{"id":"https://openalex.org/W1994041909","doi":"https://doi.org/10.1111/j.1474-8673.1981.tb00508.x","title":"STUDIES ON THE PRE\u2010 AND POSTJUNCTIONAL ACTIVITIES OF \u03b1\u2010ADRENORECEPTOR AGONISTS AND THEIR CARDIOVASCULAR EFFECTS IN THE ANAESTHETIZED RAT","display_name":"STUDIES ON THE PRE\u2010 AND POSTJUNCTIONAL ACTIVITIES OF \u03b1\u2010ADRENORECEPTOR AGONISTS AND THEIR CARDIOVASCULAR EFFECTS IN THE ANAESTHETIZED RAT","publication_year":1981,"publication_date":"1981-03-01","ids":{"openalex":"https://openalex.org/W1994041909","doi":"https://doi.org/10.1111/j.1474-8673.1981.tb00508.x","mag":"1994041909","pmid":"https://pubmed.ncbi.nlm.nih.gov/6121811"},"language":"en","primary_location":{"id":"doi:10.1111/j.1474-8673.1981.tb00508.x","doi":"https://doi.org/10.1111/j.1474-8673.1981.tb00508.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1474-8673.1981.tb00508.x","pdf_url":null,"source":{"id":"https://openalex.org/S103683400","display_name":"Journal of Autonomic Pharmacology","issn_l":"0144-1795","issn":["0144-1795","1365-2680"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autonomic Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017451755","display_name":"John C. Doxey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268051","display_name":"Reckitt Benckiser Health Limited (United Kingdom)","ror":"https://ror.org/05jqjhm27","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268051"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"J. C. DOXEY","raw_affiliation_strings":["Reckitt and Colman Pharmaceutical Division, Dansom Lane, Hull HU8 7DS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reckitt and Colman Pharmaceutical Division, Dansom Lane, Hull HU8 7DS","institution_ids":["https://openalex.org/I4405268051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022560585","display_name":"Leonie W. Frank","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268051","display_name":"Reckitt Benckiser Health Limited (United Kingdom)","ror":"https://ror.org/05jqjhm27","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268051"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"LEONIE W. FRANK","raw_affiliation_strings":["Reckitt and Colman Pharmaceutical Division, Dansom Lane, Hull HU8 7DS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reckitt and Colman Pharmaceutical Division, Dansom Lane, Hull HU8 7DS","institution_ids":["https://openalex.org/I4405268051"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041814400","display_name":"Andrew Hersom","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405268051","display_name":"Reckitt Benckiser Health Limited (United Kingdom)","ror":"https://ror.org/05jqjhm27","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268051"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. S. HERSOM","raw_affiliation_strings":["Reckitt and Colman Pharmaceutical Division, Dansom Lane, Hull HU8 7DS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Reckitt and Colman Pharmaceutical Division, Dansom Lane, Hull HU8 7DS","institution_ids":["https://openalex.org/I4405268051"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4405268051"],"apc_list":null,"apc_paid":null,"fwci":1.481,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.80148678,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"1","issue":"2","first_page":"157","last_page":"169"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9814000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.009499999694526196,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha1-adrenergic-receptors","display_name":"alpha1-adrenoceptors","score":0.6769999861717224},{"id":"https://openalex.org/keywords/alpha2-adrenergic-receptors","display_name":"alpha2-adrenoceptors","score":1.0},{"id":"https://openalex.org/keywords/receptor-selectivity","display_name":"receptor selectivity","score":0.8709999918937683},{"id":"https://openalex.org/keywords/presynaptic-alpha2-adrenoceptors","display_name":"presynaptic alpha2-adrenoceptors","score":0.871999979019165},{"id":"https://openalex.org/keywords/cardiovascular-effects","display_name":"cardiovascular effects","score":0.7099999785423279},{"id":"https://openalex.org/keywords/clonidine","display_name":"clonidine","score":0.8180000185966492},{"id":"https://openalex.org/keywords/guanabenz","display_name":"guanabenz","score":0.9760000109672546},{"id":"https://openalex.org/keywords/oxymetazoline","display_name":"oxymetazoline","score":0.968999981880188},{"id":"https://openalex.org/keywords/naphazoline","display_name":"naphazoline","score":0.8159999847412109},{"id":"https://openalex.org/keywords/lofexidine","display_name":"lofexidine","score":0.8090000152587891},{"id":"https://openalex.org/keywords/st-91","display_name":"ST-91","score":0.8059999942779541},{"id":"https://openalex.org/keywords/pressor-response","display_name":"pressor response","score":0.7860000133514404},{"id":"https://openalex.org/keywords/heart-rate-reduction","display_name":"heart rate reduction","score":0.7319999933242798},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.9279999732971191},{"id":"https://openalex.org/keywords/vas-deferens","display_name":"vas deferens","score":0.6959999799728394},{"id":"https://openalex.org/keywords/anococcygeus-muscle","display_name":"anococcygeus muscle","score":0.9959999918937683}],"concepts":[{"id":"https://openalex.org/C2778680573","wikidata":"https://www.wikidata.org/wiki/Q5613542","display_name":"Guanabenz","level":4,"score":0.9617843627929688},{"id":"https://openalex.org/C2778399450","wikidata":"https://www.wikidata.org/wiki/Q412221","display_name":"Clonidine","level":2,"score":0.890740156173706},{"id":"https://openalex.org/C2780042274","wikidata":"https://www.wikidata.org/wiki/Q417813","display_name":"Oxymetazoline","level":4,"score":0.7749214172363281},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6197877526283264},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5029997229576111},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.4857809841632843},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47402647137641907},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4656335413455963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41679757833480835},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4142951965332031},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33014634251594543},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3229061961174011},{"id":"https://openalex.org/C40465926","wikidata":"https://www.wikidata.org/wiki/Q410568","display_name":"Adrenergic receptor","level":3,"score":0.21718978881835938},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.19229987263679504},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09680542349815369}],"mesh":[{"descriptor_ui":"D000316","descriptor_name":"Adrenergic alpha-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000758","descriptor_name":"Anesthesia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009469","descriptor_name":"Neuromuscular Junction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014649","descriptor_name":"Vas Deferens","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1474-8673.1981.tb00508.x","doi":"https://doi.org/10.1111/j.1474-8673.1981.tb00508.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1474-8673.1981.tb00508.x","pdf_url":null,"source":{"id":"https://openalex.org/S103683400","display_name":"Journal of Autonomic Pharmacology","issn_l":"0144-1795","issn":["0144-1795","1365-2680"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Autonomic Pharmacology","raw_type":"journal-article"},{"id":"pmid:6121811","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6121811","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of autonomic pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1488521817","https://openalex.org/W1968005818","https://openalex.org/W1977914280","https://openalex.org/W1978977259","https://openalex.org/W1988933381","https://openalex.org/W1996011703","https://openalex.org/W1997130326","https://openalex.org/W2001433408","https://openalex.org/W2008632370","https://openalex.org/W2018108226","https://openalex.org/W2037612564","https://openalex.org/W2041376819","https://openalex.org/W2055580944","https://openalex.org/W2094399653","https://openalex.org/W2411725376","https://openalex.org/W2495434357"],"related_works":["https://openalex.org/W2001569974","https://openalex.org/W4390731149","https://openalex.org/W1998680340","https://openalex.org/W2056803212","https://openalex.org/W1983898286","https://openalex.org/W1990829367","https://openalex.org/W1984840840","https://openalex.org/W4242194979","https://openalex.org/W2441378737","https://openalex.org/W1980753781"],"abstract_inverted_index":{"1":[0],"The":[1,76,95],"selectivity":[2,89],"of":[3,6,79,90,166,191,217],"a":[4,120,210],"number":[5],"agonists":[7],"for":[8,71],"peripheral":[9],"alpha":[10,13,32,36,73,207],"1-":[11],"and":[12,18,34,46,53,63,112,119,127,135,145,169,176,195,219],"2-":[14,33],"adrenoreceptors":[15],"was":[16,39,83,142,183],"determined":[17,40],"related":[19,220],"to":[20,85,99,108],"their":[21],"cardiovascular":[22],"effects":[23,216],"in":[24,93,102,139,173,202,213],"pentobarbitone-anaesthetized":[25,109],"rats.":[26],"2":[27],"In":[28,124,179],"isolated":[29],"tissues,":[30],"presynaptic":[31,72],"postsynaptic":[35],"1-adrenoreceptor":[37],"activity":[38],"on":[41],"the":[42,80,87,91,136,203,214],"rat":[43,82],"vas":[44],"deferens":[45],"anococcygeus":[47,77],"muscle":[48,78],"respectively.":[49],"Xylazine,":[50],"guanabenz,":[51],"guanoxabenz":[52],"guanfacin":[54,113,170],"were":[55,66,97],"more":[56],"selective,":[57],"whilst":[58],"lofexidine,":[59],"tiamenidine,":[60],"naphazoline,":[61],"oxymetazoline":[62,126,194],"St":[64,128,192],"91":[65,129],"less":[67],"selective":[68],"than":[69],"clonidine":[70,218],"2-adrenoreceptors.":[74],"3":[75],"pithed":[81],"used":[84],"determine":[86],"alpha-adrenoreceptor":[88],"compounds":[92,158],"vivo.":[94],"selectivities":[96],"similar":[98],"those":[100],"obtained":[101],"vitro.":[103],"4":[104],"Following":[105],"intravenous":[106],"administration":[107,165,190],"rats":[110],"guanabenz":[111,168],"caused":[114],"small":[115],"transient":[116],"pressor":[117,133,150],"responses":[118,134,151],"prolonged":[121],"secondary":[122,137,154],"hypotension.":[123],"contrast":[125,180],"produced":[130,147],"marked":[131,148],"initial":[132,149],"reduction":[138],"blood":[140,174,181],"pressure":[141,175,182],"absent.":[143],"Clonidine":[144],"tiamenidine":[146],"followed":[152],"by":[153],"hypotensive":[155,215],"effects.":[156],"All":[157],"reduced":[159],"heart":[160,177],"rate.":[161,178],"5":[162],"Intracerebroventricular":[163],"(i.c.v.)":[164],"clonidine,":[167],"elicited":[171],"falls":[172],"either":[184],"unaffected":[185],"or":[186],"elevated":[187],"following":[188],"i.c.v.":[189],"91,":[193],"tiamenidine.":[196],"6":[197],"It":[198],"is":[199],"concluded":[200],"that":[201],"normotensive":[204],"rat,":[205],"central":[206],"2-adrenoreceptors":[208],"play":[209],"major":[211],"role":[212],"compounds.":[221]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
