MUSCETTOLA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5061049828"],"corresponding_institution_ids":["https://openalex.org/I102064193"],"apc_list":{"value":4460,"currency":"USD","value_usd":4460},"apc_paid":null,"fwci":0.1046,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.42406696,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"4","first_page":"217","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11290","display_name":"Preterm Birth and Chorioamnionitis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9419999718666077},{"id":"https://openalex.org/keywords/superantigen-stimulation","display_name":"superantigen stimulation","score":0.6639999747276306},{"id":"https://openalex.org/keywords/staphylococcal-enterotoxin-a","display_name":"staphylococcal enterotoxin A","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.597000002861023},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.8730000257492065},{"id":"https://openalex.org/keywords/vesicular-stomatitis-virus","display_name":"vesicular stomatitis virus","score":0.781000018119812},{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.6520000100135803},{"id":"https://openalex.org/keywords/cytokine-downregulation","display_name":"cytokine downregulation","score":0.734000027179718}],"concepts":[{"id":"https://openalex.org/C137061746","wikidata":"https://www.wikidata.org/wiki/Q736033","display_name":"Peripheral blood mononuclear cell","level":3,"score":0.7765679955482483},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.7121076583862305},{"id":"https://openalex.org/C2779057330","wikidata":"https://www.wikidata.org/wiki/Q162762","display_name":"Vesicular stomatitis virus","level":3,"score":0.6940044164657593},{"id":"https://openalex.org/C36333154","wikidata":"https://www.wikidata.org/wiki/Q772950","display_name":"Superantigen","level":4,"score":0.5492467880249023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5396613478660583},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5291536450386047},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.47265613079071045},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.4615016579627991},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4022689759731293},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39886757731437683},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3874417841434479},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37054476141929626},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.34524863958358765},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.30904287099838257},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2629048824310303},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2211644947528839},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.13037890195846558},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011256","descriptor_name":"Pregnancy Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011264","descriptor_name":"Pregnancy Trimesters","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018089","descriptor_name":"Superantigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.8755-8920.2001.450404.x","doi":"https://doi.org/10.1111/j.8755-8920.2001.450404.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.8755-8920.2001.450404.x","pdf_url":null,"source":{"id":"https://openalex.org/S84272931","display_name":"American Journal of Reproductive Immunology","issn_l":"0271-7352","issn":["0271-7352","1046-7408","1600-0897","2374-8184","2374-8192","8755-8920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Reproductive Immunology","raw_type":"journal-article"},{"id":"pmid:11327548","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11327548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of reproductive immunology (New York, N.Y. : 1989)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1993389644","https://openalex.org/W2025810032","https://openalex.org/W1972662701","https://openalex.org/W1972958332","https://openalex.org/W7097417666","https://openalex.org/W2108599038","https://openalex.org/W2040048976","https://openalex.org/W2314171132","https://openalex.org/W2045705845","https://openalex.org/W2058216319"],"abstract_inverted_index":{"PROBLEM:":[0],"Plasma":[1],"interferon":[2],"(IFN)-beta":[3],"levels,":[4],"lymphocyte":[5],"responsiveness,":[6],"and":[7,17,25,47,73,115,183,186],"evaluation":[8],"of":[9,32,36,49,70,80,89,144,168,178],"the":[10,30,34,90,101,129,176],"relationship":[11],"between":[12],"circulating":[13],"antiviral":[14],"activity":[15,117],"(AA)":[16],"IFN-gamma":[18,37,114,140,155,169],"production":[19,38,156],"were":[20,82],"studied":[21],"in":[22,39,84,100,123],"pregnant":[23,65,124,135],"women":[24,66,125,136],"nonpregnant":[26,76,145],"age-matched":[27,77],"controls":[28],"with":[29,57,67,154],"objective":[31],"elucidating":[33],"downregulation":[35,167],"successful":[40,164],"pregnancy.":[41],"METHOD":[42],"OF":[43],"STUDY:":[44],"In":[45],"plasma":[46,110,149],"supernatants":[48],"peripheral":[50],"blood":[51],"mononuclear":[52],"cell":[53,104],"(PBMC)":[54],"cultures,":[55],"stimulated":[56],"staphylococcal":[58],"enterotoxin":[59],"A":[60],"(SEA)":[61],"superantigen,":[62],"from":[63,134],"43":[64],"a":[68,85],"history":[69],"normal":[71],"pregnancy":[72,165,179,188],"30":[74],"healthy":[75],"controls,":[78],"levels":[79,141,151],"AA":[81,111,150],"measured":[83],"micromethod":[86],"by":[87,95,157],"inhibition":[88],"cytopathic":[91],"effect":[92],"(CPE)":[93],"caused":[94],"vesicular":[96],"stomatitis":[97],"virus":[98],"(VSV)":[99],"human":[102,187],"amnionic":[103],"line":[105],"(WISH).":[106],"RESULTS:":[107],"Significantly":[108],"higher":[109],"(60%":[112],"was":[113,118,121],"residual":[116],"acid-labile":[119],"IFN-like)":[120],"present":[122],"than":[126,142],"controls.":[127],"On":[128],"other":[130],"hand,":[131],"SEA-activated":[132],"PBMCs":[133],"produced":[137],"significantly":[138],"lower":[139],"those":[143],"women.":[146],"Furthermore,":[147],"maternal":[148],"correlated":[152],"negatively":[153],"SEA-stimulated":[158],"PBMCs.":[159],"CONCLUSION:":[160],"The":[161],"hypothesis":[162],"that":[163,175,184],"requires":[166],"is":[170,180],"only":[171],"partially":[172],"sustained,":[173],"suggesting":[174],"immunology":[177],"more":[181],"complex":[182],"murine":[185],"have":[189],"different":[190],"cytokine":[191],"profiles.":[192]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
